Category: 37481-18-8

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Combinatorial Chemistry called Solution-phase parallel synthesis of novel membrane-targeted antibiotics, Author is Vooturi, Sunil K.; Firestine, Steven M., which mentions a compound: 37481-18-8, SMILESS is NCCN1CCCC2=C1C=CC=C2, Molecular C11H16N2, Electric Literature of C11H16N2.

The increase in the incidence of antibiotic-resistant infections is a major concern to healthcare workers and requires the development of novel antibacterial agents. Recently, we described a series of benzophenone-containing antibiotics which displayed activity against antibiotic-resistant bacteria. We have shown that these agents function by disrupting the bacterial membrane. To further explore these compounds, a practical and efficient solution-phase parallel synthesis method was developed which allowed us to prepare combinatorial libraries of these agents. Using this method, we prepared 218 compounds in 58 reactions, e.g. I. All of the compounds were characterized by HPLC and MALDI-TOF mass spectrometry. Anal. of this library for antibacterial activity identified six compounds which displayed MIC values of 2.0 mg/L against Staphylococcus aureus. Examination of the structure-function relationships of these agents revealed that cationic groups were required and that cyclic, aliphatic amines were crucial for activity. Using the information generated here, we speculate on how the various structural features of the mol. are necessary for the interaction with the bacterial membrane.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《N-Substituted 1,2,3,4-tetrahydroquinolines》. Authors are Rachinskii, F. Yu.; Slavachevskaya, N. M.; Sovalkova, L. K..The article about the compound:2-(3,4-Dihydroquinolin-1(2H)-yl)ethanaminecas:37481-18-8,SMILESS:NCCN1CCCC2=C1C=CC=C2).Formula: C11H16N2. Through the article, more information about this compound (cas:37481-18-8) is conveyed.

Passage of ethylene oxide into 266 g. 1,2,3,4-tetrahydroquinoline and 1 ml. H2O at 25-30° gave 48 g. N-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoline (I), b5 140-4° n20D 1.5740, d20 1.1041, 68 g. N-[2-(2-hydroxyethoxy)ethyl]analog, b4 167-70°, 1.5523, 1.1055, and 7 g. N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]analog, b5 205-7°, 1.5420, 1.1053. I.HBr m. 120-2°. Adding 0.1 mole N-(2-cyanoethyl)1,2,3,4-tetrahydroquinoline (II) in EtOH to 40 g. powd. Ni-Al alloy in 1% NaOH and refluxing 4 hrs. gave after addition of HCl, evaporation, and treatment with NaOH, 63% N-(3-aminopropyl)-1,2,3,4-tetrahydroquinoline, b5 137-40°, 1.5777, 1.0450 (di-HBr salt m. 195-7°). II refluxed with alc. KOH gave 73% N-(2-carboxyethyl)-1,2,3,4-tetrahydroquinoline, m. 70-2°. Tetra-hydroquinoline and BrCH2CH2NH2.HBr treated with EtONa in EtOH and refluxed 2 hrs. gave 7% N-(2-aminoethyl)-1,2,3,4-tetrahydroquinoline, b5 130-2°, 1.5830, 1.0645. Similarly was prepared 10% N-(2-diethylaminoethyl)analog, b5 160-1°, 1.5475, 0.9836. Tetrahydroquinoline and ethylene sulfide in C6H6 in 5 hrs. refluxing gave 6.7% N-(2-mercaptoethyl)-1,2,3,4-tetrahydroquinoline, b5 145°, 1.5990, 1.0903, which treated with a stream of air in EtOH in the presence of FeSO4 gave the corresponding disulfide, isolated as di-HCl salt, m. 118-20°. The mercapto derivative formed an HBr salt, m. 176-7°. Tetrahydroquinoline, CS2, and KOH in C6H6-H2O gave in 2 hrs. 65% K 1,2,3,4-tetrahydroquinolyldithiocarbamate, m. 264-6°. Tetrahydroquinoline and o-C6H4(CO)2O in C6H6 refluxed 3 hrs. gave 57% N,N’-di(1,2,3,4-tetrahydroquinolyl)phthalamide, m. 173-4°. Similarly, o-MeO2CC6H4COCl gave 30% 2-carbomethoxyphthalo-1,2,3,4-tetrahydroquinolide, m. 63-5°, b5 210°. Tetrahydroquinoline and undecylenic acid heated finally at 230° gave 23% N-undecylenyl-1,2,3,4-tetrahydroquinoline, b5 152°, 1.519, 0.9872. Tetrahydroquinoline failed to react with ethylenimine. The products above were tested successfully as antioxidants, insect repellents, and anticorrosion agents.

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SDS of cas: 37481-18-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine, is researched, Molecular C11H16N2, CAS is 37481-18-8, about Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. Author is Papeo, Gianluca; Posteri, Helena; Borghi, Daniela; Busel, Alina A.; Caprera, Francesco; Casale, Elena; Ciomei, Marina; Cirla, Alessandra; Corti, Emiliana; D’Anello, Matteo; Fasolini, Marina; Forte, Barbara; Galvani, Arturo; Isacchi, Antonella; Khvat, Alexander; Krasavin, Mikhail Y.; Lupi, Rosita; Orsini, Paolo; Perego, Rita; Pesenti, Enrico; Pezzetta, Daniele; Rainoldi, Sonia; Riccardi-Sirtori, Federico; Scolaro, Alessandra; Sola, Francesco; Zuccotto, Fabio; Felder, Eduard R.; Donati, Daniele; Montagnoli, Alessia.

The nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in oncol., as testified by the number of candidates in clin. testing that unselectively target both PARP-1 and its closest isoform PARP-2. The goal of the program was to find a PARP-1 selective inhibitor that would potentially mitigate toxicities arising from cross-inhibition of PARP-2. Thus, an HTS campaign on the proprietary Nerviano Medical Sciences (NMS) chem. collection, followed by SAR optimization, allowed us to discover I. NMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, resp. Cocrystal structures of I with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 37481-18-8, is researched, Molecular C11H16N2, about 2-Methoxy-6-chloro-9-(N-substituted-amino)-acridines. II. Compounds Derived from Cyclic Secondary Amines, the main research direction is ACRIDINE DYES/chemistry.Recommanded Product: 37481-18-8.

The γ-substituted propionitriles were prepared by adding the secondary amines to an excess of CH2:CHCN: 1-pyrrolidyl, b28 110-12°, 81% (flavianate, m. 140-5°); 1-piperidyl, b27 125-30°, 74%; 2-methyl-1-piperidyl, b30 137-40°, 99%; 3-isomer, b28 126-8°, 97%; 4-isomer, b27-8 127-30°, 87%; 2,3-dimethyl-1-piperidyl, b35 140-2°, 99%; 2,4-isomer, b29 130-3°, 68%; 2, 6-isomer, b26-8 121-5°, 82%. The nitriles were reduced by Raney Ni in ether-NH3 or with Na in EtOH; 3-substituted propylamines: 1-pyrryl, b30 117-20°, 86% (picrate, m. 135-7°); 1-pyrrolidyl, b26 85-7°, 71% (picrate, m. 219-31° (decomposition)); 1-piperidyl, b31 110-15°, 77% (picrate, m. 195-204° (decomposition)); 2-methyl-1-piperidyl, b755 163-70°, 45% (picrate, m. 212-15°); 3-isomer, b27 110-12°, 85% (picrate, m. 185-7°); 4-isomer, b18 90-2°, 74% (picrate, m. 212-14°; phenylthiourea, m. 140-1°); 2, 3-dimethyl-1-piperidyl, b22 114-15°, 62% (picrate, m. 208-10°); 2,4-isomer, b34 120-2°, 52% (picrate, m. 203-5°); 2,6-isomer, b31-2 122-30°, 38% (picrate, m. 206-8°). 2-Methylpiperidine-HCl (67.7 g.), 290 g. Me2CO, 160 mL. H2O, and 90 mL. 37% HCHO, refluxed overnight, give 47.5 g. 4-(2-methyl-1-piperidyl)-2-butanone, b17-18 87-91°; the oxime b2 116-20°; reduction with Na in EtOH gives 4-(2-methyl-1-piperidyl)-2-butylamine, b26 113-16°. N-Substituted 2-methoxy-6-chloro-9-aminoacridine di-HCl salts: 3-(1-pyrryl)propyl, m. 210-13°; 3-(1-pyrrolidyl)propyl, m. 228-30°; 3-(1-piperidyl)propyl, m. 245-7°; 3-(2-methyl-1-piperidyl)propyl, m. 255-7°; 3-Me isomer, m. 241-2° (decomposition); 4-Me isomer, m. 256-7° (decomposition); 3-(2,3-dimethyl-1-piperidyl)propyl, m. 238-40°; 2, 4-di-Me isomer, m. 234-6°; 2,6-di-Me isomer, m. 239-41°; 4-(2-methyl-1-pperidyl)-3-Bu, m. 247-8°. 1,2,3,4-Tetrahydroquinoline (20 g.), 28.1 g. C6H4(CO)2NC2H4Br, 2 g. KI, and 25 mL. Methyl Cellosolve, heated on a steam bath overnight, give N-[2-(1,2,3,4-tetrahydro-1-quinolyl)ethyl]phthalimide, m. 131-3°; the resulting ethylamine gives 2-methoxy-6-chloro-9-[2-(1,2,3,4-tetrahydro-1-quinolyl)ethylamino]-acridine-2HCl, m. 156-8°. Histamine gives a small yield of 2-methoxy-6-chloro-9-[2-(4(or 5)-imidazolyl)ethylamino]acridine-2HCl, m. 250-5°.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Condensation reaction of amino alcohols with imides. IV. Condensation products of β-(cycloamino)ethanols with succinimide and with phthalimide-formation of β-(cycloamino)ethylamines》. Authors are Nakajima, Kazuo.The article about the compound:2-(3,4-Dihydroquinolin-1(2H)-yl)ethanaminecas:37481-18-8,SMILESS:NCCN1CCCC2=C1C=CC=C2).Application of 37481-18-8. Through the article, more information about this compound (cas:37481-18-8) is conveyed.

cf. CA 57, 8545h. Seven aminoalcs. (RNCH2CH2OH) (I), where RN = (CH2)4N (a), (CH2)5N (b), β-tetrahydroquinoline (c), morpholino (d), 4-ethylpiperazino (e), 4-butylpiperazino (f), and 4-phenylpiperazino (g). I and phthalimide heated at 200° while removing the H2O formed yielded RNCH2CH2N(CO)2C6H4-o (II) (RN, m.p., b10, m.p. of picrate, and decomposition point of Pt salt given): a, 109°, 220°, 218°, 212°; b, 90°, 206°, 215°, 215°; c, 137°, 273°, 144°, 204°; d, 135°, 216°, 232°, 146°; e, 115°, 227°, 245° (decomposition), 265°; f, 75°, 252°, 260° (decomposition), 271°; g, 158°, 279°, 218° (decomposition), 262°. Similarly, I and succinimide yielded RNCH2CH2N(COCH2)2 (III) (RN, m.p., b10, m.p. of picrate, and decomposition point of Pt salt given): a, 55°, 170°, 158°, 212°; b, -, 170°, 190°, 230°; c, 115°, 210°, 180°, -; d, 75°, 170°, 181°, 175°; e, -, 199°, 245°, 245°; f, 65°, 223°, 225°, 255°; g, 141°, 272°, 175°, 236°. II and III refluxed with 20% HCl 3-5 hrs., phthalic acid or succinic acid filtered off, and the filtrate concentrated yielded RNCH2CH2NH2.HCl (IV.HCl). Free RNCH2CH2NH2 (IV) was obtained by a long extraction of neutralized IV.HCl with ether. (RN, b10, b760, m.p. of picrate, and decomposition point of Pt salt given) a, 33°, 165-6°, 210° (decomposition), 207°; b, 50°, 185°, ∼200 (decomposition), 218°; c, 157°, 290°, -, -; d, 81°, 204°, 177° (decomposition), 237°; e, 88°, 223-4°, 230°, 270°; f, 120°, 255°, 116°, 252°; g, (m. 80°), 191°, 326°, -. 210-40°.

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Application In Synthesis of 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine, is researched, Molecular C11H16N2, CAS is 37481-18-8, about Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. Author is Neelakantan, Harshini; Wang, Hua-Yu; Vance, Virginia; Hommel, Jonathan D.; McHardy, Stanton F.; Watowich, Stanley J..

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small mol. inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogs resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 ∼ 1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and exptl. calculated IC50 values. Predicted binding orientation of the quinolinium analogs revealed selective binding to the NNMT substrate-binding site residues and essential chem. features driving protein-ligand intermol. interactions and NNMT inhibition. The development of this new series of small mol. NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity.

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Chlorides – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine, is researched, Molecular C11H16N2, CAS is 37481-18-8, about Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays, the main research direction is food intake reduction 5HT2C receptor agonists lead; 5-HT(2C) receptor; Agonist; GPCR; Lead identification.Recommanded Product: 37481-18-8.

A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clin. studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identification process, leading us to focus on a 6,5,7-tricyclic scaffold. A subsequent early SAR investigation provided potent agonists of the 5-HT2C receptor that were highly selective in both functional and binding assays, had good rat PK properties and that significantly reduced acute food intake in the rat.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Russian Chemical Bulletin called Salts of 2- or 3-haloalkylamines in the synthesis of N-aminoalkyl derivatives of heterocyclic and aromatic amines, Author is Vasilyeva, T. P.; Vorobyeva, D. V.; Osipov, S. N., which mentions a compound: 37481-18-8, SMILESS is NCCN1CCCC2=C1C=CC=C2, Molecular C11H16N2, SDS of cas: 37481-18-8.

Reactions of 2-haloethyl- or 3-halopropylamine salts with NH-substrates (indoline, 1,2,3,4-tetrahydroquinoline, aniline, and N-ethylaniline) in the presence of NaHCO3 in water furnished various N-aminoalkyl derivatives of heterocyclic and aromatic amines.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine(SMILESS: NCCN1CCCC2=C1C=CC=C2,cas:37481-18-8) is researched.Name: 5,10,15,20-Tetrakis (4-methoxyphenyl)-21H,23H-porphine cobalt (II). The article 《Electrooxidative cyclization of hydroquinolyl alcohols, hydroquinolylamines, and dimethyl aminomalonates》 in relation to this compound, is published in Australian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:37481-18-8).

Several hydroquinolyl alcs. and amines were electrochem. oxidized in MeOH in the presence of NaOMe and KI to afford the corresponding intramol. cyclization products. Furthermore, several aminomalonates were electrochem. oxidized to yield the corresponding heterocyclic compounds through an intramol. C-C bond formation in the presence of NaCN in MeOH.

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