Category: 480438-56-0

Gottumukkala, Aditya L. published the artcileEfficient Formation of Benzylic Quaternary Centers via Palladium Catalysis, HPLC of Formula: 480438-56-0, the publication is ChemSusChem (2013), 6(9), 1636-1639, database is CAplus and MEDLINE.

Pd(O₂CCF₃)₂ and 2,2-bipyridine catalyzed the formation of benzylic quaternary centers from arylboronic acids and β-disubstituted enones. For cyclic substrates, only 1 mol% of palladium is required for full conversion, and a variety of arylboronic acids could be reacted with yields exceeding 90%. 5-Membered cyclic enones were found to be most reactive, followed by 6-membered rings and then 7-membered rings. E.g., reaction of 3-methyl-2-cyclohexenone and PhB(OH)₂ gave 92% I. In the case of acyclic substrates, e.g. (E)-Me₃COCH₂CMe:CHCOMe, 5 mol% Pd was found to be necessary, along with the addition of 20 mol% KSbF6 to afford the highest conversion.

ChemSusChem published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, HPLC of Formula: 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gourdet, Benoit published the artcileRhodium-catalyzed carbometalation of ynamides with organoboron reagents, Product Details of C9H12BClO3, the publication is Tetrahedron (2010), 66(32), 6026-6031, database is CAplus.

In the presence of catalytic [Rh(cod)(MeCN)₂]BF₄, ynamides undergo carbometalation with boronic acids, arylboronic esters, and triarylboroxines. These reactions enable the regio- and stereocontrolled synthesis of multisubstituted enamides. E.g., reaction of 3-(2-phenylethynyl)oxazolidin-2-one with 4-chlorophenylboronic acid gave 65% 3-[(E)-2-(4-chlorophenyl)-2-phenylvinyl]oxazolidin-2-one (I).

Tetrahedron published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Product Details of C9H12BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bernardo, Paul H. published the artcileSynthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1, Recommanded Product: 3-Chloro-4-isopropoxyphenylboronic acid, the publication is Pure and Applied Chemistry (2011), 83(3), 723-731, database is CAplus.

Symposium report presented at the 18th International Conference on Organic Synthesis (ICOS) Bergen, Norway 1-6 August, 2010. A small library of pyridine-based rhodanine analogs of BH-3I-1 [i.e., 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid] was designed, the synthesis of the target compound was achieved using amino acids as starting materials and the products thus obtained were screened against B-cell lymphoma (extra large, Bcl-XL, antiapoptotic protein, inhibitor of apoptosis proteins) and myeloid cell leukemia sequence 1 (Mcl-1) for the ability to displace 5-(carboxy)fluorescein-labeled Bak peptide (Flu-Bak). Differences in selectivity toward Bcl-XL and Mcl-1 were observed and the binding modes of selected compounds were studied further. The results may be useful in designing potent small-mol. inhibitors of Bcl-XL and Mcl-1 as well as selective Mcl-1 inhibitors.

Pure and Applied Chemistry published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Recommanded Product: 3-Chloro-4-isopropoxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Haihua published the artcileControllable access to multi-substituted imidazoles via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions, Formula: C9H12BClO3, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(70), 9745-9748, database is CAplus and MEDLINE.

A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles I [R¹ = Me, CF₃, Ph, etc.; R² = H, Ph, Bn; R³ = H, Me; R⁴ = Ph, 4-FC₆H₄, 2-MeC₆H₄, etc.] via cascade palladium catalyzed C-C coupling followed by intramol. C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield. The protocol was the first report to prepare multi-substituted imidazoles from readily accessible aminoacetonitrile and boronic acid.

Chemical Communications (Cambridge, United Kingdom) published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C19H21N3O3S, Formula: C9H12BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Purohit, Priyank published the artcileC-O Bond Activation by Nickel-Palladium Hetero-Bimetallic Nanoparticles for Suzuki-Miyaura Reaction of Bioactive Heterocycle-Tethered Sterically Hindered Aryl Carbonates, Category: chlorides-buliding-blocks, the publication is ACS Catalysis (2017), 7(4), 2452-2457, database is CAplus.

Ni-Pd binary nanoclusters are reported for the activation of the C-O bond for Suzuki-Miyaura cross-coupling of bioactive heterocycle-tethered sterically hindered aryl carbonates with aryl boronic acids. The reaction does not take place in the presence of either the Pd or Ni salts/complexes or the individual Pd or Ni nanoparticles, indicating ensembling cooperativity between the Pd and Ni nanoparticles in activating the C-O bond.

ACS Catalysis published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seth, Kapileswar published the artcileCooperative Catalysis by Palladium-Nickel Binary Nanocluster for Suzuki-Miyaura Reaction of Ortho-Heterocycle-Tethered Sterically Hindered Aryl Bromides, SDS of cas: 480438-56-0, the publication is Organic Letters (2014), 16(9), 2334-2337, database is CAplus and MEDLINE.

The palladium-nickel binary nanocluster is reported as a new catalyst system for Suzuki-Miyaura cross-coupling of ortho-heterocycle-tethered sterically hindered aryl bromides. The inferior results obtained with the reported Pd/Ni salts/complexes or individual Pd/Ni nanoparticles as catalyst reveal the cooperative catalytic effect of the Pd and Ni nanoparticles in the Pd-Ni nanocluster. The broad substrate scope with respect to variation of the 2-arylbenzoxazole moiety and boronic acids, which offers a means for diversity generation and catalyst recyclability, marks a distinct advantage. E.g., in presence of palladium-nickel binary nanoclusters in DMF, Suzuki-Miyaura cross-coupling of PhB(OH)₂ with sterically hindered aryl bromide (I) gave 80% II.

Organic Letters published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C4H3Cl2N3, SDS of cas: 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Toledo-Sherman, Leticia M. published the artcileDevelopment of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease, Name: 3-Chloro-4-isopropoxyphenylboronic acid, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1159-1183, database is CAplus and MEDLINE.

We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of KMO activity in biochem. and cellular assays and their selectivity against other kynurenine pathway enzymes. We describe the optimization process that led to the identification of a program lead compound with a suitable ADME/PK profile for therapeutic development. We demonstrate that systemic inhibition of KMO in vivo with this lead compound provides pharmacodynamic evidence for modulation of kynurenine pathway metabolites both in the periphery and in the central nervous system.

Journal of Medicinal Chemistry published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C8H19NO, Name: 3-Chloro-4-isopropoxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pattison, Graham published the artcileEnantioselective Rhodium-catalyzed addition of arylboronic acids to alkenylheteroarenes, Synthetic Route of 480438-56-0, the publication is Journal of the American Chemical Society (2010), 132(41), 14373-14375, database is CAplus and MEDLINE.

In the presence of a rhodium complex containing a newly developed chiral diene ligand, alkenes activated by a range of π-deficient or π-excessive heteroarenes engage in highly enantioselective conjugate additions with various arylboronic acids.

Journal of the American Chemical Society published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Synthetic Route of 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karad, Somnath Narayan published the artcileEnantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters, Quality Control of 480438-56-0, the publication is Angewandte Chemie, International Edition (2018), 57(29), 9122-9125, database is CAplus and MEDLINE.

The enantioselective synthesis of highly functionalized chiral cyclopent-2-enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline/nickel complex, and cyclization is enabled by the reversible E/Z isomerization of alkenylnickel species. The general methodol. is also applicable to the synthesis of 1,6-dihydropyridin-3(2H)-ones.

Angewandte Chemie, International Edition published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Quality Control of 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yap, Connor published the artcileEnantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization, Quality Control of 480438-56-0, the publication is Angewandte Chemie, International Edition (2017), 56(28), 8216-8220, database is CAplus and MEDLINE.

Enantioselective nickel-catalyzed arylative cyclizations of substrates containing a Z-allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza- and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by cyclization of the resulting alkenylnickel species onto the allylic phosphate. The reversible E/Z isomerization of the alkenylnickel species is essential for the success of the reactions.

Angewandte Chemie, International Edition published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C7H5ClN2S, Quality Control of 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics