Category: 349-88-2

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Synthetic Route of 349-88-2.

Wang, Yi;Chen, Xiaoli;Lin, Shuang;Gao, Hui;Liu, Fu-Xiaomin;Zhou, Zhi;Yi, Wei research published 《 Hexafluoroisopropanol (HFIP)-prompted rearrangement of N-phenoxysulfonamides for the direct assembly of ortho-sulfonamide phenols: A combined experimental and computational study》, the research content is summarized as follows. Herein an efficient metal-free rearrangement reaction was developed for the construction of ortho-sulfonamide phenols I [R = H, 4-Me, 2,4,6-Cl₃, etc.; R¹ = H, 4-Me, 4-t-Bu, 3,5-di-Me] via HFIP-prompted intramol. sulfonamide group 1,3-migration. This protocol featured mild reaction conditions, broad functional group compatibility and good regioselectivity. Combined exptl. mechanistic study and detailed DFT calculations clarified the crucial role of HFIP mols. in facilitating this reaction and the unique hydrogen bond network had been deduced to account for the observed reactivity.

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Computed Properties of 349-88-2.

Wang, Yang;Zhang, Feng;Wang, Yi;Pan, Yi research published 《 Electrochemistry Enabled Nickel-Catalyzed Selective C-S Bond Coupling Reaction》, the research content is summarized as follows. This work describes an electrochem. enabled nickel-catalyzed chemoselective C-S bond coupling protocol for the production of aryl sulfides and sulfones. By simply switching the nickel catalysts and electrodes, this electrochem. C-S bond coupling has demonstrated excellent redox activity, scalability and sustainability. Furthermore, the mechanism for this electrochem. cross-coupling reaction has been investigated.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Computed Properties of 349-88-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. HPLC of Formula: 349-88-2.

Wang, Yali;Ji, Bo;Cheng, Zhongshui;Zhang, Lianghui;Cheng, Yingying;Li, Yingying;Ren, Jin;Liu, Wenbo;Ma, Yuanyuan research published 《 Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX》, the research content is summarized as follows. A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities. Among them, compound I exhibited the most potent affinity toward MDM2 and MDMX, with a Ki of 0.031 and 7.24μM, resp. Compound I was also the most potent agent against HCT116, MCF7, and A549, with IC₅₀ values of 6.17, 11.21, and 12.49μM, resp. Western blot anal. confirmed that compound I upregulated the expression of MDM2, MDMX, and p53 by Western blot anal. These results indicate that compound I is a potent dual p53-MDM2 and p53-MDMX inhibitor and deserves further investigation.

HPLC of Formula: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.

Wang, Xiaoxia;Li, Xueting;Tian, Baoqiang;Xiao, He;Chen, Wenwen;Wu, Haishun;Jia, Jianfeng research published 《 Immobilization of bismuth oxychloride on cellulose nanocrystal for photocatalytic sulfonylation of arylacetylenic acids with sodium arylsulfinates under visible light》, the research content is summarized as follows. A facile method was used to prepare a highly efficient heterogeneous nano-photocatalyst BiOCl/cellulose nanocrystal (CNC). Subsequently, the BiOCl/CNC was verified by XPS, ESR, BET and other characterization methods. The results show that not only the strong interaction between BiOCl and CNC increases the visible light absorption intensity of the composite, but also the combination of BiOCl and CNC makes the specific area of the catalyst more than twofold. In addition, a large number of hydroxyl groups contained in CNC can be combined with the B-O bond in BiOCl through hydrogen bonds, forming abundant oxygen vacancies on BiOCl/CNC. Excitedly, these changes enable BiOCl/CNC to exhibit excellent photocatalytic performance and regeneration performance in the sulfonation reaction of arylacetylene acid and sodium arylsulfinate, with a yield of up to 96%. This work represented a step towards a low-cost, environmentally friendly composite of cellulose and BiOCl, which will provide useful enlightenment for future exploration in related fields.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Reference of 349-88-2.

Wan, Hai-Lan;Guan, Zhi;He, Yan-Hong research published 《 Electrochemically Promoted Bifunctionalization of Alkynes for the Synthesis of β-Keto Sulfones》, the research content is summarized as follows. An electrochem. oxidative difunctionalization of internal and terminal alkynes with sulfonyl hydrazides for the synthesis of β-keto sulfones has been achieved. The reaction involves the addition of sulfonyl radicals to alkynes, and the resulting alkenyl radicals are oxidized to alkenyl cations, which are then nucleophilically attacked by H₂O, followed by tautomerization to form β-keto sulfones. The method is green and sustainable as it is catalyst-free, oxidant-free, and additive-free. The new C-O and C-S bonds can be constructed in one-pot to directly access β-keto sulfone derivatives

Reference of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.

Ullah, Saif;Pelletier, Julie;Sevigny, Jean;Iqbal, Jamshed research published 《 Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors》, the research content is summarized as follows. In this study, I [R¹ = H, CH₃; R² = C₆H₅, 4-Me(C₆H₄), 4-OMe(C₆H₄), etc.] and II [R³ = CH₃, CF₃, C₆H₅, etc.] were synthesized, characterized, and evaluated for their capability to affect the activity of isoenzymes ENPP1 and ENPP3. Among the selective inhibitors of ENPP1, compounds I [R¹ = CH₃, R² = 4-propyl(C₆H₄)] and I [R¹ = H, R² = 8-quinolinyl] exhibited sub-micromolar IC₅₀ values of 0.28 ± 0.08 and 0.37 ± 0.03μM, resp., followed by II [R³ = 2-F(C₆H₄)], with IC₅₀ equal to 0.81 ± 0.05μM, whereas out of the selective inhibitors of isoenzyme ENPP3, I [R¹ = H, R² = 4-OCF₃(C₆H₄)] and II [R³ = CH₃] preferably lessened the activity to half of the maximal inhibitory concentration of 0.15 ± 0.04 and 0.16 ± 0.01μM alternatively. In addition, many structures including I [R¹ = H, CH₃; R² = 4-I(C₆H₄), 4-OCF₃(C₆H₄), 4-F(C₆H₄), 2-F(C₆H₄), CH₂(C₆H₄), 4-propyl(C₆H₄)] and II [R³ = CF₃, 4-F(C₆H₄), 4-CH₃(C₆H₄)] inhibited the activity of both isoenzymes to a significant level. Enzyme kinetic study of compound I [R¹ = CH₃, R² = 4-n-butyl(C₆H₄)] revealed an uncompetitive mode of inhibition of ENPP1 isoenzyme, while II [R³ = 4-CH₃(C₆H₄)] competitively blocked the activity of ENPP3. Cell viability anal. revealed the compound I [R¹ = H, R² = 4-propyl(C₆H₄)] as a cytotoxic agent against MCF7 (human breast cancer cell line) with a percentage inhibition of 63.2 ± 2.51%, whereas compounds I [R¹ = CH₃, R² = 4-I(C₆H₄)], I [R¹ = CH₃, R² = 4-OCH₃(C₆H₄)], I [R¹ = H, R² = CH₂(C₆H₄)], and II [R³ = 4-CH₃] decreased the HeLa cell viability (human cervical cancer cell line) to more than 50%. The tested compounds were non-cytotoxic against HEK293 (a human embryonic kidney cell line). Mol. docking anal. of selected inhibitors of both isoenzymes produced optimistic interactions with the influential amino acids, such as Leu290, Lys295, Tyr340, Asp376, His380, and Pro323 of ENPP1, whereas residues Asn226, His329, Leu239, Tyr289, Pro272, Tyr320, and Ala205 of ENPP3 crystallog. structure formed interactions with the potent inhibitors.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application of C6H4ClFO2S.

Tokali, Feyzi Sinan;Demir, Yeliz;Demircioglu, Ibrahim Hakki;Tuerkes, Cueneyt;Kalay, Erbay;Sendil, Kivilcim;Beydemir, Suekrue research published 《 Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors》, the research content is summarized as follows. A series of novel sulfonates containing quinazolin-4(3H)-one ring derivatives I (R = Me, Et, i-Pr; R¹ = Me, F, Cl, etc.) was designed to inhibit aldose reductase (ALR2, EC 1.1.1.21). Novel quinazolinone derivatives I were synthesized from the reaction of sulfonated aldehydes II with 3-amino-2-alkylquinazolin-4(3H)-ones III in glacial acetic acid with good yields (85%-94%). All the novel quinazolinones I demonstrated nanomolar levels of inhibitory activity against ALR2 (KIs are in the range of 101.50-2066.00 nM). Besides, compound I (R = i-Pr; R¹ = H) showed higher inhibitor activity inhibited ALR2 up to 7.7-fold compared to epalrestat, a standard inhibitor. Binding interactions between ALR2 and quinazolinones I have been investigated using Schrodinger Small-Mol. Drug Discovery Suite 2021-1, reported possible inhibitor-ALR2 interactions. Both in vitro and in silico study results suggest that these quinazolin-4(3H)-one ring derivatives I require further mol. modification to improve their drug nominee potency as an ALR2 inhibitor.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Application of C6H4ClFO2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.

Sun, Bin;Tian, Hai-Xia;Ni, Zhi-Gang;Huang, Pan-Yi;Ding, Hao;Li, Bing-Qian;Jin, Can;Wu, Chun-Lei;Shen, Run-Pu research published 《 Photocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light》, the research content is summarized as follows. Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 349-88-2.

Song, Xuyan;He, Yunlu;Wang, Bo;Peng, Sanwen;Pan, Xi;Wei, Min;Liu, Qiang;Qin, Hua-Li;Tang, Haolin research published 《 Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO₂F₂) as fluoride provider》, the research content is summarized as follows. A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO₂F [Ar = 4-MeC₆H₄, 4-PhC₆H₄, 4-ClC₆H₄, etc.] was developed from aryl sulfonyl chlorides using SO₂F₂ as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Quality Control of 349-88-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Name: 4-Fluorobenzene-1-sulfonyl chloride.

Sun, Bin;Ding, Hao;Tian, Hai-Xia;Huang, Pan-Yi;Jin, Can;Wu, Chun-Lei;Shen, Run-Pu research published 《 Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group》, the research content is summarized as follows. A self-photocatalyzed sulfonylation/cyclization of quinazolinones containing unactivated alkenes with various sulfonyl chlorides was developed. The protocol provided access to sulfonyl radicals via energy transfer from quinazolinone skeleton to sulfonyl chloride. Notably, transformations proceeded without any external photocatalysts, additives, or oxidants, providing an alternative method for fabricating sulfonylated compounds I [R = Et, cyclopropyl, Ph, etc.; R¹ = H, 3-F, 2-MeO, etc.; n = 0, 1].

Name: 4-Fluorobenzene-1-sulfonyl chloride, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics