Category: 3696-23-9

Rao, Jyothi N. published the artcileSolvent free microwave-assisted synthesis of some novel pyrimidinones/thiones and their biological studies, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Chemica Sinica (2016), 7(3), 38-42, database is CAplus.

Pyrimidinone derivatives I [R = H; X = O; R¹ = CH₃, C₂H₅] and pyrimidinethione derivatives I [R = H, C₆H₅, 4-MeOC₆H₄, 4-MeC₆H₄, etc.; X = S; R¹ = C₂H₅] were synthesized via reaction of 1-phenyl-3-methyl-5-chloro-pyrazole-4-aldehyde, Et acetoacetate/methyl acetoacetate and urea/thiourea/thiourea derivatives under conventional heating as well as microwave irradiation All the newly synthesized compounds were screened for their antibacterial and antifungal activities. The antimicrobial study revealed that pyrimidinone compound I [R = H; X = O; R¹ = C₂H₅] and pyrimidinethione compounds I [ R = 4-MeOC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄; X = S; R¹ = C₂H₅] showed excellent antibacterial and antifungal activities against all the tested organisms.

Chemica Sinica published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Hongtao published the artcileIdentification of N-benzothiazolyl-2-benzenesulfonamides as novel ABCA1 expression upregulators, Category: chlorides-buliding-blocks, the publication is RSC Medicinal Chemistry (2020), 11(3), 411-418, database is CAplus and MEDLINE.

ATP binding cassette transporter A1 (ABCA1) is a critical transporter that mediates cellular cholesterol efflux from macrophages to apolipoprotein A-I (ApoA-I). Therefore, increasing the expression level of ABCA1 is anti-atherogenic and ABCA1 expression upregulators have become novel choices for atherosclerosis treatment. In this study, a series of N-benzothiazolyl-2-benzenesulfonamides, based on the structure of WY06 discovered in our laboratory, were designed and synthesized as novel ABCA1 expression upregulators. Based on an in vitro ABCA1 upregulatory cell model, ABCA1 upregulation of target compounds was evaluated. Compounds 6c, 6d, and 6i have good upregulated ABCA1 expression activities, with EC₅₀ values of 0.97, 0.37, and 0.41μM, resp. A preliminary structure-activity relationship is summarized. Replacing the methoxy group on the benzothiazole moiety of WY06 with a fluorine or chlorine atom and exchanging the ester group with a cyano group resulted in more potent ABCA1 upregulating activity. Moreover, compound 6i increased ABCA1 mRNA and protein expression and significantly promoted cholesterol efflux in RAW264.7 cells. In conclusion, N-benzothiazolyl-2-benzenesulfonamides were identified as novel ABCA1 expression upregulators.

RSC Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Hai-Bo published the artcileSynthesis of 5-acetyl-2-arylamino-4-methylthiazole thiosemicarbazones under microwave irradiation and their in vitro anticancer activity, Synthetic Route of 3696-23-9, the publication is Journal of Chemical Research (2016), 40(2), 67-72, database is CAplus.

A series of 21 new tri- and tetra-cyclic thiosemicarbazone derivatives were prepared via the condensation of morpholine, piperazine or N-(4-methoxyphenyl)piperazine with seven Me hydrazine-carbodithioate derivatives of 5-acetyl-2-arylamino-4-methylthiazoles under microwave irradiation All compounds were tested for their cytotoxic activity in-vitro against human gastric, lung and breast cancer cell lines. The results showed that some of the compounds displayed moderate anticancer activity. The most potent compound, a morpholino-substituted analog, exhibited significant activity against human breast cancer cells.

Journal of Chemical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C12H13F2N3O4S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Junsheng published the artcileDesign, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1123-1139, database is CAplus and MEDLINE.

N-arylthiazoleamines such as (arylamino)thiazolecarboxylates I (R = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 4-F₃CC₆H₄, 4-F₃CC₆H₄, 4-t-BuC₆H₄, 4-Cl-3-F₃CC₆H₃, 4-Br-3-F₃CC₆H₃, 3,4-Cl₂C₆H₃, 3,5-Cl₂C₆H₃, 4-Br-2-MeC₆H₃, 5-indanyl, 1,3-benzodioxol-5-yl, 5,6,7,8-tetrahydro-2-naphthyl, 2-naphthyl, 2-anthracenyl, 4-PhC₆H₄, 2-R¹-6-R²-4-R³C₆H₂, 3-Cl-4-R⁴OC₆H₃; R¹, R² = H, F; R³ = Ph, 3-MeOC₆H₄; R⁴ = Ph, PhCH₂, 2-Cl-6-FC₆H₃CH₂) were prepared as inhibitors of human dihydroorotate dehydrogenase (HsDHODH), a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases; their calculated and exptl. binding to HsDHODH and binding to the corresponding enzyme from Plasmodium falciparum were determined The structures of complexes of two arylaminotriazoles bound to HsDHODH were determined by X-ray crystallog.; the structures confirmed that the inhibitors bound at the putative ubiquinone binding tunnel and guided the development of improved analogs, such as I (R = 5-indanyl). I (R = 5-indanyl) inhibited inflammation and alleviated foot swelling in rats.

Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C13H16O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Reheim, Mohamed Ahmed Mahmoud Abdel published the artcileA simple and convenient synthesis of isolated fused heterocycles based on: 6-phenyl-2-thioxo-2,3- dihydropyrimidin-4(5H)-one and 5-acetyl-6-phenyl-2- thioxo-2,3-dihydropyrimidin-4(5H)-one, Category: chlorides-buliding-blocks, the publication is Heterocycles (2016), 92(8), 1397-1414, database is CAplus.

The reaction of 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one with acetyl chloride in acetic anhydride in the presence of sodium acetate afforded 5-acetyl-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one which was reacted with bromine, hydrazine hydrate, phenylhydrazine, cyanothioacetamide, aldehydes ArCHO (Ar = Ph, 4-chlorophenyl, 4-methoxyphenyl) and (malononitrile/sulfur) to give 2-thioxo-2,3-dihydropyrimidine derivatives, e.g., I. In the present investigation 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one was reacted with chloroacetyl chloride to yield the corresponding compound 5-(2-chloroacetyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one. Compound 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one was reacted with some electrophilic reagents such as benzylidene-cyanothioacetamide derivatives, 2-cyano-2-cyclopentylethanethioamide, 2-cyano-2-cyclohexyl-ethanethioamide and aromatic diazonium salts Ar¹N₂⁺Cl^– to give compounds, e.g., II (X = CH₂, CH₂CH₂). The newly synthesized heterocycles were characterized on the basis of their chem. properties and spectral data.

Heterocycles published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bourahla, Khadidja published the artcileDesign and microwave synthesis of new (5Z) 5-arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-amino-5-arylidene-1,3-thiazol-4(5H)-one as new inhibitors of protein kinase DYRK1A, Synthetic Route of 3696-23-9, the publication is Pharmaceuticals (2021), 14(11), 1086, database is CAplus and MEDLINE.

Here, we report on the synthesis of libraries of new 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones 3 (twenty-two compounds) and new 2-amino-5-arylidene-1,3-thiazol-4(5H)-ones 5 (twenty-four compounds) with stereo controlled Z-geometry under microwave irradiation The 46 designed final compounds were tested in order to determine their activity against four representative protein kinases (DYR1A, CK1, CDK5/p25, and GSK3α/β). Among these 1,3-thiazolidin-4-ones, the mols. (5Z) 5-(4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one 3e (IC50 0.028 μM) and (5Z)-5-benzo[1,3]dioxol-5-ylmethylene-2-(pyridin-2-yl)amino-1,3-thiazol-4(5H)-one 5s (IC50 0.033 μM) were identified as lead compounds and as new nanomolar DYRK1A inhibitors. Some of these compounds in the two libraries have been also evaluated for their in vitro inhibition of cell proliferation (Huh7 D12, Caco2, MDA-MB 231, HCT 116, PC3, and NCI-H2 tumor cell lines). These results will enable us to use the 1,3-thiazolidin-4-one core as pharmacophores to develop potent treatment for neurol. or oncol. disorders in which DYRK1A is fully involved.

Pharmaceuticals published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jangid, D. K. published the artcileAn efficient synthesis of 2-aminobenzothiazole and its derivatives in ionic liquids, Related Products of chlorides-buliding-blocks, the publication is International Journal of Pharmaceutical Sciences and Research (2017), 8(7), 2960-2964, database is CAplus.

The synthesis of 2-aminobenzothiazole derivatives I [R = H, MeO; R¹ = Cl, NO₂; R² = NH₂, NHEt, N=CHPh] were carried out from substituted phenyl-thiourea which was synthesized by substituted aniline in ionic liquid (1-butyl-3-methylimidazolium)bisulfate ([BMIM]⁺ [HSO₄]^–), (1-butyl-3-methylimidazolium)tetrafluoroborate ([BMIM]⁺ [BF₄]^–) and (1-butyl-3-methylimidazolium)hexafluorophosphate ([BMIM]⁺ [PF₆]^–). Ionic lquids were green alternate of volatile organic solvents, beneficiary environmentally and economically. The reactivity, reaction rate and yield were enhanced by using ionic lquids and the products were recovered by simple filtration. The characterization of synthesized compounds was done by elemental and spectral anal.

International Journal of Pharmaceutical Sciences and Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Z. L. published the artcileSynthesis and antitumor evaluation of 5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(tert-butyl)-N-arylthiazol-2-amines, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is MedChemComm (2016), 7(9), 1768-1774, database is CAplus.

A series of novel N-aryl-5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(tert-butyl)thiazol-2-amines (C1-C31) were synthesized and evaluated for their antitumor activities against HeLa, A549 and MCF-7 cell lines. Some tested compounds showed potent growth inhibition properties with IC₅₀ values generally below 5 μM against the three human cancer cells lines. Compound C27 showed potent activities against HeLa and A549 cell lines with IC₅₀ values of 2.07 ± 0.88 μM and 3.52 ± 0.49 μM, resp. Compound C7 (IC₅₀ = 2.06 ± 0.09 μM) was the most active compound against A549 cell line, while compound C16 (IC₅₀ = 2.55 ± 0.34 μM) showed the best inhibitory activity against the MCF-7 cell line. The preliminary mechanism of the inhibitory effect was investigated via further experiments, such as morphol. anal. by dual AO/EB staining and Hoechst 33342 staining, and cell apoptosis and cycle assessment by FACS anal. The results illustrated that compound C27 could induce apoptosis and cause both S-phase and G2/M-phase arrests in HeLa cell line. Therefore, compound C27 could be developed as a potential antitumor agent.

MedChemComm published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is 0, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Raju, D. Nooka published the artcileSynthesis, characterization and analgesic activity of some novel substituted 2-amino benzothiazole derivatives, Formula: C7H7ClN2S, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(5), 1815-1821, database is CAplus.

The synthesis of some novel substituted 2-amino benzothiazoles I (R = 6-Cl, 6-Br, 6-NO₂, 6-COOH) is described. The synthesized compounds were screened for analgesic activity. Compounds I (R = 6-Cl, 6-NO₂) have highly significant analgesic activity with reference to the standard aspirin and consequently further exploration of these benzothiazole derivatives should make these mols. accessible for widespread use as potent analgesic agents.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zade, Varsha S. published the artcileSynthesis and biological evaluation of S-maltosylated 1,2,4-thiadiazoline derivatives against human pathogens, Safety of 1-(4-Chlorophenyl)thiourea, the publication is Indian Journal of Heterocyclic Chemistry (2014), 24(2), 163-166, database is CAplus.

A series of new 4-aryl-5-p-tolylimino-3-S-hepta-O-acetyl maltosyl-1,2,4-thiadiazolines, e.g. I, were synthesized by the interaction of N-p-tolyl-S-chloro isothiocarbamoyl chloride with S-hepta-O-acetyl maltosyl-1-aryl isothiocarbamides. These compounds were screened for their antibacterial and antifungal activities against E. coli, S. aureus, P. aerUginosa, S. typhi, R. oligospora and A. niger. The identities of these newly synthesized thiomaltosides have been established on the basis of chem. transformations and IR, 1H NMR and mass spectral studies. These compounds show most significant activity towards these micro-organisms.

Indian Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H4BrClO2, Safety of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics