Category: 350-30-1

The author of 《Utilization of a Hydrogen Source from Renewable Lignocellulosic Biomass for Hydrogenation of Nitroarenes》 were Tan, Fang-Fang; Tang, Kai-Li; Zhang, Ping; Guo, Yan-Jun; Qu, Mengnan; Li, Yang. And the article was published in ChemCatChem in 2019. Safety of 3-Chloro-4-fluoronitrobenzene The author mentioned the following in the article:

Herein, the utilization of a hydrogen source from renewable lignocellulosic biomass, one of the most abundant renewable sources in nature, for a hydrogenation of nitroarenes was described. The hydrogenation was demonstrated by reduction of nitroarenes to arylamines e.g., I in up to 95% yields. Mechanism studies suggested that the hydrogenation occurred via a hydrogen transformation pathway.3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Safety of 3-Chloro-4-fluoronitrobenzene) was used in this study.

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 3-Chloro-4-fluoronitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guo, Haichang; Zheng, Renhua; Jiang, Huajiang; Xu, Zhenyuan; Xia, Aibao published their research in BMC Chemistry on December 31 ,2019. The article was titled 《Preparation of sub-microspherical Fe3O4@PDA-Pd NPs catalyst and application in catalytic hydroreduction reaction of halogenated aromatic nitro compounds to prepare halogenated aromatic amines》.Safety of 3-Chloro-4-fluoronitrobenzene The article contains the following contents:

A promising method for preparation of the superparamagnetic and strongly magnetic Fe3O4@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compds was reported. The catalyst showed a high selectivity of greater than 96% and effectively inhibited the occurrence of the side reactions of dehalogenation and C-N coupling. The optimum condition of the hydroredn. reaction was when THF is used as solvent and the reaction occurred at 50° for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceeded 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling byproducts were produced in the brominated aromatic compound and the iodinated aromatic compound In the experiment, the researchers used many compounds, for example, 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Safety of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Safety of 3-Chloro-4-fluoronitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 3-Chloro-4-fluoronitrobenzeneOn May 31, 2022, Li, Dingzhong; Zhang, Wensheng; Zhu, Longzhi; Yin, Shuang-Feng; Kambe, Nobuaki; Qiu, Renhua published an article in ChemistryOpen. The article was 《FeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones》. The article mentions the following:

An efficient hydrazine substitution of p-nitro-aryl fluorides viz., 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 2-fluoro-5-nitroaniline, etc. with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. These hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups such as 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 1-bromo-2,4-difluoro-5-nitrobenzene, etc. proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups such as 2-fluoro-5-nitroaniline, 1-fluoro-2-methyl-4-nitrobenzene, 2-bromo-4-fluoro-1-nitrobenzene, etc. also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines viz., (2-chloro-4-nitrophenyl)hydrazine, (3-fluoro-4-nitrophenyl)hydrazine, (2-bromo-4-nitrophenyl)hydrazine, (2,3-difluoro-4-nitrophenyl)hydrazine, (2-chloro-3-fluoro-4-nitrophenyl)hydrazine, some phthalazinones I (R = H, 4-hydroxyphenyl; R1 = 2-Cl, 2-Br, 3-F, 2-Cl-3-F, 2,3-F2), interesting as potential structures for pharmaceuticals, have been successfully synthesized in high yields. The results came from multiple reactions, including the reaction of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Reference of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Reference of 3-Chloro-4-fluoronitrobenzene The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Akintola, Oluwafemi; Ren, Weiwu; Adabala, Pal John Pal; Bhosale, Sandeep; Wang, Yang; Ganga-Sah, Yumeela; Britton, Robert; Bennet, Andrew J. published their research in ACS Catalysis on August 6 ,2021. The article was titled 《Intrinsic Nucleophilicity of Inverting and Retaining Glycoside Hydrolases Revealed Using Carbasugar Glyco-Tools》.Category: chlorides-buliding-blocks The article contains the following contents:

Hydrolyzes of cyclohexenyl-based carbasugars that mimic either α-D-glucose or α-D-galactose were explored with two Bacteroides thetaiotaomicron enzymes from glycoside hydrolase family 97: an inverting α-glucosidase (BtGH97a) and a retaining α-galactosidase (BtGH97b). Specifically, the kinetic data for the inverting α-glucosidase is consistent with the reaction giving a hydrolyzed inverted carbaglucose product by a mechanism that proceeds with little nucleophilic participation by the bound water mol. at the reaction transition state. The enzymic rate constant ratio for the Ph carbasugars contrasts with the corresponding kinetic data obtained using natural substrate Ph glycopyranosides. This modest difference in rate constants underscores our conclusion that retaining glycoside hydrolases may not have optimized the nucleophilicity of their active site nucleophiles with the result that the transition state free energies for formation and hydrolysis of the covalent enzyme intermediate are matched. After reading the article, we found that the author used 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Category: chlorides-buliding-blocks)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Category: chlorides-buliding-blocks Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Zhi-You; Liu, Min; Mao, Yi-Jun; Chen, Yu-De; Wang, Yan-Ping; Liu, Chong published an article on February 21 ,2019. The article was titled 《A microwave-assisted approach to N-(2-nitrophenyl)benzenesulfonamides that enhanced peroxidase activity in response to excess cadmium》, and you may find the article in Tetrahedron Letters.Application In Synthesis of 3-Chloro-4-fluoronitrobenzene The information in the text is summarized as follows:

A facile and efficient approach to N-(2-nitrophenyl) benzenesulfonamides was developed under microwave irradiation A series of pyrabactin analogs containing nitrophenyl scaffold was obtained in excellent yields. In addition, the method was pretty suitable to prepare flusulfamide. Significantly, the 4-bromo-N-(4-chloro-2-nitrophenyl)benzenesulfonamide could enhance POD activity in response to heavy metal stress. After reading the article, we found that the author used 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Application In Synthesis of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Application In Synthesis of 3-Chloro-4-fluoronitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C6H3ClFNO2On October 31, 2021 ,《Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy》 appeared in Acta Pharmaceutica Sinica B. The author of the article were Zhu, Jing; Xin, Meng; Xu, Congcong; He, Yuan; Zhang, Wannian; Wang, Zhibin; Zhuang, Chunlin. The article conveys some information:

Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis and inflammation. Our group previously identified TAK-632 (5) as an effective necroptosis inhibitor by dual-targeting RIP1 and RIP3. In this study, using ligand-based substituent-anchoring design strategy, we focused on the benzothiazole ring to obtain a series of TAK-632 analogs showing significantly improving on the anti-necroptosis activity and RIP1 selectivity over RIP3. Among them, a conformational constrained fluorine-substituted derivative (25) exhibited 333-fold selectivity for RIP1 (Kd = 15 nmol/L) than RIP3 (Kd > 5000 nmol/L). This compound showed highly potent activity against cell necroptosis (EC50 = 8 nmol/L) and systemic inflammatory response syndrome (SIRS) induced by TNF-α in vivo. Especially, it was able to exhibit remarkable anti-inflammatory treatment efficacy in a DSS-induced mouse model of UC. Taken together, the highly potent, selective, orally active anti-necroptosis inhibitor represents promising candidate for clin. treatment of UC. The experimental part of the paper was very detailed, including the reaction process of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Synthetic Route of C6H3ClFNO2)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Synthetic Route of C6H3ClFNO2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2021,RSC Medicinal Chemistry included an article by Lin, Runfeng; Zhang, Zheng; Cao, Shengtian; Yang, Wen; Zuo, Yinglin; Yang, Xinye; Zhang, Jiancun; Xu, Juan; Li, Jing; Wang, Xiaojun. Name: 3-Chloro-4-fluoronitrobenzene. The article was titled 《The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis》. The information in the text is summarized as follows:

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a typical survival time between three to five years. Two drugs, pirfenidone and nintedanib have been approved for the treatment of IPF, but they have limited efficacy. Thus, the development of new drugs to treat IPF is an urgent medical need. In this paper we report the discovery of a series of orally active pyrimidin-4(3H)-one analogs which exhibit potent activity in in vitro assays. Among them, HEC-866 showed promising efficacy in rat IPF models. Since HEC-866 also had good oral bioavailability, a long half-life and favorable long-term safety profiles, it was selected for further clin. evaluation.3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Name: 3-Chloro-4-fluoronitrobenzene) was used in this study.

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Name: 3-Chloro-4-fluoronitrobenzene Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Pest Management Science included an article by Liu, Jing-Bo; Li, Feng-Yun; Li, Yu-Xin; Zhang, Xiu-Lan; Hua, Xue-Wen; Xiong, Li-Xia; Li, Zheng-Ming. Reference of 3-Chloro-4-fluoronitrobenzene. The article was titled 《Synthesis, insecticidal evaluation and 3D-QSAR study of novel anthranilic diamide derivatives as potential ryanodine receptor modulators》. The information in the text is summarized as follows:

BACKGROUND : Anthranilic diamide insecticides control lepidopteran pests through selectively binding and activating insect ryanodine receptors. In order to search for potential insecticides targeting the ryanodine receptors, a series of anthranilic diamide analogs including trifluoromethyl, nitro, or chloro groups were designed and synthesized by the principle of bioisosterism and structural optimization. RESULTS : Insecticidal data indicated that some compounds displayed good activity against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). In particular, the larvicidal activity of 6p against P. xylostella was 95% at 0.01 mg L-1, equivalent to chlorantraniliprole (85%, 0.01 mg L-1). The comparative mol. similarity index anal. model obtained indicated that hydrogen bond acceptor and electron-withdrawing groups in the R’3 group are favorable for insecticidal activity against M. separata, which is consistent with the structure-activity relationships. Moreover, the calcium imaging experiment indicated, like chlorantraniliprole, that 6h and 6p are interacting with the ryanodine receptor. CONCLUSION : Introducing trifluoromethyl, nitro, or chloro groups to a specific position in the N-phenylpyrazole could improve or maintain the activity against M. separata and P. xylostella. 6h and 6p could be used as potential lead compounds for ryanodine receptor modulators.Μ. In the experiment, the researchers used many compounds, for example, 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Reference of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Reference of 3-Chloro-4-fluoronitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alepee, Nathalie; Grandidier, Marie-Helene; Cotovio, Jose published an article on February 28 ,2019. The article was titled 《Usefulness of the EpiSkin reconstructed human epidermis model within Integrated Approaches on Testing and Assessment (IATA) for skin corrosion and irritation》, and you may find the article in Toxicology In Vitro.Synthetic Route of C6H3ClFNO2 The information in the text is summarized as follows:

Predictive capacity of the EpiSkin model was evaluated on 87 chems. using the Bottom-Up and the Top-Down testing approaches recommended within Integrated Approach on Testing and Assessment for the identification of both skin irritation and corrosion hazards. Classified (UN GHS Cat. 1 and Cat. 2) chems. were identified with a very high sensitivity (≥94%) and the non-classified (UN GHS Cat. 3 and No Cat.) chems. with an appropriate specificity (70%). Very high sensitivities were obtained for the identification of Cat. 1 chems. (≥98%), very high specificities for non-Cat. 1 chems. (93%), and accuracies of -95% for the identification of skin corrosives vs. non-corrosives by both approaches. Overall accuracies of 72% were found for predicting the single (sub)categories: non-classified, Cat. 2, Subcat. 1B/1C and Subcat. 1A. Results indicated the testing strategies to be more predictive than the individual assays on a conservative safety approach. Finally, no extreme misclassifications (no under-prediction of in vivo Subcat. 1A as non-Cat. 1, and no over-prediction of non-classified chem. as Subcat. 1A) occur. These findings, independently of the approach used, confirm the usefulness of the EpiSkin in vitro model for a safe prediction of the skin irritant and corrosive hazards of chems. In addition to this study using 3-Chloro-4-fluoronitrobenzene, there are many other studies that have used 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Synthetic Route of C6H3ClFNO2) was used in this study.

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C6H3ClFNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Reductive amination using cobalt-based nanoparticles for synthesis of amines》 was written by Murugesan, Kathiravan; Chandrashekhar, Vishwas G.; Senthamarai, Thirusangumurugan; Jagadeesh, Rajenahally V.; Beller, Matthias. Recommanded Product: 350-30-1 And the article was included in Nature Protocols on April 30 ,2020. The article conveys some information:

In this protocol, the preparation of carbon-supported cobalt-based nanoparticles as efficient and practical catalysts for synthesis of different kinds of amines by reductive aminations was described. Template synthesis of a cobalt-triethylenediamine-terephthalic acid metal-organic framework on carbon and subsequent pyrolysis to remove the organic template resulted in the formation of supported single cobalt atoms and nanoparticles. Applying these catalysts, structurally diverse benzylic, aliphatic and heterocyclic primary, secondary and tertiary amines, including pharmaceutically relevant products, starting from inexpensive and easily accessible carbonyl compounds with ammonia, nitro compounds or amines and mol. hydrogen were synthesized. To prepare this cobalt-based catalyst took 26 h, and the reported catalytic reductive amination reactions could be carried out within 18-28 h. The results came from multiple reactions, including the reaction of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Recommanded Product: 350-30-1)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 350-30-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics