Category: 41965-95-1

Electric Literature of 41965-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

9-((3-chloro-4-methoxybenzyl)amino)-2-ethyl-7-methoxy-2,3-dihydro-lH- pyrrolo[3,4-b]quinolin-l-one L [00289] A solution of 43 (0.11 mmol), 3-chloro-4-methoxybenzylamine hydrochloride (0.16 mmol) and (‘pr)2NEt (0.66 mmol) in n-propanol (1.5 mL) was heated to 90 C for lh. The solvent was evaporated off and the residue was purified by flash chromatography (AcOEt: MeOH 19: 1) to give the final product L. MS ESI (m/z) 412 (M+H)+; 1H NMR (400 MHz, CDC13) delta 8.14 (t, 1H, J=6.4 Hz), 7.85 (d, 1H, J=9.6 Hz), 7.48 (d, 1H, J=2.4 Hz), 7.37-7.29 (m, 3H), 6.95 (d, 1H, J=8.8 Hz), 4.95 (d, 2H, J=6.8 Hz), 4.38 (s, 2H), 3.90 (s, 3H), 3.66 (q, 2H, J=7.2 Hz), 3.59 (s, 3H), 1.28 (t, 3H, J=7.2 Hz)

The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; FIORITO, Jole; ARANCIO, Ottavio; WASMUTH, Andrew; WO2015/9930; (2015); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, molecular formula is C8H11Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H11Cl2NO

A solution of 3-chloro-4-methoxybenzylamine hydrochloride (0.59 g, 2.8 mmol)And triethylamine (0.29 g, 2.8 mmol) were added dropwise to the above-mentioned spare solution, and the reaction was carried out for 2 hours. After addition, L-proline alcohol (0.43 g, 4.3 mmol) was added to the reaction solution, The reaction was carried out at room temperature for 4 hours.The reaction solution was poured into ice water, quenched and extracted twice with methylene chloride. The organic phase was combined and washed twice with water, dried over anhydrous sodium sulfate,The resulting crude column was concentrated to give 0.8 g of a white solid, i.e., avanafil, in 32% yield

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41965-95-1, its application will become more common.

Reference:
Patent; SUZHOU WANGSHAN WANGSHUI BIOMEDICAL CO LTD; TOPHARMAN SHANGHAI CO LTD; SHANDONG TOPHARMAN PHARMACEUTICAL CO LTD; TIAN, GUANGHUI; LI, JUNQI; (17 pag.)CN104650045; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, molecular formula is C8H11Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

10-[(3-chloro-4-methoxybenzyl)amino]-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile A mixture of 4 (0.12 mmol), 3-chloro-4-methoxybenzylamine hydrochloride (0.12 mmol), NaI (0.006 mmol), and phenol (0.12 mmol) was heated at 130 C. for 2.5 h. The reaction mixture was diluted with Et2O (10 mL) and washed with 1N NaOH (3*5 mL). The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by Flash Chromatography (AcOEt:MeOH 8:2) to give the desired compound B (33% of yield). MS ESI (m/z) 394 (M+H)+, 1H NMR (300 MHz, CDCl3) delta 8.32 (d, 1H, J=1.2 Hz), 7.97 (d, 1H, J=8.7 Hz), 7.71 (dd, 1H, J1=1.8, J2=8.7 Hz), 7.37 (d, 1H, J=2.1 Hz), 7.18 (dd, 1H, J1=2.4, J2=8.7 Hz), 6.94 (d, 1H, J=8.4 Hz), 4.57 (d, 2H, J=6.0 Hz), 4.11 (br s, 1H), 3.92 (s, 3H), 3.54 (s, 2H), 3.22 (t, 2H, J=6.3 Hz), 2.83 (t, 2H, J=6.3 Hz), 2.52 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41965-95-1, its application will become more common.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; Landry, Donald W.; Deng, Shixian; Arancio, Ottavio; Fiorito, Jole; Wasmuth, Andrew; (41 pag.)US10626113; (2020); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 41965-95-1, The chemical industry reduces the impact on the environment during synthesis 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, I believe this compound will play a more active role in future production and life.

Methyl 2-ch]oro^-[(3-chloro^-methoxybenzyi)amino]-6-cyanoquinoime-3- carboxylate, 14 [00171] To a heterogenous mixture of quinoline 13 (3.56 mmol) and 3-chloro-4-methoxy benzylamine-HCl (3.92 mmol) in NMP (15 mL) was added ‘Pr2NEt (8.90 mmol). The reaction mixture was heated to 80 C for 3 h. Subsequently, cooled the reaction mixture to ambient temperature and added 1M aqueous HC1 and EtOAc. The resulting layers were separated and the organic layer washed with water (3x) followed by brine (lx). The combined organic layers were dried over Na2S04, filtered, and concentrated in vacuo. The residue was dissolved in a minimum amount of hot EtOAc and allowed to cool to ambient temperature. Hexanes was then added to the solution and the intermediate 14 (80% yield) precipitated out and was collected by vacuum filtration. lU NMR (300 MHz, CDCI3) delta 8.20 (s, I I I ). 7.95 (d, i Pi. ./ 8.4 Hz), 7.82 (d, 1 1 1. 7 5 Hz), 7.38 (s, 1 H), 7.27-7.22 (m, 1H), 6.98 (d, 1 H, J=8.4 Hz), 6.26 is, 1H), 4.54 id, 2H J=4.8 Hz), 3.95 (s, 3H), 3.93 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-methoxybenzylamine Hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; FIORITO, Jole; ARANCIO, Ottavio; WASMUTH, Andrew; WO2015/9930; (2015); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 41965-95-1,Some common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, molecular formula is C8H11Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N,N-Diisopropylethylamine (4.0 mL, 22.9 mmol, 4.0 eq.) was added to a mixture of 28 (2.0 g, 5.23 mmol, 1.0 eq.) and (3-chloro-4-methoxyphenyl)methanamine hydrochloride [29] (1.8 g, 8.41 mmol, 1.6 eq) in n-propanol (40 mL). The resulting mixture was heated at reflux for 16 h. After cooling to room temperature, water (40 mL) was added to the reaction mixture. The formed precipitate was filtered, washed successively with water (20 mL) and ethanol (20 mL) and then dried in a desiccator to afford the desired product 29 (2.3 g, 4.44 mmol, 85%) as a white solid. Rf (SiO2, cyclohexane/ethyl acetate, 7/3, v/v): 0.48; Mp: 140-142 C; IR (cm-1): 1701 (nuC=O), 1320 (nuCF3), 1281 (nuC-O), 1110 (nuC-O), 1031 (nuC-O); 1H NMR (CDCl3, 400 MHz) delta 9.79 (brs, 1H, NH), 9.33 (s, 1H, H2), 8.41 (m, 1H, H5), 8.18 (d, 1H, 4JH7-H5 = 1.5 Hz, H7), 7.40 (d, 1H, 4JH2?-H6?= 2.2 Hz, H2?), 7.24 (m, 1H, H6?), 6.96 (d, 1H, 3JH5?-H6?= 8.5 Hz, H5?), 4.87 (d, 2H, 3JHd-NH = 5.9 Hz, Hd), 4.40 (q, 2H, 3JHb-Hc= 7.1 Hz, Hb), 3.92 (s, 3H, He), 1.41 (t, 3H, 3JHc-Hb= 7.1 Hz, Hc); 13C NMR (CDCl3, 100 MHz) delta 167.3 (Ca), 154.5 (C4), 154.1 (2C, C4?, C8a), 148.6 (C2), 131.1 (C1?), 130.2 (C2?), 129.6 (C6?), 127.9 (C7), 126.2 (C8), 125.2 (q, 2JC6-F = 33 Hz, C6), 123.8 (d, 1JCF3-F = 271 Hz, CF3), 123.4 (C3?), 121.6 (C5), 120.1 (C4a), 113.4 (C5?), 105.9 (C3), 61.5 (Cb), 56.6 (Ce), 49.9 (Cd), 14.4 (Cc); HRMS calculated for C21H1779Br35ClF3N2O3 [M+H]+ m/z 517.0141, found C21H1779Br35ClF3N2O3 [M+H]+ m/z 517.0150 (77%); C21H1781Br35ClF3N2O3 or C21H1779Br37ClF3N2O3 [M+H]+ m/z 519.0163 (100%); C21H1781Br37ClF3N2O3 [M+H]+ m/z 521.0134 (24%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-4-methoxybenzylamine Hydrochloride, its application will become more common.

Reference:
Article; Liu, Jianrong; Maisonial-Besset, Aurelie; Wenzel, Barbara; Canitrot, Damien; Baufond, Ariane; Chezal, Jean-Michel; Brust, Peter; Moreau, Emmanuel; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 548 – 560;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H11Cl2NO

Preparation of Compound IV:3-Chloro-4-methoxybenzylamine hydrochloride III (25.00 g, 0.12 mol)Suspended in 75mL acetonitrile,Add sodium bicarbonate (23.21 g, 0.27 mol),Compound II (22.02 g, 0.11 mol) was added,Stir at 40 degrees for 2.5 hours.The reaction solution was suction filtered,The filter cake was washed once with 10 mL of acetonitrile.Wash once with 10 mL of water.After the filter cake is dried by phosphorus pentoxide,32.01g of white solid compound IV,The yield was 87.37%.

The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Wu Wenchao; Song Dandan; Zhang Chi; Cui Xilin; (10 pag.)CN110117274; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 41965-95-1

To a 25 ml three-necked flask was added ethyl 2,4-dichloro-5-pyrimidinecarboxylate (150 mg, 0.679 mmol)Triethylamine (270 mg, 2.668 mmol), dichloromethane (2 ml), gradually stirred to dissolve,The ice bath was cooled to 0 C or below, and 3-chloro-4-methoxybenzylamine hydrochloride (145 mg, 0.697 mmol) was added in portions to the reaction solution, and the reaction was carried out for two hours after completion of the addition.L-proline (105 mg, 1.038 mmol) was added dropwise to the reaction solution, and the reaction was continued for 2 hours.The reaction solution was added to water (30 ml) and extracted with dichloromethane.The organic phases were combined, washed twice, dried over anhydrous sodium sulfate, the desiccant was filtered off, and the organic phase was concentrated to the crude product.The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 6: 1) to give 200 mg of product in 70% yield.

The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUZHOU WANGSHAN WANGSHUI BIOMEDICAL CO LTD; TOPHARMAN SHANGHAI CO LTD; SHANDONG TOPHARMAN PHARMACEUTICAL CO LTD; TIAN, GUANGHUI; LI, JUNQI; (17 pag.)CN104650045; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 41965-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(3-Chloro-4-methoxyphenyl) methanamine hydrochloride compound of formula-6a (76.98 g) was added to the organic layer containing ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate compound of formula-5, which is obtained in step-b). Water (100 ml), followed by sodium carbonate (110.3 g) were added to the reaction mixture at 25-30C and stirred for 4 hours at the same temperature. After completion of the reaction, water was added to it. Both the organic and aqueous layers were separated; the aqueous layer was extracted with toluene. All the organic layers were combined and washed with water. Distilled off the solvent from the organic layer under reduced pressure. The reaction mixture was cooled to 30-35C. 700 ml of cyclohexane: ethyl acetate (in 9.5:5 ratio) was added to the reaction mixture. The reaction mixture was heated to 70-75C and stirred until complete dissolution. The reaction mixture was cooled to 10-15C and stirred for 3 hours. Filtered the precipitated solid, washed with cyclohexane and then dried to get title compound.Yield: 90 gms; Melting range: 81 -84C; Purity by HPLC: 95.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-methoxybenzylamine Hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MSN LABORATORIES PRIVATE LIMITED; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; SATYANARAYANA, Komati; WO2015/1567; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, A new synthetic method of this compound is introduced below., SDS of cas: 41965-95-1

2-Amino-4-chlorobenzoic acid (1.0 g; 5.83 mmol), 15 ml of dry DCM, and TEA (4.87 ml; 35.0 mmol) were placed in a reaction flask under nitrogen. 3-Chloro-4- methoxybenzylamine hydrochloride (1.213 g; 5.83 mmol) was added slowly and then T3P (6.87 ml; 1 1.66 mmol; 50 % in EtOAc) was added keeping the temperature at rt. The mixture was stirred at rt overnight. The reaction mixture was diluted with DCM and washed three times with water. The organic phase was dried with a phase separator and evaporated to dryness to yield 1.58 g of 2-amino-4-chloro-N-(3-chloro-4-methoxybenzyl)benzamide. LC-MS (ES) [M+l]: 327.1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ORION CORPORATION; PRUSIS, Peteris; HOeGLUND, Lisa; TOeRMAKANGAS, Olli; HIETANEN, Ari; ARVELA, Riina; VESALAINEN, Anniina; HEIKKINEN, Terhi; WO2015/169999; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 41965-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41965-95-1 name is 3-Chloro-4-methoxybenzylamine Hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure N: Amide coupling (10):In a glass vial, under inert atmosphere (N2), to a solution of the carboxylic acid (1.0 eq.) in CH2CI2 (0.25 M) were added HOBt (1.20 eq.), DMAP (0.25 eq.), EDC HCI (2.5 eq.) and DIPEA (4.0 eq.). The reaction mixture was stirred at rt for 30 min. An amine (2.0 eq.) was then added and the reaction mixture stirred at rt until completion of the reaction. DMF (0.3 vol. CH2CI2) and PL-SO2CI2 (1.0 eq.) were added and after stirring at rt for 1 h the mixture was filtered (CH2CI2) and concentrated under reduced pressure. Purification of the residue by FC or HPLC gave the desired compound.; Example 374:(Sf^-Lambda/^S-Chloro^-methoxyphenyl-methyO-tef^-Lambda^^-pyrrolidino-butyO^S*^/?*)- [4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt:Following general procedure N, starting from (5R*)-5-hydroxycarbonyl-(6R*)-Lambda/6-(4- pyrrolidin-1-yl-butyl)-(4S*,7/?*)-[4,7-ethenylene-spiro[2.4]heptane]-6-carboxamide and 3- chloro-4-methoxybenzylamine hydrochloride.LC-MS-conditions FA: tR = 0.75 min; [M+H]+ = 486.24.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-4-methoxybenzylamine Hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; CORMINBOEUF, Olivier; CREN, Sylvaine; GRISOSTOMI, Corinna; LEROY, Xavier; RICHARD-BILDSTEIN, Sylvia; WO2010/134014; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics