Category: 3696-23-9

Roedl, Carmen B. published the artcileMulti-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Medicinal Chemistry (2014), 302-311, database is CAplus and MEDLINE.

Eicosanoids like leukotrienes and prostaglandins play a considerable role in inflammation. Produced within the arachidonic acid (AA) cascade, these lipid mediators are involved in the pathogenesis of pain as well as acute and chronic inflammatory diseases like rheumatoid arthritis and asthma. With regard to the lipid cross-talk within the AA pathway, a promising approach for an effective anti-inflammatory therapy is the development of inhibitors targeting more than one enzyme of this cascade. Within this study, thirty N-4-diaryl-1,3-thiazole-2-amine based compounds with different substitution patterns were synthesized and tested in various cell-based assays to investigate their activity and selectivity profile concerning five key enzymes involved in eicosanoid metabolism (5-, 12-, 15-lipoxygenase (LO), cyclooxygenase-1 and -2 (COX-1/-2)). With compound ST-1355, 2-(4-phenylthiazol-2-ylamino)phenol, a multitarget ligand targeting all tested enzymes is presented, whereas compound ST-1705, 2-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol, represents a potent and selective 5-LO and COX-2 inhibitor with an IC₅₀ value of 0.9±0.2 μM (5-LO) and a residual activity of 9.1±1.1% at 10 μM (COX-2 product formation). The promising characteristics and the addnl. noncytotoxic profile of both compounds reveal new lead structures for the treatment of eicosanoid-mediated diseases.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pundeer, Rashmi published the artcileGreen and expeditious synthesis of some 2-amino/arylamino-4-(1-naphthyl)thiazole derivatives using [hydroxy(tosyloxy)iodo]benzene, Application In Synthesis of 3696-23-9, the publication is Indian Journal of Heterocyclic Chemistry (2016), 25(3-4), 311-315, database is CAplus.

The synthesis of a series of 2-amino/arylamino-4-(1-naphthyl)thiazoles I (R = C₆H₅, 4-O₂NC₆H₄, 4-FC₆H₄, etc.) under solvent-free and eco-friendly conditions by applying ‘Grindstone Chem. Technique’ using [hydroxy(tosyloxy)iodo]benzene is described practicing the modified Hantzsch thiazole synthesis of α-tosyloxyacetonaphthone and thiourea/substituted thioureas.

Indian Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grytsai, Oleksandr published the artcileSynthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2020), 104271, database is CAplus and MEDLINE.

Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kobelev, Aleksandr I. published the artcileFacile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea, Application In Synthesis of 3696-23-9, the publication is Beilstein Journal of Organic Chemistry (2019), 2864-2871, database is CAplus and MEDLINE.

A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacol. valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatog. methods.

Beilstein Journal of Organic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Khodade, Vinayak S. published the artcileDevelopment of S-Substituted Thioisothioureas as Efficient Hydropersulfide Precursors, Product Details of C7H7ClN2S, the publication is Journal of the American Chemical Society (2018), 140(50), 17333-17337, database is CAplus and MEDLINE.

Because of their inherent instability, hydropersulfides (RSSH) must be generated in situ using precursors, but very few physiol. useful RSSH precursors have been developed to date. In this work, we report the design, synthesis, and evaluation of novel S-substituted thioisothioureas as RSSH precursors. These water-soluble precursors show efficient and controllable release of RSSH under physiol. conditions.

Journal of the American Chemical Society published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rajanarendar, E. published the artcileA Convenient and Facile Hantzsch Synthesis of Aryl Imidazo[1,2-b]Isoxazolyl-N-aryl Thiazol Amines, Quality Control of 3696-23-9, the publication is Journal of Heterocyclic Chemistry (2016), 53(6), 1983-1989, database is CAplus.

The Hantzsch synthesis of novel imidazo[1,2-b]isoxazolyl-N-arylthiazolamines analogs were described. Reaction of 3-amino-5-methylisoxazole with substituted phenacyl bromides in dry ethanol afforded the corresponding 6-methyl-3-arylimidazo[1,2-b]isoxazoles in good yields. The latter compounds on reaction with chloroacetyl chloride in 1,4-dioxane furnished the corresponding 2-chloro-1-(6-methyl-3-arylimidazo[1,2-b]isoxazol-2-yl)ethanones. These compounds on heating with N-arylthioureas in an oil bath underwent cyclization to afford the title compounds viz., imidazo[1,2-b]isoxazolyl-N-arylthiazolamines in moderate to good yields by Hantzsch synthesis.

Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Quality Control of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pendem, Venkata Bhavanarushi published the artcileIron-promoted sulfur sequestration for the substituent-dependent regioselective synthesis of tetrazoles and guanidines, SDS of cas: 3696-23-9, the publication is Journal of Sulfur Chemistry (2021), 42(5), 499-509, database is CAplus.

Herein, a facile and versatile synthetic methodol. for the construction of tetrazoles and guanidines in the presence of an eco-friendly, inexpensive and easily available iron reagent were established. Aromatic thioureas with electron-donating substituents produced their resp. target products in quant. yield. In contrast, when electron-withdrawing substituted aromatic thioureas were used, the expected products were obtained in reduced yield. However, the desired products were obtained in good yield at moderate temperature In addition, mechanistic studies revealed that the synthetic route involved iron-based subsequent reactions of addition and removal of sulfur.

Journal of Sulfur Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kavitha, K. published the artcileAn expedient one-pot tandem method for the synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones under green conditions, Name: 1-(4-Chlorophenyl)thiourea, the publication is Journal of the Iranian Chemical Society (2019), 16(9), 1913-1921, database is CAplus.

This paper describes a facile pathway for the one-pot three-component synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones starting from ethyl-4-chloroacetoacetate by treating it with equimolar amounts of various phenylthioureas and salicylaldehyde. Use of biosynthetically prepared L-proline as an efficient catalyst and naturally extracted renewable polyethylene glycol-600 (PEG-600) as an effective green reaction media are the added advantages of this method. Alternatively, tandem, stepwise methods have been proposed to isolate the intermediate and to study the possible reaction mechanism. These reactions are very simple, rapid, cost effective, industrially viable, which would be applied for various biomass conversions.

Journal of the Iranian Chemical Society published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kavitha, Kotthireddy published the artcileAn unusual synthesis of 3-(2-(arylamino)thiazol-4-yl)-2H-chromen-2-ones from ethyl 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylate via benzopyran ring opening, HPLC of Formula: 3696-23-9, the publication is Molecular Diversity (2019), 23(2), 443-452, database is CAplus and MEDLINE.

An unusual and unexpected synthesis of 3-(2-(arylamino)thiazol-4-yl)-2H-chromen-2-ones was observed by the reaction of Et 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylate with various arylthioureas in ethanol under mild reaction conditions with excellent yields. The ambiguity in the structure of the obtained products was solved by recording its single-crystal X-ray anal. This protocol was found to be a novel approach for the preparation of title compounds via benzopyran ring opening. A systematic plausible mechanism was proposed for the formation of the product. Also, an efficient one-pot three-component method was demonstrated for the formation of title compounds starting from salicylaldehyde.

Molecular Diversity published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mishra, Anu published the artcileVisible light triggered, catalyst free approach for the synthesis of thiazoles and imidazo[2,1-b]thiazoles in EtOH : H₂O green medium, Related Products of chlorides-buliding-blocks, the publication is RSC Advances (2016), 6(54), 49164-49172, database is CAplus.

The development of a visible light promoted, mild and greener approach for the synthesis of highly functionalized thiazoles and imidazo[2,1-b]thiazoles under photochem. activation in EtOH : H₂O green medium was demonstrated. The characteristic feature of the present protocol was the utilization of visible light (an omnipresent, nontoxic, environmentally benign and inexpensive reagent) to form C-S and C-N bonds and circumvent the use of catalysts or photosensitizers. The reported protocol was the first example of visible light promoted synthesis of thiazoles and imidazo[2,1-b]thiazoles with various attractive features like being catalyst free, eco-efficient and possessing cost effectiveness, short reaction time, excellent yields and sustainability to fulfill the parameters of green chem.

RSC Advances published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics