Category: 4584-49-0

Kumar, Atul published the artcileDesign and synthesis of new bioisosteres of spirooxindoles (MI-63/219) as anti-breast cancer agents, Quality Control of 4584-49-0, the publication is Bioorganic & Medicinal Chemistry (2015), 23(4), 839-848, database is CAplus and MEDLINE.

The authors report herein the design and synthesis of bioisosteres of spirooxindole (MI-63/219), a small-mol. inhibitors of the MDM2-p53 interaction as antibreast cancer agents. Compound I has been exhibiting significant antiproliferative activity in nude mice bearing MCF-7 xenograft tumor. The compound I was found to act via modulation of MDM2 and p53 expression in breast cancer cells expressing wild type p53. Compound I stimulated p53 activation, caused modulation of downstream effectors p21, pRb, and cyclin D1 which regulate cell cycle. Thus, compound triggered G1-S phase cell cycle arrest, which was evident by flow cytometric anal. of treated breast cancer cells. Thus, compound I restores the p53 function, which triggers mol. events consistent with cell cycle arrest at G1/S phase.

Bioorganic & Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Quality Control of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Couture, Axel published the artcileA convenient synthetic methodology for the elaboration of the pyrido[2,3-b]- or -[3,4-b]pyrazine and -[1,4]diazepine skeletons, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Synthesis (1991), 982-4, database is CAplus.

The condensation of the anion of (acylamino)chloropyridines I (X, Y = N, CH; R = H, Me; R¹ = H, Cl) with R²CHCl(CH₂)_nNMe₂·HCl gave efficiently tetrahydropyridopyrazines II (n = 1) and tetrahydropyridodiazepines II (n = 2).

Synthesis published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sabatini, Stefano published the artcileRe-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance, Synthetic Route of 4584-49-0, the publication is Journal of Medicinal Chemistry (2013), 56(12), 4975-4989, database is CAplus and MEDLINE.

Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, biocides, and dyes, resulting in a multidrug resistant (MDR) phenotype. In this work, a series of 2-phenylquinoline derivatives was designed by means of ligand-based pharmacophore modeling in an attempt to identify improved S. aureus NorA efflux pump inhibitors (EPIs). Most of the 2-phenylquinoline derivatives displayed potent EPI activity against the norA overexpressing strain SA-1199B. The antibacterial activity of ciprofloxacin, when used in combination with some of the synthesized compounds, was completely restored in SA-1199B and SA-K2378, a strain overexpressing norA from a multicopy plasmid. Compounds I and II also showed potent synergistic activity with the ethidium bromide dye in a strain overexpressing the MepA MDR efflux pump.

Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Synthetic Route of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cannon, Joseph G. published the artcileVinyl ethers of choline and congeners, COA of Formula: C5H13Cl2N, the publication is Journal of Medicinal Chemistry (1976), 19(7), 934-7, database is CAplus and MEDLINE.

The vinyl ethers of choline and of its α- and β-methyl homologs were prepared to determine their cholinergic effects and to determine whether a separation of the dual physiol. activity (nicotinic and muscarinic) reported for the choline vinyl ether iodide [24586-04-7] could be achieved by this modification. A literature method of vinyl transetherification of amino alcs. was studied and modified. (±)-2-(Dimethylamino)-1-propyl vinyl ether methiodide [59309-74-9] was prepared by vinyl transetherification of 2-dimethylamino-1-propanol [15521-18-3]. However, when this procedure was attempted on 1-dimethylamino-2-propanol [108-16-7], only a 4% yield of the vinyl ether was obtained. (±)-1-(Dimethylamino)-2-propyl vinyl ether methiodide [59276-15-2] was prepared by Hofmann degradation of (±)-2,4-dimethylmorpholine methiodide [59229-59-3]. Two independent, unequivocal syntheses of the (±)-1-(dimethylamino)2-propyl ethyl ether methiodide [99159-81-6] have been accomplished. The 2 literature methods for synthesis of this compound were found to be equivocal, and therefore, the biol. data previously reported for this compound may not be valid. Structure activity relationships of the ethers with respect to nicotinic and muscarinic activities are discussed.

Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, William L. published the artcileBis-basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 6. Bis-basic-substituted fluoranthenes, HPLC of Formula: 4584-49-0, the publication is Journal of Medicinal Chemistry (1974), 17(11), 1150-6, database is CAplus and MEDLINE.

Bis-basic esters, ketones, ethers, and alkanes of fluoranthene, given s.c., had potent antiviral activity against encephalomyocarditis virus in mice. The ketones were the most active when given orally. For example, 3,9-fluoranthenedicarboxylic acid bis[3-(diethylamino)propyl] ester-2HCl (I) [27086-86-8] and 1,1′-(3,9-fluoranthenediyl)bis[2-(dimethylylamino)ethanone]-2HCl (II) [35689-81-7] increased the survival time of infected mice by 1.82- 1.94-fold resp., at 50 mg/kg s.c. I and II were effective against both RNA (Semliki Forest) and DNA (vaccinia) virus infections in mice. I also enhanced the antibody response to sheep erythrocytes. II was prepared by reaction of fluoranthene [206-44-0] with 2-chloroacetyl chloride [79-04-9], followed by Me2NH.

Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, HPLC of Formula: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Magidson, O. Yu. published the artcileSynthesis of Phenadone, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Meditsinskaya Promyshlennost SSSR (1957), 11(No. 3), 25-8, database is CAplus.

The synthesis of Phenadone proceeds in 6 stages. CH₂:CHCH₂Cl (300 g.) with 600 g. tech. H₂SO₄ (d. 1.8-1.82) at 25-30° 1 hr. gives 319.3 g. MeCH(OH)CH₂Cl (I). I (300 g.) is added to 546 g. 37% aqueous Me₂NH and 300 g. 40% NaOH below 40°, the mixture stirred 30 min., 150 g. 40% NaOH added, the mixture kept 12 hrs., and the upper layer fractionated to give 183.8 g. MeCH(OH)CH₂NMe₂ (II), also prepared from propylene oxide and Me₂NH. II (250 g.) is added dropwise to 380 g. SOCl₂ and 730 g. of dry (ClCH₂)₂ during 1-1.5 hrs. at 30° and the mixture boiled 2 hrs. to give 338 g. MeCHClCH₂NMe₂.HCl (III). Ph₂CHCN (60 g.), 46.6 g. powd. NaOH, and 69 g. III heated to 90-100°, kept at this temperature 7 hrs. with stirring, cooled, diluted with 50 cc. of H₂O, and worked up gave 46 g. Ph₂C(CN)CH₂CHMeNMe₂ (IV), m. 88-90°. IV (80 g.) in 70 cc. dry xylene is treated with EtMgBr (from 10 g. Mg and 50 g. EtBr), 55-60° 3 hrs. with stirring, kept 12 hrs., and acidified with 10% HCl, the ether distilled and the temperature raised to 115° to distil ether, xylene, and H₂O. The crystals in the residue are filtered off and washed with acetone to yield 89 g. EtCOCPh₂CH₂CHMeNMe₂.HBr (V.HBr), m. 224°; V, m. 77°; V.HCl (Phenadone), m. 229-31°.

Meditsinskaya Promyshlennost SSSR published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Unterhalt, B. published the artcileSynthesis of methadone-nitrile as well as isomethadone-nitrile, and related compounds, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Scientia Pharmaceutica (2000), 68(3), 229-234, database is CAplus.

R₂NCH₂CHMeCl [R₂ = Me₂, (CH₂)₅, (CH₂)₂O(CH₂)₂, (CH₂)₄] are reacted with Ph₂CHCN under phase-transfer conditions to give a mixture of the corresponding nitriles R₂NCHMeCH₂CPh₂CN and R₂NCH₂CHMeCPh₂CN. Both R₂NCH₂CHPhCl and R₂NCHPhCH₂Cl [R₂ = Me₂, (CH₂)₅, (CH₂)₂O(CH₂)₂, (CH₂)₄] led to resp. R₂NCH₂CHPhCPh₂CN.

Scientia Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C10H2F12NiO4, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Chunsheng published the artcileSide chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides, SDS of cas: 4584-49-0, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2014), 52(5), 671-679, database is CAplus.

The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(L-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-L-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the “linkers” between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pH_t) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the “linkers.” TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched “linker” (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C7H5ClN2S, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Benalil, Aziza published the artcileSynthesis of 1,2-aminoazides. Conversion to unsymmetrical vicinal diamines by catalytic hydrogenation or reductive alkylation with dichloroboranes, SDS of cas: 4584-49-0, the publication is Tetrahedron (1991), 47(38), 8177-94, database is CAplus.

1,2-Aminoazides, e.g., I, are easily prepared from 1,2-amino alcs. Catalytic hydrogenation in the presence of palladium on charcoal or reductive alkylation with dichloroboranes afford with good yields unsym. substituted vicinal diamines.

Tetrahedron published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics