Category: 39637-74-6

COA of Formula: C10H13ClO3《Enzymatic Process for N-Substituted (3S)- and (3R)-3-Hydroxypyrrolidin-2-ones》 was published in 2015. The authors were Singh, Amarjit;Falabella, James;LaPorte, Thomas L.;Goswami, Animesh, and the article was included in《Organic Process Research & Development》. The author mentioned the following in the article:

Lipase PS 30 (immobilized on polypropylene) from Pseudomonas cepacia was used for enantioselective esterification of (RS)-1-(2-fluoro-4-iodophenyl)-3-hydroxypyrrolidin-2-one by using succinic anhydride and 2-methyltetrahydrofuran at 4 °C. The isolation of desired alc. avoided use of column chromatog., a simple solvent extraction of undesired (R)-4-((1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-yl)oxy)-4-oxobutanoic acid into 5% potassium bicarbonate solution separated pure desired (S)-1-(2-fluoro-4-iodophenyl)-3-hydroxypyrrolidin-2-one into the 2-methyltetrahydrofuran solution The reaction conditions were optimized, and (S)-1-(2-fluoro-4-iodophenyl)-3-hydroxypyrrolidin-2-one was prepared in high enantiomeric excess >99% and yield ∼40% (theor. possible yield 50%). Novozym 435 (Candida antarctica lipase B) was found to be a suitable biocatalyst for the resolution of (RS)-1-(6-bromo-2-methylpyridin-3-yl)-2-oxopyrrolidin-3-yl acetate to form the undesired S-acetate and the desired R-alc. The optimized reaction conditions gave (R)-1-(6-bromo-2-methylpyridin-3-yl)-3-hydroxypyrrolidin-2-one in ∼37% isolated yield (maximum possible yield 50%) and high enantiomeric excess (ee >99.4%). The enzymic resolution of (RS)-1-(6-bromo-2-methylpyridin-3-yl)-2-oxopyrrolidin-3-yl acetate followed by chromatog. was successfully implemented to deliver material for two successive (4.1 kg, ee >99.4% and 5.5 kg, ee >99.5%) campaigns. The undesired S-alc. was recycled back to the desired R-alc. using a Mitsunobu inversion of stereochem. in gram scale. An increase in the chain length from acetate to hexanoate improved the selectivity and subsequent optimization decreased the enzyme loading and enhanced the substrate input. Separation of the desired (R)-1-(6-bromo-2-methylpyridin-3-yl)-3-hydroxypyrrolidin-2-one from (S)-1-(6-bromo-2-methylpyrrolidin-3-yl)-2-oxopyrrolidin-3-yl hexanoate was achieved using a solvent extraction The process for the preparation of (S)-1-(2-fluoro-4-iodophenyl)-3-hydroxypyrrolidin-2-one and (R)-1-(6-bromo-2-methylpyridin-3-yl)-3-hydroxypyrrolidin-2-one is scalable, economical, and highly efficient and avoids chromatog. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 COA of Formula: C10H13ClO3) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Will, Jonas M.;Behrens, Arne;Macke, Marcel;Quarles, C. Derrick Jr.;Karst, Uwe published 《Automated chiral analysis of amino acids based on chiral derivatization and trapped ion mobility-mass spectrometry》. The research results were published in《Analytical Chemistry (Washington, DC, United States)》 in 2021.Related Products of 39637-74-6 The article conveys some information:

A fast and fully automated method for chiral anal. has been developed by combining a chiral derivatization approach with high-resolution trapped ion mobility separation Although the presented approach can be potentially applied to diverse types of chiral compounds, several benchmark amino acids were used as model compounds, focusing on the smallest amino acid alanine. An autosampler with an integrated chromatog. system was used for inline chiral derivatization with (S)-naproxen chloride and subsequent presepn. Afterwards, derivatized amino acids were directly introduced into the electrospray interface of a trapped ion mobility-mass spectrometer for rapid diastereomer separation in the gas phase. This unique combination of presepn. and trapped ion mobility spectrometry separation in the neg. ion mode enabled rapid chiral anal. within 3 min per sample. Furthermore, the diastereomer separation proved to be independent of alkali salts or other metal ions, offering robustness with regard to samples containing high amounts of salts. Highly sensitive detection of amino acid diastereomers was possible down to the lower nanomolar concentration range, and enantiomeric ratios could be readily determined from the recorded mobilograms with excellent reproducibility and precision. To demonstrate the general applicability of our method, alanine and other amino acids were analyzed from soy sauces and seasonings, which revealed extraordinarily high D-Ala contents of up to 99% in all samples. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Related Products of 39637-74-6) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Krief, Alain;Wouters, Johan;Norberg, Bernadette;Kremer, Adrian published 《Formalizing the mechanism of the allylic substitution reaction (SN’): application to the highly enantio- and diastereo-selective syntheses of 1-phenyl-2-vinylcyclopentanes》 in 2018. The article was appeared in 《ARKIVOC (Gainesville, FL, United States)》. They have made some progress in their research.Product Details of 39637-74-6 The article mentions the following:

An efficient stereoselective and high yielding syntheses of each of the four enantiomers of phenylcyclopentanes e.g., I bearing a quaternary center and a E-propenyl chain on the adjacent carbon that involves intramol. allylic substitution reactions has been reported. In complement to its synthetic value, this process models the SN’ reaction and allows prediction of its stereochem. outcome. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Product Details of 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

del Hoyo, Ana M.;Latorre, Alfonso;Diaz, Raul;Urbano, Antonio;Carreno, M. Carmen published 《Enantiopure Helical Ferrocene-Triazole-Quinone Triads: Synthesis and Properties》 in 2015. The article was appeared in 《Advanced Synthesis & Catalysis》. They have made some progress in their research.Safety of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) The article mentions the following:

The Cu(I)-catalyzed (2+3) cycloaddition between azido (or azidomethylene) ferrocenes and enantiopure (P)-14-(p-ethynylphenyl)-[5]-tetrahydro-helicenequinone afforded ferrocene-triazole-quinone triads, whereas diazido ferrocenes gave rise to the corresponding double triads. In reactions with 1,1′-diazidoferrocene, the use of CuI/MeCN or CuSO₄/Na ascorbate/THF conditions allowed the divergent formation of an open chain dimeric structure or a 1,4-diaza-[4]-ferrocenophane resulting from an intramol. oxidative coupling of the two triazole units formed after the double cycloaddition process. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Safety of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)《Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose》 was published in 2015. The authors were Chandramouli, Nagula;Ferrand, Yann;Lautrette, Guillaume;Kauffmann, Brice;MacKereth, Cameron David;Laguerre, Michel;Dubreuil, Didier;Huc, Ivan, and the article was included in《Nature Chemistry》. The author mentioned the following in the article:

The ab initio design of synthetic mol. receptors for a specific biomol. guest remains an elusive objective, particularly for targets such as monosaccharides, which have very close structural analogs. Here we report a powerful approach to produce receptors with very high selectivity for specific monosaccharides and, as a demonstration, we develop a foldamer that selectively encapsulates fructose. The approach uses an iterative design process that exploits the modular structure of folded synthetic oligomer sequences in conjunction with mol. modeling and structural characterization to inform subsequent refinements. Starting from a first-principles design taking size, shape and hydrogen-bonding ability into account and using the high predictability of aromatic oligoamide foldamer conformations and their propensity to crystallize, a sequence that binds to β-D-fructopyranose in organic solvents with at.-scale complementarity was obtained in just a few iterative modifications. This scheme, which mimics the adaptable construction of biopolymers from a limited number of monomer units, provides a general protocol for the development of selective receptors.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Application In Synthesis of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Duttagupta, Indranil;Jugniot, Natacha;Audran, Gerard;Franconi, Jean-Michel;Marque, Sylvain R. A.;Massot, Philippe;Mellet, Philippe;Parzy, Elodie;Thiaudiere, Eric;Vanthuyne, Nicolas published 《Selective On/Off-Nitroxides as Radical Probes to Investigate Non-radical Enzymatic Activity by Electron Paramagnetic Resonance》. The research results were published in《Chemistry – A European Journal》 in 2018.Recommanded Product: (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) The article conveys some information:

A nitroxide carrying a peptide specific to the binding pocket of the serine proteases chymotrypsin and cathepsin G is prepared This peptide is attached as an enol ester to the nitroxide. Upon enzymic hydrolysis of the peptide, the enol ester moiety is transformed into a ketone moiety. This transformation affords a difference of 5 G in phosphorus hyperfine coupling constant between the electronic paramagnetic resonance (EPR) signals of each nitroxide. This property is used to monitor the enzymic activity of chymotrypsin and cathepsin G by EPR. Michaelis constants were determined and match those reported for conventional optical probes. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Recommanded Product: (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qin, Linlin;Ren, Lei;Wan, Songlin;Liu, Guoliang;Luo, Xinfeng;Liu, Zhenhong;Li, Fangqiong;Yu, Yan;Liu, Jianyu;Wei, Yonggang published 《Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics》 in 2017. The article was appeared in 《Journal of Medicinal Chemistry》. They have made some progress in their research.Related Products of 39637-74-6 The article mentions the following:

A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized. The incorporation of the cyclopropyl group not only increased the steric effect but also introduced stereoselective effects over their anesthetic properties. Compounds I (R = Et, R¹ = cyclopropyl; R = R¹ = cyclopropyl; R = Me, R¹ = cyclopropyl) were selected as potential candidates for further preclin. development including studies of their water-soluble prodrugs. Clin. studies of candidate compound I (R = Me, R¹ = cyclopropyl) (Haisco HSK3486) as a general anesthetic are being performed in Australia and China. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Related Products of 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Weichu;Wright, George E.;Yanachkova, Milka;Yanachkov, Ivan B. published 《Synthesis and absolute configuration assignment of 9-hydroxyrisperidone enantiomers》 in 2014. The article was appeared in 《Letters in Organic Chemistry》. They have made some progress in their research.COA of Formula: C10H13ClO3 The article mentions the following:

The enantiomers of 9-hydroxyrisperidone, the major metabolite of risperidone and the active component of the antipsychotic drug Invega, were synthesized by efficient methods. Their optical rotation and enantiomeric purity were characterized. The absolute configurations were assigned by comparing ¹H NMR chem. shifts of Mosher esters of a key stereoisomeric intermediate. Thus, the stereoisomeric center of (+)-9-hydroxyrisperidone was assigned the S configuration, and its enantiomer has the configuration R. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 COA of Formula: C10H13ClO3) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Shasha;Sun, Xiaoyun;Liu, Daicheng published 《Preparation of (3R, 3’R)-astaxanthin monoester and (3R, 3’R)-astaxanthin from Antarctic krill (Euphausia superba Dana)》. The research results were published in《European Food Research and Technology》 in 2015.Formula: C10H13ClO3 The article conveys some information:

A special method is described for the preparation of (3R, 3’R)-astaxanthin monoester (AM) and (3R, 3’R)-astaxanthin from Antarctic krill (Euphausia superba Dana). Purified AM was obtained on a large scale from crude extract extracted from Antarctic krill in 38.14 % yield by silica gel column chromatog. After the AM was saponified with methanolic KOH (0.10 mol L^-1) and separated by high-performance thin-layer chromatog., pure astaxanthin was obtained. There was only one optical (3R, 3’R)-isomer of the esterification of astaxanthin with (-)-camphanic acid chloride detected by high-performance liquid chromatog. compared with astaxanthin standard It was further proved that the AM consists of only one optical (3R, 3’R)-isomer. Twelve types of fatty acids in the AM from Antarctic krill were found by gas chromatog.-mass spectrometer. Eicosapentaenoic and docosahexaenoic acids are the major fatty acids. It is the first time to prepare (3R, 3’R)-AM and (3R, 3’R)-astaxanthin from Antarctic krill. The purified (3R, 3’R)-AM and (3R, 3’R)-astaxanthin can be used as a standard for further related study.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Formula: C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics