Category: 349-88-2

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.

Kong, Yuan;Yi, Yong-Jia;Liu, Xiao-Qing;Yu, Pan;Zhao, Lin-Guo;Li, Dong-Dong research published ã€?Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agentsã€? the research content is summarized as follows. In this study, a focused berberine-like compound library containing 12,600 mols. was built via the introduction of various “drug-like” fragments at the C8 and C9 positions of berberine. Sixteen compounds were hit by using the inhouse QSAR models previously reported by our group. Considering synthesis feasibility and the cost of building-blocks, only four berberine analogs were selected and synthesized for investigating their lipid-lowering activities. A preliminary lipid-lowering study showed that compound I with the phenylsulfonyl group at the C9 position had potent cholesterol inhibitory activity in HepG2 cells, superior to that of the parent compound berberine. Subsequently, a total of twenty-five 9-O-phenylsulfonyl-berberines II (R¹ = H, F, Cl, NO₂, Me, R² = H, F, Cl, CF₃, NO₂, R³ = H, Cl, F, Br, NO₂, Me, OMe, R⁴ = H, CF₃, Cl, R⁵ = H, F, Me) and twenty-four 9-O-phenylsulfonyl-tetrahydroberberine III (R¹ = H, F, Cl, NO₂, CHMe₂, R² = H, F, Cl, Br, NO₂, CF₃, R³ = H, F, Cl, Br, NO₂, Me, OMe, tert-Bu, CHMe₂, R⁴ = H, Cf₃, R⁵ = H, CHMe₂) were designed, synthesized, and evaluated by lipid-lowering experiments The results showed that most compounds exhibited more lipid-lowering activities than berberine. Among them, compound II (R¹ = R³ = R⁴ = R⁵ = H, R² = CF₃) (IV) inhibited cholesterol production close to 50% in both cell models when compared with the blank control; the inhibition of triglycerides exceeded 70%. Moreover, IV also had significant pharmacol. effects on the inhibition of LDLC and promotion of HDLC production, especially in the HepG2 cell model, in which the inhibitory rate against LDLC was close to 70% and the increase rate of HDLC was more than 75%. The hypolipidemic experiment of SD rats demonstrated that after 40 days of administration IV (15 mg/kg/d), blood cholesterol was reduced by 19.6%, triglycerides were reduced by 34.52%, and LDLC was reduced by 41.49%, when compared with the high-fat diet model (HFD). In addition, after 80 days of administration, the three indexes of IV were still better than that of berberine. Oil Red O staining and H&E staining results showed that IV exhibited potent lipid scavenging activity. All in all, IV was discovered and identified as a potent lipid-lowering agent and a new berberine-like candidate, being evaluated by subsequent studies.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Related Products of 349-88-2.

Kook, Ga Young;Kim, Daegeun;Chae, Min Ki;Ko, Haye Min research published ã€?Rhodium(II)-Catalyzed Highly Selective 1,3-Insertion Reactions Using N-Sulfonyl-1,2,3-Triazoles with Heteroaryl Ethers or Heteroaryl Alcoholsã€? the research content is summarized as follows. The transformation of N-sulfonyl-1,2,3-triazoles via insertion/rearrangement was achieved using 2-hydroxybenzimidazole or 2-alkoxybenzothiazole over 3 mol % Rh₂(Oct)₄ for the synthesis of α-((1H-benzo[d]imidazol-2-yl)amino) ketones I [R¹ = 3-chloropropyl, cyclohexen-1-yl, Ph, etc.; X = O, S, NH; R² = n-Bu, Ph, 4-MeC₆H₄, etc.] or (Z)-2-alkoxy-2-phenylethenamines II [R³ = Me, Ph, Bn, etc.; X = O, S; Y = S, O]. This regio- and stereoselective reaction proceeds under mild conditions, was tolerant of functional groups, and had a broad substrate scope. Notably, while the general rhodium-catalyzed reaction involved sigmatropic rearrangement from an allyl vinyl ether, the present synthetic methodol. prevents rearrangement owing to the benzimidazole group, allowed access to (Z)-olefins.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Related Products of 349-88-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Reference of 349-88-2.

Korkmaz, Adem;Bursal, Ercan research published ã€?Synthesis, Biological Activity and Molecular Docking Studies of Novel Sulfonate Derivatives Bearing Salicylaldehydeã€? the research content is summarized as follows. Enzyme activity alterations have been associated with many metabolism disorders and have crucial roles in the pathogenesis of some diseases. Tyrosinase is a key enzyme in melanin biosynthesis, which is responsible for skin pigmentation to protect the skin from solar radiation. Pancreatic lipase has been considered a key enzyme for the treatment of obesity. Herein, we reported the synthesis and enzyme inhibitions of a series of sulfonates as possible tyrosinase and pancreatic lipase inhibitors. According to the calculated IC₅₀ values, compound 3f (74.1±11.1 μM) and compound 3c (86.6±6.9 μM) were determined to be the best inhibitors among the synthesized compounds for the tyrosinase and pancreatic lipase enzymes, resp. The approach yielded at extremely high level by creating very flexible structural domains for the chem. modified groups. The structural characterization of the target mols. was implemented by ¹H-NMR, ¹³C-NMR, and HR-MS analyses. Also, mol. docking studies of the synthesized compounds with tyrosinase and pancreatic lipase enzymes were conducted using AutoDock Vina software. Addnl., the studies of the absorption distribution, metabolism, and excretion (ADME) were performed to uncover the target compoundsâ€?pharmacokinetics, drug similarities, and medicinal properties of the novel sulfonate derivatives bearing salicylaldehyde.

Reference of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Application of C6H4ClFO2S.

Kumar, Harikesh;Dubey, Atul;Prajapati, Gurudayal;Kant, Ruchir;Ampapathi, Ravi S.;Mandal, Pintu Kumar research published �Regioselective direct sulfenylation of glycals using arylsulfonyl chlorides in the presence of triphenylphosphine: access to C2-thioaryl glycosides� the research content is summarized as follows. Direct triphenylphosphine-mediated regioselective sulfenylation of glycals by using various cheap and easily available aryl sulfonyl chlorides as a sulfur source to generate different C2-S-aryl-glycosides was developed. Notably, the features of this protocol offer a milder and easier operational procedure, and broad substrate scope with complete regioselectivity at C-2. Experiments and DFT calculations supported the proposed mechanism and regioselectivity for the formation of C2-S-aryl-glycosides.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Application of C6H4ClFO2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. COA of Formula: C6H4ClFO2S.

Khetmalis, Yogesh Mahadu;Chitti, Surendar;Umarani Wunnava, Anjani;Karan Kumar, Banoth;Murali Krishna Kumar, Muthyala;Murugesan, Sankaranarayanan;Chandra Sekhar, Kondapalli Venkata Gowri research published ã€?Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analoguesã€? the research content is summarized as follows. Based on the mol. hybridization strategy, imidazo[1,2-a]pyridine amides (IPAs) I [R = Me, t-Bu, Ph, etc.] and imidazo[1,2-a]pyridine sulfonamides (IPSs) II [R = Me, Et, Ph, etc.] were designed and synthesized. The structures of the target compounds I and II were characterized using ¹H NMR, ¹³C NMR, LCMS, and elemental analyzes. The synthesized compounds I and II were evaluated in vitro for anti-tubercular activity using the microplate Alamar Blue assay against Mycobacterium tuberculosis H37Rv strain and the MIC was determined The evaluated compounds I and II exhibited MIC in the range 0.05-â‰?00μg mL-. Among these derivatives, compound I [R = Ph] (MIC 0.05μg L^-1), compound I [R = 4-ClC₆H₄] (MIC 0.4μg L^-1), and compound II [R = Me] (MIC 0.4μg L^-1) displayed excellent anti-TB activity, whereas compounds compound I [R = cyclohexyl], compound I [R = 4-MeC₆H₄] and compound II [R = (5-bromo-2-thienyl)] showed good anti-TB activity (MIC 0.8-3.12μg L^-1). The most active compounds I [R = Ph] with MIC of <3.125μg L^-1 were screened against human embryonic kidney cells to check their cytotoxicity to normal cells. It was observed that these compounds were nontoxic (SI value â‰?6). The ADMET characteristics of the final compounds were also predicted in silico. Further, using the Glide module of Schrodinger software, a mol. docking study of compound I was carried out to estimate the binding pattern at the active site of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis (PDB 4TZK). Finally, mol. dynamics simulations were performed for 100 ns to elucidate the stability, conformation, and intermol. interactions of the co-crystal ligand and significantly active compound I on the selected target protein. IPA-6, the most active compound, was found to be 125 times more potent than the standard drug ethambutol (MIC 6.25μg mL^-1).

COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. COA of Formula: C6H4ClFO2S.

Kazancioglu, Mustafa Z.;Kendirli, Elif C. research published ã€?Synthesis, characterization, and enzyme inhibition activities of 4-(methylthio)-N-propylaniline-phenylpiperazine and sulfonamide derivativesã€? the research content is summarized as follows. Herein, piperazine, thioether, and sulfonamide structural motifs I (R = 4-fluorophenylsulfonyl, 3-fluorophenylsulfonyl, 4-methoxyphenylsulfonyl, 3-trifluoromethylphenylsulfonyl) were combined in a mainframe for biol. evaluation. The synthesis involved the alkylation of 4-aminothioanisole with 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine followed by treatment of resulting amino piperazine I (R = H) with various aryl sulfonyl chlorides RS(O)₂Cl. In addition, all obtained piperazine derivatives I were evaluated for their tyrosinase and pancreatic lipase enzyme inhibitory activities. The enzyme analyses showed that some of the piperazine derivatives possess effective tyrosinase inhibitions with IC₅₀ values of 18.7 ± 1.8 for compound I (R = 3-fluorophenylsulfonyl) and 24.7 ± 3.4 for compound I (R = 3-trifluoromethylphenylsulfonyl), which is close to the IC₅₀ value of kojic acid (19.2 ± 1.2μM). On the other hand, the synthesized compounds showed low IC₅₀ values in the range from 46.2 ± 4.9 to 86.6 ± 8.4μM against pancreatic lipase enzyme. Compound I (R = H) was found to be the most effective pancreatic lipase inhibitor among the synthesized compounds The IC₅₀ value of compound I (R = H) (46.2 ± 4.9μM) was determined slightly lower than the IC₅₀ value of orlistat (49.5 ± 3.2μM), pointing to more effective inhibition. Finally, in silico mol. docking interactions of piperazine derivatives were evaluated for their tyrosinase and pancreatic lipase enzyme inhibitory activities using Chimera mol. visualization and AutoDock Vina software.

COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Synthetic Route of 349-88-2.

Kamali, Ayfer;Cakmak, Resit;Boga, Mehmet research published ã€?Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moietyã€? the research content is summarized as follows. In this research, nine novel heterocyclic Schiff base derivatives 4-FC₆H₄S(O)₂O-R [R = 2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, 4-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl, 1-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]naphthalen-2-yl, etc.] bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl- and butyrylcholinesterase (AChE and BChE) were investigated in vitro conditions. Moreover, their antioxidant activities were examined by DPPH and ABTS methods. The results indicated that some of the tested mols. had varying enzyme inhibition and antioxidant activities. Compounds 4-FC₆H₄S(O)₂O-R [R = 5-(diethylamino)-2-formylphenyl, 1-formylnaphthalen-2-yl, 2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-5-methoxyphenyl, 5-(diethylamino)-2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, 1-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]naphthalen-2-yl] indicated inhibitory effects with IC₅₀ values ranging from 89.30 to 111.28μM against BChE, resp. compared to standard compound galanthamine (IC₅₀ = 125.88μM) were determined On the other hand, among the mols. tested, only compound 4-FC₆H₄S(O)₂O-R [R = 2-formyl-5-methoxyphenyl] (IC₅₀ = 36.64μM) displayed inhibitory activity higher than galanthamine against AChE. In DPPH assay, compounds 4-FC₆H₄S(O)₂O-R [R = 5-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl] (IC₅₀ = 161.93μM), 4-FC₆H₄S(O)₂O-R [R = 4-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl] (IC₅₀ = 191.76μM) and 4-FC₆H₄S(O)₂O-R [R = 5-(diethylamino)-2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl] (IC₅₀ = 107.55μM) showed higher antioxidant activity than BHT (IC₅₀ = 203.50μM). On the other hand, it was determined in ABTS assay that Schiff bases 4-FC₆H₄S(O)₂O-R [R = 2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, 4-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl, 5-(diethylamino)-2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, etc.] (except for compound 4-FC₆H₄S(O)₂O-R [R = 1-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]naphthalen-2-yl]) indicated higher antioxidant activity than BHT.

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Application In Synthesis of 349-88-2.

Jin, Bo;Chen, Jia-yi;Sheng, Zun-lai;Sun, Meng-qing;Yang, Hong-liang research published ã€?Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivativesã€? the research content is summarized as follows. In this study, a series of 3-(3-pyridyl)-oxazolidone-5-Me ester derivatives I [X = O, C(O)CH₂Bn, C(O)NCy, etc.; R¹ = C(O)Me, C(O)Cy, S(O)₂Me, etc.] was synthesized and characterized by ¹H NMR, ¹³C NMR and LC-MS. The conducted screening antibacterial studies of the new 3-(3-pyridyl)-oxazolidone-5-Me ester derivatives I established that the Me sulfonic acid esters have broad activity spectrum toward Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis and Staphylococcus epidermidis. Among them, compound I [X = O; R¹ = C(O)NCy] was the most potent activity, with an MIC of 16μg/mL against B.subtilis and could reduce the instantaneous growth rate of bacteria. Furthermore, mol. docking studies were also simulated for compound I [X = O; R¹ = C(O)NCy] to predict the specific binding mode of this compound In addition, anthelmintic activity of these compounds was also evaluated against adult Indian earthworms (Pheretima posthuman). The results showed that compound I [X = O, R¹ = C(O)Cy] had the best effect. These results above could provided exptl. reference for the development of novel antibacterial and anthelmintic drugs.

Application In Synthesis of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 349-88-2.

Huo, Yong-Wang;Qi, Xinxin;Wu, Xiao-Feng research published ã€?Nickel-Catalyzed Carbonylative Synthesis of α,β-Unsaturated Thioesters from Vinyl Triflates and Arylsulfonyl Chloridesã€? the research content is summarized as follows. A straightforward and efficient synthesis of α,β-unsaturated thioesters RC(O)SR¹ [R = cyclopenten-1-yl, cyclohexen-1-yl, 3,4-dihydronaphthalen-1-yl, etc.; R¹ = 4-MeC₆H₄, 4-FC₆H₄, 4-MeOC₆H₄, etc.] had been developed via a nickel-catalyzed thiocarbonylation reaction of vinyl triflates with arylsulfonyl chlorides. With Mo(CO)₆ as both CO source and reductant, a variety of α,β-unsaturated thioesters were obtained in moderate to good yields with very good functional group compatibility. It was noteworthy that the present method was the first example on nickel-catalyzed carbonylative synthesis of α,β-unsaturated thioesters by using arylsulfonyl chlorides as the coupling partner.

Electric Literature of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Name: 4-Fluorobenzene-1-sulfonyl chloride.

He, Chonglong;Zhang, Keyuan;Wang, Dan-Ning;Wang, Min;Niu, Yuejie;Duan, Xin-Hua;Liu, Le research published 《 Visible-Light-Induced Alkylarylation of Unactivated Alkenes via Radical Addition/Truce-Smiles Rearrangement Cascade》, the research content is summarized as follows. The authors disclose a visible-light-induced alkylarylation reaction of unactivated alkenes via a metal-free radical addition/aryl translocation cascade sequence. A distal olefinic sulfonate was designed as a unique mol. scaffold allowing for a domino process to synthesize valuable alkylarylated alcs. in good yields with excellent diastereoselectivity, featuring mild reaction conditions, broad substrate scope, and excellent functional group tolerance. The mechanistic investigation suggests that a visible-light-induced radical chain process dominates the cascade transformation.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Name: 4-Fluorobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics