Category: 33697-81-3

Kuchar, Miroslav published the artcileQuantitative relationships between the structure and inhibition of aggregation of thrombocytes in the group of arylaliphatic acids, Computed Properties of 33697-81-3, the publication is Cesko-Slovenska Farmacie (1983), 32(3-4), 116-21, database is CAplus and MEDLINE.

The distribution coefficients (P) of 51 previously prepared arylaliph. acids (I, II, III; R = H or Me; X = alkyl or alicyclic hydrocarbon, H, OH, alkoxy or halogenated hydrocarbon) were determined in an n-octanol-H₂O system or calculated from data available in the literature. The activity of the compounds in inhibiting the collagen-induced aggregation of human thrombocytes (C^A) was determined by comparison with that of ibuprofen. For the compounds having hydroxy or alkoxy substituents on the aryl group, the correlation between lipophilicity (log P) and the relative inhibitory activity (C^A) was described by the equation log (1/C^A) = 0.817 + 1.255 log P-0.167 (log P)²; for the remaining compounds, the equation was log (1/C^A) = 1.307 + 0.383 log P. The antiaggregative activity decreased with increasing chain length between the carboxyl and Ph groups. The activity increased in compounds with a branch on the acid α-carbon.

Cesko-Slovenska Farmacie published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Computed Properties of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gaglione, Maria published the artcileTuning RNA Interference by Enhancing siRNA/PAZ Recognition, Quality Control of 33697-81-3, the publication is ACS Medicinal Chemistry Letters (2013), 4(1), 75-78, database is CAplus and MEDLINE.

Chem. modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theor. data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.

ACS Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nongmaithem, Sapana published the artcileEnhanced Polar Auxin Transport in Tomato Polycotyledon Mutant Seems to be Related to Glutathione Levels, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Plant Growth Regulation (2021), 40(2), 761-773, database is CAplus.

Glutathione-dependent root growth in Arabidopsis is linked to polar auxin transport (PAT). Arabidopsis mutants with reduced glutathione (GSH) levels also show reduced PAT. To gain an insight into the relationship between PAT and GSH level, we analyzed tomato polycotyledon mutant, pct1-2, which has enhanced PAT. Microarray anal. of gene expression in pct1-2 mutant revealed underexpression of several genes related to glutamate and glutathione metabolism In consonance with microarray anal., enzymic as well as in vivo assay revealed higher glutathione levels in the early phase of pct1-2 seedling growth than WT. The inhibition of auxin transport by 2,3,5-triiodobenzoic acid (TIBA) reduced both GSH level and PIN1 expression in pct1-2 root tips. The reduction of in vivo GSH accumulation in pct1-2 root tips by buthionine sulfoximine (BSO) stimulated elongation of the short root of pct1-2 mutant akin to TIBA. The rescue of the short root phenotype of the pct1-2 mutant was restricted to TIBA and BSO. The other auxin transport inhibitors 1-N-naphthylphthalamic acid (NPA), 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid (BUM), 3-chloro-4-hydroxyphenylacetic acid (CHPAA), brefeldin and gravacin inhibited root elongation in both WT and pct1-2 mutant. Our results indicate a relationship between PAT and GSH levels in tomato akin to Arabidopsis. Our work also highlights that TIBA rescues the short root phenotype of the pct1-2 mutant by acting on a PAT component distinct from the site of action of other PAT inhibitors.

Journal of Plant Growth Regulation published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Doobary, Sayad published the artcileIntramolecular Alkene Fluoroarylation of Phenolic Ethers enabled by Electrochemically Generated Iodane, COA of Formula: C8H7ClO3, the publication is Journal of Organic Chemistry (2021), 86(22), 16095-16103, database is CAplus and MEDLINE.

Herein, synthesis of 3-fluorinated chromanes from allylic phenol ethers was described. Oxidant-free approach takes advantage of an electrochem. generation of a hypervalent iodine species, difluoro-λ³-tolyl iodane, which mediates the alkene fluoroarylation. High yields and selectivity for this transformation are achieved for electron poor substrates. The redox chem. has been characterized for the electrochem. generation of the iodane in the presence of fluoride, and insights into the mechanism are given. The transformation has been demonstrated on larger gram scales, which represents the potential broader utility of the process.

Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davis, Rohan A. published the artcileSynthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide, Related Products of chlorides-buliding-blocks, the publication is Magnetic Resonance in Chemistry (2007), 45(5), 442-445, database is CAplus and MEDLINE.

Parallel solution-phase chem. has yielded a series of secondary amide analogs of the fungal natural product 3-chloro-4-hydroxyphenylacetamide. 3-Chloro-4-hydroxyphenylacetic acid was coupled to a variety of primary amines using 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification All analogs were spectroscopically characterized using NMR, UV, IR and MS data. One compound displayed moderate cytotoxicity against the human melanoma and prostate cell lines, MM96L and DU145.

Magnetic Resonance in Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Perez-Rodriguez, Santiago published the artcileHighly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles, SDS of cas: 33697-81-3, the publication is European Journal of Medicinal Chemistry (2009), 44(6), 2434-2446, database is CAplus and MEDLINE.

I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) and II (R = H, MeOCH₂CH₂OCH₂) are prepared as novel adamantyl biaryl arotinoids with decreased binding to retinoic acid receptors but with anticancer activity (by selective induction of apoptosis in cancer cells). I and II are prepared using Suzuki coupling reactions of an adamantylphenylboronic acid with a trifloxyphenylacetate, a trifloxycinnamate, and a trifloxynaphthoate. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) show significant antiproliferative activity in several human cancer cell lines, with the anticancer activity correlated to the induction of apoptosis as measured by caspase activity. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH), while devoid of retinoic acid receptor binding capacity, transactivate the retinoid X receptor α.

European Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aspuria, E. T. published the artcileGFP accumulation controlled by an auxin-responsive promoter as a non-destructive assay to monitor early auxin response, HPLC of Formula: 33697-81-3, the publication is Plant Cell Reports (2002), 21(1), 52-57, database is CAplus.

We have constructed transgenic Arabidopsis lines that contain a gene for green fluorescent protein (GFP) under the control of auxin-responsive domains A and B of the promoter from the pea PS-IAA4/5 gene. The chimeric transgene was named BA-mgfp5-ER. GFP was detected after the application of indole-3-acetic acid at concentrations as low as 100 nM in epidermal cells in the root elongation zone. The induction of the reporter gene was highly specific to auxin and was correlated with the auxin-induced change in epidermal cell shape. No GFP accumulation was observed in the lateral root meristem that was formed as a result of exogenous auxin application. These results suggest that auxin signals were transmitted through several distinct pathways depending on the cell type. The intensity of the GFP signal was strong enough to be observed through the plastic lid of the culture dish using a dissecting microscope, thereby enabling GFP expression to be monitored in an aseptic environment. Thus, the BA-mgfp5-ER transgenic plant can be a powerful tool for screening mutants that are defective in auxin signaling and the expression of early auxin-response genes.

Plant Cell Reports published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, HPLC of Formula: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sauerberg, Per published the artcileIdentification and Synthesis of a Novel Selective Partial PPARδ Agonist with Full Efficacy on Lipid Metabolism In Vitro and In Vivo, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Medicinal Chemistry (2007), 50(7), 1495-1503, database is CAplus and MEDLINE.

The aim was to identify a novel selective PPARδ agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo. Using the triple PPARα,γ,δ agonist 1 (I) as the structural starting point, we wanted to investigate the possibility of obtaining selective PPARδ agonists by modifying only the acidic part of 1, while holding the lipophilic half of the mol. constant The structure-activity relationship was guided by in vitro transactivation data using the human PPAR receptors, FFA oxidation efficacy performed in the rat muscle L6 cell line, and in vivo rat pharmacokinetic properties. Compound 7 ([4-[3,3-bis-(4-bromo-phenyl)-allylthio]-2-chloro-phenoxy]-acetic acid) was identified as a selective, partial agonist with good oral pharmacokinetic properties in rat. Chronic treatment of high fat fed ApoB100/CETP-Tgn mice with 7 corrected the plasma lipid parameters and improved insulin sensitivity. These data suggest that selective PPARδ agonists have the potential to become a novel treatment of dyslipidemia.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wakatake, Takanori published the artcileAn auxin transport network underlies xylem bridge formation between the hemi-parasitic plant Phtheirospermum japonicum and host Arabidopsis, Product Details of C8H7ClO3, the publication is Development (Cambridge, United Kingdom) (2020), 147(14), dev187781, database is CAplus and MEDLINE.

Parasitic plants form vascular connections with host plants for efficient material transport. The haustorium is the responsible organ for host invasion and subsequent vascular connection. After invasion of host tissues, vascular meristem-like cells emerge in the central region of the haustorium, differentiate into tracheary elements and establish a connection, known as a xylem bridge, between parasite and host xylem systems. Despite the importance of this parasitic connection, the regulatory mechanisms of xylem bridge formation are unknown. Here, we show the role of auxin and auxin transporters during the process of xylem bridge formation using an Orobanchaceae hemiparasitic plant, Phtheirospermum japonicum. The auxin response marker DR5 has a similar expression pattern to tracheary element differentiation genes in haustoria. Auxin transport inhibitors alter tracheary element differentiation in haustoria, but biosynthesis inhibitors do not, demonstrating the importance of auxin transport during xylem bridge formation. The expression patterns and subcellular localization of PIN family auxin efflux carriers and AUX1/LAX influx carriers correlate with DR5 expression patterns. The cooperative action of auxin transporters is therefore responsible for controlling xylem vessel connections between parasite and host.

Development (Cambridge, United Kingdom) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C6H4ClNO2, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shimamura, Satoshi published the artcileEffects of anti-auxins on secondary aerenchyma formation in flooded soybean hypocotyls, SDS of cas: 33697-81-3, the publication is Plant Production Science (2016), 19(1), 154-160, database is CAplus.

In flooded hypocotyl of soybean (Glycine max), cell division in phellogen and the elongation of these cells are enhanced, and thereby a secondary aerenchyma with high porosity is produced. Auxin controls cell division and cell elongation in many plants, so we studied its role in secondary aerenchyma development. Soybean plants with fully expanded unifoliolate leaves were flooded for 6 d with solutions (100μM each) of seven anti-auxins. TIBA, NPA, HFCA, 1-NOA, or CHPAA did not restrict the secondary aerenchyma formation, while MH moderately suppressed the aerenchyma development, and PCIB strongly inhibited the development of phellogen and secondary aerenchyma. However, the endogenous IAA concentrations in the flooded hypocotyls did not increase or decrease relative to the controls until 72 h, when a secondary aerenchyma was observed From these results, it is unclear whether auxin plays an important role in the process of secondary aerenchyma formation under flooding.

Plant Production Science published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C7H8BFO2, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics