Category: 35112-27-7

Arcoleo, A. published the artcileReaction of 2-acetyltetralone with some esters of benzoic acid, Name: Ethyl 2,5-dichlorobenzoate, the main research area is acetyltetralone condensation benzoate; naphthopyranone phenyl.

Reaction of 2-acetylteralone (I) with RC6H4CO2Me (II, R = H, 4-Cl, 4-Me3C, 2-MeO, 2-EtO, 2-PrO) gave the corresponding triketones III, however reaction of I with II (R = 2-Cl) and 2,5-Cl2C6H3CO2Me gave III [R = 2-Cl, 2-MeO) and III (R = 2,5-Cl2, 2,5-(MeO)Cl] resp. Treating III with H2SO4 gave naphthopyranones IV.

Journal of Heterocyclic Chemistry published new progress about acetyltetralone condensation benzoate; naphthopyranone phenyl. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Name: Ethyl 2,5-dichlorobenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Teng, Ming-yu published the artcileSynthesis, chemo-selective properties of substituted 9-aryl-9H-fluorenes from triarylcarbinols and enantiomerical kinetics of chiral 9-methoxy-11-(naphthalen-1-yl)-11H-benzo[a]fluorene, Quality Control of 35112-27-7, the main research area is fluorene aryl preparation crystal mol structure; triarylcarbinol acidification.

9-Aryl-fluorenes were synthesized conveniently from triarylcarbinols in the presence of TsOH. Notably, the orientation of the intramol. aromatic substitution reaction was dictated by the nature of the substituents on the aryl rings of triarylcarbinols, owing to electronic and conjugated effects. In particular, triarylcarbinols with (3-methoxy)phenyl and naphthalenyl groups formed benzo[a]fluorenes selectively. Moreover, 9-methoxy-11-(naphthalen-1-yl)-11H-benzo[a] fluorene, with a center of chirality, exists as a mixture of diastereoisomers, due to the restricted rotation of a C-C single bond. First-order rate constants for the enantiomerization of 9-methoxy-11-(naphthalen-1-yl)-11H-benzo[a] fluorene in DMSO were obtained over the temperature from 297 K to 393 K, and thermodn. parameters were determined as ΔH‡ = 99.7 kJ mol-1, ΔS‡373 K = 37.7 J mol-1 K-1, and ΔG‡373 K = 85.6 kJ mol-1 by Eyring plot anal.

RSC Advances published new progress about Atropisomers. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Quality Control of 35112-27-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lakhani, Kinjal published the artcileDesign, Syntheses, and Bioevaluations of Some Novel N2-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents, Related Products of chlorides-buliding-blocks, the main research area is acryloylbenzohydrazide chemostimulant cytotoxic agent colon breast cancer human; acryloylhydrazides; antineoplastic agents; chemosensitization; cytotoxins; mitochondrial membrane potential; reactive oxygen species.

A series of novel N2-acryloylhydrazides 1a-m and a related series of compounds 6a-c were prepared as potential chemostimulants. In general, these compounds are cytotoxic to human HCT 116 colon cancer cells, as well as human MCF-7 and MDA-MB-231 breast cancer cell lines. A representative compound N1-(3,4-dimethoxyphenylcarbonyl)-N2-acryloylhydrazine 1m sensitized HCT 116 cells to the potent antineoplastic agent 3,5-bis(benzylidene)-4-piperidone 2a, and also to 5-fluorouracil. A series of compounds was prepared that incorporated some of the mol. features of 2a and related compounds with various N2-acryloylhydrazides in series 1. These compounds are potent cytotoxins. Two modes of action of representative compounds are the lowering of mitochondrial membrane potential and increasing the concentration of reactive oxygen species.

Medicines published new progress about Antitumor agents. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Klavetter, Floyd L. published the artcilePhotoluminescence and electroluminescence of transparent polyphenylene derivatives, Formula: C9H8Cl2O2, the main research area is photoluminescence electroluminescence polyphenylene derivative LED device.

Blue and violet luminescence is reported of a series of polyphenylene (PPP) derivatives containing “”waxy”” side chains. While the luminescence is red-shifted by the electron-donating amino group directly bonded to the PPP chain, the length of the side-chain in these PPP derivatives does not seem to significantly shift the photoluminescence. Investigation is underway into the effect of side-chain polarity upon electroluminescence in LED devices.

Polymeric Materials Science and Engineering published new progress about Electroluminescence. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Formula: C9H8Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yan published the artcileStereoselective synthesis and fungicidal activities of (E)-α-(methoxyimino)-benzeneacetate derivatives containing 1,3,4-oxadiazole ring, Application In Synthesis of 35112-27-7, the main research area is stereoselective synthesis fungicidal activity methoxyiminobenzeneacetate oxadiazolyl.

Fifteen novel (E)-α-(methoxyimino)benzeneacetate derivatives, the analogs of strobilurins, which contain two pharmacophoric substructures of (E)-Me methoxyiminoacetate moiety and 1,3,4-oxadiazole ring were stereoselectively synthesized. It was first found that the coupling reaction could give stereoselectively the key intermediate (E)- and (Z)-Me 2-(hydroxyimino)-2-o-tolylacetate with a ratio of 14:1. The preliminary bioassays indicated that all the compounds I (R = H, 4-MeO, 2,3-Cl2, 2-I, etc.) showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola and Bipolaris mayclis, and all of the tested compounds had more potent fungicidal activities against R. solani than Kresoxim-Me.

Bioorganic & Medicinal Chemistry Letters published new progress about Agrochemical fungicides. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Application In Synthesis of 35112-27-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Unsinn, Andreas published the artcileDirected Magnesiation of Polyhaloaromatics using the Tetramethylpiperidylmagnesium Reagents TMP2Mg.2LiCl and TMPMgCl.LiCl, COA of Formula: C9H8Cl2O2, the main research area is regioselective magnesium halo arene magnesium amide Grignard reagent preparation; chlorophenethylphenol antimicrobial natural product preparation.

A convenient and efficient functionalization of polyhaloaroms. via regioselective magnesiation has been developed. Starting from simple, inexpensive but structurally challenging arenes, metalation by magnesium amide bases was achieved under mild conditions. The desired Grignard reagents were stable towards aryne formation, were obtained in good yields within short reaction times and could be reacted with a variety of typical electrophiles, providing attractive, functionalized building blocks in good to excellent yields. As an application we have prepared the antimicrobial natural product 2,6-dichloro-3-phenethylphenol isolated from the New Zealand liverwort Riccardia marginata. This synthesis involves a mixed bimetallic compound prepared via metalation of a phenylboronic acid pinacol ester derivative and subsequent selective cross-coupling.

Advanced Synthesis & Catalysis published new progress about Amides Role: RGT (Reagent), RACT (Reactant or Reagent) (Mg amide magnesiation agents). 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, COA of Formula: C9H8Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Ikyon published the artcileDesign, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors, Recommanded Product: Ethyl 2,5-dichlorobenzoate, the main research area is aryldialkoxyphenylpyrazolopyrimidine preparation PDE4 inhibitor.

Described herein is design, synthesis, and biol. evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallog. Also, biol. effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 < 10 nM). Bioorganic & Medicinal Chemistry Letters published new progress about Asthma. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Recommanded Product: Ethyl 2,5-dichlorobenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Andres, Miriam published the artcile2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists, Application of Ethyl 2,5-dichlorobenzoate, the main research area is pyrazolylacetate preparation chemoattractant receptor antagonist; CRTh2 antagonists; Pyrazole; Structure–activity relationship (SAR).

In this manuscript, the synthesis and biol. activity of a series of pyrazole acetic acids, e.g. I [R1 = H, 4-MeO, 5-F, etc.; R2 = Ph, 2-FC6H4, 3-ClC6H4; X= SO2, S] as CRTh2 antagonists is presented. Biol. evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which two compounds I [R1 = H; R2 = Ph; X = SO2] and I [R1 = H; R2 = 4-FC6H4; X = SO2] were advanced to in vivo profiling.

European Journal of Medicinal Chemistry published new progress about Structure-activity relationship, receptor-binding. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Application of Ethyl 2,5-dichlorobenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marivingt-Mounir, Cecile published the artcileSynthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels, COA of Formula: C9H8Cl2O2, the main research area is benzoquinolizinium preparation cystic fibrosis transmembrane conductance regulator channel activation; benzoindoloquinolizinium preparation cystic fibrosis transmembrane conductance regulator channel activation.

Chloride channels play important roles in homeostasis and regulate cell volume, transepithelial transport, and elec. excitability. Despite recent progress made in the genetic and mol. aspect of chloride channels, their pharmacol. is still poorly understood. The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated epithelial chloride channel for which mutations cause cystic fibrosis. Here we have synthesized benzo[c]quinolizinium, e.g., I, and benzo[f]indolo[2,3-a]quinolizinium salts (MPB), e.g., II, and performed a SAR to identify the structural basis for activation of the CFTR chloride channel. Synthesized compounds were evaluated on wild-type CFTR and on CFTR having the glycine-to-aspartic acid missense mutation at codon 551 (G551D-CFTR), using a robot and cell-based assay. The presence of an hydroxyl group at position 6 of the benzo[c]quinolizinium skeleton associated with a chlorine atom at position 10 or 7 and an alkyl chain at position 5 determined the highest activity. The most potent product is 5-butyl-7-chloro-6-hydroxybenzo[c]quinolizinium chloride (I, MPB-104). I is 100 times more potent than the parent compound III (MPB-07).

Journal of Medicinal Chemistry published new progress about Chloride channels Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, COA of Formula: C9H8Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics