Category: 4152-90-3

Related Products of 4152-90-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4152-90-3, name is (3-Chlorophenyl)methanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 250 mL round bottom flask equipped with a stir bar was added 4-chloro-3-[(2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid (4.8 g, 12.3 mmol), DMF (50 mL), triethylamine (8.3 mL, 60.0 mmol), 3-chlorobenyzl amine (2.2 mL, 18.0 mmol) and then HATU (6.84 g, 18.0 mmol). The reaction was allowed to stir at room temperature for 12 hours, after which it was diluted with ethyl acetate, filtered and then successively rinsed with water and ethyl acetate. The collected solid was dried in an vacuum oven (70¡ã C.) overnight to provide 2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]amide. (Yield 5.5 g, 87percent).HR-MS (ES+) m/z Calculated for C23H18Cl2N5O3S ([M+H]+): 514.0502. Found: 514.0503.

The synthetic route of (3-Chlorophenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 4152-90-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4152-90-3 as follows.

To compound 2 (3 g, 9.2 mmol) at room temperatureEthanol (50mL)Et3N (2.6 mL, 18.4 mmol) was added to the solution.And 3-chlorobenzylamine (2.1 mL, 18.4 mmol),The resulting mixture was stirred at 40 ¡ã C for 5 h;Concentrated and the residue is purified by silica gel column(by volume ratio, DCM: MeOH: NH3¡¤H2O=200:10:0.1),Obtaining colorless oily compound 3(3.13g, 82percent),

According to the analysis of related databases, 4152-90-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Bio-technology Institute; The Chinese People’s Liberation Army Military Academy Of Sciences Military Medical Institute; Liu Mingliang; Lv Kai; Zhong Wu; Cao Ruiyuan; Wang Apeng; Yan Yunzheng; Tao Zeyu; He Qinghao; Wang Hongjian; Li Wei; Geng Yunhe; (29 pag.)CN108892693; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 4152-90-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4152-90-3, name is (3-Chlorophenyl)methanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of 4-tert-butylbenzylamine (1a, 0.3 mmol), K2CO3 (3.7 equiv), and MB (1.0 mol%) in dry MeCN (5 mL) in a Pyrex test tube, purged with an O2 balloon, was stirred and irradiated externally with four 22 W fluorescent lamps for 10 h. Products were purified by filtration through a pad of silica gel (3 mm thick) with Et2O, and the filtrate was concentrated.

The synthetic route of (3-Chlorophenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Okada, Akifumi; Yuasa, Hiroki; Fujiya, Akitoshi; Tada, Norihiro; Miura, Tsuyoshi; Itoh, Akichika; Synlett; vol. 26; 12; (2015); p. 1705 – 1709;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 4152-90-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4152-90-3 as follows.

A solution of tert-butyl (trans)-2-(6-bromopyridin-3-yl)cyclopropylcarbamate (Intermediate E, 350 mg, 1.118 mmol), 3-chlorobenzylamine (237 mg, 1.677 mmol), Sodium tert-butoxide (161 mg, 1.677 mmol) in 1,4-dioxane (7 mL) was degassed for 30 min, tris(dibenzylidene acetone)dipalladium(0) (51 mg, 0.055 mmol), 4,5-Bis(diphenyl phosphino)-9,0-dimethyl xanthene (193 mg, 0.335 mmol) was added and heated for 4 h at 80¡ã C. After completion, the solvent was removed, the residue was poured into ice cold water (10 mL) and extracted with EtOAc (2*20 mL). The combined extracts were washed with water (10 mL), brine (10 mL), dried over anhydrous Na2SO4, filtered and evaporated. The crude residue was purified by flash chromatography to give tert-butyl (trans)-2-(6-(3-chlorobenzylamino) pyridin-3-yl)cyclopropyl carbamate (100 mg, yield: 24percent) as white solid.

According to the analysis of related databases, 4152-90-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Laria, Julio Castro-Palomino; Fyfe, Matthew Colin Thor; Pedemonte, Marc Murtinell; Munoz, Alberto Ortega; Valls Vidal, Nurla; US2013/289076; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 4152-90-3, name is (3-Chlorophenyl)methanamine, molecular formula is C7H8ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H8ClN

To a mixture of 6-bromo-2,4-dichloroquinazoline (278 mg, 1.0 mmol) and (3-chlorophenyl)methanamine (142 mg, 1.0 mmol) in THF (2 ml) was added Et3N (0.209 ml, 1.5 mmol). The mixture was stirred at rt for 1 h. The mixture was poured into EtOAc/H2O (5 mL/5 mL). The aqueous layer was extracted with EtOAc (3 mL x 2). The combined organic layer was dried (Na2SO4) and filtered. After removal of solvent, the product was triturated with hexane and dried to give 6-bromo-2-chloro-N-(3-chlorobenzyl)quinazolin-4-amine (360 mg, 0.94 mmol, 94 percent yield) as a white solid. LC-MS (Method 1): tR = 3.69 min, m/z (M+H)+ = 384.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4152-90-3, its application will become more common.

Reference:
Article; Yang, Shyh-Ming; Urban, Daniel J.; Yoshioka, Makoto; Strovel, Jeffrey W.; Fletcher, Steven; Wang, Amy Q.; Xu, Xin; Shah, Pranav; Hu, Xin; Hall, Matthew D.; Jadhav, Ajit; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 21; (2018); p. 3483 – 3488;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4152-90-3, name is (3-Chlorophenyl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 4152-90-3

A solution of 5-chloro-jV-cyclohexylpyrazolo[ 1 ,5-alpha]pyrimidine-3-carboxamide(28 mg, 0.09 rnM, 1.0 equiv), 3-chlorobenzylamine (28 mg, 0.18 rnM, 2.0 equiv), N5N- diisopropylethylamine (26 mg, 0.18 rnM, 2.0 equiv) and 2 rnL of ethanol were microwaved at 120 0C for 10 minutes. TLC (95:5 dichloromethane methanol) showed reaction complete. The reaction mixture was cooled, the crystalline product collected by filtration, washed with cold ethanol and air dried to yield 29.7 mg (77percent) of 5-(3-chlorobenzylamino)-7V- cyclohexylpyrazolo[l,5-alpha]pyrimidine-3-carboxamide. LCMS (ESI) m+H = 384.2; 1H NMR (400 MHz, OMSO-d) delta: 8.61 (overlapping d and t, 2 H), 8.06 (s, 1 H), 7.60 (d, 1 H), 7.4- 7.25 (m, 4 H), 6.49 (d, 1 H), 3.70 (m, 1 H), 1.75-1.5 (m, 5 H), 1.4-0.8 (m, 5 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GENENTECH, INC.; BLANEY, Jeffrey; GIBBONS, Paul A.; HANAN, Emily; LYSSIKATOS, Joseph P.; MAGNUSON, Steven R.; PASTOR, Richard; RAWSON, Thomas E.; ZHOU, Aihe; ZHU, Bing-Yan; WO2010/51549; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4152-90-3, name is (3-Chlorophenyl)methanamine, A new synthetic method of this compound is introduced below., Safety of (3-Chlorophenyl)methanamine

General procedure: Benzylamine (0.214 g, 2.00 mmol), [VO(PS-BBMA]SO4 (80 mg, 0.08 mmol) and H2O2 (4 mmol) was heated at 80 C for 10 h in a round bottom flask under nitrogen atmosphere. The reaction was monitored by TLC, and after complete consumption of benzylamine, the reaction mixture was cooled to room temperature, filtered and concentrated in vacuo. The residue was purified by column chromatography (ethyl acetate: hexane=1:8) to afford benzamide. The product was analyzed by 1H NMR spectroscopy.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Renuka; Gayathri; Catalysis Communications; vol. 121; (2019); p. 89 – 94;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 4152-90-3, name is (3-Chlorophenyl)methanamine, molecular formula is C7H8ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4152-90-3

Example 1 2-amino-6-(3-chlorobenzylamino)purine 4 mmol of 2-amino-6-chloropurine were dissolved in 20 mL of butanol and then 5 mmol of 3-chlorobenzylamine and 6 mmol of triethylamine were added. The mixture was reacted at 90¡ã C. for 4 hr. After cooling, the product was filter out and washed with water and butanol and crystallized from dimethyformamide or ethanol. HPLC: purity>98percent. Yield 95percent. Table 1 compound prepared by the method of example 1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4152-90-3, its application will become more common.

Reference:
Patent; CHEN, Han-Min; KUO, Cheng-Yi; HUANG, Chun-Fang; LIN, Jiun-Tsai; US2014/303112; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics