Category: 450-96-4

Related Products of 450-96-4, A common heterocyclic compound, 450-96-4, name is 1-Chloro-2-(trifluoromethoxy)benzene, molecular formula is C7H4ClF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1 -chloro-2-(trifluoromethoxy)benzene (2.54 mmol) in 10 mL THF were added 1.42 mL n-BuLi (2.5 M solution in hexane) at -78C. After 40 min, a solution of iodine (2.8 mmol) in 2.5 mL THF was added and stirring was continued at RT overnight. The reaction was quenched with water under cooling and extracted with EtOAc (3x). The combined organic layers were dried over MgS04 and concentrated in vacuo. Purification by CC (KP-SIL from Biotage) using Hept to Hept/EtOAc (4/1 ) gives the desired compound (in a regioisomeric mixture as the major product) as colorless oil. LC-MS (A): tR = 0.99 min; 1H NMR ((CD3)2SO) delta: 7.98 (dd, 1 H), 7.70 (dd, 1 H), 7.21 (t, 1 H).

The synthetic route of 450-96-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; WO2013/14587; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 450-96-4, name is 1-Chloro-2-(trifluoromethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 450-96-4, Computed Properties of C7H4ClF3O

Step 1 : Synthesis of INT-41 INT-41 To a solution of 1 -chloro-2-(trifluoromethoxy)benzene (2.5 mmol) in THF (10 mL) is added 2.5 M n-buthyllithium in hexanes (1 .4 mmol) at -78 C. After 40 min, a solution of DMF (2.8 mmol) in THF (2.5 mL) is added and the mixture is stirred to room overnight. The reaction is quenched with water at 0 C, extracted with EtOAc (3 x 50 mL), the combined organic layers are dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Purification by silica gel chromatography provides 2-chloro-3- (trifluoromethoxy)benzaldehyde (INT-41 ).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-2-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RGENIX, INC.; MARTINEZ, Eduardo, J.; KAISER, Bernd; TAVAZOIE, Sohail, F.; KURTH, Isabel; GONSALVES, Foster, Casimir; DARST, David, M., Jr.; TAVAZOIE, Masoud, Fakhr; WO2015/106164; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 450-96-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450-96-4, name is 1-Chloro-2-(trifluoromethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1: Synthesis of INT-41 To a solution of 1-chloro-2-(trifluoromethoxy)benzene (2.5 mmol) in THF (10 mL) is added 2.5 M n-buthyllithium in hexanes (1.4 mmol) at -78 C. After 40 min, a solution of DMF (2.8 mmol) in THF (2.5 mL) is added and the mixture is stirred to room overnight. The reaction is quenched with water at 0 C., extracted with EtOAc (3*50 mL), the combined organic layers are dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Purification by silica gel chromatography provides 2-chloro-3-(trifluoromethoxy)benzaldehyde (INT-41).

The synthetic route of 1-Chloro-2-(trifluoromethoxy)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tavazoie, Sohail F.; Darst, JR., David M.; Rgenix, Inc.; MARTINEZ, Eduardo J.; KAISER, Bernd; TAVAZOIE, Sohail F; KURTH, Isabel; GONSALVES, Foster Casimir; DARST, David M.; TAVAZOIE, Masoud Fakhr; (106 pag.)US2017/66791; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics