Product Details of 4949-85-3On November 30, 2020 ,《Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds》 appeared in Bioorganic Chemistry. The author of the article were Grytsai, Oleksandr; Valiashko, Oksana; Penco-Campillo, Manon; Dufies, Maeva; Hagege, Anais; Demange, Luc; Martial, Sonia; Pages, Gilles; Ronco, Cyril; Benhida, Rachid. The article conveys some information:
Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity. In the experiment, the researchers used many compounds, for example, 1-(2,5-Dichlorophenyl)thiourea(cas: 4949-85-3Product Details of 4949-85-3)
1-(2,5-Dichlorophenyl)thiourea(cas: 4949-85-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Product Details of 4949-85-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics