In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39224-18-5 as follows. Application In Synthesis of 4-Chloro-2-fluoro-1,1′-biphenyl
Step (b) Preparation of 4-(4′-Chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester To a stirred suspension of anhydrous aluminum chloride (1.451 g, 0.0109 mol) in dichloromethane (20 mL) under nitrogen at 5 C. was added dropwise a solution of 4-chloro-2-fluorobiphenyl (0.858 g, 0.00415 mol) in dichloromethane (13 mL) over 10 minutes followed by the dropwise addition of 3-carbomethoxypropionyl chloride (0.57 mL, 0.0046 mol) in dichloromethane (13 mL) over 25 minutes. The resulting mixture was stirred for 2.5 hours then allowed to warm slowly to room temperature. Stirred for 3 days, for convenience. Then the mixture was recooled and quenched with the dropwise addition of water (145 mL). The organic layer was washed with water, aqueous sodium bicarbonate, brine, and dried (MgSO4). The mixture was rotary evaporated to give 1.25 g of 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester as a pale yellow solid; mp 90.5-92.5 C.
According to the analysis of related databases, 39224-18-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Purchase JR., Claude Forsey; Roth, Bruce David; Schielke, Gerald Paul; Walker, Lary Craswell; White, Andrew David; US2001/513; (2001); A1;,
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