Category: 37908-97-7

《Chlorometabolite production by the ecologically important white rot fungus Bjerkandera adusta》 was written by Silk, P. J.; Aubry, C.; Lonergan, G. C.; Macaulay, J. B.. Safety of 3,5-Dichloro-4-methoxybenzoic acid And the article was included in Chemosphere on August 31 ,2001. The article conveys some information:

Two strains of the basidiomycete Bjerkandera adusta (DAOM 215869 and BOS55) produce in static liquid culture Ph, veratryl, anisyl and chloroanisyl metabolites (CAM’s) (alcs., acids and aldehydes) as well as a series of compounds not previously known to be produced by Bjerkandera species: 1-Ph, 1-anisyl, 1-(3-chloro-4-methoxy) and 1-(3,5-dichloro-4-methoxy) propan-1,2-diols, predominantly as erythro diastereomers with 1R,2S absolute configurations. 1-Anisyl-propan-1,2-diol and 1-(3,5-dichloro-4-methoxy)-propan-1,2-diol are new metabolites for which the names bjerkanderol A and B, resp., are proposed. Experiments with static liquid cultures supplied with 13C6- and 13C9-L-phenylalanine showed that all identified aromatic compounds (with the exception of phenol) can be derived from L-phenylalanine. For the aryl propane diols, the 13C label appeared only in the Ph ring and the benzylic carbon, suggesting a stereoselective resynthesis from a C7- and a C2-unit, likely aromatic aldehyde and decarboxylated pyruvate, resp. Other compounds newly discovered to be derived from phenylalanine by this white rot fungus include phenylacetaldehyde and phenylpyruvic, phenylacetic, phenyllactic, mandelic and Ph glyoxylic (benzoyl formic) acids. For both strains, cultures supplied with Na37Cl showed incorporation of 37Cl in all identified chlorometabolites. Veratryl alc. and the CAM alcs., which occur in both strains and can be derived from L-phenylalanine (all 13C-labeled), have reported important physiol. functions in this white rot fungus. Possible mechanisms for their formation through the newly discovered compounds are discussed. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Safety of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 3,5-Dichloro-4-methoxybenzoic acidOn May 31, 1996, Hjelm, Olof; Boren, Hans; Oeberg, Gunilla published an article in Chemosphere. The article was 《Analysis of halogenated organic compounds in coniferous forest soil from a Lepista nuda (wood blewitt) fairy ring》. The article mentions the following:

Soil collected at the arc of a Lepista nuda fairy ring growing in a coniferous forest was examined for the occurrence of low-mol.-weight halogenated organic compounds This was done by subjecting organic soil extracts to gas chromatog.-mass spectrometry and gas chromatog.-at. emission detection analyses. Fourteen organohalogens were detected, and a number of these represented the major low-mol.-weight compounds found in the analyzed extracts The fourteen compounds were chlorinated anisoles, dimethoxybenzenes, methoxybenzaldehydes, methoxybenzoic acids, and three brominated methoxybenzaldehydes. This is the first time brominated low-mol.-weight compounds have been found in an unpolluted soil sample. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Application In Synthesis of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 3,5-Dichloro-4-methoxybenzoic acidOn November 30, 1998 ,《Organohalogen production is a ubiquitous capacity among Basidiomycetes》 appeared in Chemosphere. The author of the article were Verhagen, F. J. M.; Swarts, H. J.; Wijnberg, J. B. P. A.; Field, J. A.. The article conveys some information:

Several species of Basidiomycetes are capable of producing de novo high concentrations of chloroarom. metabolites. However, the extent to which Basidiomycetes contribute to the natural pool of adsorbable organic halogen (AOOX) found in the environment is unknown yet. The purpose of this study was to determine the ubiquity of organohalogen production among Basidiomycetes and to determine maximal specific organohalogen production rates. Finally, the fate of the fungal chloroarom. compounds in the environment was studied. Some 191 fungal strains were tested for AOX production when grown on defined liquid medium. Approx 50% of the strains tested and 55% of the genera tested produced AOX. Organohalogen production seemed to be a ubiquitous capacity among Basidiomycetes. Many highly ecol. significant fungal species were identified among the moderate and high producers. Although it was found that the final AOX concentrations produced by Hypholoma fasciculare were strongly influenced by the substrate used, all maximal specific AOX production rates on different substrates were in the same order of magnitude. Seven new species and four new genera of Basidiomycetes could be added to the list of known chlorinated anisyl metabolite (CAM)-producing Basidiomycetes. In degradation studies of the major fungal metabolite 3,5-dichloro-anisyl alc., it was found that in forest soils there seems to be ubiquitous mineralizing capacity for this chlorinated aromatic compound Burkholderia cepacia was responsible for the fast degradation of this compound in oak forest soils. The experimental process involved the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Name: 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Name: 3,5-Dichloro-4-methoxybenzoic acid However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Swarts, Henk J.; Verhagen, Frank J. M.; Field, Jim A.; Wijnberg, Joannes B. P. A. published an article in Phytochemistry. The title of the article was 《Novel chlorometabolites produced by Bjerkandera species》.COA of Formula: C8H6Cl2O3 The author mentioned the following in the article:

The EtOAc extract from the extracellular fluid of the mycelium of Bjerkandera sp. BOS55 contained four novel chlorinated benzoic acid derivatives, i.e. 3-chloro-4-hydroxybenzoic acid, 3,5-dichloro-4-hydroxy-benzoic acid, Me 3,5-dichloro-4-hydroxybenzoate and Me 3,5-dichloro-p-anisate. 3-Chloro-4-hydroxybenzoic acid was also produced by B. adusta. In addition to this study using 3,5-Dichloro-4-methoxybenzoic acid, there are many other studies that have used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7COA of Formula: C8H6Cl2O3) was used in this study.

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Reaction of chlorine dioxide and sodium chlorite with some organic compounds. XVIII. Recation of 4-methoxybenzyl and 4-hydroxybenzyl alcohols with sodium chlorite》 was published in Roczniki Chemii in 1972. These research results belong to Paluch, Karolina; Otto, Jan; Baran, Janusz. Reference of 3,5-Dichloro-4-methoxybenzoic acid The article mentions the following:

In 2N H2SO4 or 6N HCl at 45°, p-MeOC6H4CH2OH and NaClO2 gave a mixture of 4-methoxybenzoic acid, its chloro derivatives, chloroanisoles, and quinones. Similarly, 4-HOC6H4CH2OH at 14° gave a mixture of chlorinated quinones. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of 3,5-Dichloro-4-methoxybenzoic acid Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Phenolic and chlorophenolic oligomers in chlorinated pine kraft pulp and in bleach plant effluents》 was written by Erickson, M.; Dence, C. W.. Related Products of 37908-97-7 And the article was included in Svensk Papperstidning in 1976. The article conveys some information:

The estimated total concentration of phenolic substances in the undiluted oxidized spent chlorination liquor of softwood kraft pulp (kappa number 28.2) chlorinated with 6.0% Cl was ∼100 ppm but was ∼190 ppm in the oxidized caustic extraction liquor of pulp chlorinated with 3.6% Cl. Eleven phenolic derivatives were detected in the spent chlorination liquors of the 2 levels of Cl application using gas chromatog. and mass spectrometric anal. The combined yields of the phenolic oxidation products indicated a concentration of ∼10 ppm for phenolic residues in each of the original liquors. The permanganate oxidation products of the chlorinated pulps were the same as those found in the spent chlorination and caustic extraction liquors but in higher total concentration In the experimental materials used by the author, we found 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Related Products of 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Related Products of 37908-97-7 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stadler, Marc; Hellwig, Veronika; Mayer-Bartschmid, Anke; Denzer, Dirk; Wiese, Burkhard; Burkhardt, Nils published their research in Journal of Antibiotics on December 31 ,2005. The article was titled 《Novel analgesic triglycerides from cultures of Agaricus macrosporus and other Basidiomycetes as selective inhibitors of neurolysin》.Formula: C8H6Cl2O3 The article contains the following contents:

The agaricoglycerides are a new class of fungal secondary metabolites that constitute esters of chlorinated 4-hydroxy benzoic acid and glycerol. They are produced in cultures of the edible mushroom, Agaricus macrosporus, and several other basidiomycetes of the genera Agaricus, Hypholoma, Psathyrella and Stropharia. The main active principle, agaricoglyceride A, showed strong activities against neurolysin, a protease involved in the regulation of dynorphin and neurotensin metabolism (IC50 = 200 nM), and even exhibited moderate analgesic in vivo activities in an in vivo model. Agaricoglyceride monoacetates (IC50 = 50 nM) showed even stronger in vitro activities. Several further co-metabolites with weaker or lacking bioactivities were also obtained and characterized. Among those were further agaricoglyceride derivatives, as well as further chlorinated phenol derivatives such as the new compound, agaricic ester. The characteristics of the producer organisms, the isolation of bioactive metabolites from cultures of A. macrosporus, their biol. activities, and preliminary results on their occurrence in basidiomycetes, are described. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Formula: C8H6Cl2O3 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Chlorination of the esters of anisic acid》 were Szilagyi, Geza; Kasztreiner, Endre; Meszaros, Laszlone; Vargha, Laszlo. And the article was published in Magyar Kemiai Folyoirat in 1969. Synthetic Route of C8H6Cl2O3 The author mentioned the following in the article:

Esters of anisic acid (I) were chlorinated in CHCl3. Cl is passed through a solution of 200 g ethyl ester (II) of I in 40 ml CHCl3 in the presence of 2 g iodine at a rate so that no Cl leaves the reaction mixture The reaction is exothermic and yields 86.5% ethyl 4-methoxy-3,5-dichlorobenzoate, m 60-2°. Similarly were prepared 85.5% Me 4-methoxy-3,5-dichlorobenzoate, m. 75-7° (MeOH), 86.5% Pr 4-methoxy-3,5-dichlorobenzoate, m. 35-7° (EtOH), 76% Bu 4-methoxy-3,5-dichlorobenzoate, m. 28-30° (EtOH). Et 4-methoxy-3-chlorobenzoate, m. 76-6°, was prepared by chlorination of II in the presence of 1% water at 75° (method A) or in the presence of iodine (method B); the yield for method A was 28.8% and for method B 70.5%. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Synthetic Route of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Synthetic Route of C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C8H6Cl2O3On October 14, 2021 ,《Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer》 was published in Journal of Medicinal Chemistry. The article was written by Zhang, Jin; Zou, Ling; Shi, Danfeng; Liu, Jie; Zhang, Jifa; Zhao, Rongyan; Wang, Guan; Zhang, Lan; Ouyang, Liang; Liu, Bo. The article contains the following contents:

Sirtuin-3 (SIRT3) is an NAD+-dependent protein deacetylase localized primarily in the mitochondria with many links to different types of human cancers. Autophagy, which is a highly conserved lysosomal degradation process in eukaryotic cells, has been recently reported to be pos. regulated by SIRT3 in cancer; therefore, activating SIRT3-modulated autophagy may be a promising strategy for drug discovery. In this study, we discovered a small-mol. activator of SIRT3 compound 33c (ADTL-SA1215) with specific SIRT3 deacetylase activity by structure-guided design and high-throughput screening. Subsequently, compound 33c inhibited the proliferation and migration of human breast carcinoma MDA-MB-231 cells by SIRT3-driven autophagy/mitophagy signaling pathways in vitro and in vivo. Collectively, these results demonstrate that pharmacol. activation of SIRT3 is a potential therapeutic approach of triple neg. breast cancer (TNBC). More importantly, compound 33c may be a first-in-class specific small-mol. activator of SIRT3 that would be utilized for future cancer drug development. In the experimental materials used by the author, we found 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Electric Literature of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Substitution products of 4-hydroxybenzophenone and of its methyl ether》 were Blakey, Wm.; Jones, W. I.; Scarborough, H. A.. And the article was published in Journal of the Chemical Society in 1927. Category: chlorides-buliding-blocks The author mentioned the following in the article:

4-Acetoxybenzophenone m. 81°. 4-MeOC6H4Bz with Cl in AcOH gives the 3-Cl derivative, m. 98°; further chlorination gives the 3,5-di-Cl derivative, m. 74° (α-oxime, m. 146°); 3,5-dichloro-4-methoxybenzanilide, pale yellow, m. 154°, from the oxime and PCl5; hydrolysis gives PhNH2 and 3,5-dichloroanisic acid, m. 202°. 3,5-Dichloro-4-hydroxybenzophenone, from the Me ether or by passing Cl into 4-HOC6H4Bz, m. 148°. 3-Bromo-4-methoxybenzophenone, m. 94°, from 4-MeOC6H4Bz and Br in AcOH-AcONa, at 100°, in the cold or in bright sunlight; α-oxime, m. 164°; 3-bromo-4-methoxybenzanilide, m. 170°; β-oxime, m. 111.5°, transformed into benzo-3-bromo-4-methoxyanilide, m. 156°. 3-Chloro-5-bromo-4-methoxybenzophenone, m. 92°. 4-MeOC6H4Bz and ICl in AcOH give the 3-I derivative, m. 81°; α-oxime, m. 182°, converted to 3-iodo-4-methoxybenzanilide, yellow, m. 206°. The β-oxime, m. 135°, yields benz-3-iodo-4-methoxyanilide, m. 164°. 3-Iodo-4-hydroxybenzophenone, m. 184°; the 3,5-di-I derivative, m. 145°, is formed from 4-HOC6H4Bz and ICl in AcOH-AcONa. Nitration of 4-MeOC6H4Bz gives the 3-NO2 derivative, yellow, m. 105°; α-oxime, yellow, m. 179°, yielding 3-nitro-4-methoxybenzanilide, m. 163°. 3,5-Dinitro-4-methoxybenzophenone, yellow, m. 105°, from the 4-Cl derivative and MeONa. The 4-HO derivative, yellow, m. 138°. 3′-Nitro-4-methoxybenzophenone, pale yellow, m. 95°, from m-O2NC6H4COCl and PhOMe with AlCl3 in CS2; nitration gives the 3,3′-dinitro derivative, pale yellow, m. 143°; this also results from 4-MeOC6H4Bz and HNO3. 3,3′-Dinitro-4-hydroxybenzophenone, pale green, m. 165°. 3,4′-Dinitro-4-methoxybenzophenone, m. 174°, by nitrating the 4′-NO2 derivative 3,3′,5-Trinitro-4-methoxybenzophenone, m. 184°, forms about 65% of the nitration product from 4-MeOC6H4Bz with H2SO4 and HNO3 for 2 days or from the 3,5-di-NO2 derivative; the 3,3′-di-NO2 derivative gives almost quant. the 3,3′,5-tri-NO2 derivative From the crude nitration product there were also isolated 2′(?),3-dinitro-4-methoxybenzophenone, m. 125°, and the 2′(?),3,5-trinitro derivative, light yellow, m. 142°. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Category: chlorides-buliding-blocks)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics