Category: 4569-86-2

Yang, Ke published the artcileDNA photocleavage and binding modes of methylene violet 3RAX and its derivatives: Effect of functional groups, Application In Synthesis of 4569-86-2, the publication is Australian Journal of Chemistry (2017), 70(7), 830-836, database is CAplus.

With 4′-amino-N,N-diethylaniline and aniline as starting materials, methylene violet 3RAX 1 and its derivatives 2-5 were synthesized. The 5 compounds were characterized by IR, UV-visible, and ¹H NMR spectroscopy and mass spectrometry. The binding mode between the synthesized compounds and DNA were investigated. The results showed that both compounds 1 and 5 bound to DNA by an intercalative mode, while compounds 2-4 interacted with DNA through a mixed binding mode involving groove binding and electrostatic interactions. The photocleavage ability of the 5 compounds to DNA were calculated to be 38, 40, 30, 20, and 13%, resp., when their concentration was adjusted to 400 μM. The singlet oxygen production of compounds measured by the 1,3-diphenylisobenzofuran method was consistent with the trend of DNA photocleavage ability. The DNA studies suggested that the binding mode between methylene violet 3RAX and DNA, the ability of methylene violet 3RAX to generate singlet oxygen, and the DNA photocleavage activity could be adjusted through modification of the amino group on methylene violet 3RAX.

Australian Journal of Chemistry published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C9H5FO2, Application In Synthesis of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Xiu Li published the artcileα-γ-Type [Mo₈O₂₆]^4--Containing Metal-Organic Complex Possessing Efficient Catalytic Activity toward the Oxidation of Thioether Derivatives, Recommanded Product: 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Inorganic Chemistry (2021), 60(5), 3331-3337, database is CAplus and MEDLINE.

In this work, a new α-γ-type [Mo₈O₂₆]^4- anion was first synthesized and characterized by single-crystal X-ray diffraction anal. and was obtained by introducing molybdate to the synthesis of metal-organic complex (MOC) under hydrothermal conditions. An octamolybdate-based MOC, namely, {[Cu₈(H₂O)₆](dpyh)₄(α-γ-Mo₈O₂₆) }·(β-Mo₈O₂₆)·8.5H₂O (1) (H₂dpyh = N,N-bis(3-pyrazolamide)-1,2-hexahydrobenzene), was obtained. The α-γ-type [Mo₈O₂₆]^4- anion was composed of four MoO₆ octahedra and four MoO₅ trigonal bipyramids by sharing their edges and corners. The title complex exhibited a 1D structure in which an α-γ-type [Mo₈O₂₆]^4- anion was connected with [Cu₄(dpyh)₂] units in a staggered manner. Under optimized conditions, complex 1 as the catalyst can achieve a highly efficient conversion (more than 99%) of thioanisole within 30 min and above 99% selectivity toward sulfoxide. Furthermore, efficient catalytic oxidation of thioether derivatives was also performed with 1 as the catalyst. In addition, the stable electrochem. sensing performance and adsorption capacity toward organic dyes were tested.

Inorganic Chemistry published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Shengfu published the artcileDetecting the Adsorption of Dye Molecules in Homogeneous Poly(propylene imine) Dendrimer Monolayers by Surface Plasmon Resonance Sensor, HPLC of Formula: 4569-86-2, the publication is Journal of the American Chemical Society (2002), 124(13), 3395-3401, database is CAplus and MEDLINE.

In this work, we studied guest-host interactions between various dye mols. and the fifth-generation poly(propylene imine) (PPI-5) dendrimers in aqueous solutions using a surface plasmon resonance (SPR) sensor. The effect of the properties of guest and host mols. (e.g., charge and shape) and media (e.g., pH and ion strength) on affinity between guest and host mols. was studied. Based on an immobilized homogeneous monolayer of PPI-5 dendrimer tethered to carboxyl-terminal self-assembled monolayers, the adsorption behavior of a group of dye mols. in PPI-5 was obtained. The strong affinity of PPI-5 to Rose Bengal and erythrosine B is attributed to the good match in charge and shape between the cavities of the dendrimer and the dye mols. Maximum adsorption around a pH value of 7 was observed The kinetic behaviors of different dye mols. in dendrimers were also studied. A fundamental understanding of guest-host interactions in dendrimers will guide the design of new-generation sensors and drug delivery carriers.

Journal of the American Chemical Society published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, HPLC of Formula: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Haolan published the artcileSelf-assembly of methylene violet-conjugated perylene diimide with photodynamic/photothermal properties for DNA photocleavage and cancer treatment, Formula: C22H23ClN4, the publication is Colloids and Surfaces, B: Biointerfaces (2020), 111351, database is CAplus and MEDLINE.

Near-IR (NIR) light-activated phototherapy, such as photothermal therapy (PTT) and photodynamic therapy (PDT), has gained considerable attention due to the advantages of high efficiency and minimally invasiveness. However, the development of a single component therapeutic agent with clear structure and mol. weight that achieve photodynamic/photothermal synergistic therapy is still challenging. Herein, we design and synthesize a new smart photosensitizer (PRX) by conjugation of perylene diimide (PDI) and methylene violet (RAX). The typical donor-acceptor (D-A) structure of RAX facilitates the red-shift of absorption to the near-IR (NIR) region. The amphiphilic PRX could self-assemble into monodispersed nanoparticles (PRX NPs) with enhanced and broadened absorption. Under a single 808 nm laser irradiation, PRX NPs could generate efficient reactive oxygen species (ROS) and heat simultaneously with the photothermal conversion efficiency as high as 59%. PRX NPs displays strong interaction with DNA and can damage plasmid DNA upon light irradiation The biocompatibility and high phototoxicity of PRX NPs against A549 cells are further confirmed through MTT assay. Therefore, the as-prepared PRX NPs could be served as a promising antitumor nanoagent through photothermal/photodynamic combination manner.

Colloids and Surfaces, B: Biointerfaces published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Formula: C22H23ClN4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jonnalagadda, S. B. published the artcileUncatalyzed and ruthenium(III)-catalyzed reaction of acidic chlorite with methylene violet, Computed Properties of 4569-86-2, the publication is International Journal of Chemical Kinetics (2003), 35(7), 294-303, database is CAplus.

The kinetics and mechanism of the uncatalyzed and Ru(III)-catalyzed oxidation of methylene violet [3-amino-7-(diethylamino)-5-phenylphenazinium chloride] (MV) by acidic chlorite is reported. With excess concentrations of other reactants, both uncatalyzed and catalyzed reactions had pseudo-first-order kinetics with respect to MV. The uncatalyzed reaction had first-order dependence on chlorite and H⁺ concentrations, but the catalyzed reaction had first-order dependence on both chlorite and catalyst, and a fractional order with respect to [H⁺]. The rate coefficient of the uncatalyzed reaction is (5.72 ± 0.19) M^-2 s^-1, while the catalytic constant for the catalyzed reaction is (22.4 ± 0.3) × 10³ M^-1 s^-1. Stoichiometry is dependent on the initial concentration of chlorite present. Consistent with the exptl. results, pertinent mechanisms are proposed. The proposed 15-step mechanism is simulated using literature; exptl. and estimated rate coefficients and the simulated plots agreed well with the exptl. curves.

International Journal of Chemical Kinetics published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Computed Properties of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jonnalagadda, S. B. published the artcileKinetics and mechanism of the oxidation of methylene violet by bromate at acidic pH and the dual role of bromide ion, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Journal of Physical Chemistry A (2009), 113(19), 5540-5549, database is CAplus and MEDLINE.

A phenazinium-type dye during oxidation by bromate ion under acidic conditions exhibited a complex nonlinear behavior. The intricate kinetics of reaction of 3-amino-7-(dimethylamino)-5-phenylphenazium chloride (MV⁺) with acidic bromate was investigated using the stopped flow technique. Under excess acid and bromate concentration conditions, MV⁺ exhibited a very slow reaction initially but a very rapid reaction after an induction time. The reaction had first-order dependence on both H⁺ and BrO₃^– ions. The overall stoichiometric reaction is 2MV⁺ + 2BrO₃^– + H2O → 2MP + 2HONEt₂ + N₂O + 2H⁺ + 2Br^–, where MP is dioxophenylphenazine. The active roles of various bromo and oxybromo species in the mechanism are discussed. The rapid kinetics of the direct reaction of bromine with MV⁺ is also reported. A 19-step mechanism, consistent with the exptl. data and validated by simulations using Simkine-2, is proposed.

Journal of Physical Chemistry A published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Milani, Amir H. published the artcileLight-Triggered Programming of Hydrogel Properties Using Sleeping Photoactive Polymer Nanoparticles, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Chemistry of Materials (2021), 33(7), 2319-2330, database is CAplus.

A key characteristic of programmable hydrogels is that their phys. and chem. properties can be changed postsynthetically. In order to achieve this, we used sub-50 nm photoacid/base generator nanoparticles, which could alter the charge d./polarity of a host macroscopic hydrogel (e.g., polyacrylamide). The photoacid generator (PAG) nanoparticles, were composed of poly(Me methacrylate-co-4,5-dimethoxy-2-nitrobenzyl methacrylate-co-1,6-hexanediol diacrylate) and exhibited a pH-dependent swelling behavior when they were irradiated with UV light. Thus, using PAG nanoparticles enabled space-selective light-triggered swelling of host hydrogels by increasing the charge d. at alk. pH. Using photobase generator (PBG) nanoparticles, consisting of poly(Me methacrylate-co-2-nitrobenzyl Me 4-methacryloyloxy piperidine-1-carboxylate-co-1,6-hexanediol diacrylate), it was possible to space-selectively produce pos. charge, at acidic pH, within the host hydrogel network. PBG nanoparticles added several functionalities to the host hydrogel, including reversible writing/erasing patterns as well as postpolymn. in desired sites. Including mixtures of PAG and PBG nanoparticles caused deswelling of the host hydrogel upon UV-irradiation By increasing the mass fraction of PAG/PBG nanoparticles within the hydrogel, the deswelling effect was limited only to the top surface area, resulting in a monolayer actuator with a large bending angle. This study has successfully demonstrated the excellent potential of using PAG/PBG nanoparticles to confer photoresponsive behaviors that transform nonresponsive hydrogels into responsive hydrogels on demand. This system could be spatially tailored to provide a wide range of useful properties such as initiation sites for synthesis, writing/erasing, and actuation.

Chemistry of Materials published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Proevska, L. I. published the artcile¹H NMR spectra and structure of safranines. Hindered rotation of the 3-dialkylamino group in 7-azo derivatives, HPLC of Formula: 4569-86-2, the publication is Dyes and Pigments (1998), 36(2), 177-190, database is CAplus.

The ¹H NMR spectra of safranine derivatives are reported. Semiempirical calculations indicate that the high shielding of the 4- and 6-proton adjacent to an amino or hydroxyl group (resonating between 5.5 and 6.0 ppm) is due to accumulation of neg. charge on the 4-and 6-C atoms, augmented by the magnetic anisotropy effect of the orthogonal 5-Ph ring. The ortho protons of the latter resonate up field to the meta and para protons. Hindered rotation of dialkylamino groups, altogether unexpected in view of the rather low barriers in similar anilines, is observed only in the azo derivatives AM1 suggests that this is due to destabilization of the transition state when an amino group is substituted for an azo group.

Dyes and Pigments published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, HPLC of Formula: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

da Rocha, Caroline O. published the artcileMethylene violet 3 RAX dye as a new reagent for the determination of nitrite in cured meats and vegetables, SDS of cas: 4569-86-2, the publication is Journal of the Brazilian Chemical Society (2017), 28(8), 1528-1533, database is CAplus.

In this contribution we propose, for the first time, the use of Methylene Violet 3 RAX dye for the detection and determination of nitrite in cured meats and vegetables. Quantification is based on the decrease in absorbance of the dye, which is proportional to the nitrite concentration The proposed method presents linear response (r > 0.99) in the range from 1.8 to 9 μmol L-1 of nitrite, with a limit of detection of 0.14 μmol L-1. Satisfactory accuracy with the official Association of Official Agricultural Chemists (AOAC) method was achieved, and the method was successfully applied to a wide range of cured meats and vegetables. The proposed method offers similar or superior performance to other optical methods used for the determination of nitrite in different matrixes, with advantage in terms of reduction of chem. waste for each anal., by minimizing amounts of reagents and products.

Journal of the Brazilian Chemical Society published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, SDS of cas: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rangelov, S. published the artcileDoes the five-block copolymer of ethylene oxide and propylene oxide form ordered films?, Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Journal of Materials Science Letters (1996), 15(3), 271-4, database is CAplus.

The possibility of the formation of ordered structures in ethylene oxide-propylene oxide block copolymer when adsorbed from aqueous solutions onto a solid hydrophobic surface in the presence of low-mol.-weight organic or inorganic substrates is studied. Addition of azorubin, thiourea, 2-aminothiazole, 3,3′-dithiobispropanesulfonate, and diethylsafranine derivatives brought about the formation of ordered textures in the copolymer.

Journal of Materials Science Letters published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics