Category: 34662-36-7

New information indexes for interactions in biological systems was written by Motoo, Ioan. And the article was included in MATCH in 1981.Application of 34662-36-7 This article mentions the following:

The superposition of n effectors in a given series reflects the topol. of the receptor space explored by the considered effectors. The investigated receptor space (IRS) is defined as the graph G whose overlap partition is G₁, …, G_n. The graph, G₁ (1 鈮?L 鈮?n), is the hydrogen-suppressed graph corresponding to the effector mol., L. One computes the mean [I虆(G)] and total [I(G)] quantity of information contained in the IRS. I(G) or I虆(G) induces an ordering of IRS’s and constitutes a criterion for IRS relevance. These indexes are of use in quant. structure-activity relations. Two concrete series of hapten-antibody interactions and one series of carboxypeptidase inhibitors were studied. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Application of 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molecular shape descriptors. 3. Steric mapping of biological receptor was written by Motoc, I.;Marshall, G. R.;Labanowski, J.. And the article was included in Zeitschrift fuer Naturforschung, Teil A: Physik, Physikalische Chemie, Kosmophysik in 1985.HPLC of Formula: 34662-36-7 This article mentions the following:

An improved version of the SIBIS algorithm is presented and illustrated. SIBIS is a self-consistent type algorithm which is well suited to delineate the main steric features of the biol. receptor, identify missing relevant atoms and(or) the presence of superfluous atoms in the mols. studied, and to provide an approx. estimate for the receptor bulk tolerance. SIBIS calculations for a set of substituted benzoates in the anti-p-(p‘-azophenylazo)benzoate antibody system yield an excellent QSAR which is further supported by the information correlation coefficients, R (R‘s express quant. the pairwise degree of the mol. shape relatedness); the optimal receptor steric map is in agreement with exptl. evidences. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7HPLC of Formula: 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins was written by Povedano, Juan Manuel;Rallabandi, Rameshu;Bai, Xin;Ye, Xuecheng;Liou, Joel;Chen, Hong;Kim, Jiwoong;Xie, Yang;Posner, Bruce;Rice, Luke;De Brabander, Jef K.;McFadden, David G.. And the article was included in Journal of Medicinal Chemistry in 2020.Quality Control of 3-Chloro-5-nitrobenzoic acid This article mentions the following:

A phenotypic high-throughput screen identified a benzamide small mol. with activity against small cell lung cancer cells. A “clickable” benzamide probe was designed that irreversibly bound a single 50 kDa cellular protein, identified by mass spectrometry as β-tubulin. Moreover, the anti-cancer potency of a series of benzamide analogs strongly correlated with probe competition, indicating that β-tubulin was the functional target. Addnl. evidence suggested that benzamides covalently modified Cys239 within the colchicine binding site. Consistent with this mechanism, benzamides impaired growth of microtubules formed with β-tubulin harboring Cys239, but not β₃ tubulin encoding Ser239. We therefore designed an aldehyde-containing analog capable of trapping Ser239 in β₃ tubulin, presumably as a hemiacetal. Using a forward genetics strategy, we identified benzamide-resistant cell lines harboring a Thr238Ala mutation in β-tubulin sufficient to induce compound resistance. The disclosed chem. probes are useful to identify other colchicine site binders, a frequent target of structurally diverse small mols. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Quality Control of 3-Chloro-5-nitrobenzoic acid).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 3-Chloro-5-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives was written by Liu, Wukun;Zhou, Jinpei;Bensdorf, Kerstin;Zhang, Huibin;Liu, Haoran;Wang, Yubin;Qian, Hai;Zhang, Yanchun;Wellner, Anja;Rubner, Gerhard;Huang, Wenlong;Guo, Cancheng;Gust, Ronald. And the article was included in European Journal of Medicinal Chemistry in 2011.Synthetic Route of C7H4ClNO4 This article mentions the following:

A series of C(5)-substituted licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid) derivatives were developed by a parallel synthesis approach and investigated for cytotoxicity against MCF-7 and MDA-MB-231 cells as well as for anti-inflammatory potency in vitro and in vivo. Dependent on the substituent, the compounds showed high selectivity for MCF-7 cells. Especially benzoyloxyacetyl derivatives were inactive at the MDA-MB-231 cell line and as active as 5-FU at MCF-7 cells. The acetyl, formyloxyacetyl,, acetoxyacetyl, and propionyloxyacetyl derivatives showed growth inhibition at both cell lines, comparable with cisplatin. Modifications significantly reduced the inhibitory potency at COX-1 and COX-2 in vitro and in the xylene-induced ear swelling assay in mice. Only the acetyl derivative was equipotent to licofelone, ibuprofen and celecoxib in vivo. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Synthetic Route of C7H4ClNO4).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics