Category: 461432-23-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C15H14BrClO

Synthesis of compound 63C35H36F206/ C35H34F205I9F NMR (CDCU. 282.5MHz):Hydrate form: -1 17.3 (dd, Jl=257Hz, J2=30Hz, IF, CFF); -125.6 (d, Jl=258Hz, IF, CFF).Ketone form: -112.1 (ddd, Jl=260Hz, J2=32Hz, J3=6Hz, IF, CFF); -119.4 (dd, Jl=260Hz, J2=4Hz, IF, CFF).ass (ESf): 608.4 [M+H20]+; 613.5 [M+Na]+; 619.5 [M+K]+ To a solution of 62 (200mg; 0.35mmol; leq) in dry dichloromethane, under inert atmosphere, was added Dess-Martin periodinane (295mg; 0.70mmol; 2eq). The reaction medium was stirred for 3h at room temperature before a IN aqueous solution of sodium hydroxide (lOmL) was added. The aqueous layer was extracted with dichloromethane and dried over sodium sulphate, filtered and concentrated to afford ketone 63 (158mg, 77% yield) as a light orange solid which rapidly evolves toward the formation of the hydrate form until equilibrium is reached.Synthesis of compound 64C50H49CIF2O6 M=819.37g.mor1 19 F NMR fCDCk 282.5MHz): -1 12.3 (dd, Jl=266Hz, J2=27Hz, IF, CFF); -113.7 (dd, Jl=266Hz, J2=6Hz, IF, CFF).Mass (ESf): 836.7[M+H20]+; 841.8[M+Na]+; 857.7[M+K]+ In a Schlenk tube under inert atmosphere containing magnesium turnings (50mg, 2.04mmol, 1.2eq) was added 2inL (out of 5mL) of a solution of 10 (552mg, 1.70mmol, leq) and 1,2-dibromoethane (15mu, 0.17mmol, O. leq) in dry THF (5mL). The mixture was heated at 75C for 5 min to initiate the reaction and the last 3mL of the solution of 10 and 1,2-dibromoethane were then added dropwise at room temperature. This solution was then stirred at 75C for lh.2.4mL of this Grignard solution, previously cooled to room temperature, were then added to a solution of 63 (158mg, 0.27mmol) in dry THF (2mL). The reaction mixture was stirred at room temperature for 2h before a saturated aqueous solution of ammonium chloride was added. The aqueous layer was extracted with diethyl ether and the combined organic layers were washed with brine, dried over sodium sulphate, filtered and concentrated. The residue was purified on silica gel chromatography (cyclohexane/ethyl acetate 100:0 to 77:23) to afford compound 64 (152mg) as a mixture of two diastereomers with 69% yield. These diastereomers can be separated by semi- preparative HPLC.

The synthetic route of 461432-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig; WO2012/160218; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 461432-23-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1: (3R, 4S, 5S) -3, 4-bis (benzyloxy) -5- (benzyloxymethyl) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) tetrahydrofuran-2-ol (1b) To a stirred -78solution of 5-bromo-2-chloro-4? -ethoxydiphenylmethane (0.64 g, 1.54 mmol) in THF (5 mL) under N2was added n-BuLi (0.77 mL, 2.4 M, 1.84 mmol) dropwise while keeping the temperature below -70. After 30 min, a solution of lactone 1a (500 mg, 1.54 mmol) in THF (10 mL) was added to the above solution and the mixture was stirred at -78for another 2 h. the reaction mixture was quenched by adding saturated aqueous NH4Cl solution and extracted with EtOAc (3 × 5 mL) , combine the organic layer, dried and concentrated, the resulting residue was purified by flash column chromatography (silica gel, EtOAc:PE 1:6) to give 0.56 g of lactol 1b as colorless oil, yield: 55.1H NMR (400 MHz, CDCl3) delta 7.53 (d, J 2.0 Hz, 1H) , 7.45-7.43 (m, 1H) , 7.37-7.24 (m, 14H) , 7.10-7.08 (m, 2H) , 7.05 (d, J 8.4 Hz, 1H) , 6.85-6.82 (m, 1H) , 6.80-6.73 (m, 2H) , 4.67-4.44 (m, 6H) , 4.35-4.29 (m, 2H) , 4.14-3.93 (m, 6H) , 3.67-3.60 (m, 1H) , 3.54 (dd, J 3.6, 10.4 Hz, 1H) , 1.39 (t, J 7.2 Hz, 3H) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; ZHANG, Zhiyuan; HUANG, Shaoqiang; ZHANG, Zhaolan; SU, Yaning; REN, Yan; (73 pag.)WO2016/41470; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

Accurately weigh 65.12g (0.2Mol) of raw material A, then add toluene / tetrahydrofuran mixture (V toluene / tetrahydrofuran = 2:1), dilute to 500ml, mix and pump into the microreactor at a flow rate of 14ml / min a reaction unit,At the same time, the concentration of 2.0mol / L n-butyl lithium solution was pumped into the first reaction unit at a flow rate of 3.4ml / min for thorough mixing to produce lithium halide exchange reaction, the residence time was 27 seconds, and the reaction temperature was controlled at -15 C. After the reaction solution flows out of the first reaction unit,At the same time, the raw material C was flowed into the second reaction unit of the microreactor at a flow rate of 2.2 ml/min to carry out a lactone condensation reaction.The residence time of the reaction in this step was 22 seconds, and the reaction temperature of the second reaction unit was controlled to be -15 C. Accurately prepare a mixture of 300 ml of methanol and methanesulfonic acid (V methanol / methanesulfonic acid = 4:1),It is pumped into the third reaction unit of the microreactor at a flow rate of 3.5 ml/min, and mixed with the reaction liquid flowing out from the second reaction unit.The residence time of the reaction in this step is 19 seconds, and the reaction temperature controlled by the reaction unit is 5 C. After the reaction liquid flows out from the third reaction unit,At the same time, the prepared mixture of boron trifluoride diethyl ether and triethylsilane was pumped into the fourth reaction unit at a flow rate of 3.5 ml/min.The residence time of the reaction unit is 15 seconds, the temperature of the fourth reaction unit is controlled to be 5 C, and the liquid discharged from the fourth reaction unit is continuously collected 100 ml.Finally, it was added to 200 ml of n-heptane, stirred and crystallized, and kept at 0 C for 1 hour, and filtered to obtain a crude product of dapagliflozin.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Heroic Chemical Co., Ltd.; Ning Jiabin; Ren Miaomiao; Ge Yuan; Wang Wei; Sheng Zhen; Zheng Hao; (12 pag.)CN109400561; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461432-23-5, Formula: C15H14BrClO

To the 20 cc THF and 20 cc Toluene added 0.25 mole 2-ehloro-5-bromo-4′- ethoxydiphenylmethane under argon atmosphere. Cooled the reaction mass to – 78 C. Slowly added n-Butyl lithium (1.9 M in hexane) at – 78 C and stirred for 30 min. Slowly added 20 % Ammonium chloride solution to the reaction mass. Brought the reaction mass to ambient temperature and stirred for 30 min. Settled and separated layers. Extracted the aqueous layer with 50 cc toluene. Washed the combined organic layer with 500 cc brine solution. Distilled out the toluene and charged heptanes, stirred for 2 – 3 hrs at ambient temperature. Filtered the product and dried the product at 45 – 50C under reduced pressure to get 93 % titled compound. Mass: (m+1) 247 m/z found 247.1 1 HPLC purity: 96.33 %

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; HARMAN FINOCHEM LIMITED; KADAM, Vijay Trimbak; SAIKRISHNA; CHOUDHARE, Tukaram Sarjerao; MINHAS, Harpreet Singh; MINHAS, Gurpreet Singh; (26 pag.)WO2016/147197; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461432-23-5, HPLC of Formula: C15H14BrClO

Step 6: (3R, 4S, 5R, 6R) -3, 4, 5-tris (benzyloxy) -6- ( ( (tert-butyldimethylsilyl) oxy) methyl) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) tetrahydro-2H-pyran-2-ol (5f) To a solution of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene (619 mg, 1.91 mmol) in anhydrous PhMe /THF (2:1, 12 mL) was added n-BuLi (2.4M in hexane, 0.8 mL, 1.91 mmol) dropwised at -78under nitrogen. The mixture was stirred at -78for 1 h. A mixture of compound 5e (978 mg, 1.74 mmol) in anhydrous PhMe /THF (2:1, 12 mL) was added dropwise and stirred -78for another 1 h. Then the mixture was increased from -78to -25 , and to the mixture was dropwisely added saturated NH4Cl solution (20mL) and extracted with DCM (3×15 mL) . The organic extracts were dried over MgSO4, and concentrated to produce a residue, which was purified by chromatography (200300 mesh silica gel, eluted with EtOAc/PE 1:3-1:1) to give compound 5f as a pale oil (mainly beta-epimer, 760 mg, 54) LC-MS (ESI) : 826.34 [M+NH4]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; ZHANG, Zhiyuan; HUANG, Shaoqiang; ZHANG, Zhaolan; SU, Yaning; REN, Yan; (73 pag.)WO2016/41470; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

Step 8: (3R, 4R, 5R) -3, 4, 5-tris (benzyloxy) -6- (benzyloxymethyl) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) tetrahydro-2H-pyran-2-ol (19h) To an ice-cold solution of compound 19g (540 mg, 1.0 mmol) in anhydrous THF (10 mL) was added a solution of (4-chloro-3- (4-ethoxybenzyl) phenyl) magnesium bromide in anhydrous THF (10 mL) , which was prepared freshly from 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene (486 mg, 1.5 mmol) and magnesium (54 mg, 2.25 mmol) . The reaction mixture was then allowed to stir at room temperature overnight, then quenched with saturated NH4Cl aqueous solution (10 mL) and extracted with ethyl acetate (2×40 mL) . The combined organic phase was washed with H2O (10 mL) , brine (10 mL) , dried (Na2SO4) , and concentrated to produce a residue, which was purified by column chromatography (200300 mesh silica gel, eluted with EtOAc/PE 1:20-1:10) to give compound 19h as a white solid (150 mg, 20) LC-MS (ESI) : 803.36 [M+NH4]+.

The synthetic route of 461432-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; ZHANG, Zhiyuan; HUANG, Shaoqiang; ZHANG, Zhaolan; SU, Yaning; REN, Yan; (73 pag.)WO2016/41470; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 461432-23-5,Some common heterocyclic compound, 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, molecular formula is C15H14BrClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen protection, in a 250 ml three-necked flask (numbered bottle A) was added 5-bromo-2-chloro-4′-ethoxydiphenylmethane (III-1) (12.5, 0.038 mol), 40 ml of dry tetrahydrofuran. And 80 ml of toluene (dried by chlorination of hydrazine), and the dried ice acetone was cooled to -72 C with stirring, and a 2.5 Mu n-BuLi n-hexane solution (18.4 ml, 0.046 mol) was added dropwise to ensure that the temperature was not higher than -60 C, stir for 30 min. Prepare a 500ml three-neck bottle (No. B), nitrogen protection, add 2,3,4,6-tetra-O-trimethylsilyl-FD-gluconolactone (19.7g, 0.042mol) and 110ml toluene (dried by chlorination of hydrazine), dry ice acetone was cooled to -72V. After the reaction time in the bottle A was reached, the solution in the bottle A was introduced into the bottle B, the reaction was continued for 2 hours at a low temperature, methanesulfonic acid (14.8 g, 0.154 mol) and 110 ml of methanol were added, and the dry ice bath was removed, and the temperature was naturally raised to room temperature. The reaction was overnight. After completion of the reaction, a saturated sodium hydrogencarbonate solution was added to adjust the pH to neutrality. After separation, the aqueous phase was extracted with ethyl acetate. The organic phase was washed once with saturated sodium chloride and dried over anhydrous sodium sulfate. After suction filtration, the solvent was evaporated, and after chromatography, 10.8 g (64.3%) of white foam solids were obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, its application will become more common.

Reference:
Patent; Huarun Shuang He Pharmaceutical Co., Ltd.; Zhai Jianguo; He Yang; Zhu Yingjie; Zhou Yisui; Ma Hongmin; Song Meng; (46 pag.)CN108218928; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461432-23-5, name: 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

Compound 6 5.0g (15.4mmol) was dissolved in 20mL tetrahydrofuran and 40mL of dry toluene was dried in nitrogen atmosphere, cooled to -78 C, n-butyllithium was slowly dropwise added 10.6mL (16.94mmol, 1.6M), was added after -78 C the reaction 0.5 h, then 5mL of dry toluene was slowly added dropwise trimethylchlorosilane dissolved glucose protected lactone, addition was complete the reaction at -78 C 1h, then 10mL of methanesulfonic acid was added 3.0mL (46.2mmol dissolved in methanol ), after the addition the reaction warmed to room temperature for 16 h, after completion of the reaction, the reaction solution was added dropwise with saturated sodium bicarbonate, ethyl acetate (50mL ¡Á 3). the combined organic phases with saturated sodium bicarbonate ¡Á 2, saturated sodium chloride ¡Á 2, dried over anhydrous Na2SO4 dry. Suction filtration to give a yellow oil, toluene / petroleum ether (1:5) was recrystallized to give a pale yellow solid was separated by column chromatography (dichloromethane: methanol = 20) to give 7 as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, and friends who are interested can also refer to it.

Reference:
Patent; CHINA PHARMACEUTICAL UNIVERSITY; HUANG, WENLONG; QIAN, HAI; WANG, XUEKUN; LI, YING; YANG, BAOWEI; LI, ZHENG; (23 pag.)CN103739581; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 461432-23-5, Name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, SMILES is CCOC1=CC=C(CC2=C(Cl)C=CC(Br)=C2)C=C1, in an article , author is Akbari, Mosayeb, once mentioned of 461432-23-5, Safety of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene.

An efficient method is applied for the synthesis of novel 2-(2-chloroquinolin-3-yl)-N-alkylimidazo[1,2-a]pyridin-3-amine derivatives. The method is based on a two-step approach from acetanilide, 2-chloro-3-formyl quinoline, 2-aminopyridine, and isocyanide under mild reaction conditions. In the first step, acetanilide forms 2-chloroquinoline-3-carbaldehyde in the presence of phosphoryl chloride. The synthesized 2-chloroquinoline-3-carbaldehyde takes part in a multicomponent reaction with 2-aminopyridine, and isocyanide in the presence of trimethylsilyl chloride. The reaction is facile and the products are synthesized in high isolated yields under mild reaction conditions.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 461432-23-5, you can contact me at any time and look forward to more communication. Safety of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Electric Literature of 461432-23-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 461432-23-5, Name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, SMILES is CCOC1=CC=C(CC2=C(Cl)C=CC(Br)=C2)C=C1, belongs to chlorides-buliding-blocks compound. In a article, author is Zheng, Xiaohan, introduce new discover of the category.

In this work, a novel zirconium-based metal-organic framework (MOF) composite material, UiO-(OH)(2)@RhB, has been solvothermally prepared with zirconyl chloride octahydrate, 2,5-dihydroxyterephthalic acid, and rhodamine B (RhB) for ratiometric fluorescence sensing of Al3+ ions in an aqueous medium. The luminescence measurement results showed that, at the single excitation wavelength of 420 nm, the fluorescence intensity of the ligand at 500 nm increased significantly in the case of Al3+, while that of RhB at 583 nm changed slightly, together with an apparent color change. Under optimal conditions, UiO-(OH)(2)@RhB exhibited an extraordinary sensitivity (10 nM), good selectivity, and a fast response (2 min) for Al3+. As far as we know, the limit of detection is superior to that of the current reported MOF-based Al(3+)fluorescence sensors. The response mechanism suggested that -OH could capture Al3+ in water through coordination and high electrostatic affinity and achieved turn-on ratiometric fluorescence through the excited-state intramolecular proton transfer process and stable fluorescence of RhB. In addition, this sensor was also applied to actual food samples (grain beans), with the recoveries ranging from 89.08% to 113.61%. Such a turn-on ratiometric fluorescence sensor will provide a constructive strategy for the ultrasensitive detection of Al3+ in practical applications.

Electric Literature of 461432-23-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 461432-23-5.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics