Category: 350-30-1

Blake, Steven published the artcileSalicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice, Product Details of C6H3ClFNO2, the publication is Journal of Medicinal Chemistry (2020), 63(13), 6898-6908, database is CAplus and MEDLINE.

Clostridioides difficile infection (CDI) causes serious and sometimes fatal symptoms like diarrhea and pseudomembranous colitis. Although antibiotics for CDI exist, they are either expensive or cause recurrence of the infection due to their altering the colonic microbiota, which is necessary to suppress the infection. Here, we leverage a class of known membrane-targeting compounds that we previously showed to have broad inhibitory activity across multiple Clostridioides difficile strains while preserving the microbiome to develop an efficacious agent. A new series of salicylanilides was synthesized, and the most potent analog was selected through an in vitro inhibitory assay to evaluate its pharmacokinetic parameters and potency in a CDI mouse model. The results revealed reduced recurrence of CDI and diminished disturbance of the microbiota in mice compared to standard-of-care vancomycin, thus paving the way for novel therapy that can potentially target the cell membrane of C. difficile to minimize relapse in the recovering patient.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Product Details of C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Egbert, Jonathan D. published the artcileDevelopment and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated Aldehydes, Application In Synthesis of 350-30-1, the publication is Organic Process Research & Development (2019), 23(9), 1803-1812, database is CAplus.

Electrolysis flow reactors based on the filter-press architecture of redox flow batteries have proven to be effective and scalable toward the production of com. relevant, pharmaceutical quantities of anilines ( > 500 kg/yr) from halogen-, hydroxyl-, and carbonyl-substituted nitroarenes. Turbulent flow through the carbon felts on which the catalysts were supported facilitated scaling toward production levels because it conferred on the reactors scale-independent, plug flow-like residence time distributions and high mass transfer coefficients Equipping the cells with microreference electrodes made it possible to transfer reaction conditions first developed in batch systems to the continuous flow reactors. The catalysts prepared by incipient wetness impregnation of metal salts into lightly oxidized carbon felt supports were readily generalizable.

Organic Process Research & Development published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tan, Fang-Fang published the artcileUtilization of a Hydrogen Source from Renewable Lignocellulosic Biomass for Hydrogenation of Nitroarenes, COA of Formula: C6H3ClFNO2, the publication is ChemCatChem (2019), 11(16), 4189-4195, database is CAplus.

Herein, the utilization of a hydrogen source from renewable lignocellulosic biomass, one of the most abundant renewable sources in nature, for a hydrogenation of nitroarenes was described. The hydrogenation was demonstrated by reduction of nitroarenes to arylamines e.g., I in up to 95% yields. Mechanism studies suggested that the hydrogenation occurred via a hydrogen transformation pathway.

ChemCatChem published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C65H82N2O18S2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V. published the artcileNanoscale Fe₂O₃-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines, Product Details of C6H3ClFNO2, the publication is Science (Washington, DC, United States) (2013), 342(6162), 1073-1076, database is CAplus and MEDLINE.

Production of anilines-key intermediates for the fine chem., agrochem., and pharmaceutical industries relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe₂O₃)-based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe₂O₃ particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.

Science (Washington, DC, United States) published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Product Details of C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yabe, Osamu published the artcileA convergent scale-up synthesis of a HER2/EGFR dual kinase inhibitor, Quality Control of 350-30-1, the publication is Heterocycles (2017), 94(4), 702-715, database is CAplus.

A practical and scalable synthesis of the human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual kinase inhibitor I has been developed. The key features of the process development include convenient construction of the benzisothiazole skeleton directly from com. available materials in high yield, a practical O-demethylation utilizing an ethanethiol or octanethiol/aluminum chloride system without harsh conditions, and development of a more convergent alternative route that coupled two key intermediates in the final step. The novel synthesis allowed the manufacturing process to produce high quality API I (>99% purity (LCAP)) over 7 steps, compared to 9 steps in the original route, without chromatog. purification

Heterocycles published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C10H10O2, Quality Control of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wienhoefer, Gerrit published the artcileGeneral and Selective Iron-Catalyzed Transfer Hydrogenation of Nitroarenes without Base, Application In Synthesis of 350-30-1, the publication is Journal of the American Chemical Society (2011), 133(32), 12875-12879, database is CAplus and MEDLINE.

The first well-defined iron-based catalyst system for the reduction of nitroarenes to anilines has been developed applying formic acid as reducing agent. A broad range of substrates possessing other reducible functional groups were converted to the corresponding anilines in good to excellent yields at mild conditions with other function group untouched. Notably, the process constitutes a rare example of base-free transfer hydrogenations.

Journal of the American Chemical Society published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C9H8BNO2, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Changchun published the artcileSynthesis and fungicidal activity of (2-chloropyridin-5-yl)methyl carbamates, Safety of 3-Chloro-4-fluoronitrobenzene, the publication is Nongyaoxue Xuebao (2015), 17(1), 97-100, database is CAplus.

Eleven novel (2-ehloropyridin-S-yl)methyl carbamates were synthesized by Pd-Fe/TiO₂ catalyzed carbonylation of aromatic nitro-compounds and (2-chloropyridin-S-yl) methanol with carbon monoxide. Their structures were confirmed by ¹H NMR and MS. Preliminary fungicidal activity tests indicated that some of the target compounds exhibited certain degree of inhibiting effect against four tested strains at the concentration of 50 mg/L. The inhibition rate against Gibberella zeae was over 77.3% for compound I [(2-chloropyridin-5-yl)methyl (4-methoxyphenyl) carbamate], II [(2-chloropyridin-5-yl)methyl (2,4-dichlorophenyl) carbamate] and III [(2-ehloropyridin-S-yl)methyl (3,4-dichlorophenyl) carbamate]. Compound I showed 82.5% of inhibition rate against Physalospora piricola, that was almost equal to carbendazim. All compounds showed better fungicidal activities against Botrytis cinerea than carbendazim.

Nongyaoxue Xuebao published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Safety of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yang-hua published the artcileDevelopment of QSAR model for predicting mutagenicity of aromatic compounds, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Chinese Journal of Structural Chemistry (2015), 34(3), 324-334, database is CAplus.

Quant. structure-activity relationship (QSAR) model was developed for predicting the mutagenicity of aromatic compounds The log revertants data of S. typhimurium TA98 strain from Ames test have been collected. 225 Aromatic compounds were randomly divided into the training set with 186 mols. and test set with 39 mols. Multiple linear regression (MLR) anal. was used to select six descriptors from thousands of descriptors calculated by semi-empirical AM1 and E-dragon methods. The final QSAR model with six descriptors was internal and external validated. In addition, to validate the utility of our QSAR model for the chem. evaluation, three aromatic compounds were taken to test the predictive ability and reliability of the model exptl. The compounds selected for testing were not based on the predictions, thus spanning the range of predicted probabilities. The subsequently generated results of the Ames test were in good correspondence with the predictions and confirmed this approach as a useful means of predicting likely mutagenic risk of aromatic compounds

Chinese Journal of Structural Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xiao-Long published the artcileQSTR studies on acute toxicity and mutagenicity of halogenated benzenes, Computed Properties of 350-30-1, the publication is Asian Journal of Chemistry (2014), 26(9), 2707-2710, database is CAplus.

In this paper, a quant. structure toxicity relationship study was performed for the prediction of the acute toxicity and mutagenicity of halogenated benzenes. The mol. descriptors of halogenated benzenes have been calculated with semi-empirical AM1 and E-dragon methods and both quant. structure toxicity relationship models for mice via the oral LD₅₀ model and the S. typhimurium (TA98 + S9) mutagenic model of halogenated benzenes were developed using multiple linear regression (MLR) anal. The validation results obtained from the test set indicate that the proposed models are robust and satisfactory.

Asian Journal of Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C9H8BNO2, Computed Properties of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Dong published the artcileDiscovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres, Quality Control of 350-30-1, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(15), 3609-3613, database is CAplus and MEDLINE.

A unified strategy was conceived and implemented to deliver conformationally constrained anilides based on their preferred cis-amide conformers. The imidazole/triazole mimicing amide bonds were designed, building upon an earlier discovery of a novel series of tricyclic lactams MK2 kinase inhibitors. This approach enabled rapid, modular synthesis of structurally novel analogs. The efficient SAR development led to the discovery of low mol. weight and potent MK2 non-ATP competitive inhibitors with good ligand efficiency, which led to improved permeability and oral exposure in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C20H17FO4S, Quality Control of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics