Category: 36556-52-2

Application of 36556-52-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36556-52-2, name is 2,3-Dichloro-4-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 67 7-[(2,3-dichloro-4-fluorophenyl)amino]-5-{[2-methoxy-4-(piperazin-l – yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol EXAMPLE 67A tert-buty ] 4-(4-(7-(2,3-dichloro-4-fluorophenylamino)-4-oxo-3,4-dihydropyrido[3,4- c/|py ndazin-5-ylamino)-3-metho.xyphenyl)piperazine- l -carbox late A mixture of EXAMPLE 24A ( 162 mg, 0.33 mmol), 2,3-dichloro-4- fluorobenzenamine (90 mg, 0.50 mmol), tris(dibenzylideneacetone)dipalladium (3 1 mg, 0.03 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthenexanthene (20 mg, 0.03 mmol) and potassium 2-methylpropan-2-olate (1 12 mg, 1 mmol) in 2-methylpropan-2-ol (2 mL) was degassed with nitrogen twice and stirred in a sealed tube at 130C for 15 hours. After cooling to ambient temperature, the solution was concentrated and the residue was purified by flash chromatography on silica gel eluting with 100/1 dichloromethane/methanol to give the title compound. MS: 630 (M + H+).

The synthetic route of 2,3-Dichloro-4-fluoroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 36556-52-2, These common heterocyclic compound, 36556-52-2, name is 2,3-Dichloro-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a vial containing 2,3-dichloro-4-fluoroaniline (307.4 mg, 1.7 mmol) in 2 mL toluene was added 4M HCl in 1,4-dioxane (0.43 mL, 1.7 mmol) followed by phosgene (20% in toluene; 3.6 mL, 6.8 mmol). Precipitate formed upon HCl addition. The vial was capped and heated to 100 C. After 30 min, all the solids had disappeared. After 6.5 h, the solvent was removed under vacuum. Material was re-dissolved in toluene, and solvent was again removed under vacuum to eliminate any remaining phosgene. The resulting material was a brown oil that crystallized upon standing and was used without further purification. A capped vial containing 7 (108.8 mg, 0.55 mmol) and 2,3-dichloro-1-fluoro-4-isocyanatobenzene from above (~0.55 mmol) was heated to 70 C. After 2 days, solvent was removed under vacuum. The oil residue was treated with DCM, producing a precipitate. The resulting mixture was left to stand at room temperature for >30 min. The solids were filtered, washed with minimal amount of DCM and dried under vacuum to give119.1 mg (54%) of 8k as an off-white solid. The material was used without further purification.

The synthetic route of 36556-52-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Moffett, Kristofer; Konteatis, Zenon; Nguyen, Duyan; Shetty, Rupa; Ludington, Jennifer; Fujimoto, Ted; Lee, Kyoung-Jin; Chai, Xiaomei; Namboodiri, Haridasan; Karpusas, Michael; Dorsey, Bruce; Guarnieri, Frank; Bukhtiyarova, Marina; Springman, Eric; Michelotti, Enrique; Bioorganic and Medicinal Chemistry Letters; vol. 21; 23; (2011); p. 7155 – 7165;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 36556-52-2, name is 2,3-Dichloro-4-fluoroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36556-52-2, 36556-52-2

Acetone (7.95 mL, 107 mmol) is added to a solution of 2,3-dichloro-4-fluoroaniline (1.93 g, 10.7 mmol) in DMSO (20 mL). Palladium(ll)acetate (0.481 g, 2.14 mmol) and copper(ll) acetate (5.84 g, 32.2 mmol) are added, and the mixture is heated at 85C for 17h. The mixture is concentrated, filtered over a plug of silica and rinsed with DCM. The filtrate is washed with HCI 2N and brine, dried over MgSC and concentrated. The residue is purified by FC, eluting with heptane / EtOAc from 100:0 to 95:5, affording the title compound as an orange solid (0.52 g, 23%). LC-MS A: tR = 0.92 min; [M+H]+ = 218.07.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichloro-4-fluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; FRETZ, Heinz; LYOTHIER, Isabelle; POTHIER, Julien; RICHARD-BILDSTEIN, Sylvia; SIFFERLEN, Thierry; WYDER PETERS, Lorenza; POZZI, Davide; CORMINBOEUF, Olivier; (306 pag.)WO2017/85198; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics