Category: 3460-24-0

Related Products of 3460-24-0, These common heterocyclic compound, 3460-24-0, name is 1,4-Dibromo-2-chlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Dibromo-2-Chloro-Benzene 1eq(45.8 g), 2-aminophenylboronic acid 2eq (46.5 g), Pd (PPh3) 4 5 mol% (9.8 g) and K2CO3 2eq (46.9 g) were dissolved in toluene 1-fold, 550 ml) and distilled water (5 times as much as K2CO3, 235 ml), and the mixture was stirred under reflux for 18 hours under a nitrogen stream. After completion of the reaction, the reaction mixture was extracted with toluene and distilled water. The organic layer was dried with magnesium sulfate (MgSO4) and filtered, and the filtrate was concentrated under reduced pressure. The organic solution was removed, and the residue was subjected to silica gel column chromatography with hexane: dichloromethane = 7: 3 (v / v), and the resulting solid was recrystallized from dichloromethane and acetone to obtain intermediate d-1 (23.5 g, Y = 47%).

The synthetic route of 3460-24-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Jang Gi-po; Kim Jun-seok; Lee Seung-jae; Hong Jin-seok; Kim Chang-u; Jeong Seong-hyeon; Kim Yeong-gwon; Ryu Eun-seon; Jeong Ho-guk; (30 pag.)KR2017/111538; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 3460-24-0, These common heterocyclic compound, 3460-24-0, name is 1,4-Dibromo-2-chlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Dibromo-2-Chloro-Benzene 1eq(45.8 g), 2-aminophenylboronic acid 2eq (46.5 g), Pd (PPh3) 4 5 mol% (9.8 g) and K2CO3 2eq (46.9 g) were dissolved in toluene 1-fold, 550 ml) and distilled water (5 times as much as K2CO3, 235 ml), and the mixture was stirred under reflux for 18 hours under a nitrogen stream. After completion of the reaction, the reaction mixture was extracted with toluene and distilled water. The organic layer was dried with magnesium sulfate (MgSO4) and filtered, and the filtrate was concentrated under reduced pressure. The organic solution was removed, and the residue was subjected to silica gel column chromatography with hexane: dichloromethane = 7: 3 (v / v), and the resulting solid was recrystallized from dichloromethane and acetone to obtain intermediate d-1 (23.5 g, Y = 47%).

The synthetic route of 3460-24-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Jang Gi-po; Kim Jun-seok; Lee Seung-jae; Hong Jin-seok; Kim Chang-u; Jeong Seong-hyeon; Kim Yeong-gwon; Ryu Eun-seon; Jeong Ho-guk; (30 pag.)KR2017/111538; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3460-24-0, name is 1,4-Dibromo-2-chlorobenzene, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

1.00 g (3.02 mmol) of 1- [4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl] isoquinoline,370 mg (1.37 mmol) of 1,4-dibromo-2-chlorobenzene,83.9 mg (0.0726 mmol) of tetrakis (triphenylphosphine) palladium,And 5.45 mL (5.45 mmol) of 1 M potassium carbonate aqueous solution were dissolved in 40 mL of dioxane,And the mixture was heated and stirred at 100 C. After cooling to room temperature, 400 mL of pure water was added and separation and extraction was performed with chloroform. After distilling off the solvent under reduced pressure, the obtained crude product was purified by silica gel column chromatography (developing solvent: chloroform)2′-Chloro-4,4 “-di (1-isoquinolyl) -1,1 ‘: 4’, 1″Of a light yellow solid (Yield 490 mg, yield 68.9%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TOSOH CORPORATION; FUJITA, KANA; ARAI, NOBUMICHI; NOMURA, KEISUKE; IIDA, TAKASHI; TANAKA, TSUYOSHI; (76 pag.)JP6264877; (2018); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics