Category: 3919-74-2

Kang, Tao published the artcileMicrowave assistant synthesis and crystal structures of two substituted oxazole isoxazole carboxamides, HPLC of Formula: 3919-74-2, the publication is Chinese Journal of Structural Chemistry (2020), 39(10), No pp. given, database is CAplus.

Two novel substituted Ph oxazole isoxazole carboxamides I was synthesized by microwave assistant technol. The target compounds were characterized by IR, ¹H NMR, ¹³C NMR and HRMS, and their single-crystal structures were further determined by X-ray diffraction. Compound I [R¹=R² = H; R³ = Me; R⁴ = isopropyl] crystallizes in monoclinic system, space group P21/c with a = 6.2137(12), b = 19.923(4), c = 13.748(3) Å, β = 92.30(3)°, V = 1700.6(6) Å3, Dc = 1.228 Mg/m3, Z = 4, F(000) = 672, μ(MoKα) = 0.084 mm-1, R = 0.0526 and wR = 0.1259. Compound I [R¹ = F; R² = Cl; R³ = Me, R⁴ = Et] crystallizes in triclinic system, space group P1̅ with a = 7.8750(16), b = 10.596(2), c = 11.725(12) Å, β = 102.05(3)°, V = 859.5(3) Å3, Dc = 1.363 Mg/m3, Z = 2, F(000) = 368, μ(MoKα) = 0.250 mm-1, R = 0.0738 and wR = 0.1941. Both of the mols. prefer to form crystal packing through C-H···O hydrogen bonds. Compounds I [R¹=R² = H; R³ = Me; R⁴ = Et] and [R¹ = F; R² = Cl; R³ = Me; R⁴ = Et] show safener activity on maize against the injury of chlorsulfuron.

Chinese Journal of Structural Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, HPLC of Formula: 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sedelmeier, Jorg published the artcileKMnO₄-Mediated Oxidation as a Continuous Flow Process, SDS of cas: 3919-74-2, the publication is Organic Letters (2010), 12(16), 3618-3621, database is CAplus and MEDLINE.

An efficient and easily scalable transformation of alcs. and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant within a continuous flow reactor is reported. Notably, the generation and downstream processing of MnO₂ slurries was not found to cause any blocking of the reactor when ultrasound pulses were applied to the flow system.

Organic Letters published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C16H10O5, SDS of cas: 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, You-Yuan published the artcileSynthesis, crystal structure, and herbicidal activity of 3-(2-chloro-6-fluorophenyl)-4-(2-oxooxazolidine-3-carbonyl)-5-methylisoxazole, Computed Properties of 3919-74-2, the publication is Indian Journal of Heterocyclic Chemistry (2020), 30(4), 503-508, database is CAplus.

A novel N-aroyl diketone derivative, I (C₁₄H₁₀ClFN₂O₄, Mr = 324.69), was designed via fragment anal. and coupling strategy that led to highly potent and bio-selective herbicide. The title compound I was prepared by a multistep-reaction, including nucleophilic addition and N-acylation reaction using 2-chloro-6-fluorobenzaldehyde as the starting materials in 83.4% yield. The title compound I crystallized in the monoclinic system, space group P2₁/n with a = 10.7119(4) Å, b = 17.5875(7) Å, c = 11.5151(7) Å, β = 100.927(2)°, Z = 8, V = 2870.0(2) ų, F(000) = 1328, D_c = 1.503 Mg/m³, crystal size: 0.130 x 0.120 x 0.100 mm. The herbicidal activity was tested against the gramineous weed Echinochloa crus-galli and broadleaf Abutilon juncea.

Indian Journal of Heterocyclic Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Niswender, Colleen M. published the artcileContext-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor, COA of Formula: C11H7ClFNO3, the publication is Molecular Pharmacology (2010), 77(3), 459-468, database is CAplus and MEDLINE.

Phenotypic studies of mice lacking metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor may be promising for the treatment of central nervous system disorders such as anxiety and depression. Suzuki et al. recently reported the in vitro characterization of a novel mGluR7 antagonist called 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), which noncompetitively inhibited the activity of orthosteric and allosteric agonists at mGluR7. We describe that MMPIP acts as a noncompetitive antagonist in calcium mobilization assays in cells coexpressing mGluR7 and the promiscuous G protein Gα₁₅. Assessment of the activity of a small library of MMPIP-derived compounds using this assay reveals that, despite similar potencies, compounds exhibit differences in neg. cooperativity for agonist-mediated calcium mobilization. Examination of the inhibitory activity of MMPIP and analogs using endogenous G_i/o-coupled assay readouts indicates that the pharmacol. of these ligands seems to be context-dependent, and MMPIP exhibits differences in neg. cooperativity in certain cellular backgrounds. Electrophysiol. studies reveal that, in contrast to the orthosteric antagonist (2S)-2-amino-2-[(1S,2S)-2-carboxyclycloprop-1-yl]-3-(xanth-9-yl) propanoic acid (LY341495), MMPIP is unable to block agonist-mediated responses at the Schaffer collateral-CA1 synapse, a location at which neurotransmission has been shown to be modulated by mGluR7 activity. Thus, MMPIP and related compounds differentially inhibit coupling of mGluR7 in different cellular backgrounds and may not antagonize the coupling of this receptor to native G_i/o signaling pathways in all cellular contexts. The pharmacol. of this compound represents a striking example of the potential for context-dependent blockade of receptor responses by neg. allosteric modulators.

Molecular Pharmacology published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, COA of Formula: C11H7ClFNO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kang, Tao published the artcileDesign, Synthesis, and SAR of Novel 1,3-Disubstituted Imidazolidine or Hexahydropyrimidine Derivatives as Herbicide Safeners, Related Products of chlorides-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2021), 69(1), 45-54, database is CAplus and MEDLINE.

Herbicide safeners enhance herbicide detoxification in crops without reducing their herbicidal efficacy against target weeds. To alleviate maize injury caused by the sulfonylurea herbicide nicosulfuron, a series of 1,3-disubstituted imidazolidine or hexahydropyrimidine derivatives were rationally designed via bioisosterism and active subunit combinations. Thirty novel compounds were synthesized using an efficient one-pot method and low-cost raw materials and characterized by IR, ¹H NMR, ¹³C NMR, and high-resolution mass spectrometer (HRMS). Bioactivity and structure-activity relationship (SAR) were evaluated for herbicide safeners tested against nicosulfuron injury. Most of the compounds effectively protected sensitive maize against nicosulfuron damage. The parent skeletons and substituents of the target compounds both substantially influenced their safener activity. Compound (I) exhibited superior bioactivity compared to the safener isoxadifen-Et. Mol. docking simulations disclosed that compound I competed with nicosulfuron for the acetolactate synthase active site and demonstrated that this is the protective mechanism of safeners. The target compound I presented with strong herbicide safener activity in maize and is, therefore, a potential candidate for the development of a novel herbicide safener.

Journal of Agricultural and Food Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cui, Y. published the artcileSynthesis of novel oxazolidinone derivatives for antibacterial investigation, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Current Science (2005), 89(3), 531-534, database is CAplus.

A series of oxazolidinones were synthesized and evaluated as antibacterial agents. They were screened in vitro against a panel of Gram-pos. organisms. Compound I was found to exhibit activity comparable to linezolid.

Current Science published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics