Category: 3919-74-2

Chandrasekhar, T. published the artcileSynthesis and biological evaluation of some new aryl acid N’-(1H-indazole-3-carbonyl)-hydrazide derivatives, Formula: C11H7ClFNO3, the publication is Journal of Chemical and Pharmaceutical Research (2012), 4(5), 2795-2802, database is CAplus.

Amide coupling of 1H-indazole-3-carboxylic acid hydrazide with substituted aryl acids affords thirteen novel Aryl acid N’-(1H-indazole-3-carbonyl)-hydrazide derivatives The acid hydrazide was synthesized by the hydrazine reaction with 1-H-indazole-3-carboxylic acid Me ester which was obtained by esterification of indazole-3-carboxylic acid.

Journal of Chemical and Pharmaceutical Research published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Formula: C11H7ClFNO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fawzy, Ahmed published the artcileRemoval of toxic tellurium (IV) compounds via bioreduction using flucloxacillin in aqueous acidic medium: A kinetic and mechanistic approach, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Journal of Molecular Liquids (2019), 111436pp., database is CAplus.

This paper describes a novel method for the removal of potassium tellurite (Te^IV), a toxic tellurium (IV) compound, via its bioreduction using the drug flucloxacillin (Flx) in an aqueous sulfuric acid solution The kinetics of the bioreduction process were monitored using UV-Vis absorption spectra at an ionic strength of 2.0 mol dm^-3 and 298 K. The reaction between Te^IV and Flx was set at a 1:1 stoichiometry. The reduction reaction followed first-order kinetics for [Flx] and fractional-first-order kinetics for [Te^IV] and [H⁺]. The effects of ionic strength and relative permittivity of the reaction medium were also explored. Supplementation with divalent transition metal ions enhanced the reduction rate. The reaction products were identified, in order of their stoichiometric results, spot tests and FT-IR spectra as 3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-carbocylic acid, 5,5-dimethyl-thiazolidine-2,4-dicarboxlic acid, ammonium ion, carbon dioxide and elemental tellurium (Te⁰). The reaction rate dependence on temperature was studied, and the activation and thermodn. parameters were assessed and discussed. The derived rate-law expression was found to be in excellent accordance with the acquired investigational outcomes. A conceivable reaction mechanism has been provided, which includes a reaction between the protonated flucloxacillin (Flx⁺) and tellurous acid (H₂TeO₃) as the essential reactive species, resulting in the construction of an intermediate complex. Such complex decays in the rate-determining step to yield the final reaction products.

Journal of Molecular Liquids published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Ke-Liang published the artcileDesign, Synthesis, and Bioevaluation of Substituted Phenyl Isoxazole Analogues as Herbicide Safeners, Computed Properties of 3919-74-2, the publication is Journal of Agricultural and Food Chemistry (2020), 68(39), 10550-10559, database is CAplus and MEDLINE.

Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted Ph isoxazole derivatives was designed by an intermediate derivatization method as herbicide safeners. Microwave-assisted synthesis was used to prepare the Ph isoxazole analogs, and all of the structures were confirmed via IR, ¹H NMR, ¹³C NMR, and HRMS. Compound (I) was further characterized by X-ray diffraction anal. Bioassay results showed that most of the obtained compounds provided varying degrees of safening against ACT-induced injury by increasing the corn growth recovery, glutathione content, and glutathione S-transferase activity. In particular, compound (II) showed excellent safener activity against ACT toxicity, comparable to that of the com. safener benoxacor. Gaussian calculations have been performed and the results indicated that the nucleophilic ability of compound II is higher than that of benoxacor, thus the activity is higher than that of benoxacor. These findings demonstrate that Ph isoxazole derivatives possess great potential for protective management in corn fields.

Journal of Agricultural and Food Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Zi-Wei published the artcileFragments recombination, design, synthesis, safener activity and CoMFA model of novel substituted dichloroacetylphenyl sulfonamide derivatives, Formula: C11H7ClFNO3, the publication is Pest Management Science (2021), 77(4), 1724-1738, database is CAplus and MEDLINE.

Isoxaflutole (IXF), as a kind of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, has been widely used in many kinds of plants. IXF can cause injury in corn including leaf and stem bleaching, plant height reduction or stunting, and reduced crop stand. Safeners are co-applied with herbicides to protect crops without compromising weed control efficacy. With the ultimate goal of addressing Zea mays injury caused by IXF, a series of novel substituted dichloroacetylphenyl sulfonamide derivatives was designed on the basis of scaffold hopping and active substructure splicing. A total of 35 compounds were synthesized via acylation reactions. All the compounds were characterized by IR (IR), proton and carbon-13 NMR (¹H-NMR and ¹³C-NMR), and high-resolution mass spectrometry (HRMS). The configuration of compound II-1 was confirmed by single crystal X-ray diffraction. The bioassay results showed that all the title compounds displayed remarkable protection against IXF via improved content of carotenoid. Especially compound II-1 which possessed better glutathione transferases (GSTs) activity and carotenoid content than the contrast safener cyprosulfamide (CSA). All the satisfied parameters suggested that the Comparative Mol. Field Anal. (CoMFA) model was reliable and stable [with a cross-validated coefficient (q²) = 0.527, r² = 0.995, r²_pred = 0.931]. The mol. docking simulation indicated that the compound II-1 and CSA could compete with diketonitrile (DKN) at the active site of HPPD, which is a hydrolyzed product of IXF in plants, causing the herbicide to be ineffective. The present work revealed that the compound II-1 deserves further attention as the candidate structure of safeners.

Pest Management Science published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C22H18O2, Formula: C11H7ClFNO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileDiscovery of N-Aroyl Diketone/Triketone Derivatives as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibiting-Based Herbicides, Application In Synthesis of 3919-74-2, the publication is Journal of Agricultural and Food Chemistry (2019), 67(43), 11839-11847, database is CAplus and MEDLINE.

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most promising targets for the discovery of new bleaching herbicides. To discover novel HPPD inhibitors with excellent herbicidal activity, a series of novel N-aroyl diketone/triketone derivatives were rationally designed by splicing active groups and bioisosterism. All the compounds were characterized by IR, ¹H and ¹³C NMR, and high-resolution mass spectrometry. Bioassays revealed that most of these derivatives displayed preferable herbicidal activity against Echinochloa crus-galli at 0.045 mmol/m² and Abutilon juncea at 0.090 mmol/m². In particular, compound (I) was more potent compared with the commercialized compound mesotrione. Mol. docking indicated that the corresponding active mols. of target compounds and mesotrione shared similar interplay with surrounding residues, which led to a perfect interaction with the active site of Arabidopsis thaliana HPPD. These promising findings demonstrate that these compounds could be considered as potential herbicide candidates for further development of novel HPPD inhibitors.

Journal of Agricultural and Food Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application In Synthesis of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Zhi-wei published the artcileSynthesis of 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Zhongguo Xiandai Yingyong Yaoxue (2008), 25(4), 308-309, database is CAplus.

A method for the synthesis of the title compound [i.e., 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride] is reported here. The synthesis of the target compound was achieved by a synthetic sequence involving an oximation reaction, chlorination, cyclization, hydrolysis, acyl chlorination using 2-chloro-6-fluorobenzaldehyde as starting material. The structure was determined by IR, NMR, ¹³C-NMR, MS (overall yield 60.2%). This is a practical and low-cost synthetic route. The above-mentioned target compound is an intermediate for flucloxacillin [i.e., (2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid].

Zhongguo Xiandai Yingyong Yaoxue published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Macsari, Istvan published the artcilePhenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship, Computed Properties of 3919-74-2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(13), 3871-3876, database is CAplus and MEDLINE.

Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Ph isoxazole carbamate (I) was identified as a potent and selective Na_V1.7 blocker. Structural analogs of I, both carbamates, ureas and amides, were proven to be useful in establishing the structure-activity relation and improving ADME related properties. Amide II showed a good overall in vitro profile, that translated well to rat in vivo PK.

Bioorganic & Medicinal Chemistry Letters published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramana, P. Venkata published the artcileSynthesis of 1,2,3-triazole substituted isoxazoles via copper(I) catalyzed cycloaddition, Application In Synthesis of 3919-74-2, the publication is Journal of Heterocyclic Chemistry (2012), 49(3), 621-627, database is CAplus.

The synthesis of a series of 3,5-disubstituted isoxazole-4-carboxylic esters containing N-substituted 1,2,3-triazoles starting from various benzaldehydes was reported. Initially, the benzaldehydes underwent oximation with NH₂OH.HSO₄. Later, chlorination followed by condensation with AcCH₂CO₂Me and hydrolysis of the resulting ester afforded the resp. carboxylic acids, which on chlorination with PCl₅ gave the corresponding acid chlorides. Subsequent propargylation gave propargylic esters, which led to the title compounds on click reaction.

Journal of Heterocyclic Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application In Synthesis of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramana, Parikibanda Venkata published the artcileSynthesis of dihydrooxazoylarylisoxazoles by conventional and under microwave conditions, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is European Journal of Chemistry (2011), 2(3), 300-307, database is CAplus.

The synthesis of series of 3-aryl-4-dihydrooxazolyl-5-Me trisubstituted isoxazoles I(R¹ = R² = H, Cl, R¹ = H, R² = Cl, R¹ = Cl, R² = F; R³ = R⁴ = H, Me, R³ = Me, iPr, R⁴ = H ) is reported, both under thermal and microwave conditions starting from various benzaldehydes. Benzaldehydes undergo oximation with hydroxylamine hydrosulfate to provide oximes that upon chlorination, followed by condensation with methylacetoacetate, resulted in the formation of esters. Hydrolysis of the esters to acids followed by treatment with PCl₅, resulted in the formation of acid chlorides that upon reaction with hydroxyamines, gave N-β-hydoxyalkyl amides. These on further reaction with SOCl₂, followed by cyclization with 2 N NaOH provided oxazoline substituted isoxazoles in good yields. The conversion acidchlorides to isoxazoles was also achieved by microwave irradiation in moderate to excellent yields, with shorter reaction times compared to the conventional thermal method.

European Journal of Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hanson, J. C. published the artcileDerivatives of 6-aminopenicillanic acid. VIII. Further analogs of 3-o-chlorophenyl-5-methyl-4-isoxazolylpenicillin, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Journal of the Chemical Society (1965), 5976-83, database is CAplus.

cf. CA 60, 5475c. Various analogs of 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid containing addnl. substituents in the benzene ring have been synthesized. Chlorides of these acids, together with certain other dihalogen derivatives of 5-methyl-3-phenyl- and 3-methyl-5-phenylisoxazole-4-carbonyl chlorides, were condensed with 6-aminopenicillanic acid to give new penicillins with useful anti-bacterial properties.

Journal of the Chemical Society published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics