Category: 42265-67-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42265-67-8, name is 4-(tert-Butyl)-2-chloroaniline, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 42265-67-8

a) 4-t-Butyl-2-chloroaniline (30 g) was dissolved in dichloromethane (1.21) and the solution was cooled to -5 C. N-Chlorosuccinimide (21.7 g) was added portionwise to the vigorously stirred solution and stirring was continued for 1 h. Dimethyl sulfide (36 ml) was added to the solution (-5 C.) and stirring was continued for a further 1 h. The solution was then cooled to -65 C. and triethylamine (27 ml) was added. This solution was evaporated to half volume, washed successively with sodium hydroxide (1N), water and brine. The organic solution was dried (MgSO4) and evaporated in vacuo and the residue was purified on silica using hexane to 3% ether in hexane as eluent. This afforded 4-t-butyl-2-chloro-6-(methylthiomethyl)aniline (31.2 g) as a red oil. 1 H NMR (250 MHz, CDCl3) delta1.27 (9H, s, (CH3)3, 1.99 (3H, s, SCH3), 3.69 (2H, s, CH2 SCH3), 4.38 (2H, brs, NH2), 6.92 (1H, d, J=2.0 Hz, Ar–H), 7.21 (1H, d, J=2.0 Hz, ArH). m/z (CI+)=244 (M+ +1, 100%).

According to the analysis of related databases, 42265-67-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck Sharp & Dohme Ltd.; US5633281; (1997); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 42265-67-8, name is 4-(tert-Butyl)-2-chloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 42265-67-8, Recommanded Product: 4-(tert-Butyl)-2-chloroaniline

c) Compound 1.4; To a solution of compound 1.3 (765 mg, 4.16 mmol) in CH2CI2 (5 mL) was added di-2- pyridylthiocarbonate (966 mg, 4.16 mmol). The solution was stirred at room temperature overnight. The reaction mixture was washed successively with saturated aqueous NaHC03 solution and brine, dried (MgS04), filtered and concentrated under reduced pressure to give compound 1.4 (930 mg, 99%yield).

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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2005/118575; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics