Adding a certain compound to certain chemical reactions, such as: 43141-66-8, name is 1-Chloro-4-(difluoromethyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 43141-66-8, name: 1-Chloro-4-(difluoromethyl)benzene
Synthesis of compound 21 Bromine (17 muL; 0.34 mmol; 1.1 eq.) is added to a quartz reactor under an inert atmosphere, which is surmounted by a mercury vapour UV lamp equipped with a cooling system, and which contains a solution of para-chloro (difluoromethyl) benzene20 (50 mg; 0.3 mmol; 1 eq.) in carbon tetrachloride (5 mL; distilled over P2O5) and potassium carbonate (0.212 g; 1.54 mmol; 5 eq.). The reaction medium is refluxed and is irradiated for 5 h (84% conversion rate determined by GC). The mixture is then filtered and concentrated. The product 2j_ is involved in the following step without purification.2h C7H4BrClF2 M = 241.46 g.mol”1NMR 19F (CDO1. 282.5 Mz): – 43.9 (s, 2F). Mass: (IE): (M +) 240-242-244.
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Reference:
Patent; TFCHEM; WO2009/121939; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics