Category: 35852-58-5

Zhang, Qinghua; Zhang, Lei; Li, Zehua; Zhang, Lixia; Li, Daping published the artcile< Enhancement of fipronil degradation with eliminating its toxicity in a microbial fuel cell and the catabolic versatility of anodic biofilm>, Electric Literature of 35852-58-5, the main research area is fipronil degradation anodic biofilm microbial fuel cell toxicity; Catabolic versatility; Fipronil degradation; Microbial cell fuel; Microbial community; Toxicity elimination.

The degradation of fipronil was investigated in microbial fuel cells (MFCs). Almost 79% of 30 mg/L fipronil was rapidly degraded within 12 h by MFC biofilm. Based on the constructed quadratic polynomial model, a maximum fipronil degradation rate of 94.22% could be theor. achieved at pH of 7.01, 33.39 °C, and the initial fipronil concentration 74 mg/L after incubation for 72 h. The high acute toxicity of fipronil toward zebrafish was largely eliminated after degradation by the MFC. In addition, the MFC biofilm showed catabolic versatility to 4-chloronitrobenzene, sulfanilamide, fluoroglycofen, and azoxystrobin. The microbial community anal. revealed that the functional bacteria Sphaerochaeta, Pseudomonas, Azospirillum, Azoarcus, and Chryseobacterium were major predominant bacteria in the anodic biofilm. Therefore, the MFC offers a promising approach in treating the environmental contaminants due to its abilities of energy capture from waste substances and catabolic versatility to different organic compounds

Bioresource Technology published new progress about Azoarcus. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Electric Literature of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T. published the artcile< Novel 2,3-dihydrobenzofuran-2-carboxylic acids: Highly potent and subtype-selective PPARα agonists with potent hypolipidemic activity>, Reference of 35852-58-5, the main research area is hydroxydihydrobenzofurancarboxylate phenoxyalkyl iodide alkylation; phenoxyalkoxydihydrobenzofurancarboxylate preparation hydrolysis; phenoxylalkoxy dihydrobenzofurancarboxylic acid preparation PPAR ligand; dihydrobenzofurancarboxylic acid preparation phenoxylalkoxy asym preparation PPAR ligand.

The design and synthesis of a class of 2,3-dihydrobenzofuran-2-carboxylic acids, e.g., I, as highly potent and subtype-selective PPARα agonists are reported. Systematic study of structure-activity relationships has identified several key structural elements within this class for maintaining the potency and subtype selectivity. Select compounds were evaluated in animal models of dyslipidemia using Syrian hamsters and male Beagle dogs, and all these compounds displayed excellent cholesterol- and triglyceride-lowering activity at dose levels that were much lower than the marketed weak PPARα agonist fenofibrate.

Journal of Medicinal Chemistry published new progress about Alkylation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Reference of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jui, Nathan T.; Buchwald, Stephen L. published the artcile< Cascade Palladium Catalysis: A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazoles>, Electric Literature of 35852-58-5, the main research area is regioselective preparation arylbenzimidazole; cascade intermol amination amidation chloroaryl sulfonate halide; chemoselectivity; cross-coupling; heterocycles; palladium; synthetic methods.

Regioselective N-arylbenzimidazole was prepared via cascade intermol. amination and amidation reactions of 2-chloroaryl sulfonates (or halides). A single catalyst, based on iBuBrettPhos, is able to selectively perform both catalytic elements of this process for a broad range of arylamine (or heteroarylamine), amide, and bifunctional electrophile substrates to afford the corresponding benzimidazole products with complete regioselectivity. Moreover, it was demonstrated that different 2-chloroaryl sulfonates (triflate vs. mesylate), which are derived from the same chlorophenols, can be reacted under very similar reaction conditions to exclusively afford the opposite regioisomeric heterocycles.

Angewandte Chemie, International Edition published new progress about Amidation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Electric Literature of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koyama, Hiroo; Boueres, Julia K.; Miller, Daniel J.; Berger, Joel P.; MacNaul, Karen L.; Wang, Pei-ran; Ippolito, Marc C.; Wright, Samuel D.; Agrawal, Arun K.; Moller, David E.; Sahoo, Soumya P. published the artcile< (2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents>, Product Details of C7H4ClF3O, the main research area is chromanecarboxylate preparation PPARalpha hypolipidemic SAR.

A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonism. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound I exhibited robust lowering of total cholesterol levels in hamster and dog animal models.

Bioorganic & Medicinal Chemistry Letters published new progress about Glycerides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Product Details of C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Weidlich, Tomas; Kamenicka, Barbora; Melanova, Klara; Cicmancova, Veronika; Komersova, Alena; Cermak, Jiri published the artcile< Hydrodechlorination of different chloroaromatic compounds at room temperature and ambient pressure-differences in reactivity of Cu- and Ni-based Al alloys in an alkaline aqueous solution>, Application of C7H4ClF3O, the main research area is chloroarom compound copper nickel aluminum alloy hydrodechlorination.

It is well known that the hydrodechlorination (HDC) of chlorinated aromatic contaminants in aqueous effluents enables a significant increase in biodegradability. HDC consumes a low quantity of reactants producing corresponding non-chlorinated and much more biodegradable organic compounds Two commonly used precious metals free Al alloys (Raney Al-Ni and Devarda’s Al-Cu-Zn) were compared in reductive action in an alk. aqueous solution Raney Al-Ni alloy was examined as a universal and extremely effective HDC agent in a diluted aqueous NaOH solution The robustness of Raney Al-Ni activity is illustrated in the case of HDC of polychlorinated aromatic compounds mixture in actual waste water. In contrast, Devarda’s Al-Cu-Zn alloy was approved as much less active for HDC of the tested chlorinated aromatic compounds, but with a surprisingly high selectivity on cleavage of C-Cl bonds in the meta and sometimes the ortho position in chlorinated aniline and sometimes chlorinated phenol structures. The reaction of both tested alloys with chlorinated aromatic compounds in the aqueous NaOH solution is accompanied by dissolution of aluminum. Dissolved Al in the alk. HDC reaction mixture is very useful for subsequent treatment of HDC products by coagulation and flocculation of Al(OH)3 caused by simple neutralization of the alk. aqueous phase after the HDC reaction.

Catalysts published new progress about Biodegradability. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application of C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brodskii, E. S.; Kluev, N. A.; Zhil’nikov, V. G.; Bocharov, B. V.; Dovgilevich, A. V.; Mel’nikova, N. P.; Grandberg, I. I. published the artcile< Photodegradation of the herbicide Goal>, Synthetic Route of 35852-58-5, the main research area is herbicide Goal photolysis product.

Photodegradation products of the herbicide Goal active ingredient were obtained with a xenon lamp and analyzed using direct inlet mass spectrometry (MS), MS/MS and gas chromatog./MS. A number of products were identified and their generation pathways were established to be mainly Ar-O bond cleavage, dechlorination and photocyclization. The latter process gives chlorinated and unchlorinated dibenzofurans some of which may be toxic.

Toxicological and Environmental Chemistry published new progress about Herbicides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Pengfei; Guan, Aiying; Xia, Xiaoli; Sun, Xufeng; Wei, Siyuan; Yang, Jinlong; Wang, Junfeng; Li, Zhinian; Lan, Jie; Liu, Changling published the artcile< Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides>, Computed Properties of 35852-58-5, the main research area is pyrimidine ether preparation fungicidal activity structure activity relationship; fungicidal activities; intermediate derivatization method (IDM); pyrimidine ether derivatives; structure−activity relationship.

To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound I (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of com. fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound I was a promising fungicide candidate for further development.

Journal of Agricultural and Food Chemistry published new progress about Fungicides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Computed Properties of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chakraborty, Subhasish K.; Chakraborty, Savitri; Bhattacharyya, Anjan; Chowdhury, Ashim published the artcile< Photolysis of oxyfluorfen in aqueous methanol>, Synthetic Route of 35852-58-5, the main research area is UV sunlight oxyfluorfen methanol photolysis.

Photolysis of oxyfluorfen, an herbicide of the nitrodiphenyl ether class, was studied in aqueous methanol under UV and sunlight. UV irradiation was carried out in a borosilicate glass photoreactor (containing 250 ppm oxyfluorfen in 50% aqueous methanol) equipped with a quartz filter and 125 W mercury lamp (maximum output 254 nm) at 25 ± 1°C. Sunlight irradiation was conducted at 28 ± 1°C in borosilicate Erlenmeyer flasks containing 250 ppm oxyfluorfen in 50% aqueous methanol. The samples from both the irradiated conditions were withdrawn at a definite time interval and extracted to measure oxyfluorfen content by gas chromatog.-flame ionization detector for rate study. The half-life values were 20 h and 2.7 days under UV and sunlight exposure, resp. Photolysis of oxyfluorfen yielded 13 photoproducts of which three were characterized by IR spectrophotometer and 1H NMR and 13C NMR spectroscopy. The rest of the photoproducts were identified by gas chromatog.-mass spectrometry (GC-MS) and thin layer chromatog. (TLC). An ionization potential 70 eV was used for electron impact-mass spectrometry (EI-MS) and methane was used as reagent gas for chem. ionization-mass spectrometry (CI-MS). Two of the photoproducts were also synthesized for comparison. The main phototransformation pathways of oxyfluorfen involved nitro reduction, dechlorination, and hydrolysis as well as nucleophiles displacement reaction.

Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes published new progress about Chemical ionization mass spectrometry. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Yonghui; Yang, Ting; Liu, Qian; Ma, Yingli; Yang, Liuqing; Zhou, Ling; Xiang, Zhijun; Cheng, Ziqiang; Lu, Sijie; Orband-Miller, Lisa A.; Zhang, Wei; Wu, Qianqian; Zhang, Kathleen; Li, Yi; Xiang, Jia-Ning; Elliott, John D.; Leung, Stewart; Ren, Feng; Lin, Xichen published the artcile< Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists>, Application In Synthesis of 35852-58-5, the main research area is arylaryloxy thiazolyl amide preparation RORt inverse agonist immunomodulator; Crystal structure; RORγt inverse agonists; Th17 cell differentiation; Thiazole ether amides.

A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode anal. of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not directly interfere with the interaction between H12 and the RORγt LBD. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 3m with a pIC50 of 8.0. Selected compounds in the series showed reasonable activity in Th17 cell differentiation assay as well as low intrinsic clearance in mouse liver microsomes.

Bioorganic & Medicinal Chemistry published new progress about Cell differentiation inducers. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scrano, Laura; Bufo, Sabino A.; D’Auria, Maurizio; Meallier, Pierre; Behechti, Akbar; Shramm, Karl Werner published the artcile< Photochemistry and photoinduced toxicity of acifluorfen, a diphenyl-ether herbicide>, Synthetic Route of 35852-58-5, the main research area is photochem photoinduced toxicity acifluorfen UV photolysis.

Photochem. studies can be helpful in assessing the environmental fate of chems. Photochem. reactions lead to the formation of byproducts that can exhibit different toxicol. properties from the original compound For this reason the photochem. behavior of the herbicide acifluorfen (5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid) in the presence of different solvents was studied. Photochem. reactions were carried out using a high-pressure mercury arc and a solar simulator. Kinetic parameters and quantum yields were determined The identification of photoproducts was performed by mass spectrometry and [1H] NMR. Nitrofluorfen, hydroxy-nitrofluorfen, 2-chloro-4-(trifluoromethyl)-phenol, 5-trifluoromethyl-5′-nitrodibenzofuran, and other derivatives were identified. The photochem. reactions were also carried out in the presence of either a singlet or a triplet quencher, and in the presence of either a radical initiator or a radical inhibitor. Substances used as inhibitors of the excited levels T1 and S1 showed that photodegradation of acifluorfen begins from a singlet state S1 through a π,π* transition. The role of free radicals in the photodegradation of acifluorfen was determined and a radical mechanism was proposed. Toxicity tests against Daphnia magna Strauss showed that acifluorfen was not toxic at a concentration of 0.1 mM; however, photoproducts formed after 36 h of UV exposure of the herbicide induced a remarkable toxicity to the test organism.

Journal of Environmental Quality published new progress about Daphnia magna. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics