Category: 39885-50-2

Application of 39885-50-2,Some common heterocyclic compound, 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, molecular formula is C7H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-1-(2-chloro-4-trifluoromethylphenyl)-3-cyanopyrazole in the form of an orange crystalline solid, m.p. 133°-135° C., from 2-chloro-4-trifluoromethylaniline. 5-Amino-3-cyano-1-(2,4,6-trichlorophenyl)pyrazole in the form of a light brown solid, m.p. 155-156° C., from 2,4,6-trichloroaniline.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-4-(trifluoromethyl)aniline, its application will become more common.

Reference:
Patent; Hatton; Leslie R.; Buntain; Ian G.; Hawkins; David W.; Parnell; Edgar W.; Pearson; Christopher J.; Roberts; David A.; US5232940; (1993); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 39885-50-2,Some common heterocyclic compound, 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, molecular formula is C7H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 6 A mixture (301 g) of 2-chloro-4-trifluoromethylaniline, 2-chloro-5-trifluoromethylaniline and N-methylpyrrolidone (NMP) (1.06 m/m) was mixed with 500 ml chlorobenzene. Sulfuryl chloride (148.4 g) was added to the mixture at 55-60° C. over a period of 4 hours and the reaction mixture was maintained at 55-60° C. for 4 hours. Reaction medium on treatment and fractionation gave 0.84 m of 2,6-dichloro-4-trifluoromethylaniline, 95percent yield on 2-chloro-4-trifluoromethyl aniline.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-4-(trifluoromethyl)aniline, its application will become more common.

Reference:
Patent; Gharda, Keki Hormusji; US2013/30190; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Chloro-4-(trifluoromethyl)aniline

General procedure: Aniline (140mg, 1.5mmol) and Et3N (202mg, 2mmol) were dissolved in 5mL of dichloromethane and slowly added dropwise to a solution of triphosgene (BTC) (223mg, 0.75mmol) in 10mL of dichloromethane at 0°C. The mixture was then stirred at 0°C for 1h. Then, 5a (300mg, 1mmol) in 1mL of DMF was added at 0°C, and the mixture was then stirred at room temperature for 30min, and the solvent was distilled with a rotary evaporator. The residue was washed with water (10mL×3) and purified via silica gel flash column chromatography to afford 1-(3-((2S,5S)-5-((1H-indol-3-yl)methyl)-3,6-dioxopiperazin-2-yl)propyl)-3-phenylurea (6a) as a pale powder in 74percent yield. Compounds 6b?v, 7a?k and 8a?k were prepared similar to 6a.

The synthetic route of 39885-50-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sun, Haiyang; Li, Hui; Wang, Jiayi; Song, Gonghua; Chinese Chemical Letters; vol. 29; 6; (2018); p. 977 – 980;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 39885-50-2, A common heterocyclic compound, 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, molecular formula is C7H5ClF3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 4Preparation of 2-chloro-6-iodo-4-(trifluoromethyl)benzenamineIodine monochloride (17.2 g, 108 mmol) in hydrochloric acid (36percent, 21.4 g) and water (35 mL) was added dropwise to 2-chloro-4-(trifluoromethyl)benzenamine (20.0 g, 102 mmol) in hydrochloric acid (36percent, 20.7 g) and water (140 mL). The mixture was warmed to 50 0C for a total of 8 h. Sodium hydroxide (50percent, 33.5 g, 419 mmol) was added to the mixture at room temperature. The mixture was extracted with dichloromethane (2 x 250 mL), and the extracts were dried and evaporated to give the product as an oil (31.83 g, 97percent yield). 1H NMR (CDCl3) 7.78 (s, IH), 7.5 (s, IH), 4.87 (br s, 2H).

The synthetic route of 39885-50-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2009/126668; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39885-50-2 as follows. Quality Control of 2-Chloro-4-(trifluoromethyl)aniline

EXAMPLE 59 8-Chloro-N-((4-chlorophenyl)methyl)-4-hydroxy-5-trifluoromethyl-3-quinolinecarboxamide [] A mixture of 2-chloro-5-trifluoromethylaniline (3.91 g) and diethyl ethoxymethylenemalonate (4.0 mL) is heated at 190°C for 2 h and is then diluted with diphenyl ether (30 mL). The mixture is allowed to cool to rt, filtered, and the white solid is washed with hexane (2 x 10 mL) to afford 1.632 g of the diethyl aminomethylenemalonate. The resulting intermediate (2.63 g) is suspended in diphenyl ether (30 mL) and heated to reflux with a Dean-Stark trap for 3 h. The mixture is allowed to cool to rt and is then poured into hexane (50 mL). The solid is filtered and then washed with hexane (20 mL) and hexane/diethyl ether (1/1, 20 mL) to afford 1.273 g of the quinolinecarboxylate ethyl ester. The ester (400 mg) and 4-chlorobenzylamine (1.52 mL) are heated at 190 °C for 1 h. The resulting mixture is diluted with toluene (4 mL), allowed to cool to rt, and then poured into hexane (50 mL). The solvent is decanted and the remaining oil is crystallized (acetic acid, water) to afford 285 mg of the title compound as a brown solid. Physical characteristics are as follows: Mp 270-1 °C.1H NMR (300 MHz, DMSO) delta 12.33, 10.06, 8.68, 8.10, 7.86, 7.36, 4.52.13C NMR (100 MHz, DMSO) delta 175.05, 164.07, 144.36, 139.12, 138.20, 132.42, 131.85, 129.84, 128.77, 128.44, 126.70 (q), 125.84, 125.20, 122.22, 113.75, 42.00.IR (mull) 3187, 3091, 2925, 2855, 1657, 1604, 1567, 1531, 1462, 1417, 1377, 1366, 1348, 1307, 1272, 1210, 1158, 1139, 1128, 1106, 854, 841, 802, 726 cm-1.Anal. Found: C, 52.12; H, 2.78; N, 6.70; Cl, 16.85.MS (ESI-) for C18H11Cl2F3N2O2m/z 412 (M-H)-.

According to the analysis of related databases, 39885-50-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pharmacia & Upjohn Company LLC; EP1042295; (2005); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-4-(trifluoromethyl)aniline

A mixture of 2-chloro-7- ( 1-ethylpropyl) -4-methoxy-l- methyl-ltf-benzimidazole (200 mg, 0.750 mmol) and 2-chloro- 4-trifluoromethylaniline (450 mg, 2.25 mmol) in l-methyl-2- pyrrolidone (0.5 mL) was stirred at 12O0C for 96 h under nitrogen atmosphere. The mixture was diluted with aqueous saturated sodium hydrogen carbonate solution and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel with a 5-30percent ethyl acetate/n- hexane gradient mixture. The filtrate was concentrated in vacuo to give the solid, which was recrystallized from methanol to afford the title compound as colorless crystals(103 mg, 32percent) . mp 170-1710C.1H NMR (CDCl3) delta 0.85 t, J = 7.5 Hz, 6H), 1.60-1.85 (m, 4H), 3.15-3.20 (m, IH) 3.88 (s, 3H), 4.00 (s, 3H), 6.71 (d, J = 8.4 Hz, IH) , 6.85 (s, IH), 6.99 (d, J = 7.8 Hz, IH), 7.50 (d, J = 8.4 Hz, IH) , 7.65 (s, IH), 8.00 (d, J = 7.8 Hz, IH) .MS Calcd. : 425; MS Found: 426 (M+H) , 428.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/51533; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Computed Properties of C7H5ClF3N

Reference Example 13 7-Benzyloxy-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine A mixture of 7-(Benzyloxy)-5-chloro-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine(53.0 g), 2-chloro-4-(trifluoromethyl)aniline(38.1 g), tris(dibenzylideneacetone)dipalladium(0)(5.10 g), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene(9.66 g)(a compound obtained in Reference Example 12), cesium carbonate(90.7 g) and 1,4-dioxane(1.05 L) was heated under reflux for 16 hours under argon atmosphere. After being cooled to room temperature, ethyl acetate(1 L) was added to the reaction mixture and filtered through Celite. The residue on the Celite was washed with ethyl acetate(1 L) and chloroform(500 mL), the washings were combined with the filtrate, and concentrated under reduced pressure. The resulting residue was crystallized and triturated in ethyl acetate-diethyl ether(1:1) and the crystalline was filtered and washed with ethyl acetate-diethyl ether(1:1). The obtained crystalline was dried to give the titled compound(43.7 g, 58percent yield) as a pale yellow crystalline. mp.189-192¡ãC, MS(APCI)M/z:540/S42[M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1903045; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 39885-50-2, The chemical industry reduces the impact on the environment during synthesis 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life.

5-Amino-1-(2-chloro-4-trifluoromethylphenyl)-3-cyanopyrazole in the form of an orange crystalline solid, m.p. 133-135¡ãC, from 2-chloro-4-trifluoromethylaniline. 5-Amino-3-cyano-1-(2,4,6-trichlorophenyl)pyrazole in the form of a light brown solid, m.p. 155-156¡ãC, from 2,4,6-trichloroaniline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RHONE-POULENC AGRICULTURE LIMITED; EP295117; (1988); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 39885-50-2,Some common heterocyclic compound, 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, molecular formula is C7H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of ethyl (2E) -3- (4- (2-methoxyethoxy) -2- { [ (trifluoromethyl) sulfonyl] oxy}phenyl) acrylate (1.66 g) in tetrahydrofuran (20 ml) were added 2-chloro-4- . (trifluoromethyl) aniline (1.89 g) , racemic-2, 2′ – bis(diphenylphosphino)-l,l’-binaphthyl (519 mg) , palladium acetate (140 mg) and cesium carbonate (2.06 g) , and the mixture was heated under reflux for 8 hr. After cooling, water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl -acetate layer was washed with saturated brine, dried (MgSO4) , and concentrated. The obtained residue was subjected to silica gel column chromatography, and eluted with ethyl acetate-hexane (1:3, v/v) to give ethyl (2E) -3- [2-{ [2-chloro-4- (trifluoromethyl) phenyl] amino} -4- (2- methoxyethoxy) phenyl] acrylate (1.00 g, yield: 54percent) as yellow crystals.1H-NMR (300 MHz, CDCl3) 6:1-29 (3 H, t, J = 7.2 Hz), 3.44 (3 H, s) , 3.73 – 3.79 (2 H, m) , 4.16 – 4.27 (4 H, m) , 6.23 (1 H, s) , 6.34 (1 H, d, J = 15.9 z) , 6.55 – 6.59 (1 H, m) , 6.85 – 6.91 (2 H, m),.7.32 – 7.62 (-3 H, m) , 7.77 (I H, d, J = 15.9 Hz)..

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-4-(trifluoromethyl)aniline, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

39885-50-2, A common compound: 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

(b) raney Nickel (0.7 g) was added to a solution of the above isomer mixture (35.85 g) in ethanol in a hydrogenation reactor at 50¡ã C. under hydrogen at 5 bar for 5 hours.. The mixture was cooled, filtered and evaporated to give a 95/5 mixture of 2-chloro-4-trifluoromethylaniline and 2-chloro-5-trifluoromethylaniline (33.1 g).. hydrogen chloride gas was added over 0.5 hour to a solution of the above mixture in ethanol and chlorobenzene, cooled to 0¡ã C., and filtered to give 2-chloro-4-trifluoromethylaniline hydrochloride (33.5 g), having a purity of >99percent.. The overall yield from 3,4-dichlorobenzotrifluoride was 85percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Aventis CropScience, S.A.; US6410737; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics