Category: 433-94-3

Reference of 433-94-3, These common heterocyclic compound, 433-94-3, name is 2-Chloro-6-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 9 2-Chloro-6-trifluoromethyl-phenyl)-hvdrazine hydrochlorideTo a 0 0C solution of 2-chloro-6-trifluoromethyl-phenylamine (35.7 mmol, 7.0 g) in THF (100 mL) is added 48% BF3OEt (143 mmol, 36 mL) followed by addition of isoamyl nitrite (143 mmol, 19 mL). The reaction is stirred for 1 hour and is filtered to collect the tetrafluoroborate diazonium salt (48.7 mmol, 9.0 g). The salt is dissolved in a mixture of cone. HCl (30 mL) and water (10 mL) at 0 0C. To the resulting mixture is added ascorbic acid (48.7 mmol, 8.5 g). The reaction is heated to 50 0C for 3 hours and cooled to room temperature. The solid is filtered and washed with ice water. The wet solid is dissolved in a mixture of cone. HCl (30 mL) and water (20 mL) and heated to 90 0C for 2 hours. The reaction is cooled to 0 0C and filtered to yield the title compound (5.0 g, 60%). LC-ES/MS m/e 157.0 (M+l).

The synthetic route of 433-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2007/140183; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 433-94-3,Some common heterocyclic compound, 433-94-3, name is 2-Chloro-6-(trifluoromethyl)aniline, molecular formula is C7H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

First, 30 g (0.153 mol) 2-chloro-6-trifluoromethylaniline (commercially available)765 ml of dimethyl sub-grind (DMSO)Followed by the addition of 68.1 g (0.23 mol) of 2-iodoheptafluoropropane,46 ml 1 molar aqueous solution of iron (II) sulfate with 15.4 g 98% strength sulfuric acid.The mixture was then degassed with argon,And using a syringe pump,Then 34.8 g of a 30% strength aqueous hydrogen peroxide solution was added dropwise over 30 minutes.During the addition,The temperature rose to 70 C.The mixture was allowed to stir for another 20 minutes,During that period,The temperature dropped to 30 C.The reaction mixture was then poured onto a saturated aqueous solution of sodium hydrogencarbonate,And extracted with ethyl acetate.The combined extracts were washed with water,Followed by washing with a saturated aqueous solution of sodium hydrogen sulfate and a saturated aqueous solution of sodium chloride,Dried over sodium sulfate,And concentrated on a rotary evaporator under reduced pressure. In terms of purification,The residue was placed in cassettes containing 330 g of silica gel,Gradient chromatography using pure cyclohexane to 90:10 (v / v) cyclohexyl acetate / ethyl acetate. This gave 46.1 g of 2-chloro-4-heptafluoroisopropyl-6-trifluoromethylaniline.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-6-(trifluoromethyl)aniline, its application will become more common.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; HALLENBACH, WERNER; SCHWARZ, HANS-GEORG; GOERGENS, ULRICH; ILG, KERSTIN; TURBERG, ANDREAS; HORSTMANN, SEBASTIAN; KOEHLER, ADELINE; (178 pag.)TW2016/7938; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 433-94-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 433-94-3 name is 2-Chloro-6-(trifluoromethyl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: 4-bromo-2-chloro-6-(trifluoromethyl)aniline N-bromo succinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was heated at reflux, with stirring, for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-(trifluoromethyl)aniline, and friends who are interested can also refer to it.

Reference:
Patent; Valeant Pharmaceuticals North America; US2008/139610; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 433-94-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 433-94-3 name is 2-Chloro-6-(trifluoromethyl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: 4-bromo-2-chloro-6-(trifluoromethyl)aniline N-bromo succinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was heated at reflux, with stirring, for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-(trifluoromethyl)aniline, and friends who are interested can also refer to it.

Reference:
Patent; Valeant Pharmaceuticals North America; US2008/139610; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 433-94-3, The chemical industry reduces the impact on the environment during synthesis 433-94-3, name is 2-Chloro-6-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life.

The reaction flask was charged with 2-chloro-6-trifluoromethylaniline (460 mg, 2.36 mmol)Sodium hydride (130 mg,60%, 3.25 mmol) and 10 ml of tetrahydrofuran,Stirring at room temperature was added dropwise 4-difluoromethyl-1,2,3-thiadiazole-5-carboxylic acid chloride (470 mg, 2.36 mmol) in 10 ml tetrahydrofuran.Drop finished, reaction at room temperature,2 hours after the reaction is completed.The reaction solution was poured into 30 ml of water,Take the organic layer,The organic layer was washed successively with saturated aqueous sodium bicarbonate,Saturated brine washing,Dried over anhydrous magnesium sulfate,Heat the solvent under reduced pressure.The residue was purified by column chromatography (eluent: ethyl acetate: petroleum ether = 1: 8)To give 190 mg of compound 79 in 23% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.; Lv Liang; Wang Gang; Li Keke; Zhang Wen; Liu Shaowu; Liang Shuang; Wu Shasha; Li Bin; (17 pag.)CN106831647; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

433-94-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 433-94-3, name is 2-Chloro-6-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A) 15 g of hydrochloric acid (0.15 mol) are added to the reaction apparatus,After cooling, 9.2 g (0.047 mol) of 2-chloro-6-trifluoromethylaniline was dropwise added to the system,Dropping added insulation reaction 60min,Then sodium nitrite solution 13.5g (0.09mol) was added dropwise to the system,Process temperature 3 ,Dropping added insulation reaction 2h; B) 32 g (0.32 mol) of hydrochloric acid was added to the above system,1.6 g (0.01 mol) of copper sulfate,Stirring until dissolved,Then 33.84 g (0.141 mol) of sodium bisulfite solution was added dropwise,After the addition was complete, the temperature was raised to 60 C. and incubated for 1.5 hours.The reaction is completed and extracted with methylene chloride, separated, the organic phase is dried, filtered, and the solvent is removed to give 2-chloro-6-trifluoromethylbenzenesulfonyl chloride;

The synthetic route of 433-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yellow River Delta Jingbo Chemical Institute Co., Ltd.; Yu Long; Yao Gang; Chang Jinlei; Chen Zhimin; Liu Kefeng; Fan Qiyan; (6 pag.)CN106478464; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 433-94-3 name is 2-Chloro-6-(trifluoromethyl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 433-94-3

General procedure: The salicylic acid (1.2 equiv) was added to a mixture of toluene (0.3 M), aniline (1.0 equiv), phosphorus trichloride (1.1 equiv), and pyridine (0.05 equiv) in a Radley?s Carousel reaction tube (modified from Itai et al.20). The mixture was refluxed under nitrogen for 12 h then cooled to room temperature. Aqueous sodium bicarbonate was added dropwise to attain pH 6-7. The resultant mixture was extracted with EtOAc. The organic extracts were combined, dried (MgSO4), and concentrated under vacuum. After chromatography (1:10 EtOAc:Hex) compounds were recrystallized (EtOAc/Hex).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-(trifluoromethyl)aniline, and friends who are interested can also refer to it.

Reference:
Article; Lee, Ill-Young; Gruber, Todd D.; Samuels, Amanda; Yun, Minhan; Nam, Bora; Kang, Minseo; Crowley, Kathryn; Winterroth, Benjamin; Boshoff, Helena I.; Barry III, Clifton E.; Bioorganic and Medicinal Chemistry; vol. 21; 1; (2013); p. 114 – 126;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics