Category: 4584-49-0

Zeiger, Errol published the artcileThe Proportions of Mutagens among Chemicals in Commerce, Product Details of C5H13Cl2N, the publication is Regulatory Toxicology and Pharmacology (2000), 32(2), 219-225, database is CAplus and MEDLINE.

It has been estimated that there are approx. 80,000 chems. in commerce. Thus, it is not possible to test all these substances for mutagenicity and carcinogenicity; it is possible, however, to test or make estimates from selected subsets of these chems. For example, in the U.S. National Toxicol. Program (NTP), 35% of the chems. tested for mutagenicity in Salmonella were pos., as were 52% of the chems. tested for carcinogenicity in rodents. In contrast, in the U.S. EPA Gene-Tox database, the proportions of chems. that are Salmonella mutagens is 56%. These and other databases may be biased toward pos. responses because they generally have been developed to look at specific structural or use classes of chems. or chems. suspected of genetic or carcinogenic activity. To address the question of the proportions of mutagens among all chems. in commerce, a database of 100 chems. was created from a random selection of chems. in commerce. These chems. were tested for mutagenicity in Salmonella and 22% were mutagenic. The mutagenicity of the 46 highest U.S. production organic chems. was also compiled; 20% were mutagenic. These values provide a more accurate estimate of the proportions of mutagens among chems. in commerce than can be derived from published mutagenicity databases. (c) 2000 Academic Press.

Regulatory Toxicology and Pharmacology published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H4KNO6S, Product Details of C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Golzadeh, Robab published the artcileGreen synthesis of methadone in eutectic solvent, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Main Group Chemistry (2021), 20(4), 463-474, database is CAplus.

Synthesis of di-Ph acetonitrile with 1-dimethylamino-2-chloropropane by a eutectic’s solvent was described. In addition, methadone I was synthesized from the reaction of 2,2-diphenyl-4-dimethylaminovaleronitrile with Et magnesium bromide in the presence of solvent eutectic, which was in optimal and environmentally compatible conditions and by principles of green chem.

Main Group Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rhee, Hee-Kyung published the artcileSynthesis, cytotoxicity and topoisomerase II inhibitory activity of benzonaphthofurandiones, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Bulletin of the Korean Chemical Society (2011), 32(7), 2391-2396, database is CAplus.

Benzonaphthofurandiones containing 4 coplanar fused aromatic rings were synthesized and evaluated for their cytotoxicity against human cancer cell lines and for their inhibitory activity on topoisomerases. These benzonaphthofurandiones were prepared by condensation of 2,3-dichloronaphthoquinone and aromatic diols with base catalysts in alc. The synthesized compounds were O-alkylated with (dialkylamino)alkyl halides. The resulting hydroxy derivatives exhibited relatively potent cytotoxicity among the prepared compounds These compounds were evaluated as excellent inhibitors against topoisomerase II (topo II). Especially, a hydroxy analog with a branched Me side chain showed high cytotoxicity against cancer cell lines and good inhibitory activity on topo II.

Bulletin of the Korean Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dey, Sandip published the artcileStructural variety and multiple isomerism in 1-(dimethylamino)propyl-2-chalcogenolate and 2-(dimethylamino)propyl-1-chalcogenolate complexes of palladium(II) and platinum(II): Synthesis, spectroscopy and structures, SDS of cas: 4584-49-0, the publication is European Journal of Inorganic Chemistry (2004), 4510-4520, database is CAplus.

Isomeric dichalcogenides [Me₂NCH(Me)CH₂E]₂ [(N^{âˆ?/sup>E**)₂] and [Me₂NCH₂CH(Me)E]₂ [(Nâˆ?/sup>E*)₂] (E = S, Se, Te) were obtained by the reactions of NaSH or M’₂E₂ (M’ = Na or K) with Me₂NCH₂CHMeCl. The former reaction affords mainly (Nâˆ?/sup>E**)₂ (E = S) while from the latter mixtures of (Nâˆ?/sup>E**)₂ and (Nâˆ?/sup>E*)₂ [referred to as (Nâˆ?/sup>E)₂, E = S, Se, Te] were isolated, the ratios in the mixtures depending on the chalcogen. Reactions of (Nâˆ?/sup>E)Na with [M₂Cl₂(μ-Cl)₂(PR₃)₂] gave [MCl(Nâˆ?/sup>E)(PR₃)] (M = Pd or Pt). These chiral, mixed-ligand complexes were characterized by elemental anal., IR, UV/visible and NMR (1H, 13C, 31P, 77Se, 125Te, 195Pt) spectroscopy, and, in part, by x-ray structure anal. The complexes display a typical pattern of mutually trans-oriented neutral (P and N) and anionic (Cl and E) donor atoms in an approx. square-planar environment. In contrast to the Pt(II) analogs, the x-ray structures of [PdCl(Nâˆ?/sup>E)(PMePh₂)] (E = S or Se) revealed both a conformational isomerism of the five-membered chelate ring and, for Se, the co-crystallization of complexes with both the Nâˆ?/sup>E* and Nâˆ?/sup>E** isomeric ligands. The thermal behavior of some complexes was studied.}

European Journal of Inorganic Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hachey, D. L. published the artcileQuantitative analysis of methadone in biological fluids using deuterium-labeled methadone and GLC-chemical-ionization mass spectrometry, Category: chlorides-buliding-blocks, the publication is Journal of Pharmaceutical Sciences (1977), 66(11), 1579-82, database is CAplus and MEDLINE.

The (+)-, (-)-, and (±)-²H₅-methadones which contained 5 deuterium atoms in 1 aromatic ring, were synthesized for use in clin. pharmacol. studies and as internal standards GLC-chem.-ionization mass spectrometry was used to determine plasma and urinary methadone [76-99-3] levels by an inverse isotope dilution assay. Plasma drug levels could be determined to 10 pmol/mL, and urine levels could be measured to 5 pmol/mL. Plasma methadone levels were examined in several patients undergoing methadone maintenance therapy. These levels generally ranged between 100 and 400 ng/mL (320-1300 pmol/mL) after an average oral dose of 1 mg/kg/day. The methadone half-life was 28.8 h.

Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Jung Kul published the artcileModification of chitosan to improve its hypocholesterolemic capacity, SDS of cas: 4584-49-0, the publication is Bioscience, Biotechnology, and Biochemistry (1999), 63(5), 833-839, database is CAplus and MEDLINE.

Cholestyramine is the most widely used bile acid sequestrant in the treatment of hypercholesterolemia. However, cholestyramine has unpleasant side effects as a consequence of its hydrophobic backbone. Therefore, high-capacity bile acid sequestering biopolymers with cationic chitosan derivatives were developed, because electrostatic interactions are important for binding with bile acid anions. Dialkylaminoalkylation and reductive amination of chitosan were done to add dialkylaminoalkyl and an addnl. free amino group at a hydroxyl site in the chitosan backbone resp. and the aminoderivatized chitosan derivatives were quaternized with Me iodide to produce a cationic polyelectrolyte. The in vitro bile acid binding capacity of the chitosan derivatives in aqueous NaCl was measured by reversed-phase HPLC. The binding capacities of sodium glycocholate (a major bile acid) to chitosan, DEAE-chitosan, quaternized DEAE-chitosan, and cholestyramine were 1.42, 3.12, 4.06, and 2.78 mmol/g resin, resp. With quaternized DEAE-chitosan, the bile acid binding capacity increased ∼50% over that of cholestyramine. The bile acid binding capacity of dialkylaminoalkyl chitosan derivatives increased with the number of carbons in the alkyl groups, indicating that hydrophobic interaction is a secondary factor for the sequestration of bile acids.

Bioscience, Biotechnology, and Biochemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huerta, Pedro L. published the artcileSynthesis of various geometric and enantiomeric oxime O-(α- and β-methylcholinyl) ethers as potential anticholinergic agents, Quality Control of 4584-49-0, the publication is Journal of Pharmaceutical Sciences (1977), 66(8), 1120-4, database is CAplus and MEDLINE.

Various enantiomeric and geometric oxime O-(α- and β-methylcholinyl) ethers were prepared as potential anticholinergic agents. The synthesis, separation, resolution, and structural characterization of these compounds are reported. The 1st step of the synthetic pathway involved an oxime formation, with subsequent O-alkylation of the resp. oxime with 2-chloro-N,N-dimethylpropylamine hydrochloride. The separation of the α- and β-structural isomers utilized vacuum fractional distillation and/or column chromatog., and the resolution of the enantiomers was accomplished via the formation of tartrate diastereoisomers. A preliminary pharmacol. evaluation for anticholinergic activity was conducted using a rat ileum assay. Structure-activity relationships, including some stereochem. properties and antimuscarinic activity, are discussed.

Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Quality Control of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ford-Moore, A. H. published the artcileSynthetic mydriatics, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of the Chemical Society (1947), 55-60, database is CAplus and MEDLINE.

Tertiary (chloroalkyl)amine HCl salts were prepared by the method of Gough and King (C.A. 23, 91). Quaternary (chloroalkyl)ammonium chlorides were prepared by addition of MeI to the tertiary base and subsequent digestion with AgCl or by keeping the quaternary hydroxyalkylammonium chloride in CHCl₃, with SOCl₂. Dimethylethyl(2-hydroxyethyl)ammonium picate, yellow, m. 251°; dimethylethyl(2-chloroethyl)ammonium chloride, hygroscopic, m. 213° (decomposition) (picrate, orange, m. 200°); dimethyl(2-hydroxyethyl)isopropylammonium chloride, hygroscopic; (2-chloroethyl)isopropylamine-HCl m. 180-1° (2-chloroethyl)diisopropylamine-HCl m. 110°; dimethyl(2-chloropropyl)amine-HCl, hygroscopic, m. 196°; Me dimethylaminotert-butyl ketone-HBr m. 174° (picrate, yellow, m. 150°); 3-chloro-1-dimethylamino-2,2-dimethylbutane picrate m. 160°; 3-dimethylamino-2,2-dimethyl-1-propanol-HBr m. 158-9°; 1-(2-chloroethyl)piperidine-MeI m. 176-7°; 1,1-dimethyl-3-(chloromethyl)piperidinium iodide m. 176-7°. 4-(2-Hydroxyethyl)thiamorpholine-MeCl, m. 258° (decomposition), from 4-methylthiamorpholine and Cl(CH₂)₂OH; 4-(2-chloroethyl)thiamorpholine-MeCl decompose 232-5°. Me₂N(CH₂)₂NH₂ forms a monobenzilate, m. 152°, and a dibenzilate, m. 168-9°; the former, heated at 185° 2 hrs. and 0.5 hr. in vacuo, gives N-(2-dimethylaminoethyl)benzilamide-HO₂CC(OH)Ph₂, m. 126°; the free amide m. 124°. 1-Naphthyl isonitrosobenzyl ketone (I), yellow, m. 130-1°; 1,2-dioxo-1-phenyl-2-(1-naphthyl)ethane (II) m. 102-3°. Phenyl(1-naphthyl)glycolic acid (III), with 2 mols. H₂O, m. 117° and then 147-8°; concentrated H₂SO₄ gives a greenish-yellow color turning green. The 2-isomer of I m. 159-60°; of II m. 88-9°; of III m. 145-6° and with concentrated H₂SO₄ gives a greenish-blue color turning mauve. 2-Dimethylaminoethyl benzilate m. 91-2°; H benzilate m. 159-60°. 2-Diethylaminoethyl benzilate m. 54°. 2-(Methylpropylamino)ethyl benzilate-HCl, m. 154°. 3-Dimethylamino-2,2-dimethylpropyl benzilate, m. 66-7°; piperidinoethyl benzilate, m. 71-2°. β-4-Benziloyloxy-1,2,2,6-tetramethylpiperidine m. 155-6°; the α-form m. 137-8°; 4-benzilyloxy-1,2,2,6,6-pentamethylpiperidine m. 94°. The benzilic esters were prepared as follows: An intimate mixture of the (chloroalkyl)dialkylamine-HCl and K benzilate is heated at 140-60° 3-4 hrs., the cooled melt extracted with hot EtOH, and the residue from the EtOH stirred with Me₂CO; in a few cases, the amine and the acid were heated in boiling PHCl, from which the ester-HCl separated (IV). The (chloroalkyl)trialkylammonium chloride (or iodide) is heated in boiling EtOH with K (or Ag) benzilate 1 hr., and the filtrate evaporated and heated at 100° until solid (V). The tertiary aminoalkyl benzilate and an alkyl halide are heated without solvent or in Me₂CO; the methiodide and AgCl in MeOH give the methochloride (VI). The dry tertiary amino alc.-HCl is heated with Ph₂ClCCOCl until HCl evolution ceases (3-5 hrs.) (VII). The potency of these compounds is discussed in C.A. 40, 159.6. The following benzilates, Ph₂C(OH)CO₂R.R’X, were prepared by the methods indicated: R.R’X = CH₂CH₂NMe₂.HCl (IV), m. 188-9°; CH₂CH₂NMe₂.MeCl.-0.5H₂O (V), m. 218°; CH₂CH₂NMe₂.EtCl (VI, V), m. 213°; CH₂CH₂NMe₂.iso-PrCl (V), m. 199-200°; CH₂CH₂NMe₂.PrBr (VI), m. 186-7°; CH₂CH₂NMe₂.CH₃CH:CH₂Br (VI), m. 161-2°; CH₂CH₂NMe₂.BuBr (VI), m. 143-4°; CH₂CH₂NMe₂.AmBr (VI), m. 129-30; CH₂CH₂NMe₂.BrCH₂CH₂Br (VI), m. 173°; CH₂CH₂NEt₂.HCl (IV), m. 174-5°; CH₂CH₂NEt₂.MeCl (V), m. 184-5°; CH₂CH₂NEt₂.EtBr (VI), m. 220°; CH₂CH₂NEt₂.PrBr (VI), m. 171°; CH₂CH₂N(iso-Pr)₂.HCl (IV), m. 147-8°; CH₂CH₂N(iso-Pr)₂.MeCl (VI), m. 174-5°; CH₂CH₂NMeEt.PrBr (VI), m. 189°; (CH₂)₃NEt₂.MeCl (V), m. 195°; (CH₂)₃NMeEt.MeCl (V), m. 181°; CHMeCH₂NMe₂.EtBr (VI), m. 213°; CHMeCMe₂CH₂NMe₂.HCl (VII), m. 174-5°; CH₂CMe₂CH₂NMe₂.EtI (VI), m. 136-7°; CH₂CH₂NC₅H₁₀.HCl (IV), m. 170-1°; 2-(1-piperidyl)ethyl MeCl (V), m. 215°; 2-(1-piperidyl)isopropyl-HCl (VI), m. 167-8°; CH₂CH₂NC₄H₈O.HCl (IV), m. 181°; 2-(4-morpholinyl)ethyl-MeCl (V), m. 207-8°; 2-thiamorpholinyl)ethyl-MeCl (V), m. 227° (decomposition) (dioxide, CH₂CH₂N(CH₂.CH₂)₂SO₂.MeCl (V), m. 225° (decomposition)); (1-methyl-3-piperidyl) methyl-Me Cl (V), m. 238° (decomposition); β-form of 1,2,2,6-tetramethyl-4-piperidyl-HCl (VII), m. 244° (decomposition) (methiodide (VI), m. 225° (decomposition); methochloride, with 1 mol. iso-PrOH, m. 224° (decomposition)); α-form methiodide (VI), m. 239° (decomposition) (methochloride (VI), with 1 mol. iso-PrOH, m. 212° (decomposition)); 1,2,2,6,6-pentamethyl-4-piperidyl-HCl (VII), m. 253° (decomposition) (ethobromide (VI), m. 255° (decomposition)). PhMeC(OH)CO₂CH₂CH₂NMe₂.MeCl.H₂O (V) m. 170°; PhCH(CH₂OH)CO₂CH₂CH₂NMe₂.MeCl.0.5H₂O (V) m. 178-9°; PhMeC(OH)CO₂CH₂CH₂NC₅H₁₀.MeCl (V) m. 164-5°; (C₆H₄)₂C(OH)CO₂CH₂CH₂NC₄H₈O.HCl (IV) m. 195-6°; PhMeC(OH)CO₂CH₂CH₂NC₄H₈O.HCl (IV) m. 192° (decomposition); Ph₂C(OH)CONHCH₂CH₂NMe₂.EtBr (VI) m. 227°; 2-C₁₀H₇ CPh(OH) CO₂CH₂CH₂NMe₂.EtCl (IV) m. 221° (decomposition); 1-C₁₀H₇CPh(OH) CO₂CH₂CH₂NMe₂.EtCl (V) m. 194-5°.

Journal of the Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brode, Wallace R. published the artcileRearrangement of the isomeric 1,2-(dimethylamino)-chloropropanes. The synthesis of amidone, Related Products of chlorides-buliding-blocks, the publication is Journal of the American Chemical Society (1947), 724, database is CAplus and MEDLINE.

Chlorination of MeCH(OH)CH₂NMe₂ (I) (b. 124-4.5°) and MeCH(NMe₂)CH₂OH (II) (b. 145-5.5°) with SOCl₂ in anhydrous CHCl₃ yields MeCHClCH₂NMe₂.HCl (III) and MeCH(NMe₂)CH₂Cl.HCl (IV), resp.; IV is much more soluble in CHCl₃ than III. IV and III and a mixture of the 2 all m. 191-1.5°, indicating rearrangement to the same compound on heating. The free base from III or IV b₁₁₀ 60-3°; with Ag₂O it gives 12% II.

Journal of the American Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maurya, Hardesh K. published the artcileSynthesis of 4-phenyl-5,6-dihydrobenzo[h]quinazolines and their evaluation as growth inhibitors of carcinoma cells, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is RSC Advances (2016), 6(22), 18607-18618, database is CAplus.

The synthesis of various benzo[h]quinazoline analogs (4a-f, 6a-d, 8a and 8b) was accomplished through the reaction of chalcone with guanidine. The synthesized compounds (4a-f, 6a-d, 8a and 8b) were screened for their anticancer potential against different cancer cells viz MCF-7, DLD1, A549, DU145 & FaDu cell lines. Compounds 4a, 6a-d & 8b showed significant anticancer activity in these cancer cell lines with a range of IC₅₀ values of 1.5-12.99 μM. A functional study of promising mol. 6d at 7 μM (at the IC₅₀ value) over 24 and 48 h showed that it possesses anticancer activity through triggering apoptosis. In a tubulin polymerization assay, 6d effectively inhibited tubulin polymerization with an IC₅₀ of 2.27 μM. In silico docking studies of 6d revealed that 6d has good affinity with an estrogen receptor as well as a tubulin protein on its β-sheet of the colchicines binding site.

RSC Advances published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics