Category: 38362-15-1

Xie, Chao; Wang, Jian-hui; Gong, Zheng-li published their research in Chaye Kexue on August 15 ,2008. The article was titled 《Analysis on aromatic constituents of fragrant flower [Chimonanthus praecox (L.) Link] in aroma releasing》.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole The article contains the following contents:

The change of essential oil extracted by SDE method was studied by the gas chromatog. (GC), GC/MS and evaluation methods during Lamei [Chimonanthus praecox (L.) Link] blooming. The number and content of fragrant components of essential oil were changed during aroma releasing. The results showed that 26, 37, 43, 49 aromatic components in Lamei were identified by GC/MS data during the following four stages (bud, early spread, spread, blooming). In compared with the unbloomed bud, the content of alkyl compounds raised 0.590, 7.152 and 13.820 times and the alkenes compounds raised 0.424, 1.078 and 4.286 times, the alc. compounds raised 0.895, 3.324 and 5.091 times and the ester compounds raised 1.071, 2.182 and 15.101 times, resp. with the increase of opening of Lamei flower. The ketone compounds were appeared only during the later period of blooming. The content of ketone were increased steadily during the full blooming period and was 12.3 times higher than that in spreading flower period. Organoleptic evaluation showed that the Lamei buds expressed a low aroma and with green grass taste, and the specific aroma was only appeared during the flower-spreading period. It is characterized that the intensity of aroma was increased from low to high with the increasing of the flower opening. On the basis of above experiments results, the trend of fragrant components’ content by GC and GC/MS method and the results from organoleptic evaluation method were similar. The experimental process involved the reaction of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application In Synthesis of 5-Chloro-1,2,4-thiadiazole)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C2HClN2SOn November 1, 2011 ,《Antibacterial comparison and GC/MS analysis of three aromatic plants》 appeared in Shipin Gongye Keji. The author of the article were Kong, Jingsi; Chen, Jiwu; Wang, Bangzheng; Yao, Lei. The article conveys some information:

The antibacterial activities of volatile oils and aqueous extracts from residue of Myrtle, Lavender Mint and Rosemary were studied and compared by the method of agar diffusion. Under the treatments of changing the pH, temperature and UV, the antimicrobial stabilities of the oils were also measured. By the side, gas chromatog.-mass spectrometry (GC/MS) was used to analyze the volatile components. The results revealed that the volatile oil had a both significant and stable antibacterial activity. The antimicrobial activity of Lavender Mint was especially higher than the others, while, which of the other two were very close to each other. By GC/MS, terpenoids contained in the three oils were analyzed Myrtle 59.80%, Lavender Mint 79.63%, Rosemary 60.36%, resp. Although the extraction rates of the aqueous extracts were much higher than the oils, the antibacterial activities were lower. And the antimicrobial sensitivities of the three water extracts were as followed: Myrtle > Rosemary > Lavender Mint. In the experiment, the researchers used 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Formula: C2HClN2S)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C2HClN2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《1,2,4-Thiadiazoles. VIII. The synthesis of 5-chloro-1,2,4-thiadiazoles from perchloromethylmercaptan and amidines》 were Goerdeler, Joachim; Groschopp, Heinz; Sommerlad, Ursula. And the article was published in Chemische Berichte in 1957. Application In Synthesis of 5-Chloro-1,2,4-thiadiazole The author mentioned the following in the article:

cf. C.A. 51, 8731c. Adding dropwise (about 7 hrs.) with vigorous stirring 100 g. NaOH in 150 cc. H2O to 47 g. MeC(:NH)NH2.HCl and 83 g. CCl3SCl in 500 cc. CH2Cl2 at -8°, extracting the aqueous layer with CH2Cl2, and fractionally distilling the washed and dried CH2Cl2 solution give 60% N:CR.N:CR’.S (Ia) (R = Me, R’ = Cl) (I), b18 45°, b21 51°, nD22.5 1.52075, d20 1.355; 68% Ia (R = Et, R’ = Cl) (II), b17 60°, nD24 1.5129, d20 1.203. Adding 1.6 g. NaOH in 50 cc. H2O to 1.8 g. PhC(:NH)NH2.HCl.H2O and 1.8 g. CCl3SCl in 50 cc. H2O and a small amount of Na dodecylsulfate at below 10° and stirring the mixture 15 min. give 80% Ia (R = Ph, R’ = Cl), b3 115°, b12 136°, prisms, m. 52°; 45% Ia (R = PhCH2, R’ = Cl), b1.5 105-7°, b3 122-3°, m. 3-4°, nD19 1.5904, d16 1.305. Warming 4.5 g. II in 20 cc. concentrated H2SO4 1.5 hrs. on a H2O bath, pouring the mixture into ice-H2O, and extracting with Et2O give 85% Ia (R = Et, R’ = OH), needles, m. 89°; 90% Ia (R = Ph, R’ = OH), small rods, m. 204-6° (decomposition); 94% Ia (R = PhCH2, R’ = OH), leaflets, m. 106-7°. Adding 0.23 g. Na in 25 cc. MeOH to 1.96 g. II in 50 cc. MeOH, evaporating the filtered solution, and extracting the residue with Et2O yield Ia (R = Ph, R’ = OMe), leaflets, m. 32.5°; Ia (R = PhCH2, R’ = OMe), b2 124-5°, nD20 1.5713, d16 1.213; 100% Ia (R = Ph, R’ = EtO), b1.5 120-1°, nD20 1.5910, d16 1.206; 90% Ia (R = PhCH2, R’ = OEt), b1.26 118-20°, nD20 1.5584, d16 1.168; 36% Ia (R = Me, R’ = OEt), b19 71°, nD22.5 1.4898, d20 1.1521. Heating 5.4 g. I in 8 cc. EtOH with 3 g. CS(NH2)2 1.5 hrs. on a H2O bath, adding 50 cc. H2O and 5 cc. 33% KOH, boiling the mixture 5 min., acidifying the filtered solution with concentrated HCl, and extracting with Et2O yield 75% Ia (R = Me, R’ = SH), slightly yellow crystals, m. 151°; 72% Ia (R = Et, R’ = SH), m. 149° (decomposition). Treating 2.7 g. I in 5 cc. EtOH 2 hrs. with 25 cc. alc. MeNH2 solution, evaporating the solution, and extracting the residue with Et2O give 97% Ia (R = Me, R’ = NHMe), m. 96°; Ia (R = Et, R’ = NHMe), needles, m. 70°. The acidity constants of some of the compounds have been determined5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application In Synthesis of 5-Chloro-1,2,4-thiadiazole) was used in this study.

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1956,Chemische Berichte included an article by Goerdeler, Joachim; Ohm, Josef; Tegtmeyer, Otto. Formula: C2HClN2S. The article was titled 《1,2,4-Thiadiazoles. VI. Preparation and properties of 1,2,4- and 1,3,4-thiadiazole》. The information in the text is summarized as follows:

cf. C.A. 51, 2753a. Adding (40 min.) 7 g. NaNO2 in the min. amount of H2O to 5 g. 5-amino-1,2,4-thiadiazole in 150 cc. 37% HCl and a small amount of Cu powder at -10° and stirring the mixture 1.5 hrs. at -10° and 0.5 hr. at 50-60° yield 58% 5-chloro-1,2,4-thiadiazole, b758 122-2.5°, m. -8° to -7°, d20 1.496, nD21 1.5388; HBr in lieu of HCl gives 74% 5-Br analog (I), stars or needles, m. 27.5-8°. 3-Methyl-5-amino-1,2,4-thiadiazole (II) and HBr yield the 3-Me homolog of I, m. 24-5°. Shaking 49.5 g. I and 30.4 g. Et3N in 70 cc. MeOH with 30 g. Raney Ni and H at atm. pressure and 20°, adding 350 cc. Et2O to precipitate the Et3N.HBr, then adding CaCl2 to the filtered solution, and distilling the Et2O solution give 72% 1,2,4-thiadiazole (III), b753 120.7-1.2°, d20 1.3298, nD21.9 1.5316; III.HCl and III.HBr readily sublime; III.H2SO4 is very hygroscopic; III.MeI, m. 164° (decomposition); III.AgNO3 needles, m. 80-1°; III.HgCl2 sublimes on heating; III.0.5 CoCl2, violet needles, soluble in H2O. 3-Me derivative of III, prepared like III from I in 78% yield, b753 131.8-2.9°, d20 1.2104, nD21 1.5149. Heating 3.3 g. I in 10 cc. concentrated H2SO4 2 hrs. on a water bath, pouring the mixture into 50 cc. ice H2O, and extracting with Et2O yield 64% 5-HO derivative of III, m. 120.5°. Treating 1.32 g. I in 5 cc. EtOH with MeNH2, refluxing the mixture 0.5 hr., evaporating it in vacuo, and extracting with Et2O give 92% 5-methylamino derivative of III, m. 58.5-60°. Heating 9.1 g. dry powd. H2NNHCSNH2 and 7 g. anhydrous HCO2H rapidly with stirring 45-60 min. at 140° and pouring the mixture into H2O yield 50-60% formylthiosemicarbazide (IV), m. 173-4° (decomposition), also obtained in 85% yield by stirring 4.5 g. H2NNHCSNH2 and 8.8 g. HCO2Ac 45 min. below 50°. Treating 11.9 g. IV with 23.6 g. AcCl 5-6 hrs. while the reaction is controlled by occasional cooling in H2O, and pouring the mixture into ice H2O give 80% 2-amino-1,3,4-thiadiazole (V), m. 190-1°. Adding an intimate mixture of 10 g. V and 32 g. NaNO2 in small portions to 160 cc. 40% HBr containing a small amount of Cu powder at -10°, stirring the mixture 1 hr. at -5° and 1.5 hrs. at 20°, neutralizing it with cooling with concentrated NaOH, adding NaHSO3 until KI-starch paper is no longer blued, warming the mixture a short time at 60°, extracting the filtered solution 6-7 hrs. with Et2O, and subliming the residue of the Et2O at 56°/12 mm. yield 75-90% 2-bromo-1,3,4-thiadiazole (VI), stout crystals, m. 72-3°; 2-Me homolog, prepared similarly from 2-methyl-5-amino-1,3,4-thiadiazole in 80-90% yield, m. 107.5-8°. Adding (1 hr.) a mixture of 10.1 g. V and 32 g. NaNO2 to 180 cc. 25% HCl containing a small amount of Cu at -10° yields 70-75% 2-Cl analog of VI, m. 32.5-3°. VI and MeNH2 give 80% 2-methylamino-1,3,4-thiadiazole, m. 164.5-65°. Refluxing 2.5 g. VI and 1.2 g. CS(NH2)2 in 10 cc. EtOH 1.5 hrs., adding 1.12 g. KOH in 16 cc. H2O, boiling it a few min., acidifying it, and extracting it with Et2O give 75% 2-mercapto-1,3,4-thiadiazole, m. 143°. Hydrogenating 8.2 g. VI and 5.3 g. Et3N in 40 cc. MeOH at slightly superatm. pressure and 20° with 100 mg. freshly reduced PtO2 with intermediate addition of fresh PtO2 until the theoretical amount of H has been absorbed, evaporating the filtered solution, and triturating the residue with Et2O yield 90% 1,3,4-thiadiazole (VII), b15 86-8°, b13 82-3.5°, b760 204-5° (decomposition), nD20 1.5470, m. 42-3°; 2-Me homolog, prepared similarly in almost 100% yield, b17 93°, b760 200.5-1.3° (decomposition), d20 1.2395, nD20 1.5320, m. 22-2.7° [HCl salt, very hygroscopic crystals, m. 116-19° (decomposition); picrate, yellow needles, m. 103-5° (decomposition); HgCl2 addition compound, m. 151-2° (decomposition); AgNO3 complex, m. 168-9° (decomposition)]. VII.HCl is very hygroscopic; VII.HBr is not hygroscopic; VII picrate, lemon-yellow needles, m. 98° (decomposition); VII.MeI m. 240-1° (decomposition); VII.AgNO3 m. 169°; VII.HgCl2, long shiny needles, m. 124-6° (decomposition). The results came from multiple reactions, including the reaction of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Formula: C2HClN2S)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C2HClN2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《1,2,4-Thiadiazoles. IX. Synthesis and reactions of 3-alkylthio-5-chloro-1,2,4-thiadiazoles》 was published in Chemische Berichte in 1957. These research results belong to Goerdeler, Joachim; Sperling, Gerhard. Related Products of 38362-15-1 The article mentions the following:

cf. C.A. 51, 12077d. In general, 0.5 mole RSC(:NH)NH2.HBr (I) in 300 cc. H2O, 0.5 mole CCl3SCl (II), and about 0.5 g. emulsifier treated dropwise (3-5 hrs.) at 0° and with vigorous stirring with 80 g. NaOH in 320 cc. H2O, the excess II decomposed with 20-30 cc. 25% NH4OH, and the mixture neutralized and steam-distilled gave RSC:N.S.CCl:N (III) as the lower layer of the distillate, sufficiently pure for further reactions, or it could be purified by distillation in vacuo, R, % yield, b.p./mm., d18, and n21D of the III: Me, 50-5, 98°/17 (m. 29-30°), -, -; Et, 65-70, 115°/13, 1.3861, 1.58285; Pr, 45-50, 131°/18, 1.3177, 1.56865; Bu, 37, 140°/14, 1.2650, 1.55805; tert-Bu, 58, 118°/14, 1.2560, 1.55635; iso-C5H11, 36, 148°/14, 1.2233, 1.54785; PhCH2 (IV), 45-50, 120°/0.2 (m. 49-50°), -, -. The preparation of IV was modified by adding 20-30 cc. ether at first, stirring longer after neutralization, and extracting with ether instead of steam-distilling III treated with a concentrated solution of MeNH2 in MeOH, the resulting MeNH2.HCl and most of the solvent removed, and H2O added gave RSC:N.S.C(NHMe):N (R, m.p., and m.p. of picrate given): Me, 144.5-5.0°, 164.5°; Et, 101-2°, 145°; Pr, 75-6°, 128°; Bu, 89-90°, 123°; tert-Bu, 119-20°, 138°; iso-C5H11, 82-3°, 126.5°; PhCH2, 139-40°, 141.5°. Similarly, with PhCH2NH2 in place of MeNH2, the solvent not removed, and dilute HCl added in place of H2O (to keep the excess PhCH2NH2 in solution) were formed RSC:N.S.C(NHCH2Ph):N (R and m.p. given): Me, 114.5-15.5°; Et, 101-1.5°; tert-Bu, 149.5-50°. Other reagents in very similar reactions with III gave RSC:N.S.CR’:N (V) (reagent used, R, R’, % yield, and m.p. given): PhNH2, tert-Bu, NHPh, 60-5, 146-7.5°; Me2NH, Me, NMe2, -, – (picrate, m. 70.5-1.0°); Me3N, Me, NMe3.HCl, 100, 105° (decomposition) (picrate, m. 128.5-30.0°); N2H4.H2O, Et, NHNH2, 100, 112-14° (decomposition) (the product with BzH and AcONa, R’ = NHN:CHPh, m. 208°); H2S with (NH4)2CO3, Me, HS, 55 g. from 74 g. III, 150-1° (decomposition); SC(NH2)2 (followed by hydrolysis with 10% NH4OH), PhCH2, HS, -, 136° (decomposition) [the product with PhCH2Cl and NH4OH at room temperature for 2 days, R’ = SCH2Ph, m. 51°, identical with the compound from PhCH2Cl and HSC:N.C(SH):N.S (VI)]; concentrated H2SO4 (warmed 3 hrs. and poured onto ice), Me, OH, 65%, 139-40°; KOH-MeOH, Me, OMe, 100, 46-7°. MeSC:N.S.C(SH):N (VII) oxidized 15 min. with 2N HNO3 at 50-60° gave [S.N:C(SMe).N:C]2S2, m. 112.5-13°; VII kept 5 hrs. at room temperature with the calculated amount of NH3 and MeI in EtOH gave V (R = Me, R’ = SMe), m. 40-1°, formed also from III (R = Me) with NH3 and excess MeSH in MeOH, and identical with the product from methylation of VI; VII kept several hrs. at room temperature with NH3-MeOH yielded almost 100% [S.N:C(SMe).N:C]2S, m. 169.5-70°. III (R = Me) (1.7 g.) refluxed 6 hrs. with NaOCMe:CHCO2Et (from 2 cc. AcCH2CO2Et kept 4 hrs. with 0.23 g. Na in 15 cc. dry C6H6), the resulting precipitate with the residue from the filtrate extracted with dilute NH4OH, and the extract acidified yielded 85% V [R = Me, R’ = HC(Ac)CO2Et] (VIII), m. 119-20° (decomposition). Similarly, with 2.9 cc. H2C(CO2Et)2 in place of AcCH2CO2Et was obtained 60% V [R = Me, R’ = HC(CO2Et)2] (IX), m. 143° (decomposition); and with 5 cc. NCCH2CO2Et and 0.5 g. Na 1.7 g. III (R = Me) yielded 80% V [R = Me, R’ = HC(CN)CO2Et], m. above 200°. III (R = Me) (3.65 g.) kept 24 hrs. with 5 cc. Ac2CH2 and 3.5 g. powd. K2CO3 in 25 cc. MeOH, then refluxed 6 hrs. on an H2O bath, kept overnight, the MeOH largely distilled, the residue warmed to 60-70° with 40 cc. H2O containing a little NH4OH, filtered, and the filtrate acidified yielded 35% V (R = Me, R’ = HCAc2), m. 144.5-5.0°. IX (2 g.) in 5-6 cc. 75% H2SO4 heated slowly to 130°, kept at 130° until no more gas evolved (4-6 min.), cooled, H2O added cautiously, and the mixture filtered after 3 hrs. yielded 70% V (R = Me, R’ = CH2CO2H), m. about 150-60° (decomposition) (Et ester, m. 70-1°), formed also from VIII (0.4 g.) with 5 cc. concentrated H2SO4. The experimental part of the paper was very detailed, including the reaction process of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Related Products of 38362-15-1)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Related Products of 38362-15-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Mass spectra of some 1,2,4-thiadiazoles》 were Potts, K. T.; Armbruster, R.. And the article was published in Journal of Heterocyclic Chemistry in 1972. Recommanded Product: 5-Chloro-1,2,4-thiadiazole The author mentioned the following in the article:

2,4-Thiadiazoles (I, R1 = SMe, H, Ph, Me, R2 = H, Cl, SH, SCH2CO2H, EtOCH:NNH) underwent fragmentation by loss of RCN(R = R1, R3) from the mol. ion with 3- and 5-substituents involved to some extent. This was followed by loss of S to yield a nitrilium ion. With 5-hydrazino substituents, H transfer was observed from the substituent to a ring N. In addition to this study using 5-Chloro-1,2,4-thiadiazole, there are many other studies that have used 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Recommanded Product: 5-Chloro-1,2,4-thiadiazole) was used in this study.

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 5-Chloro-1,2,4-thiadiazole

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kondo, Takashi; Nekado, Takahiro; Sugimoto, Isamu; Ochi, Kenya; Takai, Shigeyuki; Kinoshita, Atsushi; Hatayama, Akira; Yamamoto, Susumu; Kishikawa, Katsuya; Nakai, Hisao; Toda, Masaaki published an article on February 15 ,2008. The article was titled 《Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group》, and you may find the article in Bioorganic & Medicinal Chemistry.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole The information in the text is summarized as follows:

A series of (4β-substituted)-L-prolylpyrrolidine analogs lacking the electrophilic nitrile function were synthesized and their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and duration of ex vivo activity were evaluated. Structural optimization of the analog (I), which was found by high-speed analog synthesis, was carried out to improve the potency and duration of action. A representative compound (II) was evaluated to assess its effect on the plasma glucose level after the oGTT (oral glucose tolerance test) in normal rats. Structure-activity relationships (SAR) are also presented. The results came from multiple reactions, including the reaction of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application In Synthesis of 5-Chloro-1,2,4-thiadiazole)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

MacLeod, Angus M.; Baker, Raymond; Freedman, Stephen B.; Patel, Shailendra; Merchant, Kevin J.; Roe, Michael; Saunders, John published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and muscarinic activities of 1,2,4-thiadiazoles》.Application of 38362-15-1 The author mentioned the following in the article:

A series of novel 1,2,4-thiadiazoles bearing a mono- or bicyclic amine at C-5 were prepared Quinuclidine and 1-azabicyclo[2.2.1]heptane derivatives e.g., I (R = H, Me, Et, Me2CH, cyclopropyl, CH2Ph, OMe; n = 1, 2) were synthesized by reaction of the lithium enolate of the 3-methoxycarbonyl compounds followed by ester hydrolysis and decarboxylation. The receptor binding affinity and efficacy of these compounds as muscarinic ligands was assessed by radioligand binding assays using [3H]-N-methylscopolamine and [3H]oxotremorine-M. Optimal agonist affinity was observed for 3′-Me compounds Smaller substituents (H) retained efficacy with reduced affinity while larger groups led to substantially lower efficacy. The observed binding affinity was influenced both by the conformational energy of rotation around the C(3)-C(5′) bond and the steric requirement of the mono- or bicyclic amine. In the experimental materials used by the author, we found 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application of 38362-15-1)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 38362-15-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics