Category: 36428-96-3

Wang, Qi published the artcileA fluorescent light-up probe as an inhibitor of intracellular β-tryptase, SDS of cas: 36428-96-3, the main research area is fluorescence light inhibitor animal cell tryptase.

A pyrene-functionalized peptidic inhibitor 1 binds to and inhibits β-tryptase in a non-competitive and reversible manner even in cells. Upon protein binding a fluorescence increase of the two pyrene fluorophores is observed which allows using 1 as a fluorescent light-up probe for this enzyme.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cell. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, SDS of cas: 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Takaishi, Kazuto published the artcileEvolving Fluorophores into Circularly Polarized Luminophores with a Chiral Naphthalene Tetramer: Proposal of Excimer Chirality Rule for Circularly Polarized Luminescence, Application of Pyrene-2-carboxylic acid, the main research area is fluorophore polycyclic aromatic circularly polarized luminescence excimer chirality.

A versatile method for converting various fluorescent polycyclic aromatic hydrocarbons into circularly polarized luminescence (CPL) excimer dyes with high glum and ΦFL values is reported. This method involves the functionalization of a chiral quaternaphthyl with six fluorophores via ester linkages in the last step of the synthesis. The usefulness of this approach was demonstrated for 1-, 2-, and 4-pyrenyl, 2- and 3-perylenyl, and 2-anthryl dyes. Most of them are the first or rare examples of CPL dyes. In the ground state, the fluorophores are tightly arranged by cumulative steric and electronic effects. In the excited state, the fluorophores form a twist excimer that maintains the ground-state conformations. The local chiral excimer directly affected the CPL properties. The systematic study on the signs of the CPLs allowed us to find a rule called the excimer chirality rule: right- and left-handed excimers exhibit (+)- and (-)-CPL, resp.

Journal of the American Chemical Society published new progress about Chirality. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Berg, Arne published the artcileMetalation of pyrene, Application of Pyrene-2-carboxylic acid, the main research area is .

By the action of excess BuLi in Et2O, pyrene (I) is not only metalated, as evidenced by pyrenecarboxylic acid formation on carbonation of the reaction mixture, but is also attacked in the 1, 3, and 4 positions in the ratio of 2:1:0.2. In a typical experiment, 85% I is converted to pyrene-1-carboxylic acid (II), m. 275-6° (PhCl) [Me ester, m. 107-8° (MeOH)], 3-isomer, m. 273° (AcOH-PhCl) [Me ester, m. 83-4° (MeOH)] and 4-isomer, m. 327-8° (AcOH-PhCl) [Me ester, m. 139° (MEOH)]. II with LiAlH4 in Et2O refluxed 5 hrs. gave 1-pyrenylcarbinol (III), m. 155-5.5°. The chloride of III treated with LiAlH4 in boiling Et2O and the product chromatographed from 1:1 C6H6-C6H14 on alumina gave 1-methylpyrene, m. 147.5-8.0° (EtOH) [picrate, m. 228-9° (C6H6)].

Acta Chemica Scandinavica published new progress about Metalation. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hansen, Poul Erik published the artcileInfrared spectra of pyrene derivatives. Relation to the substitution pattern, Recommanded Product: Pyrene-2-carboxylic acid, the main research area is IR pyrene substituent effect.

The IR of one-hundred and thirty-seven pyrene derivatives with 21 different types of substitution patterns are examined and a set of empirical rules based on band positions and intensities are formulated which allow most types of pyrene derivatives to be structurally assigned. The examination of 1-, 1,3-, 1,6-, 1,8- and 1,3,6,8-substituted pyrenes are used to reassign the 680 cm-1 band to an Au species.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about IR spectra. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Recommanded Product: Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Barfield, Michael published the artcileBond-order dependence of orthobenzylic coupling constants involving a methyl group [4J(MeC-CH)], Application of Pyrene-2-carboxylic acid, the main research area is spin coupling bond order relation; NMR bond order relation; methyl aromatic NMR bond order relation; orthobenzylic coupling bond order relation.

A relation between exptl. measured orthobenzylic coupling constants (Job) in a series of methyl-substituted aromatic hydrocarbons was examined by using extensive, accurate data and a variety of criteria for the π-bond orders of the C1-C2 bonds. The best linear correlations of Job were found with squares of the SCF MO bond orders and with the Pauling (VB) bond orders, as would be expected from the theor. expressions for coupling constants within the average-energy approximation In fact, the standard deviation in the correlation of the Job with the Pauling bond order is almost within the exptl. error of the measurements (0.06 Hz). Thus, Job emerge as an exptl. criterion for examining π-bond orders in conjugated systems.

Journal of the American Chemical Society published new progress about Bond order. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nazarov, A. P. published the artcileElectron polarizability of molecules of carboxylic acids and their dimers and trimers, Recommanded Product: Pyrene-2-carboxylic acid, the main research area is carboxylic acid dimer trimer hydrogen bond electron polarizability.

Components of the tensor of the electron polarizability of mols. of carboxylic acids and their dimers and trimers with conjugated chem. bonds are calculated according the Hartree-Fock method. The dependences of a change in the anisotropy of polarizability on the average polarizability of a mol. and the number of electrons in a conjugated system are determined An increase in the anisotropy of electron polarizability during the formation of intermol. associates through hydrogen bonds is observed

Russian Journal of Physical Chemistry A published new progress about Anisotropy. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Recommanded Product: Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Casas-Solvas, Juan M. published the artcileA Practical, Large-Scale Synthesis of Pyrene-2-Carboxylic Acid, COA of Formula: C17H10O2, the main research area is pyrenecarboxylic acid preparation electrophilic aromatic substitution cyclization ring opening.

Pyrene-2-carboxylic acid is a versatile intermediate for introducing the unusual 2-pyrenyl unit into functional organic mols. A classical preparation for this mol. has been revised and improved to give a robust and efficient three-step process. The method has been applied on a multigram scale to give pyrene-2-carboxylic acid in >70% overall yield from pyrene.

Synlett published new progress about Cyclization. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, COA of Formula: C17H10O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sakurai, Toshihiko published the artcileFormation of nanofibrillar aggregates by water-soluble β-structural oligopeptide, (L-Leu-L-Lys)8, SDS of cas: 36428-96-3, the main research area is leucine lysine pyrenyl peptide nanofibrillar aggregate.

The oligopeptide with an alternating sequence, Pyr(LK)8 (Pyr = pyrenyl-2-carbonyl; L = L-leucine, K = L-lysine), formed helical tape-like aggregates in an aqueous solution at pH 7. Addition of NaCl induced random coil-to-β-structure transition to show the excimer peak of pyrenyl groups, although no similar result was observed in the corresponding non-alternating, random oligopeptide Pyr(LKLKKLLLKKLLKLKK).

Chemistry Letters published new progress about Aggregation. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, SDS of cas: 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Villalonga, Reynaldo published the artcileImmobilization of Xanthine Oxidase on Carbon Nanotubes Through Double Supramolecular Junctions for Biosensor Construction, Synthetic Route of 36428-96-3, the main research area is xanthine oxidase immobilization carbon nanotube double supramol junction biosensor.

A novel approach for the noncovalent functionalization of single-walled carbon nanotubes with enzymes, using a β-cyclodextrin-modified pyrene derivative, mono-6-ethylenediamino-(2-pyrene carboxamido)-6-deoxy-β-cyclodextrin (Pyr-βCD), as a mol. bridge for the construction of a supramol. assembly between the nanotube surface and an adamantane-modified enzyme, is reported. The Pyr-βCD derivative was synthesized and its stacking to SWNT through π-π interactions accomplished. The functionalized nanotubes showed low capacity for the nonspecific adsorption of proteins, but were able to immobilize adamantane-modified xanthine oxidase via host-guest associations This double supramol. junctions-based approach was employed to modify a glassy carbon electrode with the enzyme/nanotubes complex for designing a biosensor device toward xanthine. The biosensor showed fast electroanal. response (10 s), high sensitivity (5.9 mA/M cm2) low detection limit (2 μM) and high stability.

Electroanalysis published new progress about Carbon nanotubes. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Synthetic Route of 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cabral, Lilia I. L. published the artcileSynthesis and structure of 2-substituted pyrene-derived scaffolds, Safety of Pyrene-2-carboxylic acid, the main research area is functionalized pyrene synthesis tetrahydropyrene intermediate.

Pyrenes bear a propensity to form fluorescent excimers, and thus this chromophore is often found in sensors and fluorescent probes. 2-Functionalized pyrenes are of particular interest, however the preparation of these scaffolds is not trivial, involving synthetic routes that require 4,5,9,10-tetrahydropyrene as a key intermediate. Herein, the development and optimization of routes for the synthesis of 2-functionalized pyrene-derived building blocks, with potential to be used as tags in the preparation of fluorescent probes, is described. Addnl., the crystal structures of Et 4,5,9,10-tetrahydro-2-pyrene-5-oxopentanoate and 2-acetyl-4,5,9,10-tetrahydropyrene revealed distinct conformations of the saturated tetrahydropyrene rings.

Tetrahedron Letters published new progress about Crystal structure. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Safety of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics