Category: 3696-23-9

Cheng, Xinlai published the artcileEthyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4, Synthetic Route of 3696-23-9, the publication is Journal of Medicinal Chemistry (2015), 58(15), 5742-5750, database is CAplus and MEDLINE.

The octamer-binding transcription factor 4 (Oct3/4) is a master gene in the transcriptional regulatory network of pluripotent cells. Repression of Oct3/4 in embryonic stem cells (ESCs) is associated with cell differentiation and loss of pluripotency, whereas forced overexpression in cooperation with other transcriptional factors, such as Nanog, Sox2, and Lin28, can reprogram somatic cells back into pluripotent cells, termed induced pluripotent stem cells (iPSCs). However, random integration and potential tumorigenic transformation caused by viral transduction limit the clin. application of iPSCs. By performing a cell-based high throughput screening (HTS) campaign, the authors identified several potential small mols. as inducers of Oct3/4 expression. Here the authors report a lead structure Et 2-((4-chlorophenyl)amino)-thiazole-4-carboxylate, termed O4I2, showing high activity in enforcing Oct3/4 expression. On the basis of chem. expansion, the authors further identified derivatives having increased activities toward Oct3/4 induction. Thus, O4I2 and its derivatives should provide a new class of small mols. suitable for iPSC generation.

Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maiti, Rakesh published the artcileCarbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihydropyrimidin-4-ones, HPLC of Formula: 3696-23-9, the publication is Organic Chemistry Frontiers (2021), 8(4), 743-747, database is CAplus.

A carbene-catalyzed addition reaction between isothioureas and enals under oxidative conditions was reported. The key steps of these reactions was the formation of two carbon-nitrogen bonds in a highly regioselective manner. A variety of sulfur-containing 5,6-dihydropyrimidin-4-ones were obtained with high optical purity.

Organic Chemistry Frontiers published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ye, Jiao published the artcileSynthesis and Cytotoxicity in Vitro of N-Aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine, Name: 1-(4-Chlorophenyl)thiourea, the publication is Journal of the Chinese Chemical Society (Weinheim, Germany) (2015), 62(7), 627-631, database is CAplus.

A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines I [R = H, 4-Me, 2-F, etc.] were synthesized in a green way. H₂O₂-NaBr brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. Structures of the target compounds were confirmed by ¹H NMR and elemental anal. and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound I [R = 3-F₃C] was the most potent compound with the IC₅₀ values of 9μM against Hela cells and 15μM against Bel-7402 cells resp.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C10H16Br3N, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lei, Ying-jie published the artcileUltrasound assisted synthesis and antibacterial activity of 4-(coumarin-3-yl)-2-arylaminothiazoles, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2018), 40(6), 518-522, 588, database is CAplus.

In this work, 3-(2-bromoacetyl)-2H-chromen-2-ones prepared from 3-acetyl coumarins with tetrabutylammonium tribromide on bromination were used as the raw material. An efficient approach toward the synthesis of 4-(coumarin-3-yl)-2-arylaminothiazoles was carried out by the reaction of the starting compounds with certain Ph thioureas in presence of PEG-400 under ultrasound irradiation at a frequency of 40 kHz in 20âˆ?0 min, with a yield of 81.6%âˆ?3.0%. The structures of target compounds were confirmed by IR, ¹HNMR, ¹³CNMR, MS and elemental anal. Preliminary bioassay results showed that some of them have certain antibacterial activities against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. This method is operationally simple and environmentally benign and the solvent could be reused for several times.

Huaxue Shiji published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Huarong published the artcileA novel and green method for the synthesis of 4-thiazolidinones with 2-chloroacetamide and thioureas, HPLC of Formula: 3696-23-9, the publication is Youji Huaxue (2014), 34(4), 761-766, database is CAplus.

A novel, green synthetic method for 4-thiazolidinones in the ionic liquids was reported. 4-Thiazolidinones were prepared with the substituted thioureas and 2-chloroacetamide in the ionic liquids This method offers several advantages such as high yield, short reaction time and mild reaction conditions. The reaction mechanism was studied and the result showed that ammonia was removed in the reaction, which was the first reported.

Youji Huaxue published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C3H6O2, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pieroni, Marco published the artcileDesign, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents, Name: 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Medicinal Chemistry (2014), 26-34, database is CAplus and MEDLINE.

Tuberculosis (TB) is one of the deadliest infectious diseases of all times, and its recent resurgence is a supreme matter of concern. Co-infection with HIV and, in particular, the continuous isolation of new resistant strains, makes the discovery of novel anti-TB agents a strategic priority. The research of novel agents should be driven by the accessibility of the synthetic procedure and, in particular, by the lack of cross-resistance with the drugs already marketed. Moreover, in order to shorten the duration of the therapy, and therefore decrease the rate of resistance, these mols. should be active also against the nonreplicating persistent form (NRP-TB) of the infection. The availability of an inhouse small library of compounds prompted us to investigate their anti-TB activity. Two compounds, embodying a 2-aminothiazole scaffold, were found to possess a certain inhibitory activity toward Mycobacterium tuberculosis H₃₇Rv, and therefore a medicinal chem. campaign was initiated in order to increase the activity of the hit compounds and, especially, construct a plausible body of structure-activity relationships. The potency of the hit compound was successfully improved, and, much more importantly, some of the mols. synthesized were found to be active toward the persistent phenotype, and, also, toward a panel of resistant strains. These findings encourage further investigations around this interesting antitubercular chemotype.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tayade, D. T. published the artcileDesign, synthesis, characterization and anti-microbial screening of some novel thiocarbamidochalcones, Quality Control of 3696-23-9, the publication is American Journal of PharmTech Research (2016), 6(3), 605-612, database is CAplus.

Interactions of (2E)-1-(4-chlorophenyl)-3-(3,4 dimethoxyphenyl)prop-2-en-1-one with various substituted thioureas such as thiourea, N-phenylthiourea, 2-chlorophenylthiourea, 3-chlorophenylthiourea and 4-chlorophenylthiourea in presence of isopropanol as a medium. The products isolated in these reactions were characterized on the basis of conventional elemental anal., chem. characteristics and spectral data. All the synthesized compounds screened against various microorganisms such as gram pos. Staphylococcus aureus, gram-neg. Escherichia coli. Ciprofloxacin was used as a standard drug for the antimicrobial screening.

American Journal of PharmTech Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C6H4ClNO2, Quality Control of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sahu, Meeta published the artcileDesign, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2017), 166-178, database is CAplus and MEDLINE.

Several new 5,6-dihydropyrimidine-2(1H)-thione derivatives have been prepared and investigated for their potencies for anticonvulsant activity against maximal electroshock (MES) and s.c. pentylenetetrazole (scPTZ) test in mice. The acute neurotoxicity was measured by rotarod test. Compounds 3c (1-(4-methoxyphenyl)-4,6-diphenyl-5,6-dihydropyrimidine-2(1H)-thione) and 3l (4-(4-hydroxyphenyl)-1-(2-nitrophenyl)-6-phenyl-5,6-dihydropyrimidine-2(1H)-thione) were found active in both of the animal models. Further, in vitro GABA-AT enzyme activity assay was carried out to investigate the possible mechanism of action through GABA-AT inhibition. The most potent compounds 3c and 3l showed inhibitory potency (IC₅₀) of 18.42 μM and 19.23 μM, resp. The mol. modeling was performed for all the synthesized compounds The docking results were found in concordant with the observed animal studies.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nishad, Ravi K. published the artcileDesign and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents, Application of 1-(4-Chlorophenyl)thiourea, the publication is Current Bioactive Compounds (2020), 16(8), 1242-1248, database is CAplus.

An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among the various substitutions possible in this nucleus, substitutions at position-2 have already been reported with potential bioactivities. Thus, different substituted compounds have been synthesized which could serve as antimicrobials and antioxidants. Benzothiazole derivatives (B₁-B₇) were synthesized by two-step reactions and the structures were confirmed through IR, mass and NMR spectroscopy. The compounds were evaluated for in vitro antioxidant and antimicrobial activities using standard methods. The results of antibacterial and antifungal activity showed that compound B₄ exhibited maximum activity against all the tested strains of microorganisms with the zone of inhibition 17.1-18.5 mm and MIC value 1.1-1.5μg/mL. Compound B₅ exhibited potent antioxidant activity. The compounds substituted with halogen on the aryl ring showed increased antimicrobial activity as seen in the case of compound B₄ (6-fluoro). The compounds substituted with a hydroxyl group (B₅) exhibited good antioxidant activity.

Current Bioactive Compounds published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thakare, Prashant published the artcileSynthesis and biological evaluation of novel 4-(6-substituted quinolin-4-yl)-N-aryl thiazol-2-amine derivatives as potential antimicrobial agents, HPLC of Formula: 3696-23-9, the publication is Journal of Heterocyclic Chemistry (2021), 58(9), 1867-1877, database is CAplus.

Cyclocondensation reaction of 4-(2-bromoacetyl)quinolin-1-ium bromide with substituted arylthiourea, afforded 4-(6-substituted quinolin-4-yl)-N-aryl/pyridyl thiazol-2-amine I (R = H, Cl, F, Br; Ar = C₆H₄NH₂, 2-pyridylamine, 4-MeC₆H₄NH₂, etc.). These newly synthesized derivatives were evaluated for in vitro antibacterial activity against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) (Gram-neg. strains), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178) (Gram-pos. strains) and in vitro antifungal activity against Aspergillus niger (ATCC 504) and Candida albicans (NCIM 3100). Most of the compounds showed moderate to good antibacterial activity against S. albus. Ten derivatives showed moderate to good activity against A. niger. N-[4-(Quinolin-4-yl)-1,3-thiazol-2-yl]pyridin-2-amine presented comparable activity against A. niger with respect to standard drug Rouconazole.

Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C16H12O, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics