Category: 33697-81-3

Moggio, Loredana published the artcileSolid-Phase Synthesis of Cyclic PNA and PNA-DNA Chimeras, SDS of cas: 33697-81-3, the publication is Organic Letters (2006), 8(10), 2015-2018, database is CAplus and MEDLINE.

A new and versatile online automated solid-phase approach to obtain cyclic PNA and cyclic PNA-DNA chimeras in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic mols. by standard peptide and phosphoramidite-based chem. has been achieved.

Organic Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Manach, Claire published the artcileIdentification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts, Quality Control of 33697-81-3, the publication is Journal of Medicinal Chemistry (2021), 64(4), 2291-2309, database is CAplus and MEDLINE.

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp³-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Utkin, Ilya published the artcileSpecificity of reductive dehalogenation of substituted ortho-chlorophenols by Desulfitobacterium dehalogenans JW/IU-DC1, Category: chlorides-buliding-blocks, the publication is Applied and Environmental Microbiology (1995), 61(1), 346-51, database is CAplus and MEDLINE.

Resting cells of D. dehalogenans JW/IU-DC1 grown with pyruvate and 3-chloro-4-hydroxyphenylacetate (3-Cl-4-OHPA) as the electron acceptor and inducer of dehalogenation reductively ortho-dehalogenate pentachlorophenol (PCP), tetrachlorophenols (TeCPs), the trichlorophenols 2,3,4-TCP, 2,3,6-TCP, and 2,4,6-TCP, the dichlorophenols 2,3-DCP, 2,4-DCP, and 2,6-DCP, 2,6-dichloro-4-R-phenols, where R is -H, -F, -Cl, -NO₂, -CO₂^–, or -COOCH₃, 2-chloro-4-R-phenols (2-Cl-4-RPs, where R is -H, -F, -Cl, -Br, -NO₂, -CO₂^–, -CH₂CO₂^–, or -COOCH₃), and bromophenols (2-BrP, 2,6-DBrP, and 2-Br-4ClP). Monochlorophenols, the dichlorophenols 2,5-DCP, 3,4-DCP, and 3,5-DCP, the trichlorophenols 2,3,5-TCP, 2,4,5-TCP, and 3,4,5-TCP, and the fluorinated analog of 3-Cl-4-OHPA, 3-F-4-OHPA, are not dehalogenated. A Cl substituent in position 3 (meta), 4 (para), or 6 (2nd ortho) of the phenolic moiety facilitates ortho dehalogenation in position 2. Cl in the 5 (2nd meta) position has a neg. effect on the dehalogenation rate or even prevents dechlorination in the 2 position. In general, 2,6-DCl-4-RPs are dechlorinated faster than the corresponding 2-Cl-4-RPs with the same substituent R in the 4 position. The highest dechlorination rate, however, was found for dechlorination of 2,3-DCP, with a maximum observed 1st-order rate constant of 19.4/h-g (dry weight) biomass. There is no strong linear correlation between the logarithm of pseudo-1st-order rate constants for the dehalogenation of 2,6-DCl-4-RPs and 2-Cl-4-RPs and electronic (Hammett σ_m), hydrophobic (π), and stearic (E_s) constants of the substituent R. The substrate specificity and induction pattern found for dehalogenation with the pure culture of D. dehalogenans and the original 2,4-DCP-enrichment, derived from a methanogenic sediment, were similar, suggesting that the conditions used led to only 1 type of dechlorinating organism.

Applied and Environmental Microbiology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H6KNO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boersma, Brenda J. published the artcileNeutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties, Product Details of C8H7ClO3, the publication is Free Radical Biology & Medicine (2003), 35(11), 1417-1430, database is CAplus and MEDLINE.

Soy isoflavones and other polyphenolics have a number of potentially important beneficial effects on the pro-oxidant aspects of chronic inflammation. The impact of inflammatory cell-specific metabolism of polyphenolics, which can include halogenation and nitration, on the properties of these compounds has not been examined Using either human neutrophils or differentiated human leukemia cells (HL-60) stimulated with phorbol ester to elicit a respiratory burst, the hypothesis that local generation of reactive oxygen and nitrogen species may metabolize and modify the biol. properties of the soy isoflavones was examined Coincubation of the stimulated cells with genistein or daidzein had no effect on the respiratory burst. Medium from stimulated cells in the presence of the isoflavones and NO₂^– increased the inhibition of copper-induced LDL oxidation Mass spectrometry anal. of this medium revealed that monochlorinated, dichlorinated, and nitrated isoflavones, formed through a myeloperoxidase-dependent mechanism, were present. The consumption of genistein in the presence of cells was both extensive and rapid with > 95% of the genistein converted to either the chlorinated or nitrated metabolites within 30 min. Chem. synthesized 3′-chlorogenistein and 3′-chlorodaidzein increased the inhibition of LDL oxidation by approx. 4-fold and 2-fold over genistein and daidzein, resp. These results lead to the hypothesis that inflammatory cell-specific metabolism of polyphenolics can modify the properties of these compounds at the local site of inflammation.

Free Radical Biology & Medicine published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Onofrio, Jennifer published the artcileNovel cyclic phosphate-linked oligosaccharides (CyPLOSs) covalently immobilized on solid supports for potential cation scavenging, SDS of cas: 33697-81-3, the publication is European Journal of Organic Chemistry (2007), 3849-3858, database is CAplus.

For potential cation scavenging both from water and from organic solvents, a synthetic procedure for functionalization of a Tentagel solid support with novel cyclic phosphate-linked oligosaccharide (CyPLOS) analogs I (R = TBDMS, H) is described. To establish the feasibility of the synthetic strategy, the cyclic dimer was the model compound selected to be incorporated onto the solid support. This functionalization was achieved through a stepwise solid-phase synthesis of the linear dimer, obtained by standard phosphoramidite protocols, followed by a synthesis of the cyclic mol. on the resin. The key intermediate was a suitably derivatized sugar phosphoramidite building block II, with the secondary hydroxy functions masked as TBDMS ethers. This proved to be an orthogonal protection with respect to the DMT ether, fully compatible with the phosphoramidite and the phosphotriester chem. used for the oligomerization and the cyclization process onto the solid support, resp. Conditions for the total unmasking of the hydroxy groups of the cyclic dimer, not affecting the integrity of the cyclic structure nor its linkage with the solid matrix, have been optimized. Gel-phase ³¹P NMR spectroscopy has been used extensively here to monitor the efficiency of the reactions carried out on the solid support.

European Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Di Fabio, Giovanni published the artcileA versatile synthetic approach for the development of libraries of 5′,3′-bis-conjugated oligonucleotides, Quality Control of 33697-81-3, the publication is Nucleic Acids Symposium Series (2008), 52(1), 299-300, database is CAplus and MEDLINE.

A symposium. A versatile approach to develop libraries of diverse 5′,3′-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming d(^5′TGGGAG^3′) sequence, as a potential anti-HIV agent, has been here used as a model system.

Nucleic Acids Symposium Series published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Huaisheng published the artcileDiscovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(9), 1647-1651, database is CAplus and MEDLINE.

A series of natural products-based Ph sulfone derivative and their property-based analogs were investigated as potential growth inhibitors of Trypanosoma brucei. Trypanosoma brucei is a kinetoplastid protozoan parasite that causes trypanosomiasis. In this work, the authors found that nopol- and quinoline-based Ph sulfone derivative were the most active and selective for T. brucei, and they were not reactive towards the active thiol of T. brucei’s cysteine protease rhodesain. A thiol reactive variant of the quinoline-based Ph sulfone was subsequently investigated and found to be a moderate inhibitor of rhodesain. The quinoline-based compound that is not reactive towards rhodesain can serve a template for phenotypic-based lead discovery while its thiol-active congener can serve as template for structure-based investigation of new antitrypanosomal agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C24H12, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Su, Yuan-Hsiao published the artcileSolution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries, Synthetic Route of 33697-81-3, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(5), 1320-1324, database is CAplus and MEDLINE.

The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid Bu amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs, e.g. I, II and III, were found to have a good anti-tumor activity comparable to cisplatin.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C14H12N2S, Synthetic Route of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pierens, Gregory K. published the artcileDetermination of analyte concentration using the residual solvent resonance in ¹H NMR spectroscopy, Category: chlorides-buliding-blocks, the publication is Journal of Natural Products (2008), 71(5), 810-813, database is CAplus and MEDLINE.

An NMR protocol that uses the residual proton signal from DMSO-d₆ (i.e., DMSO-d₅) to determine the concentration of an analyte in a NMR sample was developed. This technique provides an alternative method for determining the molar concentration of compounds in solution without prior knowledge of their mol. weight The method is particularly useful when submilligram quantities of compound are to be analyzed and is applicable to a variety of different research areas such as compound management, and natural product, combinatorial, and medicinal chem.

Journal of Natural Products published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics