ScienceRise: Pharmaceutical Science published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C38H74Cl2N2O4.
Kucherenko, Ludmila published the artcileTheoretical study of the possibility of decamethoxin complexes with thiotriazoline to be formed, COA of Formula: C38H74Cl2N2O4, the publication is ScienceRise: Pharmaceutical Science (2021), 37-42, database is CAplus.
Over the last decade, much attention has been paid to the prevention and treatment of chronic diseases of the oral mucosa. This is primarily due to the increase in the number of patients who seek dental care for diseases of the oral muco-sa (DOM). Currently, due to the lack of special epidemiol. studies, information on the pathol. of the oral mucosa in the literature is almost non-existent. The etiol. and pathogenesis have not been definitively elucidated. It is established that a significant role in the pathogenesis of chronic inflammatory processes belongs to the state of the microbiocenosis of the oral mucosa. One of the most striking examples of domestic drugs of the antioxidant group is thiotriazoline, developed by the staff of the NGO ‘Pharmatron’, as well as specialists of the Department of Pharmaceutical Chem. of Zaporozhye State Medical University under the leadership of professor Mazur I. This drug has an antioxidant and membrane-stabilizing effect. The combined use of several drugs can be complicated by the formation of their supramol. complexes. Therefore, before the introduction of several substances in it is necessary to model the possibility of intermol. interactions between them. For this purpose, methods of quantum chem. are used. We examined the structures and energy characteristics of the complexes, formed thiotriazoline and decamethoxin, also carried out anal. and established at what temperature the formation of a substance from two active components was possible. As a result, the probability of the formation of intermol. hydrogen bonds is reduced, which is very well seen in the trend of interactions between acid and morpholine. Quantum chem. study of a two-component system consisting of thiotriazoline and decamethoxine showed that the most energetically advantageous three-component complexes have a sufficiently low interaction energy of thiotriazoline and decamethoxine. In addition, the data that are provided in the anal. of the tree diagram suggest that in the technol. process in the manufacture of dosage forms, it is advisable to use a temperature not higher than 115°C.
ScienceRise: Pharmaceutical Science published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C38H74Cl2N2O4.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics