Category: 39183-20-5

Kamoshita, Masahiro; Kosaka, Koji; Endo, Osamu; Asami, Mari; Aizawa, Takako published an article on January 31 ,2010. The article was titled 《Mutagenic activities of a chlorination by-product of butamifos, its structural isomer, and their related compounds》, and you may find the article in Chemosphere.Quality Control of 2-Methyl-5-nitro-6-chlorophenol The information in the text is summarized as follows:

The mutagenic activities of 5-methyl-2-nitrophenol (5M2NP), a chlorination byproduct of butamifos, its structural isomer 2-methyl-5-nitrophenol (2M5NP), and related compounds were evaluated by the Ames assay. The mutagenic activities of 5M2NP and 2M5NP were neg. or not particularly high. However, those of their chlorinated derivatives were increased in Salmonella typhimurium strain TA100 and the overproducer strains YG1026, and YG1029 in the absence and/or presence of a rat liver metabolic activation system (S9 mix), particularly for YG1029. The mutagenic activities of 6-chloro-2-methyl-5-nitrophenol (6C2M5NP) in YG1029 in the absence and presence of S9 mix were 70 000 and 110 000 revertants mg-1, resp. When nitro functions of 6C2M5NP and 4-chloro-5-methyl-2-nitrophenol (4C5M2NP) were reduced to amino functions, their mutagenic activities were markedly decreased. The mutagenic activities of 5M2NP and 4C5M2NP were lower than those of 2M5NP and 6C2M5NP, resp. Thus, it was shown that substituent position is a key factor for the mutagenic activities of methylnitrophenols (MNPs) and related compounds The mutagenic activities of the extracts of 2M5NP in chlorination increased early during the reaction time and then decreased. The main chlorination byproduct contributing to the mutagenic activities of the extracts of 2M5NP in chlorination was 6C2M5NP. The results of chlorination of 2M5NP suggested that MNPs were present as their dichlorinated derivatives or further chlorination byproducts in drinking water. In addition to this study using 2-Methyl-5-nitro-6-chlorophenol, there are many other studies that have used 2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5Quality Control of 2-Methyl-5-nitro-6-chlorophenol) was used in this study.

2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 2-Methyl-5-nitro-6-chlorophenol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Efficient One-Pot Multifunctionalization of Alkynes en Route to α-Alkoxyketones, α-Thioketones, and α-Thio Thioketals by using an Umpolung Strategy》 was published in Chemistry – A European Journal in 2017. These research results belong to Xu, Zhou; Zhai, Rongliang; Liang, Ting; Zhang, Liming. Product Details of 39183-20-5 The article mentions the following:

The use of polarized synthons is a highly desirable strategy, as it generally enables unprecedented retrosynthetic disconnections for the synthesis of unique substances. Herein, a new approach for α-alkoxy and α-alkylthio ketones R1C(O)CH2XR2 [X = O, S; R1 = n-nonyl, R2 = Me, i-Pr, H2C:CHCH2, cyclohexyl, etc.; R1 = Cl(CH2)3, HO(CH2)4, (EtO2C)2CH, etc., R2 = Et] and α-thio thioketals R1C(SR2)2CH2SR2 (R1 = n-Bu, 2-phthalimidoethyl, PhOCH2CH2, etc.; R2 = Et, n-Pr, i-Pr) via an intermol. umpolung reaction between nucleophiles, such as alcs. or thiols R2XH and N-alkenyloxypyridinium salts H2C:CR1OPy+ -NTf2 (Py+ = 1-pyridinium), which were generated from the corresponding alkynes R1CCH, has been developed for the first time. The reactions proceed with good substrate scope and excellent functional group tolerance in one-pot manner. Applications of the products, α-oxygenated ketones, to the synthesis of other valuable synthetic moieties have also been successfully achieved.2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5Product Details of 39183-20-5) was used in this study.

2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 39183-20-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1973,Journal of the Chemical Society included an article by Bowman, R. E.; Brunt, K. D.; Godfrey, K. E.; Kruszynska, L.; Reynolds, A. A.; Thrift, R. I.; Waite, D.; Williamson, W. R. N.. Product Details of 39183-20-5. The article was titled 《Syntheses of flufenamic acid metabolites I and II and other N-arylanthranilic acids》. The information in the text is summarized as follows:

(Addnl. data considered in abstracting and indexing are available from a source cited in the original document.) 2,5-Cl(HO)C6H3CO2Et reacted with PhCH2Cl-NaOEt-EtOH to give, after hydrolysis, 2,5-Cl(PhCH2O)C6H3CO2H, which was condensed with n-F3CC6H4NH2 in the presence of Cu2+ to give 5-(benzyloxy)-N-(α,α,α-trifluoro-m-tolyl) anthranilic acid (I, R = PhCH2O, R1 = H). Hydrogenolysis gave I (R = OH, R1 = H). 2,5-Cl(O2N)C6H3CF3 was similarly converted into 2,5-PhCH2O(O2N)C6H3CF2; reduction of the NO2 group and condensation with 2-BrC6H4CO2K gave N-[4-(benzyloxy)-α,α,α-trifluoro-m-tolyl] anthranilic acid (I, R = H, R1 = PhCH2O) which gave I (R = H, R1 = OH) on hydrogenelysis. Other N-arylanthranilic acids were prepared by similar Cu- or Cu salt-catalyzed condensations. In the experimental materials used by the author, we found 2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5Product Details of 39183-20-5)

2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Product Details of 39183-20-5 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iwanowicz, Edwin J.; Watterson, Scott H.; Guo, Junqing; Pitts, William J.; Murali Dhar, T. G.; Shen, Zhongqi; Chen, Ping; Gu, Henry H.; Fleener, Catherine A.; Rouleau, Katherine A.; Cheney, Daniel L.; Townsend, Robert M.; Hollenbaugh, Diane L. published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl] moiety》.Recommanded Product: 39183-20-5 The author mentioned the following in the article:

The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl] moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell proliferation (for select analogs) are given. The results came from multiple reactions, including the reaction of 2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5Recommanded Product: 39183-20-5)

2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 39183-20-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics