Category: 37908-97-7

Formula: C8H6Cl2O3On May 23, 1997, Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Xu, Xiang D.; Koszyk, Francis J.; Collins, Paul W.; Koboldt, Carol M.; Veenhuizen, Amy W.; Perkins, William E.; Casler, Jacquelen J.; Masferrer, Jaime L.; Zhang, Yan. Y.; Gregory, Susan A.; Seibert, Karen; Isakson, Peter C. published an article in Journal of Medicinal Chemistry. The article was 《1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective and orally active antiinflammatory agents》. The article mentions the following:

Series of 1,2-diarylimidazoles has been synthesized and found to contain highly potent and selective inhibitors of the human COX-2 enzyme. The paper describes a short synthesis of the target 1,2-diarylimidazoles starting with aryl nitriles. Different portions of the diarylimidazole were modified to establish SAR. Systematic variations of the substituents in the aryl ring has yielded very potent (IC50 = 10-100 nm) and selective (1000-12500) inhibitors of the COX-2 enzyme. The study on the influence of substituents in the imidazole ring established that a CF3 group at position 4 gives the optimum oral activity. A number of the diarylimidazoles showed excellent inhibition in the adjuvant induced arthritis model (e.g., ED50 = 0.02 mpk for 22 and 34). The diarylimidazoles are also potent inhibitors of carrageenan-induced edema (ED50 = 9-30 mpk) and hyperalgesia (ED50 = 11-40 mpk). Several orally active diarylimidazoles show no GI toxicity in the rat and mouse up to 200 mpk. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Formula: C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《The natural production of organohalogens by basidiomycetes》 were Verhagen, Frank J. M.; Field, J. A.; Swarts, H. J.; Wijnberg, J. B. P. A.. And the article was published in Organohalogen Compounds in 1996. Computed Properties of C8H6Cl2O3 The author mentioned the following in the article:

The ubiquity of organohalogen production among basidiomycetes was investigated in 191 fungal strains by monitoring the production of adsorbable organic halogen (AOX) and by determination of chlorinated anisyl metabolites (CAM). For a AOX screening the strains were grown in a liquid medium and AOX was determined in the culture fluid. Almost 25% of the strains tested had a low AOX production (0.1-5.0 mg AOX/L), 16% a moderate production (0.5-5.0 mg AOX/L), and 9% a high production (5-67 mg AOX/L). The highest producers were species of the genera Hypholoma, Mycena, and Bjerkandera with AOX productions of 1074-30,893 mg AOX per kg dry weight of mycelia biomass. These species produced also AOX when cultivated on natural lignocellulosic substrates. CAM were detected in the extracellular fluid of the mycelium of 7 different basidiomycetes; in the genera Mycena, Peniophora, Phellinus, and Phylloporia CAM production was observed for the first time. Organohalogen production was a ubiquitous capacity among commonly occurring basidiomycetes fungi and they might be a major source of natural organohalogens in forest ecosystems. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Computed Properties of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Computed Properties of C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 37908-97-7On March 7, 2008, Vaswani, Rishi G.; Chamberlin, A. Richard published an article in Journal of Organic Chemistry. The article was 《Stereocontrolled Total Synthesis of (-)-Kaitocephalin》. The article mentions the following:

This paper describes the successful implementation of a stereocontrolled strategy for the total chem. synthesis of the pyrrolidine-based alkaloid (-)-kaitocephalin (I). This scalable synthetic route profits from the strategic utilization of substrate-controlled manipulations for the iterative installation of the requisite stereogenic centers. The key transformations include a diastereoselective modified Claisen condensation, a chemo- and diastereoselective reduction of a β-keto ester, and the substrate-directed hydrogenation of a dehydroamino ester derivative During the course of our investigations, an interesting stereoconvergent cyclization reaction was discovered for the efficient assembly of the kaitocephalin 2,2,5-trisubstituted pyrrolidine core. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Related Products of 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Related Products of 37908-97-7 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 37908-97-7On October 8, 2020 ,《Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity》 was published in ACS Medicinal Chemistry Letters. The article was written by Uda, Junichiro; Kobashi, Seiichi; Miyata, Sachiho; Ashizawa, Naoki; Matsumoto, Koji; Iwanaga, Takashi. The article contains the following contents:

To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a 1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole scaffold. The selected compound 11 (dotinurad, 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole, FYU-981, [1285572-51-1]) demonstrated remarkable inhibitory activity on uric acid uptake by primary human renal proximal tubule epithelial cells (RPTECs) and URAT1-mediated uric acid transport, with weak inhibitory activity against mitochondrial respiration. Dotinurad also displayed favorable pharmacokinetic profiles and higher potency in decreasing uric acid than BBR did in Cebus monkeys. Dotinurad has been approved as a new uricosuric medicine in Japan. Our strategy, which focuses on the structural features resulting in unfavorable effects, could be applied to the future developments of other drugs with disadvantages, particularly those having a bis-aryl ketone structure.3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7HPLC of Formula: 37908-97-7) was used in this study.

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. HPLC of Formula: 37908-97-7 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 3,5-Dichloro-4-methoxybenzoic acidOn November 30, 1999 ,《Reduction of aryl acids by white-rot fungi for the biocatalytic production of aryl aldehydes and alcohols》 appeared in Applied Microbiology and Biotechnology. The author of the article were Hage, A.; Schoemaker, H. E.; Field, J. A.. The article conveys some information:

Ligninolytic basidiomycetes were screened for their ability to reduce aryl acids to the corresponding aldehydes and alcs. Seven fungal strains converted p-anisic acid in high molar yields to the reduced products. The white-rot fungus Bjerkandera sp. strain BOS55 was one of the best reducing strains and was highly tolerant towards high concentrations of different aromatic acids. It was tested for the reduction of p-anisic, veratric, 3-chloro-4-methoxybenzoic, 3,5-dichloro-4-methoxybenzoic, 3,4-dichlorobenzoic, 4-fluorobenzoic, and 3-nitrobenzoic acids. All of these compounds were reduced to their corresponding aldehydes and alcs. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Recommanded Product: 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Recommanded Product: 3,5-Dichloro-4-methoxybenzoic acid Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verhagen, Frank J. M.; Van Assema, Friso B. J.; Boekema, Bouke K. H. L.; Swarts, Henk J.; Wijnberg, Joannes B. P. A.; Field, Jim A. published an article on January 15 ,1998. The article was titled 《Dynamics of organohalogen production by the ecologically important fungus Hypholoma fasciculare》, and you may find the article in FEMS Microbiology Letters.Reference of 3,5-Dichloro-4-methoxybenzoic acid The information in the text is summarized as follows:

The ecol. important white rot basidiomycete Hypholoma fasciculare was previously shown to produce large amounts of adsorbable organic halogens (AOX). The purposes of this study were to identify the time period of AOX production in relation to the primary and secondary metabolic phases of the growth cycle of the fungus, to determine the maximal specific AOX production rates and final AOX yields on the different substrates and to account for the measured AOX in identifiable compounds The AOX production was observed to take place during the transition between the primary and secondary metabolic phases of the growth cycle of the fungus. The maximum AOX production rates ranged from 0.63 to 3.23 mg AOX per g of dry mycelium per day and the final AOX yields ranged from 0.88 and 1.50 percent of dry weight of mycelium on five different substrates including natural woody substrates. The AOX produced by the fungus was stable in all five substrates, even after prolonged incubation periods. However, the composition of the AOX changed drastically. Initially most of the AOX was accounted for by the compound 3,5-dichloro-p-anisyl alc.; however, after prolonged incubation this compound was largely converted into 3,5-dichloro-p-anisic acid in N-rich medium and into unidentified organohalogens in N-limited medium. The experimental process involved the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of 3,5-Dichloro-4-methoxybenzoic acid Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Horng-Chih; Li, James J.; Garland, Danny J.; Chamberlain, Timothy S.; Reinhard, Emily J.; Manning, Robert E.; Seibert, Karen; Koboldt, Carol M.; Gregory, Susan A. published an article on January 5 ,1996. The article was titled 《Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure-Activity Relationships》, and you may find the article in Journal of Medicinal Chemistry.Formula: C8H6Cl2O3 The information in the text is summarized as follows:

A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4-disubstituted Ph analogs are generally more selective than 4-substituted Ph analogs and that replacement of the Me sulfone group on the 6-Ph ring with a sulfonamide moiety results in compounds with superior in vivo pharmacol. properties, although with lower COX-2 selectivity. Several compounds have been shown to possess promising pharmacol. properties in adjuvant-induced arthritis and edema analgesia models. The absence of gastrointestinal (GI) toxicity at 200 mpk of several selected compounds in rats and mice corresponds well with the weak potency for inhibition of COX-1 observed in the enzyme assay. Thus, 5-(3,5-dichloro-4-methoxyphenyl)-6-[4-(methylsulfonyl)phenyl]spiro[2.4]hept-5-ene was shown to have superior in vivo pharmacol. profiles, low GI toxicity, and good oral bioavailability and duration of action. In the experiment, the researchers used many compounds, for example, 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zotova, S. A.; Gololobova, T. M.; Stolyarchuk, A. A.; Stepanyuk, G. I.; Bobruk, V. P.; Ivanova, N. I.; Mostovaya, N. I. published an article on January 31 ,1988. The article was titled 《Synthesis and pharmacological activity of 2-aryl-3-carbethoxy-5-oxybenzofuran derivatives》, and you may find the article in Khimiko-Farmatsevticheskii Zhurnal.Electric Literature of C8H6Cl2O3 The information in the text is summarized as follows:

A series of 9 title derivatives (I, R1 = H, OMe, Br, Cl, I; R2 = H, CH2NMe2; R3 = H, OMe, Br, Cl, I) was prepared by condensation of substituted 5-methoxybenzoylacetic Et esters with p-benzoquinone and subsequent reaction with Me2NH. Acute toxicity and cardiotropic and neurotropic effects of I were tested in mice and isolated rabbit intestine. I had a hypotonic effect on intestinal smooth muscles and some increased coronary circulation. However, their activities were inferior to those of the related known drugs fenikaberan and cordarone. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Electric Literature of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C8H6Cl2O3On June 11, 2015, Keurulainen, Leena; Vahermo, Mikko; Puente-Felipe, Margarita; Sandoval-Izquierdo, Elena; Crespo-Fernandez, Benigno; Guijarro-Lopez, Laura; Huertas-Valentin, Leticia; de las Heras-Duena, Laura; Leino, Teppo O.; Siiskonen, Antti; Ballell-Pages, Lluis; Sanz, Laura M.; Castaneda-Casado, Pablo; Jimenez-Diaz, M. Belen; Martinez-Martinez, Maria S.; Viera, Sara; Kiuru, Paula; Calderon, Felix; Yli-Kauhaluoma, Jari published an article in Journal of Medicinal Chemistry. The article was 《A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides》. The article mentions the following:

Malaria continues to be a major global health problem, being particularly devastating in the African population under the age of five. Artemisinin-based combination therapies (ACTs) are the first-line treatment recommended by the WHO to treat Plasmodium falciparum malaria, but clin. resistance against them has already been reported. As a consequence, novel chemotypes are urgently needed. Herein the authors report a novel, in vivo active, fast-acting antimalarial chemotype based on a benzimidazole core. This discovery is the result of a medicinal chem. plan focused on improving the developability profile of an antichlamydial chem. class previously reported by the group. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Formula: C8H6Cl2O3 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Johnson, Steven M.; Connelly, Stephen; Wilson, Ian A.; Kelly, Jeffery W. published an article on February 26 ,2009. The article was titled 《Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies》, and you may find the article in Journal of Medicinal Chemistry.SDS of cas: 37908-97-7 The information in the text is summarized as follows:

Transthyretin (TTR) amyloidogenesis inhibitors are typically composed of two aromatic rings and a linker. We have previously established optimal structures for one aromatic ring and the linker. Herein, we employ a suboptimal linker and an optimal aryl-X substructure to rank order the desirability of aryl-Z substructures-using a library of 56 N-(3,5-dibromo-4-hydroxyphenyl)benzamides. Coconsideration of amyloid inhibition potency and ex vivo plasma TTR binding selectivity data reveal that 2,6, 2,5, 2, 3,4,5, and 3,5 substituted aryls bearing small substituents generate the most potent and selective inhibitors, in descending order. These benzamides generally lack undesirable thyroid hormone receptor binding and COX-1 inhibition activity. Three high-resolution TTR·inhibitor crystal structures (1.31-1.35 Å) provide insight into why these inhibitors are potent and selective, enabling future structure-based design of TTR kinetic stabilizers. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7SDS of cas: 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 37908-97-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics