Category: 41332-02-9

Reference of 41332-02-9,Some common heterocyclic compound, 41332-02-9, name is 1-(2-Chloroethyl)naphthalene, molecular formula is C12H11Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A borosilicate glass tube (OD 0.6 mm, length 12 cm) was packed with PS-supported P2tBu (150 muiotatauiotaomicron base, loading 1.6 mmol/g, 93.75 mg) mixed with glass beads (212-300 mutaueta, 100-500 mg) and placed in a column oven in a LabView controlled automation apparatus. 18F- trapping: 18F- (target water, 3.5 mL, 500-5000 MBq) passed through the column at room temperature (flow 1.5 mL/min) . MeCN (dry, 4 ml, flow 2 mL/min) was passed through the column at room temperature followed by a helium gas flush through the column until excess of solvent was removed. Radiofluorination : Radiofluorination solvent (MeCN for mannose triflate, MeCN/tBuOH 1:5 for FLT-ONs, toluene for the naphthalene analogues and 2-nitro-3-methoxypyridine, dry, 4 mL, flow 2 mL/min) was passed through the column at room temperature followed by the substrate (50-100 muiotatauiotaomicron) dissolved in radiofluorination solvent (dry, 3 mL) and passed through the column at 120C (flow 0.55 mL/min) . Radiofluorination solvent (dry, 2 mL, flow 0.55 mL/min) was then passed through the column to elute the remaining product. The fluorinated product wasanalyzed by radio-TLC (eluent heptane : EtOAc 80:20 for the naphthalene analogues, MeCN:H20 95:5 for hydrolyzed FDG, DCM : MeOH 9:1 for hydrolyzed FLT, petroleum ether :EtOAc for the pyridine analogue).

The synthetic route of 41332-02-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TECHNICAL UNIVERSITY OF DENMARK; ZHURAVLEV, Fedor; MATHIESSEN, Bente; WO2014/20035; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 41332-02-9,Some common heterocyclic compound, 41332-02-9, name is 1-(2-Chloroethyl)naphthalene, molecular formula is C12H11Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An aqueous solution of [18F]F- (0.5-3.5 mL, flow rate 0.5-30 mL/min) was passed through the column (borosilicate glass tubing, ID 4 mm, OD 0.6 cm, length 12 cm) packed with the resin (5-500 mumol; glass beads to fill the remaining volume). To remove the bulk of water, the column was flushed with He(gas) (flow rate 100 mL/min, 3 min). The column was dried by passing MeCN oracetone (1-10 mL, flow rate 1.5-20 mL/min) through, followed by a helium flush (100 mL/min,2-5 min). The column was primed by passing the radiofluorination solvent (MeCN for mannosetriflate, MeCN/tBuOH 1:5 for FLT-ONs, toluene for the naphthalene derivatives and 2-nitro-3-methoxypyridine, dry, 4 mL, flow rate 2 mL/min) through the column at room temperature followed by the substrate (50-100 mumol) dissolved in the radiofluorination solvent (dry, 3 mL) at 60-120 C (flow rate 0.55 mL/min). The radiofluorination solvent (dry, 2 mL, flow rate 0.55 mL/min) was then passed through the column again to elute the remaining product. The reaction mixture was analyzed by radio-TLC (eluent heptane:EtOAc 80:20 for the naphthalene derivatives, MeCN:H2O 95:5 for FDG, DCM:MeOH 9:1 for hydrolyzed FLT, petroleum ether:EtOAc 3:1 for the pyridine derivative. Total timeof radiosynthesis was 35-45 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Chloroethyl)naphthalene, its application will become more common.

Reference:
Article; Mathiessen, Bente; Zhuravlev, Fedor; Molecules; vol. 18; 9; (2013); p. 10531 – 10547;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics