Category: 38902-87-3

Yuan, Xiao; Yan, Ning; Xiao, Chaoxian; Li, Changning; Fei, Zhaofu; Cai, Zhipeng; Kou, Yuan; Dyson, Paul J. published an article on February 28 ,2010. The article was titled 《Highly selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines with ionic-liquid-like copolymer stabilized platinum nanocatalysts in ionic liquids》, and you may find the article in Green Chemistry.HPLC of Formula: 38902-87-3 The information in the text is summarized as follows:

Platinum nanoparticles (PtNPs stabilized by an ionic-liquid-like-copolymer (IP) immobilized in various ionic liquids (ILs)) effectively catalyze the selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines, a reaction of considerable com. significance. The preparation of 2,4-dichloro-3-aminophenol (DAP) has been primarily studied due to its important industrial applications. DAP is usually prepared from 2,4-dichloro-3-nitrophenol (DNP) by reduction with hydrogen using Ni- or Pt-based catalysts. Compared to reactions in mol. (organic) solvents, the ILs system provides superior selectivity with functionalized ILs containing an alc. group demonstrating the best recyclability, and ultimately achieving a turnover number of 2025 which is 750 fold higher than Raney nickel catalyst. A universal catalyst-ionic liquid system for the conversion of aromatic chloronitro compounds to aromatic chloroamines was also established. TEM, XPS, IR spectroscopy were used to characterize the morphol. of the nanocatalysts allowing their structure to be correlated to their activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-3-nitrophenol(cas: 38902-87-3HPLC of Formula: 38902-87-3)

2,4-Dichloro-3-nitrophenol(cas: 38902-87-3) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.HPLC of Formula: 38902-87-3 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Metabolism of 2,3-, 2,6-, and 3,5-dichloronitrobenzene and the formation of a mercapturic acid from 2,3,4,5-tetrachloronitrobenzene in the rabbit》 were Bray, H. G.; James, Sybil P.; Thorpe, W. V.. And the article was published in Biochemical Journal in 1957. Safety of 2,4-Dichloro-3-nitrophenol The author mentioned the following in the article:

cf. C.A. 52, 16882f. The metabolism of 2,3-, 2,6-, and 3,5-dichloronitrobenzene has been studied in the rabbit. The main products excreted are phenols, conjugated with glucuronic and sulfuric acids, and dichloroanilines (2,3-dichloroaniline (acetyl and picrate derivatives), 4-amino-3,5-dichlorophenol, 3,5-dichloroaniline (acetyl derivative), 3,5,3′,5′-tetrachloroazoxybenzene, 2-amino-4,6-dichlorophenol, 4-amino-2,6-dichlorophenol). A small amount of a pyrocatechol derivative is probably formed from the 2,6-isomer. No mercapturic acids were detected in the urines. A mercapturic acid (N-acetyl-S-(2,3,4-trichloro-6-nitrophenyl)-L-cysteine) has been isolated from the urine of rabbits given 2,3,4,5-tetrachloronitrobenzene. The chief features of the metabolism of 19 chloromononitrobenzenes have been summarized and discussed. The experimental process involved the reaction of 2,4-Dichloro-3-nitrophenol(cas: 38902-87-3Safety of 2,4-Dichloro-3-nitrophenol)

2,4-Dichloro-3-nitrophenol(cas: 38902-87-3) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Safety of 2,4-Dichloro-3-nitrophenol Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Scission of diaryl ethers and related compounds by means of piperidine. II. The nitration of 2,4,4′-trichlorodiphenyl ether and of 2,4-dichlorophenyl p-toluenesulfonate and benzoate》 was published in Journal of the Chemical Society in 1929. These research results belong to Groves, Leslie G.; Turner, Eustace E.; Sharp, Gladys Irene. Recommanded Product: 38902-87-3 The article mentions the following:

cf. C. A. 21, 2673. 2,4-Cl2C6H2OH is obtained in 80% yield from p-ClC6H4OH; the p-toluenesulfonate, m. 125°; nitration gives 2,4-dichloro-5-nitrophenyl o-nitro-p-toluenesulfonate (I), m. 103°; reduction with Fe and a little AcOH gives the diamino derivative, m. 159-61°; the diazo solution, with CuCl-HCl, gives a red gum which, refluxed 3 hrs. with piperidine, gives 2,4,5-Cl3C6H2OH, m. 66-7°. 1-p-Toluenesulfonylpiperidine, m. 103°; o-NO2 derivative (II), pale greenish yellow, m. 112°. Heating I with 1/3 of its weight of piperidine for 1.5 hr. at 100° gives II and 2,4-dichloro-5-nitrophenol (III), m. 105-6°. N-2,4-Dichlorophenylphthalimide, m. 155°; HNO3 in cocnd. H2SO4 gives the 5-NO2 derivative, pale yellow, m. 217-9°, saponified by 90% H2SO4 to 2,4,5-Cl2(O2N)C6H2NH2. 2,4-(O2N)2C6H3Cl and 2,4-Cl2C6H3OH in KOH give 2,4-dichloro-2′,4′-dinitrodiphenyl ether, pale greenish yellow, m. 118-9°; nitration gives the 5,2′,4′-tri-NO2 derivative, m. 128°; scission with piperidine gives III, while PhNH2 gives III and 2,4-(O2N)2C6H3NHPh. 4,4′-Dichloro-2-aminodiphenyl ether, m. 67°, results in 90% yield by reduction of the NO2 derivative with Fe and a little AcOH; through the diazo reaction there results 2,4,4′-trichlorodiphenyl ether, b11 183°, m. 54-5°; 2′-NO2 derivative, m. 86-7°, decomposed by piperidine into 2,4-Cl2C6H3OH and 4-chloro-2-nitrophenylpiperidine. The 5,2′-di-NO2 derivative, pale yellow, m. 103-4°, is decomposed by piperidine to give III. 2,4,4′-Trichloro-5,2°-diamino-diphenyl ether, m. 93-4°. 2,4,4′-Trichloro-5,2,5′-trinitrodiphenyl ether, yellowish green, m. 155-7°; piperidine gives III and 4-chloro-2,5-dinitrophenylpiperidine, red, m. 70-1°. 4-Chloro-2,6-dinitrophenylpiperidine, golden, m. 165-6°, results from 4,2,6-Cl(O2N)2-C6H2OMe. 2,4-Dichloro-5-nitrophenyl m-nitrobenzoate, m. 154°; 2,4-dichlorophenyl m-nitrobenzoate, m. 115-6°, gives the same product on nitration. 2,4-Dichloro-6-nitrophenyl m-nitrobenzoate, m. 149-50°, was prepared for purposes of comparison. Chlorination of m-O2NC6H4OH gives 2,4-dichloro-3-nitrophenol, pale yellowish green, m. 85-7°; p-totuenesulfonyl derivative, m. 122°, reduced by Fe and a little AcOH to the 3-NH2 derivative, m. 113-4°; the diazo solution, treated with CuCl-HCl and the crude product heated with piperidine, gives 2,3,4-trichlorophenol, m. 80-1°, identical with that obtained by chlorinating 3,4-Cl2C6H3OH. III does not react with SOCl2 and gave no definite product with PCl3. 4,5,1,2,-Cl2C6H2(NO2)2 and PhOK give 4,5-dichloro-2-nitrodiphenyl ether, yellow, m. 69-70°. 4,5,4′-Trichloro-2-nitrodiphenyl ether, pale yellow, m. 131-2°, decomposed by piperidine, giving 4-chloro-2-nitrophenylpiperidine. 4,5,2′,4′-Tetra-chloro-2-nitrodiphenyl ether, pale yellow, m. 125-6°; the 2-NH2 derivative m. 97-8°. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloro-3-nitrophenol(cas: 38902-87-3Recommanded Product: 38902-87-3)

2,4-Dichloro-3-nitrophenol(cas: 38902-87-3) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Recommanded Product: 38902-87-3 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics