Category: 35444-44-1

Sun, Chang-Liang; Fuerstner, Alois published an article in 2013, the title of the article was Formal Ring-Opening/Cross-Coupling Reactions of 2-Pyrones: Iron-Catalyzed Entry into Stereodefined Dienyl Carboxylates.COA of Formula: C7H11ClO3 And the article contains the following content:

In the presence of Fe(acac)3, α-pyrones such as 4,6-dimethyl-2-pyrone underwent stereoselective and chemoselective ring opening reactions with MeMgBr in Et2O at -60° to give (2Z)-2,4-pentadienoic acids such as (Z)-Me2C:CHCMe:CHCO2H in 68-94% yields and in 7:1->20:1 diastereoselectivities; if the reactions were warmed to ambient temperature during reaction, (E)-alkadienoic acids were isolated stereoselectively. The method was used to prepare the dodecadienamide natural product granulatamide B and a fragment of the marine natural product pateamine A. The structure of (Z)-Me2C:CHCMe:CHCO2H was determined by X-ray crystallog. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to alkadienoic acid stereoselective preparation, pateamine a fragment stereoselective preparation, granulatamide b stereoselective preparation, alpha pyrone stereoselective ring opening iron catalyst methyl grignard, methylhexadienoic acid mol crystal structure, cross-coupling, dienes, heterocycles, iron, natural products and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 8, 2011, LaMarche, Matthew J.; Leeds, Jennifer A.; Amaral, Kerri; Brewer, Jason T.; Bushell, Simon M.; Dewhurst, Janetta M.; Dzink-Fox, JoAnne; Gangl, Eric; Goldovitz, Julie; Jain, Akash; Mullin, Steve; Neckermann, Georg; Osborn, Colin; Palestrant, Deborah; Patane, Michael A.; Rann, Elin M.; Sachdeva, Meena; Shao, Jian; Tiamfook, Stacey; Whitehead, Lewis; Yu, Donghui published an article.HPLC of Formula: 35444-44-1 The title of the article was Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: Identification of the cycloalkylcarboxylic acids. And the article contained the following:

4-Aminothiazolyl analogs of the antibiotic natural product GE2270 A were designed, synthesized, and optimized for their activity against Gram pos. bacterial infections. Optimization efforts focused on improving the physicochem. properties (e.g., aqueous solubility and chem. stability) of the 4-aminothiazolyl natural product template while improving the in vitro and in vivo antibacterial activity. Structure-activity relationships were defined, and the solubility and efficacy profiles were improved over those of previous analogs and GE2270 A. These studies identified novel, potent, soluble, and efficacious elongation factor-Tu inhibitors, which bear cycloalkylcarboxylic acid side chains, and culminated in the selection of development candidates amide (I) (R1 = C:O) and urethane I (R1 = OC:O). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).HPLC of Formula: 35444-44-1

The Article related to antibiotic natural product ge2270a aminothiazolyl analog synthesis structure activity, macrocyclic peptidomimetic antibacterial structure activity solubility stability pharmacokinetic, elongation factor tu inhibitor aminothiazolyl ge2270a analog cycloalkylcarboxylic acid, ge2270a acylation azidation curtius rearrangement and other aspects.HPLC of Formula: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamazoe, Sayumi; Liu, Qingyang; McQuade, Lindsey E.; Deiters, Alexander; Chen, James K. published an article in 2014, the title of the article was Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.SDS of cas: 35444-44-1 And the article contains the following content:

Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chem. probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine the mechanisms of mesoderm patterning. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to wavelength selective caged morpholino oligonucleotide preparation gene targeting zebrafish, mesoderm patterning gene targeting wavelength selective caged morpholino oligonucleotide, nb deacm mn bifunctional linker caged morpholino oligonucleotide, antisense agents, cage compounds, developmental biology, gene expression, oligonucleotides and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics