Category: 42413-03-6

Hannout, I. B.; El-Sharief, A. M. S.; Ismail, I. M.; Mohamed, Y. A.; Ammar, Y. A.; Zahran, M. A. published the artcile< Some alkylated and chlorinated benzenesulfonamides with expected insecticidal and bactericidal activities>, Computed Properties of 42413-03-6, the main research area is benzenesulfonamide chloro preparation bactericide; chlorobenzenesulfonamide preparation bactericide.

Benzenesulfonic acid derivatives I (R1 = alkylamino, cyclohexylamino, substituted anilino, furfurylamino, pyrimidinylamino, substituted phenoxy) and II (R2 = cyclohexylamino, substituted anilino, pyridylamino, piperidino, morpholino) were prepared from the resp. benzenesulfonyl chlorides. I and II exhibited bactericidal activity.

Egyptian Journal of Pharmaceutical Sciences published new progress about 42413-03-6. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Computed Properties of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fotsch, Christopher; Biddlecome, Gloria; Biswas, Kaustav; Chen, Jian Jeff; D’Amico, Derin C.; Groneberg, Robert D.; Han, Nianhe Bruce; Hsieh, Feng-Yin; Kamassah, Augustus; Kumar, Gondi; Lester-Zeiner, Dianna; Liu, Qingyian; Mareska, David A.; Riahi, Babak Bobby; Wang, Yueh-Ju Judy; Yang, Kevin; Zhan, James; Zhu, Joe; Johnson, Eileen; Ng, Gordon; Askew, Benny C. published the artcile< A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core>, COA of Formula: C7H6Cl2O2S, the main research area is bradykinin receptor antagonist piperidine tetralin preparation SAR.

The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC50s < 20 nM in a B1 receptor functional assay. One of these compounds, I, shows modest oral bioavailability in rats. Bioorganic & Medicinal Chemistry Letters published new progress about Bradykinin B1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, COA of Formula: C7H6Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiwen; Fu, Zice; Wang, Yingcai; Schmitt, Mike; Huang, Alan; Marshall, Derek; Tonn, George; Seitz, Lisa; Sullivan, Tim; Lucy Tang, H.; Collins, Tassie; Medina, Julio published the artcile< Discovery and optimization of CRTH2 and DP dual antagonists>, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is phenylacetic acid derivative preparation prostanoid CRTH2 DP dual antagonist.

A series of phenylacetic acid derivatives was discovered as CRTH2 antagonists. Modification of the series led to compounds that are also antagonists of DP. Since activation of CRTH2 and DP are believed to play key roles in mediating responses of asthma and other immune diseases, this series was optimized to increase the dual antagonistic activities and improve pharmacokinetic properties. These efforts led to selection of AMG 009 as a clin. candidate.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiasthmatics. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lian, Chang; Yue, Guanglu; Zhang, Haonan; Wei, Liyan; Liu, Danyang; Liu, Sichen; Fang, Huayi; Qiu, Di published the artcile< Synthesis of arylstannanes by palladium-catalyzed desulfitative coupling reaction of sodium arylsulfinates with distannanes>, Product Details of C7H6Cl2O2S, the main research area is palladium catalyzed desulfitative cross coupling reaction arylsulfinate hexaalkyl distannane; arylstannane functionalized preparation.

A novel Pd-catalyzed desulfitative cross-coupling reaction of Na arylsulfinates with hexaalkyl distannanes is realized, allowing the facile synthesis of functionalized arylstannanes with moderate to excellent yields. The successful implement of gram-scale synthesis and tandem Stille coupling reaction demonstrates the potential applications of this method in organic synthesis.

Tetrahedron Letters published new progress about Arylation. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Product Details of C7H6Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Edman, Karl; Furber, Mark; Hemsley, Paul; Johansson, Cristian; Pairaudeau, Garry; Petersen, Jens; Stocks, Michael; Tervo, Anu; Ward, Alison; Wells, Edward; Wissler, Lisa published the artcile< The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger>, SDS of cas: 42413-03-6, the main research area is MMP MMP7 selectivity trigger.

MMP7 inhibitors employing a novel selectivity trigger.

ChemMedChem published new progress about Enzyme inhibitors. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, SDS of cas: 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics