Category: 37908-97-7

Quality Control of 3,5-Dichloro-4-methoxybenzoic acidOn September 25, 2006 ,《Proton mobility in 2-substituted 1,3-dichlorobenzenes: “”ortho”” or “”meta”” metalation?》 was published in European Journal of Organic Chemistry. The article was written by Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario. The article contains the following contents:

Nine 1,3-dichlorobenzene congeners were selected as model compounds to assess the relative rates of proton abstraction from 4- and 5-positions (“”ortho”” vs. “”meta”” metalation). Using lithium 2,2,6,6-tetramethylpiperidide as the basic reagent, the chlorine-adjacent 4-position underwent metalation exclusively. In contrast, attack at the chlorine-remote 5-position became significant even in the case of moderately sized 2-substituents (such as dimethylamino or ethyl) when sec-butyllithium was employed. The “”ortho/para”” (4-/5-) ratios ranged from 80:20 to 65:35. The more pronounced “”meta-orienting”” effect of silicon as opposed to carbon substituents can be attributed to dissimilarities in the π polarization of the aromatic ring.3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Quality Control of 3,5-Dichloro-4-methoxybenzoic acid) was used in this study.

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 3,5-Dichloro-4-methoxybenzoic acid Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Oxidative chlorination of various iodoarenes to (dichloroiodo)arenes with chromium(VI) oxide as the oxidant》 was published in Journal of Chemical Research, Synopses in 1999. These research results belong to Kaimierczak, Pawet; Skulski, Lech; Obeid, Nicolas. Quality Control of 3,5-Dichloro-4-methoxybenzoic acid The article mentions the following:

Chromium(VI) oxide dissolved in a mixture of acetic acid with concentrated hydrochloric acid converts, at or near room temperature, iodoarenes to (dichloroiodo)arenes, in a very simple and efficient procedure. In the experimental materials used by the author, we found 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Quality Control of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 37908-97-7On October 14, 2020 ,《Marine Natural Product for Pesticide Candidate: Pulmonarin Alkaloids as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents》 was published in Journal of Agricultural and Food Chemistry. The article was written by Zhang, Mingjun; Ding, Xin; Kang, Jin; Gao, Yongyue; Wang, Ziwen; Wang, Qingmin. The article contains the following contents:

Plant diseases are seriously endangering agricultural production The emergence of drug resistance has brought great challenges to the prevention and control of plant diseases. There is an urgent need for the emergence of new drug candidates. In this work, we achieved the efficient synthesis of pulmonarins A and B in 64% and 59% overall yield, resp. Pulmonarins A and B were found to have good antiviral activities against tobacco mosaic virus (TMV) for the first time. A series of pulmonarin derivatives were designed, synthesized, and evaluated for their antiviral and fungicidal activities systematically. Most compounds displayed higher anti-TMV activities than com. ribavirin. Compounds Pulmonarin B, -Benzyl-2-((3,5-dibromo-4-methoxybenzoyl)oxy)-N,N-dimethylethan-1-aminium Bromide (I), and 2-((4-(Allyloxy)-3,5-dibromobenzoyl)oxy)-N,N,N-trimethylethan-1-aminium Iodide with better inactivation effects than ningnanmycin emerged as new antiviral candidates. We selected I for further antiviral mechanism research, which revealed that it could inhibit virus assembly by interacting with TMV coat protein (CP). The mol. docking results further confirmed that these compounds could interact with CP through hydrogen bonding. These compounds also displayed broad spectrum fungicidal activities. Especially compound 2-(2-(3,5-Dibromo-4-methoxyphenyl)acetoxy)-N,N,N-trimethylethan-1-aminium Iodide with prominent antifungal activity emerged as a new fungicidal candidate for further research. The current work provides a reference for understanding the application of pulmonarin alkaloids in plant protection. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Recommanded Product: 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Recommanded Product: 37908-97-7 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C8H6Cl2O3On October 31, 2008 ,《Bioactive metabolites from Penicillium sp., an endophytic fungus residing in Hopea hainanensis》 appeared in World Journal of Microbiology & Biotechnology. The author of the article were Wang, F. W.; Hou, Z. M.; Wang, C. R.; Li, P.; Shi, D. H.. The article conveys some information:

The metabolites of endophytic fungus Penicillium sp. from the leaf of Hopea hainanensis were reported for the first time. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded six compounds, which were identified through a combination of spectral and chem. methods (IR, MS, 1H- and 13C-NMR) to be monomethylsulochrin (1), rhizoctonic acid (2), asperfumoid (3), physcion (4), 7,8-dimethyl-iso-alloxazine (5) and 3,5-dichloro-p-anisic acid (6). Compounds 2, 3 and 6 were obtained from Penicillium sp. for the first time. All of the six isolates were subjected to in vitro bioactive assays including antifungal action against three human pathogenic fungi Candida albicans, Trichophyton rubrum and Aspergillus niger and cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line and human liver cancer HepG2 cell line. As a result, compounds 2-4 and 6 inhibited the growth of C. albicans with MICs of 40.0, 20.0, 50.0 and 15.0 μg/mL, resp. and the compound 6 showed growth inhibition against A. niger with MICs of 40.0 μg/mL. In addition, compounds 1-3 and 6 exhibited cytotoxic activity against KB cell line with IC50 value of 30.0, 20.0, 20.0, 5.0 μg/mL, resp. and against HepG2 cell line with IC50 value of 30.0, 25.0, 15.0, 10.0 μg/mL, resp. The results came from multiple reactions, including the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Computed Properties of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1977,Acta Chimica Academiae Scientiarum Hungaricae included an article by Varsanyi, G.; Horvath, G.; Imre, L.; Schawartz, J.; Sohar, P.; Soti, F.. Formula: C8H6Cl2O3. The article was titled 《Infrared spectra of 1,2,3,5-tetrasubstituted benzene derivatives》. The information in the text is summarized as follows:

The ring vibration in the IR of one-hundred and fifteen 1,2,3,5-tetrasubsituted benzenes are classified into 3 groups, depending on whether all 4 substituents are light or 1 or 2 of them are heavy (constants Cl, Br and/or I). The substituent effects on the fundamental vibrations of the benzene ring and their intensities, and the character of the bands associated with internal substituent vibrations are discussed. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Fred S.; Wien, Ronald G.; Zaylskie, Richard G.; Hoffer, Barry L. published an article on February 28 ,1990. The article was titled 《Synthesis of possible ring-hydroxylated metabolites of diclofop-methyl》, and you may find the article in Journal of Agricultural and Food Chemistry.Reference of 3,5-Dichloro-4-methoxybenzoic acid The information in the text is summarized as follows:

In the metabolism of diclofop-Me by tolerant plant species, three ring-hydroxylated metabolites were formed as major metabolites. For conclusive identification of these metabolites, authentic standards were required. Therefore, the following five isomers of hydroxylated diclofop-Me were synthesized as possible standards for identification of the diclofop-Me metabolites: Me 2-[4-(2,4-dichloro-5-hydroxyphenoxy)phenoxy]propanoate, Me 2-[4-(2,4-dichloro-3-hydroxyphenoxy)phenoxy]propanoate, Me 2-[4-(2,4-dichloro-6-hydroxyphenoxy)phenoxy]propanoate, Me 2-[4-(2,5-dichloro-4-hydroxyphenoxy)phenoxy]propanoate, and Me 2-[4-(2,3-dichloro-4-hydroxyphenoxy)phenoxy]propanoate. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Reference of 3,5-Dichloro-4-methoxybenzoic acid Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C8H6Cl2O3On March 31, 2002, Kousaka, Takeshi; Mori, Kenji published an article in Bioscience, Biotechnology, and Biochemistry. The article was 《Synthesis of (1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol) and (1R,2S)-1-(3′,5′-dichloro-4′-methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment》. The article mentions the following:

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (trametol), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asym. dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro-4′-methoxyphenyl)-1,2-propanediol, another metabolite of Bjerkandera sp. BOS55, was synthesized by asym. dihydroxylation. The experimental process involved the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Computed Properties of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Infrared spectra of 1,2,3,5-tetrasubstituted benzene derivatives. II》 were Varsanyi, Gyorgy; Sohar, Pal. And the article was published in Acta Chimica Academiae Scientiarum Hungaricae in 1973. HPLC of Formula: 37908-97-7 The author mentioned the following in the article:

A detailed interpretation is given of the ir spectra of 35 1,2,3,5-tetrasubstituted benzenes containing light atoms (at. weight <20) in positions 2 and 5 and heavy atoms (at. weight >20) in positions 1 and 3. Correlations were established between the intensity and frequency of the spectral bands, and the influence of substituents on the electron distribution. The coupling of certain vibrations having identical symmetry was demonstrated and the association structure of the individual compounds was established. The results came from multiple reactions, including the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7HPLC of Formula: 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 37908-97-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thines, Eckhard; Daussmann, Thomas; Semar, Martin; Sterner, Olov; Anke, Heidrun published their research in Zeitschrift fuer Naturforschung, C: Biosciences on December 31 ,1995. The article was titled 《Fungal melanin biosynthesis inhibitors: introduction of a test system based on the production of dihydroxynaphthalene (DHN) melanin in agar cultures》.Reference of 3,5-Dichloro-4-methoxybenzoic acid The article contains the following contents:

In a screening for inhibitors of fungal melanin biosynthesis a novel test system was successfully employed. With this test system, based on the production of dihydroxynaphthalene melanin (DHN melanin) by a Lachnellula species in agar cultures, extracts of cultures of basidiomycetes, ascomycetes and deuteromycetes were tested. From fermentation of Collybia dryophila, 6-methylpurine and 6-methyl-9-β-D-ribofuranosyl purine were isolated as the active principles and 3,5-dichloro-4-methoxybenzoic acid (I) was obtained from cultures of Stropharia squamosa. The corresponding alc. (II) and aldehyde (III) previously isolated from several basidiomycetes were also active in this test system. In a screening of fungal metabolites, 1-methoxy-8-hydroxynaphthalene and 1,8-dimethoxynaphthalene inhibited biosynthesis of DHN melanin. Among the inhibitors identified, compounds I-III were the most selective ones. They were the only metabolites without cytotoxic activities. In the experiment, the researchers used many compounds, for example, 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Baliah, V.; Balasubramanian, Theymoli Mrs. published an article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The title of the article was 《Steric enhancement of resonance: Part I. Dissociation constants of some mono-, di- and tri-substituted benzoic acids》.Reference of 3,5-Dichloro-4-methoxybenzoic acid The author mentioned the following in the article:

The dissociation constants of 20 benzoic acids were determined in 50 volume % EtOH-H2O using the conductometric method. The calculated acidity constants of 3,4-R(MeO)C6H3CO2H (R = halo, Me) are appreciably higher than exptl. determined acidity constants which indicates that the 3-substituent enhances the resonance interaction between the MeO and CO2H groups. The expected steric inhibition of resonance is observed in 3,5,4-R2(MeO)C6H2CO2H. The acidity constants were also analyzed in terms of their free energies of ionization. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics