Category: 3438-16-2

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids was written by Quibell, Jacob M.;Perry, Gregory J. P.;Cannas, Diego M.;Larrosa, Igor. And the article was included in Chemical Science in 2018.Computed Properties of C8H7ClO3 This article mentions the following:

A transition metal-free decarboxylative bromination of aromatic acids was reported. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggested that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Computed Properties of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection was written by Xu, Jimin;Berastegui-Cabrera, Judith;Chen, Haiying;Pachon, Jeronimo;Zhou, Jia;Sanchez-Cespedes, Javier. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The effective treatment of adenovirus (HAdV) infections in immunocompromised patients still poses great challenges. Herein, we reported our continued efforts to optimize a series of salicylamide derivatives as potent inhibitors of HAdV infection. Of these, nine compounds (11, 13, 14, 17, 20, 58, 60, 62, and 70) showed significantly improved anti-HAdV activities with nanomolar to submicromolar IC₅₀ values and high selectivity indexes (SI > 100), indicating better safety windows, compared to those of the lead compound niclosamide. Our mechanistic assays suggest that compounds 13, 62, and 70 exert their activities in the HAdV entry pathway, while compounds 14 and 60 likely target the HAdV DNA replication, and 11, 17, 20, and 58 inhibit later steps after DNA replication. Given the broad anti-viral activity profile of niclosamide, these derivatives may also offer therapeutic potential for other viral infections. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application In Synthesis of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Esters of p-nitrophenol in synthesis of 1-N-monoamide and 1,7-bis-N,N’-amide derivatives of 1,4,7,10-tetraazacyclododecane was written by Skwierawska, A.. And the article was included in Polish Journal of Chemistry in 2006.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The efficient synthesis of N-monoamide and bis-N,N-amide-1,4,7,10-tetraazacyclododecanes is reported. Compounds thus prepared included 1-benzoyl-1,4,7,10-tetraazacyclododecane derivatives and 1-[(pyridinyl)carbonyl]-1,4,7,10-tetraazacyclododecane derivatives and analogs. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Crystal Structure, and Thermal Decomposition Kinetics of the Ternary Complex [Sm(5-Cl-2-MOBA)₃phen]₂ was written by Wang, Juan-Fen;Zhang, Da-Hai;Liu, Xin;Wu, Ke-Zhong;Zhang, Jian-Jun. And the article was included in Journal of Chemical & Engineering Data in 2010.Name: 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The synthesis and structure determination of the Sm(III) complex with 1,10-phenanthroline (phen) and 5-chloro-2-methoxybenzoate (5-Cl-2-MOBA) are reported. The crystal and mol. structure of the complex, as well as its mol. formula and composition [Sm(5-Cl-2-MOBA)₃phen]₂, were determined by single-crystal x-ray diffraction, elemental analyses, and IR and thermogravimetric/differential thermogravimetric (TG-DTG) measurements. Meanwhile, the molar conductance and the UV spectra of the complex were measured and depicted. The crystal of the complex belongs to the triclinic crystal system, space group P1虆 with a 10.729(2), b 13.0971(18), c 13.5925(19) 脜, 伪 64.376(5), 尾 84.571(6), 纬 87.733(7)掳, Z = 1, d_c = 1.719 t m^-3, 渭 = 2.006 mm^-1, and F(000) = 882. Each Sm(III) ion in the crystal is nine-coordinate with a distorted monocapped square antiprismatic conformation. The Sm(III) ion in the complex is coordinated by two O atoms of one chelating bidentate carboxylate group, five O atoms of two bridging bidentate, and two bridging-chelating tridentate carboxylate groups and two N atoms of one 1,10-phenanthroline mol. The thermal decomposition of [Sm(5-Cl-2-MOBA)₃phen]₂ can be divided into three stages. By the Malek method, SB(m,n) was defined as the kinetic model of the 1st-step thermal decomposition The activation energy E of this step is 183.63 kJ mol^-1, and the pre-exponential factor ln A is 39.59. The thermodn. parameters 螖G^{鈮?/sup>, 螖H鈮?/sup>, and 螖S鈮?/sup> of activation at the peak temperature were also calculated In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Name: 5-Chloro-2-methoxybenzoic acid).}

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Cascade Decarboxylative Amination/6-endo-dig Benzannulation of o-Alkynylarylketones with N-Hydroxyamides To Access Diverse 1-Naphthylamine Derivatives was written by Zuo, Youpeng;He, Xinwei;Tang, Qiang;Hu, Wangcheng;Zhou, Tongtong;Shang, Yongjia. And the article was included in Organic Letters in 2020.Related Products of 3438-16-2 This article mentions the following:

An efficient and practical one-pot strategy to produce highly substituted 1-naphthylamines I [R¹ = t-Bu, Ph, 1-naphthyl, etc.; R² = H, 7-Me, 6-Cl, etc.; R³ = i-Pr, Ph, 4-MeC₆H₄, etc.; R⁴ = H, Me, CO₂Et] via sequential palladium-catalyzed decarboxylative amination/intramol. 6-endo-dig benzannulation reactions was described. In this reaction, a broad range of electron-rich, electron-neutral and electron-deficient o-alkynylarylketones reacted well with N-hydroxyl aryl/alkylamides to give a diversity of 1-naphthylamines in good to excellent yields under mild reaction conditions. The gram-scale synthesis, with benefits such as undiminished product yield and easy transformation, illustrated the practicality of this method. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Related Products of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of high-affinity 5-HT₃ receptor antagonists. 1. Initial structure-activity relationship of novel benzamides was written by Youssefyeh, R. D.;Campbell, H. F.;Klein, S.;Airey, J. E.;Darkes, P.;Powers, M.;Schnapper, M.;Neuenschwander, K.;Fitzpatrick, L. R.. And the article was included in Journal of Medicinal Chemistry in 1992.Recommanded Product: 3438-16-2 This article mentions the following:

Novel benzamides, e.g. I (X = H, Cl, Br, n = 1; X = Cl, n = 2), II (R = Me, Me₂CHCH₂, CH₂:CHCHMe, MeCOCHMe), and S–III which are orally active, highly potent, specific antagonists of serotonin 5-HT₃ receptors were prepared and the structure-activity relationships that led to these novel structures with improved potency in selectivity are described. (S)-III was identified and selected for further evaluation as a 5-HT₃ receptor antagonist. Compared with 5-HT₃ antagonists such as GR 38032F, BRL 43694, and metoclopramide, (S)-III was most active in (a) inhibiting binding to 5-HT₃ receptor binding sites in rat entorhinal cortex with a K_i value of 0.19 nM and (b) blocking cisplatin-induced emesis in the ferret with an ED₅₀ value determined to be 9 mg/kg, i.d. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and thermal decomposition mechanism of rare earth complexes with 5-chloro-2-methoxybenzoic acid and 1,10-phenanthroline was written by Zhang, Jie;Wang, Juan-Fen;Zhang, Jian-Jun. And the article was included in Wuli Huaxue Xuebao in 2012.Reference of 3438-16-2 This article mentions the following:

Three rare earth complexes of [Ln(5-Cl-2MOBA)₃phen]₂ (Ln = Nd(1), Eu(2), Ho(3); 5-Cl-2MOBA: 5-chloro-2-methoxybenzoate; phen: 1,10-phenanthroline) were synthesized and characterized by elemental anal., TG-differential TG-DSC (TG-DTG-DSC), IR spectra, UV spectra, and molar conductance techniques. The fluorescence spectra showed that complex 2 emitted a characteristic fluorescence of the Eu³⁺ ions. The thermal properties are discussed by TG – DSC / FTIR (TG-DSC/FTIR) techniques. And the three-dimensional IR accumulation spectra for the three complexes were also analyzed. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Reference of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and in vitro antimicrobial evaluation of new 1,3,4-oxadiazoles bearing 5-chloro-2-methoxyphenyl moiety was written by Basavapatna, N. Prasanna Kumar;Kikkeri, N. Mohana;Lingappa, Mallesha;Kikkeri, P. Harish. And the article was included in International Journal of Medicinal Chemistry in 2013.Electric Literature of C8H7ClO3 This article mentions the following:

A series of new 1,3,4-oxadiazole derivatives containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, ¹H NMR, mass spectra and also by elemental anal. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that some of the compounds showed significant activity against tested strains. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Electric Literature of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions was written by Magnus, Christopher J.;Lee, Peter H.;Atasoy, Deniz;Su, Helen H.;Looger, Loren L.;Sternson, Scott M.. And the article was included in Science (Washington, DC, United States) in 2011.Category: chlorides-buliding-blocks This article mentions the following:

Ionic flux mediates essential physiol. and behavioral functions in defined cell populations. Cell type-specific activators of diverse ionic conductances are needed for probing these effects. We combined chem. and protein engineering to enable the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharmacol. selectivity and divergent functional properties. The LGICs and their small-mol. effectors were able to activate a range of ionic conductances in genetically specified cell types. LGICs constructed for neuronal perturbation could be used to selectively manipulate neuron activity in mammalian brains in vivo. The diversity of ion channel tools accessible from this approach will be useful for examining the relationship between neuronal activity and animal behavior, as well as for cell biol. and physiol. applications requiring chem. control of ion conductance. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Category: chlorides-buliding-blocks).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient synthesis of (R)-ochratoxin alpha, the key precursor to the mycotoxin ochratoxin A was written by Lenz, Cesar Antonio;Rychlik, Michael. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 3438-16-2 This article mentions the following:

Two new routes for the synthesis of enantiomerically pure ochratoxin 伪 (I) ((3R)-OT伪) are presented, which is the key intermediate for the synthesis of ochratoxin A (OTA) by coupling reaction with the amino acid L-phenylalanine. The key step of both routes is the one pot directed ortho-metalation/alkylation/lactonization of unprotected and suitably functionalized aromatic carboxylic acids, using lithium tetramethylpiperidide (LTMP) and (R)-propylene oxide. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics