Category: 35444-44-1

On April 30, 2022, Hu, Chen; Ye, Baijun; Huang, Zedu; Chen, Fener published an article.COA of Formula: C7H11ClO3 The title of the article was Development of an engineered ketoreductase with improved activity, stereoselectivity and relieved substrate inhibition for enantioselective synthesis of a key (R)-α-lipoic acid precursor. And the article contained the following:

Me (R)-8-chloro-6-hydroxyoctanoate ((R)-MCHO, (R)-2a) is a key precursor that can be utilized in the production of (R)-α-lipoic acid ((R)-LA) of pharmaceutical and dietary significance. Owing to its high atom economy, maximum theor. yield of 100%, and environmentally friendliness, ketoreductase (KRED)-catalyzed stereoselective reduction of Me 8-chloro-6-oxooctanoate (MCOO, 1a), an ε-keto ester, represents an efficient yet challenging approach to the synthesis of (R)-2a. We report herein the development of a versatile KRED, referred to as SsCRL211H/V127A/L135I, through enzyme screening followed by structure-guided protein engineering, which was assisted by comparative anal. of enzyme-/substrate- binding modes in prereaction-state and free-state mol. dynamics (MD) simulations. This enzyme variant displayed 2.8-fold increased kcat (16.77 s-1) towards 1a relative to the wild-type SsCR, improved stereoselectivity (98.0% ee), and no substrate inhibition. Insights were gained on the origin of the enhancement of enzyme’s catalytic activity and stereoselectivity, by conducting complete deconvolution experiments and MD simulations. In the presence of 60 g·L-1 of wet E. coli cells coexpressing SsCRL211H/V127A/L135I and glucose dehydrogenase (GDH), and 0.05 mM NADP+, complete reduction of 260 g·L-1 of 1a was achieved furnishing (R)-2a with 98.0% ee with a space-time yield of 391 g·L-1·d-1, thereby showcasing the promising potential of this ketoreductase in the asym. synthesis of (R)-2a. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to escherichia enantioselective ketoreductase alpha lipoic acid, Fermentation and Bioindustrial Chemistry: Other and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 24, 2010, Jiang, Xiaolu; London, Emma K.; Morris, David J.; Clarkson, Guy J.; Wills, Martin published an article.Synthetic Route of 35444-44-1 The title of the article was Gold-catalysed cyclic ether formation from diols. And the article contained the following:

Gold(I) and (III) salts have been found to be highly effective at the catalysis of ether formation from alcs. Intramol. ether formation of a 1,5-diol was also achieved to give cyclic ethers, e.g. 2-phenyltetrahydropyran, with a stereoselectivity that indicates that an SN1 mechanism predominates. In an attempt to form a seven-membered ring, a stable 14-membered dimer product was also formed. Attempts to control the diastereoselectivity of the reaction using a chiral anionic counterion did not give products with a high de. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Synthetic Route of 35444-44-1

The Article related to gold catalyzed intramol etherification cyclic ether preparation diol reactant, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Synthetic Route of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 29, 2015, Kalek, Marcin; Fu, Gregory C. published an article.Category: chlorides-buliding-blocks The title of the article was Phosphine-Catalyzed Doubly Stereoconvergent γ-Additions of Racemic Heterocycles to Racemic Allenoates: The Catalytic Enantioselective Synthesis of Protected α,α-Disubstituted α-Amino Acid Derivatives. And the article contained the following:

Methods have recently been developed for the phosphine-catalyzed asym. γ-addition of nucleophiles to readily available allenoates and alkynoates to generate useful α,β-unsaturated carbonyl compounds that bear a stereogenic center in either the γ or the δ position (but not both) with high stereoselectivity. The utility of this approach would be enhanced considerably if the stereochem. at both termini of the new bond could be controlled effectively. In this report, we describe the achievement of this objective, specifically, that a chiral phosphepine can catalyze the stereoconvergent γ-addition of a racemic nucleophile to a racemic electrophile; through the choice of an appropriate heterocycle as the nucleophilic partner, this new method enables the synthesis of protected α,α-disubstituted α-amino acid derivatives in good yield, diastereoselectivity, and enantioselectivity. Thus, e.g., γ-addition of oxazolone (±)-I with (±)-allenoate II in presence of chiral phosphepine (S)-III yielded IV (91% ee, 14:1 dr). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Category: chlorides-buliding-blocks

The Article related to phosphine catalyzed stereoconvergent addition racemic heterocycle allenoate, enantioselective synthesis protected amino acid derivative, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Lei; Chen, Yingjie; Chen, Lei; Xiao, Xiao; Wang, Xingxing; Li, Jinbo; Zhang, Yan published an article in 2017, the title of the article was Photo-clickable microRNA for in situ fluorescence labeling and imaging of microRNA in living cells.Computed Properties of 35444-44-1 And the article contains the following content:

A photo-clickable microRNA whose fluorescence was able to be turned on by mild light irradiation was constructed and the in situ fluorescence turn-on of the photo-clickable microRNA-122 in living cells was demonstrated by light irradiation with spatial and temporal resolution The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Computed Properties of 35444-44-1

The Article related to microrna tetrazole conjugate fluorescence probe photo clickable cell imaging, Biochemical Methods: Spectral and Related Methods and other aspects.Computed Properties of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2014, Afri, Michal; Alexenberg, Carmit; Aped, Pinchas; Bodner, Efrat; Cohen, Sarit; Ejgenburg, Michal; Eliyahu, Shlomi; Gilinsky-Sharon, Pessia; Harel, Yifat; Naqqash, Miriam E.; Porat, Hani; Ranz, Ayala; Frimer, Aryeh A. published an article.Computed Properties of 35444-44-1 The title of the article was NMR-based molecular ruler for determining the depth of intercalants within the lipid bilayer. And the article contained the following:

The development of “mol. rulers” would allow one to quant. locate the penetration depth of intercalants within lipid bilayers. To this end, an attempt was made to correlate the 13C NMR chem. shift of polarizable “reporter” carbons (e.g., carbonyls) of intercalants within DMPC liposomal bilayers – with the polarity it experiences, and with its Angstrom distance from the interface. This requires families of mols. with two “reporter carbons” separated by a known distance, residing at various depths/polarities within the bilayer. For this purpose, two homologous series of dicarbonyl compounds, Me n-oxooctadecanoates and the corresponding n-oxooctadecanoic acids (n = 4-16), were synthesized. To assist in assignment and detection several homologs in each system were prepared 13C-enriched in both carbonyls. Within each family, the number of carbons and functional groups remains the same, with the only difference being the location of the second ketone carbonyl along the fatty acid chain. Surprisingly, the head groups within each family are not anchored near the lipid-water interface, nor are they even all located at the same depth. Nevertheless, using an iterative best fit anal. of the data points enables one to obtain an exponential curve. The latter gives substantial insight into the correlation between polarity (measured in terms of the Reichardt polarity parameter, ET(30)) and penetration depth into the liposomal bilayer. Still missing from this curve are data points in the moderate polarity range. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Computed Properties of 35444-44-1

The Article related to keto ester acid mol ruler lipid bilayer nmr, (13)c nmr, dmpc, e(t), liposome, molecular ruler, oxooctadecanoates, Biochemical Methods: Spectral and Related Methods and other aspects.Computed Properties of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 19, 2014, Yamazoe, Sayumi; McQuade, Lindsey E.; Chen, James K. published an article.Recommanded Product: Methyl 6-chloro-6-oxohexanoate The title of the article was Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing. And the article contained the following:

Phosphorodiamidate morpholino oligonucleotides are widely used to interrogate gene function in whole organisms, and light-activatable derivatives can reveal spatial and temporal differences in gene activity. The authors describe here a new class of caged morpholino oligonucleotides that can be activated by the bacterial nitroreductase NfsB. The authors characterize the activation kinetics of these reagents in vitro and demonstrate their efficacy in zebrafish embryos that express NfsB either ubiquitously or in defined cell populations. In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: Methyl 6-chloro-6-oxohexanoate

The Article related to nitroreductase activatable caged morpholino oligonucleotide preparation gene silencing, ntla mnx1 pdx1 gene silencing nitroreductase caged morpholino oligonucleotide, Biochemical Genetics: Genetic Engineering and Cloning and other aspects.Recommanded Product: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 2, 2019, Chen, Junyi; Li, Cong; Hong, Hanyu; Liu, Hui; Wang, Chunhong; Xu, Mengxin; Han, Yuxiang; Liu, Zhibo published an article.Reference of Methyl 6-chloro-6-oxohexanoate The title of the article was Side Chain Optimization Remarkably Enhances the in Vivo Stability of 18F-Labeled Glutamine for Tumor Imaging. And the article contained the following:

Similar to glycolysis, glutaminolysis acts as a vital energy source in tumor cells, providing building blocks for the metabolic needs of tumor cells. To capture glutaminolysis in tumors, 18F-(2S,4R)4-fluoroglutamine ([18F]FGln) and 18F-fluoroboronoglutamine ([18F]FBQ) have been successfully developed for positron emission tomog. (PET) imaging, but these two mols. lack stability, resulting in undesired yet significant bone uptake. In this study, we found that [18F]FBQ-C2 is a stable Gln PET tracer by adding two more methylene groups to the side chain of [18F]FBQ. [18F]FBQ-C2 was synthesized with a good radiochem. yield of 35% and over 98% radiochem. purity. [18F]FBQ-C2 showed extreme stability in vitro, and no defluorination was observed after 2 h in phosphate buffered saline at 37°C. The competitive inhibition assay results indicated that [18F]FBQ-C2 enters cells via the system ASC and N, similar to natural glutamine, and can be transported by tumor-overexpressed ASCT2. PET imaging and biodistribution results indicated that [18F]FBQ-C2 is stable in vivo with low bone uptake (0.81 ± 0.20% ID/g) and can be cleared rapidly from most tissues. Dynamic scan and pharmacokinetic studies using BGC823-xenograft-bearing mice revealed that [18F]FBQ-C2 accumulates specifically in tumors, with a longer half-life (101.18 ± 6.50 min) in tumor tissues than in other tissues (52.70 ± 12.44 min in muscle). Biodistribution exhibits a high tumor-to-normal tissue ratio (4.8 ± 1.7 for the muscle, 2.5 ± 1.0 for the stomach, 2.2 ± 0.9 for the liver, and 17.8 ± 8.4 for the brain). In conclusion, [18F]FBQ-C2 can be used to perform high-contrast Gln imaging of tumors and can serve as a PET tracer for clin. research. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate

The Article related to fluorine 18 glutamine preparation stability tumor pet imaging, boramino acid, glutamine, in vivo stability, positron emission tomography, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tabero, Andrea; Garcia-Garrido, Fernando; Prieto-Castaneda, Alejandro; Palao, Eduardo; Agarrabeitia, Antonia R.; Garcia-Moreno, Inmaculada; Villanueva, Angeles; de la Moya, Santiago; Ortiz, Maria J. published an article in 2020, the title of the article was BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis.Category: chlorides-buliding-blocks And the article contains the following content:

Endowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Conversely, this fact opens the way to the development of highly bright ROS photosensitizers for performing photodynamic theragnosis (fluorescence bioimaging and photodynamic therapy) from a single simple agent. On the other hand, the noticeable capability of some of the reported dyes to probe lipid droplets in different cell lines under different conditions reveals their use as privileged probes for advancing the study of interesting lipid droplets by fluorescence microscopy. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Category: chlorides-buliding-blocks

The Article related to bodipy lipid droplet target pdt photosensitize imaging, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 22, 2021, Nardella, Flore; Halby, Ludovic; Dobrescu, Irina; Viluma, Johanna; Bon, Corentin; Claes, Aurelie; Cadet-Daniel, Veronique; Tafit, Ambre; Roesch, Camille; Hammam, Elie; Erdmann, Diane; Mairet-Khedim, Melissa; Peronet, Roger; Mecheri, Salah; Witkowski, Benoit; Scherf, Artur; Arimondo, Paola B. published an article.Related Products of 35444-44-1 The title of the article was Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites. And the article contained the following:

Epigenetic post-translational modifications are essential for human malaria parasite survival and progression through its life cycle. Here, we present new functionalized suberoylanilide hydroxamic acid (SAHA) derivatives that chem. combine the pan-histone deacetylase inhibitor SAHA with the DNA methyltransferase inhibitor procainamide. A three- or four-step chem. synthesis was designed starting from cheap raw materials. Compared to the single drugs, the combined mols. showed a superior activity in Plasmodium and a potent inhibition against human HDAC6, exerting no cytotoxicity in human cell lines. These new compounds are fully active in multidrug-resistant Plasmodium falciparum Cambodian isolates. They target transmission of the parasite by inducing irreversible morphol. changes in gametocytes and inhibiting exflagellation. The compounds are slow-acting and have an additive antimalarial effect in combination with fast-acting epidrugs and dihydroartemisinin. The lead compound decreases parasitemia in mice in a severe malaria model. Taken together, this novel fused mol. offers an affordable alternative to current failing antimalarial therapy. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Related Products of 35444-44-1

The Article related to procainamide saha fused inhibitor hhdac6 dnmt multidrug resistant plasmodium, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Related Products of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 1, 2012, de Mesquita, Joao P.; Donnici, Claudio L.; Teixeira, Ivo F.; Pereira, Fabiano V. published an article.Recommanded Product: Methyl 6-chloro-6-oxohexanoate The title of the article was Bio-based nanocomposites obtained through covalent linkage between chitosan and cellulose nanocrystals. And the article contained the following:

Bio-based nanocomposites were obtained through covalent linkage between cellulose nanocrystals (CNCs) and the natural polymer chitosan (CH). The CNCs were first functionalized with Me adipoyl chloride (MAC) and the reactive end groups on the surface of the CNCs were reacted with the amino groups of the CH biopolymer in an aqueous medium. The functionalized CNCs and the resulting nanocomposites were characterized using FTIR, TEM, XRD, and elemental analyses. Characterization of the functionalized CNCs showed that up to 8% of the hydroxyl groups in the nanocrystals were substituted by the MAC residue. The covalent linkage between the CNCs and CH was confirmed by FTIR spectroscopy. The nanocomposites demonstrated a significant improvement in the mech. performance and a considerable decrease in the hydrophilicity relative to the neat chitosan. The approach used in this work can be extended to other natural polymers. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: Methyl 6-chloro-6-oxohexanoate

The Article related to bionanocomposite covalent linkage chitosan cellulose nanocrystal, Cellulose, Lignin, Paper, and Other Wood Products: Cellulose and other aspects.Recommanded Product: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics