Category: 3972-56-3

These common heterocyclic compound, 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C10H13Cl

The method for synthesizing the aphid butyl fluoride ester intermediate p-tert-butyl phenylacetonitrile comprises the following steps: 1) Under argon conditions,Ethyl acetonitrile,Potassium tert-butoxide,Mix the t-butanol,Warming up to 98 ¡ã C,The control pressure is 4.5 atmospheres.Within 30min1 mol of tert-butylchlorobenzene and DMSO solution were added in 3 batches,Then control the reaction temperature to 112 ¡ã C,The reaction pressure is 5 atmospheres.The reaction ended at 2.5h.Then add deionized water,Control reaction temperature is 142¡ãC, the reaction pressure is 8 atmospheres,Continue the reaction 5h end;The ratio of 4-tert-butylchlorobenzene to ethyl cyanoacetate is 1:1.35,The amount of ethyl cyanoacetate and potassium t-butoxide is 1:1.55,The ratio of ethyl cyanoacetate to tert-butanol is 1g: 10ml,The ratio of 4-tert-butylchlorobenzene to DMSO is 1g: 5ml.The ratio of potassium t-butoxide to deionized water is 1:11.2) The system removes the solvent by a rotary evaporator.Then transfer the residue to the water,Add toluene and stir,The layers were separated, and the organic phase was collected and dried over anhydrous sodium sulfate.Then the filtrate was collected by filtration.The filtrate was distilled under reduced pressure to collect a fraction of 78 to 79 ¡ã C (0.1 torr).The product was obtained in a molar yield of 97.7percent and an HPLC purity of 98.9percent.

The synthetic route of 1-tert-Butyl-4-chlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Nong Pharmaceutical Xue Institute; Jinan Kehai Co., Ltd.; Yang Chaohui; Fu Hongxin; Wang Ling; (6 pag.)CN109053491; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-56-3, category: chlorides-buliding-blocks

General procedure: To an ice-cold mixture of DPMPA (816 mg, 3.76 mmol) and THF (3.0 mL) was added 1.50 mL of a 2.5 M solution of n-BuLi (3.8 mmol) in hexane. This mixture was stirred for 5 min, and 9.7 mL of a 0.097 M solution of SmI2 (0.94 mmol) in THF was added, and stirred for 5 min. After cooling the reductant to -66 C, a solution of the organochlorine substrate (0.285 mmol) and t-BuOH (54 muL, 0.57 mmol) in THF (1.4 mL) was added. The mixture was allowed to warm to 21 C over 2 h and, where appropriate, tetradecane (10.0 muL, 0.0384 mmol) was added. Water (8 mL) was added, and the mixture was extracted with a 2:1 mixture of hexanes and Et2O (5¡Á5 mL). The concentrated mixture was purified by silica gel column chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; McDonald, Chriss E.; Ramsey, Jeremy R.; Sampsell, David G.; Anderson, Laura A.; Krebs, Jordan E.; Smith, Samantha N.; Tetrahedron; vol. 69; 14; (2013); p. 2947 – 2953;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-56-3, category: chlorides-buliding-blocks

General procedure: An oven-dried Schlenk tube was evacuated and backfilled with nitrogen. The Schlenk tube was charged with NaH (60.0 mg, 60percent,1.2 mmol) and o-xylene (1 mL), and then phenol (1.2 mmol) wasadded. After stirring for 15 min, aryl halide (1.0 mmol) and the solution of Pd(dba)2 (11.5 mg, 0.02 mmol) and L1 (13.7 mg, 0.03 mmol) in o-xylene (1.5 mL) were added sequentially. The septum was replaced with an inside reflux condenser, and then the reaction mixture was stirred for 18 h at 110 C. Then, reaction mixture was cooled to room temperature and quenched with saturated NH4Cl(5 mL). After separating the organic phase, the aqueous phase was extracted with diethyl ether (3 mL3), and the combined organic phase was dried over anhydrous Na2SO4. The solvent was concentrated under reduced pressure, and then the crude material was purified by column chromatography on silica gel.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Zhang, Yi; Ni, Gang; Li, Chengjun; Xu, Sheng; Zhang, Zhaoguo; Xie, Xiaomin; Tetrahedron; vol. 71; 30; (2015); p. 4927 – 4932;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 3972-56-3, A common heterocyclic compound, 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, molecular formula is C10H13Cl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) 800Kg of p-tert-butylchlorobenzene was added to the autoclave A, and the temperature of the reaction vessel A was controlled to 0 C, and the mixed acid was mixed with concentrated sulfuric acid and nitric acid at a temperature of 0 C,Nitric acid is 580L, and the temperature of the reactor A is raised to 20 C to 25 C. The reaction vessel A is stirred and the reaction is carried out overnight. After the reaction is completed, the reaction solution is poured into water to obtain an organic phase layer and an inorganic phase layer,And then the organic phase layer solution was dried and the ethyl acetate was recovered and distilled under reduced pressure to collect 180 C / 30 mmHg column fraction. The fraction was 1-chloro-4-tert-butyl 2-nitrobenzene;

The synthetic route of 3972-56-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rudong Zhongyi Chemical Co., Ltd.; Ye Zhenjun; Dong Jiansheng; Yuan Shaozhi; Dai Yixu; Wang Zhengrong; Zhu Feng; Lu Jianhua; (7 pag.)CN105198710; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 3972-56-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(2) To 25 g of 4-tert-butylchlorobenzene synthesised in (1) above were added 20 g of sulfuryl chloride and a catalytic amount of benzoyl peroxide, and the temperature was elevated and the mixture was maintained at 100¡ã C. for 1 hour. Then, the mixture was distilled under reduced pressure to give 17.0 g of 2-(4-chlorophenyl)-2-methyl-1-chloropropane (bp.: 121¡ã-123¡ã C./10 mmHg).

The synthetic route of 1-tert-Butyl-4-chlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsuitoatsu Chemicals, Inc.; US4599362; (1986); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 3972-56-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of the aryl chloride (1 mmol), arylboronic acid (1.5 mmol), Pd(OAc)2 (0.5 molpercent), dre-NHC (0.5 molpercent), K2CO3 (1.5 mmol), in DMF:water (6 mL (1:1)) in a round bottom flask was stirred at the appropriate temperature and indicated time under an air atmosphere. The mixture was added to cold water (10 mL) and extracted with ethyl acetate (2×5 mL). The organic phase was dried with MgSO4 and filtrated through a short on silica gel column. Then volatiles were removed under reduced pressure and yields were determined by GC using undecane as an internal standard. All catalytic reactions were duplicated.

The chemical industry reduces the impact on the environment during synthesis 1-tert-Butyl-4-chlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Karaca, Emine Oezge; Akkoc, Mitat; Nawaz Tahir, Muhammad; Ar?c?, Cengiz; ?mik, Fatma; Guerbuez, Nevin; Ya?ar, Sedat; Oezdemir, ?smail; Tetrahedron Letters; vol. 58; 36; (2017); p. 3529 – 3532;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 3972-56-3,Some common heterocyclic compound, 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, molecular formula is C10H13Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a sealable reaction tube equipped with a stirring bar was charged with PdCl2(CH3CN)2 (2.6 mg, 0.01 mmol), TIP-Cy*Phine (11.1 mg, 0.02 mmol), Cs2CO3 (652 mg, 2 mmol), 1-tert-butyl-4-chlorobenzene (169 mg, 1 mmol), phenylacetylene (123 mg, 1 mmol) and 2 mL of acetonitrile. The tube was then sealed with a Teflon-lined septum and heated to 90¡ã C. for 6 h with vigorous stirring. The resulting suspension was cooled to room temperature, diluted with EtOAc and filtered through a pad of Celite. The filtrate was concentrated in vacuo affording the crude product which was purified by flash chromatography on silica gel using hexanes as the eluent to give a pure white solid (213 mg, 91percent). 1H NMR (600 MHz, CDCl3) delta=7.54 (d, J=5.8 Hz, 2H), 7.49 (d, J=8.5 Hz, 2H), 7.37 (dd, J=21.8, 7.6 Hz, 5H), 1.35 (s, 9H). 13C NMR (151 MHz, CDCl3) delta=152.08, 132.13, 131.88, 128.86, 128.61, 125.90, 124.07, 120.79, 90.09, 89.28, 35.35, 31.75.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-tert-Butyl-4-chlorobenzene, its application will become more common.

Reference:
Patent; Agency for Science, Technology and Research; Johannes, Charles W.; Robins, Edward G.; Jong, Howard; Lim, Yee Hwee; Chia, Saei Weng; Yang, Yong; Podichetty, Anil; (84 pag.)US2016/207034; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 3972-56-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

To a 30 ml of two necked flask, 26.3 mg of PdCl2(PCy3)2, 667.8 mgof Cs2CO3 were introduced. To the mixture, 5ml of DMF, 168.7 mg of 4-tert-butyl-1-chlorobenzene, 368.6 mg of 2,5-norbornadiene and 170 mg of diethylenegycohol (internal standard) were added. The mixture was stirred for 6 hours at 120 ¡ãC. The mixture was cooled to ambient temperature and poured into 30 ml of water. The combined mixture was extracted with ether (50 ml, 3 times). The organic layer was washed with water and brine. The washed organic layer was dried over MgSO4, filtered and condensed in vacuo. The residue analyzed via GC quantitatively, using internal standard. Also the residue was chromatographed on SiO2 withhexane – ethyl acetate to give 6-tert-butyl-1,4,4a,8b-tetrahydro-1,4-methanobiphenylene (2) in 62percent yield. The purified compound was determined its chemical structure with NMR analysis.

The chemical industry reduces the impact on the environment during synthesis 1-tert-Butyl-4-chlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Aida, Fuyuki; Sone, Hisashi; Ogawa, Ryuhei; Hamaoka, Takeharu; Shimizu, Isao; Chemistry Letters; vol. 44; 5; (2015); p. 715 – 717;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3972-56-3 as follows. name: 1-tert-Butyl-4-chlorobenzene

100 ml of 60% nitric acid was added dropwise to 100 ml of 95% sulfuric acid, at a temperature of 35C or less, under ice-cooling, to prepare a mixed acid solution. 100 g (0.593 mol) of 4-tert-butylchlorobenzene (A-1) was added dropwise to this mixed acid solution, at a temperature of 30C or less, followed by after-reaction (20 to 25C) for 2.5 hours. The reaction solution was poured into cold water, and it was then extracted with 100 ml of toluene, followed by washing with water, to obtain a toluene solution of (A-2).

According to the analysis of related databases, 3972-56-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJI PHOTO FILM CO., LTD.; EP1535898; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, This compound has unique chemical properties. The synthetic route is as follows., 3972-56-3

General procedure: An oven-dried Schlenk tube was evacuated and backfilled with nitrogen. The Schlenk tube was charged with Pd(bda)2 (11.5 mg,0.02 mmol), L1 (13.7 mg, 0.03 mmol), K3PO4 (424.5 mg, 2 mmol), and toluene (1.0 mL). After stirring for 15 min, the solution of arylhalide (1.0 mmol) and phenol (1.2 mmol) in toluene (1.5 mL) was added. The septum was replaced with an inside reflux condenser, and then the reaction mixture was stirred for 18 h at 110 C. Then,the reaction mixture was cooled to room temperature and quenched with water (5 mL). After separating the organic phase, the aqueous phase was extracted with ethyl acetate (3 mL3), and the combined organic phase was dried over anhydrous Na2SO4. The solvent was concentrated under reduced pressure, and then the crude material was purified by column chromatography on silica gel

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Zhang, Yi; Ni, Gang; Li, Chengjun; Xu, Sheng; Zhang, Zhaoguo; Xie, Xiaomin; Tetrahedron; vol. 71; 30; (2015); p. 4927 – 4932;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics