Category: 367-21-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 367-21-5, name is 3-Chloro-4-fluoroaniline, A new synthetic method of this compound is introduced below., COA of Formula: C6H5ClFN

To a stirred solution of 3-chloro-4-fluoroaniline (Tokyo Chemical Industry, 5.00 g, 34.4 mmol) and dry pyridine (3.50 mL, 43.3 mmol) in dry CH2Cl2 (17.0 mL) was added dropwise a solution of bromine (1.90 mL, 36.9 mmol) in CH2Cl2 (10.0 mL) at 0 C under N2. The reaction mixture was stirred at the temperature under N2 for 1 h, warmed up to room temperature, and stirred for 1 h. The mixture was poured into H2O and then extracted with AcOEt. The extracts were dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, hexane/AcOEt = 10:1) to afford 2.76 g of the title product 18 in 36% yield as a brown solid. 1H NMR (270 MHz, CDCl3) delta 7.22 (1H, d, J = 8.6 Hz), 6.77 (1H, d, J = 6.4 Hz), 3.84 (2H, br s).

The synthetic route of 367-21-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hayashi, Shigeo; Ueno, Naomi; Murase, Akio; Nakagawa, Yoko; Takada, Junji; European Journal of Medicinal Chemistry; vol. 50; (2012); p. 179 – 195;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 367-21-5, Name is 3-Chloro-4-fluoroaniline, SMILES is C1=C(N)C=CC(=C1Cl)F, in an article , author is Rezaei, Ramazan, once mentioned of 367-21-5, Product Details of 367-21-5.

Aims: EMT is the process by which a polarized epithelial cell undergoes several changes leading to highly invasive and fibroblast-like morphology. It has been described that miR-375 is inversely associated with EMT in cancerous patients and can effectively inhibit invasion and migration of tumor cells. Here, we investigate whether miR-375 mimic delivered by tumor-derived exosomes could reverse EMT process. Main methods: The exosomes were isolated from HT-29 and SW480. Subsequently, exosomes were loaded with miR-375-3p mimic applying modified calcium chloride method. Quantitative real-time PCR was used for evaluation of the loading efficiency of miR-375 mimic in the exosomes. The effects of miR-375 loaded tumor exosomes (TEXomiR) on EMT process investigated using flow cytometry, cell morphology, and invasion and migration assay. Key findings: The in vitro results showed that the tumor derived exosomes can efficiently deliver miR-375 mimic to reduce the expression of beta-catenin, vimentin, ZEB1, and snail. In contrast, TEXomiR significantly increased the expression of E- cadherin in EMT process. Furthermore, the migration and invasion abilities of HT-29 and SW480 cells were inhibited by TEXomiR. The expression of CD44 and CD133 are increased in EMT process. Flow cytometry evaluation demonstrated that treatment with TEXomiR significantly decreased the expression of CD44 and CD133 in SW480 cell line. Significance: Our results imply that colon cancer cells-derived exosomes could be used as an effective nonvehicle to deliver miR-375-3p mimic. Moreover, TEXomiR may be a potent therapeutic agent for the treatment of metastatic colorectal cancer.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 367-21-5, Name is 3-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN. In an article, author is Safaeian, Leila,once mentioned of 367-21-5, Computed Properties of https://www.ambeed.com/products/367-21-5.html.

Background and objectives: Sargassum angustifolium is a brown alga in southwestern coastline of Persian Gulf. Regarding the presence of various bioactive compounds and evidence of antihypertensive effects in other species of Sargassum, we evaluated the effect of S. angustifolium ethanol extract in CdCl2-induced hypertension in Wistar rats. Methods: Alga extract was prepared by maceration method using 70% ethanol and assessed for total phenolics and salt content. CdCl2 (1.5 mg/kg/day) was administered intraperitoneally to the rats for two weeks. Treatment groups received S. angustifolium extract (20, 40 and 80 mg/kg) or nifedipine (10 mg/kg) orally and simultaneously were given CdCl2 for two weeks. Systolic blood pressure (SBP) and heart rate were measured using tail-cuff method. Total antioxidant capacity, urea, creatinine, electrolytes including sodium, potassium, calcium and chloride were estimated in blood samples. The weight and histopathology of kidney tissues were also evaluated. Results: The content of total phenolic as gallic acid equivalent and the salt as NaCl was 67.42 +/- 9.5 mg/g and 6.9 g/100 g in dried ethanol extract, respectively. CdCl2 caused significant increase in SBP, kidney/body weight ratio, serum sodium and urea level and decrease in plasma total antioxidant capacity, and also histopathological alterations in kidney tissues. Treatment with S. angustifolium extract at the doses of 40 and 80 mg/kg significantly reversed hypertension and improved kidney weight, urea level and electrolyte changes, and enhanced antioxidant capacity and prevented histopathological changes of kidney. Conclusion: Findings of the present study indicated antihypertensive and antioxidant effects of S. angustifolium extract against CdCl2-induced hypertension in rats.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 367-21-5, 367-21-5, Name is 3-Chloro-4-fluoroaniline, SMILES is C1=C(N)C=CC(=C1Cl)F, belongs to chlorides-buliding-blocks compound. In a document, author is Jing, JiaQiang, introduce the new discover.

The additive drag reduction technology has wide application and high economic value in drag reduction of oilfield water injection system. With CTAC/NaSal (cetyltrimethyl ammonium chloride/sodium salicylate) aqueous solution as the research object, this paper explores the effects of oilfield water component on its rheological characteristics under the experimental condition of 10-60 degrees C, .1-1 000 s(-1), and 0.01-0.21 wt %. The experimental results reveal that the oil cannot inhibit the formation of shear-induced structure in the solution and strengthen the temperature resistance of the solution; NaHCO3 and CaCl2, two types of salts, have similar effects on rheological characteristics of the CTAC/NaSal solution. The solution viscosity increases first and then decreases with the increase of salt concentration. And the viscosity peak gradually moves to the left lower with the increase of temperature, which means that the salt tolerance of the solution decreases with the increase of temperature. Moreover, the Giesekus model has the best performance for describing the rheological characteristics of surfactant solutions. Within the experimental concentration range, the relative error is +/- 25%.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 367-21-5. Recommanded Product: 367-21-5.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In an article, author is Nikitina, E., V, once mentioned the application of 367-21-5, Name: 3-Chloro-4-fluoroaniline, Name is 3-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN, molecular weight is 145.562, MDL number is MFCD00007767, category is chlorides-buliding-blocks. Now introduce a scientific discovery about this category.

The synthesis of materials with a developed electrode surface of the electropositive component of the alloy and a significant near-surface layer was performed by anodic selective dissolution of copper alloys (Cu63-Zn37, Cu40-Zn37, Cu65-Ni35, Cu35-Ni65 and Cu50-Al50). The morphological and electro-chemical characteristics of the obtained electrode materials based on mesoporous copper demonstrate its prospects for catalysis substrate application, electrodeposition of materials with specified parameters, and for the low-wear anode base formation. The media was combination of lithium, sodium, potassium carbonates (30 : 30: 40 mol. %), as well as low-melting eutectic mixtures of alkali metal chlorides of various compositions (especially CsCl-KCl-LiCl (54.4: 15.3: 30.3 wt %) in the temperature range of 623-923 K. The object of the study was copper alloys such as copper-zinc, copper-aluminum, copper-nickel. Anodic selective dissolution was performed under the following electrolysis modes: galvanostatic and potentiostatic modes; rectangular polariza-tion; cyclic voltammetry. The values of geometric current densities were 100, 200, 300, 900, 1400 A/m(2). The applied anode potential was +0.1, +0.2 and + 0.5 V (from the open circuit potential of the material). The platinum reference electrode was used. The resulting surface structures were investigated using micro-and X-ray phase analysis. The composition of frozen melt samples after electrolysis completion was studied by atomic absorption analysis. The resulting surface structures were investigated using micro-and X-ray phase analysis. The influence of the following factors on the surface structure of the final anode product was studied and discussed: composition of the studied alloy (the amount of electronegative component in the alloy, as well as its nature); electrolyte composition (chloride and carbonate melt); temperature of selective dissolution (350, 500 and 650 degrees C) It was shown that it is possible to change the nature of the binary alloy dissolution by changing the kinetic parameters (electrolyte composition, temperature), and to obtain a mesoporous material with a developed surface, suitable for heterogeneous catalysis, structural design of electrochemical and elec-trical devices. a) the most perspective copper-based alloy for the formation of nanoporous and mesoporous materials in salt melts is brass Cu63-Zn37; b) the smallest average pore size had samples of brass Cu63-Zn37 in experiments with chloride melt; in galvanostatic mode the pore size was 500 nm (under given conditions -200 A/m(2), 350 degrees C); in potentiostatic mode -250 nm (+0.1 V, 500 degrees C). With the temperature decreasing it is possible to reduce this indicator by 1.5-3.0 times; c) the square-wave potentiometry method was used to form a developed near-surface layer in several stages; g) cyclic voltammetric curves were obtained, which can be used to prognosticate and describe the stages of the anode process; e) the potentials of open circuits were obtained for the studied samples; g) by dissolution of copper-aluminum alloy in galvanostatic mode was formed the nanofiber on the surface with thread size less than 20 nm. 2. The influence of the temperature, the nature of the second component of the alloy and the salt electrolyte (chloride) on the formation of the developed surface layer of the alloys under study was established: a) the increase in temperature leads to a decrease in the development of the surface layer; b) copper-nickel samples are depleting by copper due to the fact that copper is an electronegative component of the alloy in chloride melts, while the formation of developed surface layer enriched with nickel takes place; c) the increase in the content of the electronegative component leads to a decrease in the development of the surface. It was shown that it is possible to change the nature of the binary alloy dissolution by changing the kinetic parameters (electrolyte composition, temperature), and to obtain a mesoporous material with a developed surface, suitable for heterogeneous catalysis, structural design of electrochemical and elec-trical devices. (C) 2020 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 367-21-5, you can contact me at any time and look forward to more communication. Name: 3-Chloro-4-fluoroaniline.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 367-21-5, Name is 3-Chloro-4-fluoroaniline, formurla is C6H5ClFN. In a document, author is Ebadnezhad, Hassan, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/367-21-5.html.

In this study, an ultrasonic and heat-assisted liquid-liquid extraction method combined with deep eutectic solvent-based dispersive liquid-liquid microextraction procedure was developed for the extraction of four phytosterols from cow milk butters. The analytes were determined by gas chromatography-flame ionization detector without derivatization. Initially, the sample was transferred into a falcon tube and placed into a sonication bath adjusted at 50 degrees C. Afterward, ethanol was mixed with the butter and the mixture was sonicated. After centrifugation, the ethanolic phase collected on top of the sample was withdrawn. After addition of a few microliters, ethyl (methyl) ammonium chloride/pivalic acid deep eutectic solvent, the mixture was sucked into a glass syringe and injected hastily into deionized water. The turbid solution was centrifuged and the sedimented phase was removed. Then, it was contacted with sodium hydroxide solution to remove the extracted fatty acids. The proposed method presented high enrichment factors (340-425) and extraction recoveries (68-85%), low limits of detection (0.51-1.3 ng g(-1)) and quantification (1.7-4.3 ng g(-1)) and acceptable relative standard deviations (<= 8.4%). The analytes contents of several cow milk butter samples were extracted and quantified with the developed method and the results were compared with ISO 23349. If you are hungry for even more, make sure to check my other article about 367-21-5, COA of Formula: https://www.ambeed.com/products/367-21-5.html.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 367-21-5, Name is 3-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN. In an article, author is Lin, Chunhua,once mentioned of 367-21-5, Safety of 3-Chloro-4-fluoroaniline.

Melamine has biological toxicity and is forbidden to be used in food processing and food additives. The long-term ingestion of melamine will cause renal malfunction and metabolic problems of the urinary system, so it is of great significance for the rapid and selective detection of melamine. Herein, a zirconium-based metal-organic frameworks (Zr-based MOFs) encapsulated tris(2,2-bipyridyl)ruthenium (II) chloride hexahydrate ([Ru (bpy)(3)](2+)) composite, donated as UiO-66-NH2@Ru, was reported and further studied its sensing performance for melamine based on ratiometric fluorescent method. The UiO-66-NH2@Ru was prepared from ZrCl4, 2-amino-terephthalic acid (TPA-NH2) and [Ru(bpy)(3)](2+) by one pot reaction through solvothermal method, which exhibited dual emission signals at 445 and 595 nm from single excitation of 350 nm. The corresponding two peaks showed different responses to melamine, that was, the obvious enhancement at 445 nm and the slow decrease at 595 nm, thus achieving the on-off ratiometric fluorescence detection. When the concentration of melamine was in the range of 0.27 to 110 mu M, the ratio of fluorescence intensity F-445/F-595 had a good linear relation with the correlation coefficient R-2 = 0.995 and the detection limit of 90 nM. The synthetic UiO-66-NH2@Ru probe implemented rapid determination of melamine in real sample of milk powder with high sensitivity and selectivity. Compared with the reported carbon dots, quantum dots, metal nanoclusters, nanocomposites and other fluorescent sensors, MOFs-based sensor have broadened the application of nanomaterials in melamine detection for the first time. This study also demonstrates the Zr-based MOFs as a platform to encapsulate fluorescent dye for constructing ratiometric sensor in the determination of melamine is feasible and exciting.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Electric Literature of 367-21-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 367-21-5, Name is 3-Chloro-4-fluoroaniline, SMILES is C1=C(N)C=CC(=C1Cl)F, belongs to chlorides-buliding-blocks compound. In a article, author is Wu, Xinhe, introduce new discover of the category.

Ultra-small molybdenum sulfide nanodot-coupled graphitic carbon nitride nanosheets: Trifunctional ammonium tetrathiomolybdate-assisted synthesis and high photocatalytic hydrogen evolution

The preparation of nanoscale molybdenum sulfide (MoS2)-modified graphitic carbon nitride (g-C3N4) nanosheets usually contains complex and multiple-step operations, including the separate synthesis of nanoscale MoS2 and g-C3N4 nanosheet, and their subsequent composite process. To effectively overcome the above drawbacks, herein, a facile one-step trifunctional ammonium tetrathiomolybdate ((NH4)(2)MoS4)-assisted approach has been designed to produce ultra-small MoSx nanodot-coupled g-C3N4 nanosheet photocatalyst, including the first addition of ammonium chloride (NH4Cl) and (NH4)(2)MoS4 into melamine precursors and their following one-step calcination. During high-temperature calcination, except for the promoting generation of the g-C3N4 nanosheets by produced ammonia (NH3) and hydrogen sulfide (H2S) gases, the above (NH4)(2)MoS4 decomposition not only can efficiently clip the s-heptazine framework to produce more terminal amino groups and cyano groups, but also can produce ultra-small MoSx nanodots on the resultant g-C3N4 nanosheet surface, resulting in the final production of ultra-small MoSx nanodot-coupled g-C3N4 nanosheets. The resultant MoSx nanodot-coupled g-C3N4 nanosheets evidently exhibit increased photocatalytic hydrogen (H-2)-generation rate, about 8-fold increase to the traditional MoS2-modified g-C3N4 photocatalyst. The ncreased H-2 -generation rate can be mainly attributed to the synergism of MoS x nanodots and cyano group on the g-C3N4 nanosheet surface. The current facile technology could open the sights for the preparation of other high-efficiency photocatalysts. (C) 2020 Elsevier Inc. All rights reserved.

Electric Literature of 367-21-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 367-21-5.

Let¡¯s face it, organic chemistry can seem difficult to learn, Computed Properties of C6H5ClFN, Especially from a beginner¡¯s point of view. Like 367-21-5, Name is 3-Chloro-4-fluoroaniline, molecular formula is chlorides-buliding-blocks, belongs to chlorides-buliding-blocks compound. In a document, author is Zhang, Zhen, introducing its new discovery.

Molecular study of heterogeneous mercury conversion mechanism over Cu-MOFs: Oxidation pathway and effect of halogen

Copper-based metal-organic frameworks is one new porous sorbent to efficiently remove elemental mercury (Hg-0) in the flue gas. The lack of an in-depth understanding of heterogeneous mercury conversion mechanism over Cu-MOFs significantly limits their potential application and further targeted modification for gaseous mercury removal. Therefore, mercury adsorption profiles and oxidation pathways had been established, based on the density functional theory (DFT). The results show that the chemisorption mechanism dominates the adsorption processes of different mercury species (Hg-0, HgO, HgCl, and HgBr), with the adsorption energy ranging from -33.13 to -383.99 kJ/mol. The oxidizing mercury species are with higher adsorption energy than elemental mercury. The unsaturated C site is a more effective site for mercury adsorption than the unsaturated Cu site. However, halogen addition at the unsaturated Cu site is more helpful in mercury removal than the unsaturated C site. The reaction pathway for elemental mercury oxidation over Cu-MOFs with halogen activation includes three basic reaction steps: Hg-0 -> HgX(ads) -> HgX2(ads) -> HgX2 (X refers Cl or Br). The formation of desorbed HgCl2 and HgBr2 is endothermic with an energy barrier of 185.43 and 175.31 kJ/mol, which is the rate-limiting step of the whole elemental mercury oxidation process. As a whole, bromide activation is more beneficial to mercury removal than chloride activation over Cu-MOFs, because of lower energy barrier, which is cross-checked by the calculation and experimental results.

If you are hungry for even more, make sure to check my other article about 367-21-5, Computed Properties of C6H5ClFN.

Application of 367-21-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 367-21-5, Name is 3-Chloro-4-fluoroaniline, SMILES is C1=C(N)C=CC(=C1Cl)F, belongs to chlorides-buliding-blocks compound. In a article, author is Ghasemloo, Elham, introduce new discover of the category.

The neuroprotective effect of MicroRNA-149-5p and coenzymeQ10 by reducing levels of inflammatory cytokines and metalloproteinases following focal brain ischemia in rats

The increase in some factors following cerebral ischemia, especially Matrix metalloproteinase (MMPs) and inflammatory factors lead to blood-brain barrier (BBB) damages, edema and neuronal death. Previous studies have shown that these molecules are miRNA-149-5p (miR-149) and Coenzyme (Co) Q10 targets. Therefore, in this study, the effect of mimic of miRNA-149-5p (mimic miR) and CoQ10 on the expression of metalloproteinase 1 and 2 and inflammatory cytokines following injury caused by cerebral ischemia is investigated. Cerebral ischemia was modeled by Middle Cerebral Artery Occlusion (MCAO). Male Wistar rats were randomly divided into 6 groups: sham (without surgery and treatment), control (MCAO), negative control (NC): MCAO + – scrambled miR, vehicle: MCAO + Ethanole, first treatment: MCAO + mimic miR, second treatment: MCAO + Q10. Each group was divided into 6 subgroups to evaluate neurological defects, the volume of tissue damage using 2,3,5-triphenyl tetrazolium chloride (TTC) staining, blood-brain barrier permeability using cerebral Evans Blue (EB) staining, edema by measuring the percentage of brain water, MMP-2,9 mRNA and miR-149-5p levels using Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and the levels of IL-6 and TNF-alpha proteins using ELISA. The data obtained from this study showed that the use of mimic miR and Q10 increased the level of miR-149, decreased the extent of neurological defects and tissue damage, increased BBB integrity, decreased brain water percentage and also decreased the level of inflammatory cytokines and MMPs. It seems that the use mimic of miRNA-149-5p and Q10 can have a protective effect on the brain by reducing MMPs and inflammatory factors following cerebral ischemia and this could lead to a new treatment strategy to reduce the complications of cerebral ischemia.

Application of 367-21-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 367-21-5 is helpful to your research.