Category: 50-84-0

I found the field of Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents published in 2020. Name: 2,4-Dichlorobenzoic acid, Reprint Addresses Yuan, ZG; Jiang, YY (corresponding author), Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen 518055, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTF assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo II inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 50-84-0, If you have any questions, you can contact Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY or send Email.. Name: 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocks. I found the field of Crystallography very interesting. Saw the article Three closely related 1-[(1,3-benzodioxol-5-yl)-methyl]-4-(halobenzoyl)pinerazines: similar molecular structures but different intermolecular interactions published in 2019, Reprint Addresses Yathirajan, HS (corresponding author), Univ Mysore, Dept Studies Chem, Mysuru 570006, India.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

In each of the compounds 1-[(1,3-benzodioxol-5-yl)methyl]-4-(3-fluorobenzoyl)piperazine, C19H19 FN2O3 (I), 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,6-difluorobenzoyl)piperazine, C19H18F2N2O3 (II), and 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,4-dichlorobenzoyl)piperazine, C19H19Cl2N2O3 (III), the piperazine rings adopt a chair conformation with the (1,3-benzodioxol-5-yl)methyl substituent occupying an equatorial site: the five-membered rings are all slightly folded across the O center dot center dot center dot O line leading to envelope conformations. The dihedral angle between the planar amidic fragment and the haloaryl ring is 62.97 (5)degrees in (I) but 77.72 (12)degrees and 75.50 (5)degrees in (II) and (III), respectively. Despite their similarity in constitution and conformation, the supramolecular interactions in (I)-(III) differ: in (I), a combination of C-H center dot center dot center dot O and C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into a three-dimensional framework structure, but there are no hydrogen bonds of any sort in either (II) or (III), although the structure of (III) contains a short Cl center dot center dot center dot Cl contact between inversion-related pairs of molecules.

Category: chlorides-buliding-blocks. Welcome to talk about 50-84-0, If you have any questions, you can contact Mahesha, N; Sagar, BK; Yathirajan, HS; Furuya, T; Haraguchi, T; Akitsu, T; Glidewell, C or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Wu, QF; Zhao, B; Fan, ZJ; Guo, XF; Yang, DY; Zhang, NL; Yu, B; Zhou, S; Zhao, JB; Chen, F in [Wu, Qifan; Zhao, Bin; Fan, Zhijin; Guo, Xiaofeng; Yang, Dongyan; Zhang, Nailou; Yu, Bin; Zhou, Shuang; Zhao, Jiabao; Chen, Fan] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; [Fan, Zhijin] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China published Discovery of Novel Piperidinylthiazole Derivatives As Broad-Spectrum Fungicidal Candidates in 2019, Cited 40. HPLC of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Oxathiapiprolin is one of the best active fungicides discovered for oomycetes control. To develop a fungicide candidate with a broad spectrum of activity, 22 new piperidinylthiazole derivatives were designed and synthesized. Compound 51 showed the best activity against Pseudoperonospora cubensis (Berk. et Curt.) Rostov and Phytophthora infestans in vivo with 100% and 80% of inhibition, respectively, at 1 mg/L, and 72.87% of field efficacy against P. cubensis at 1 g ai/667 m(2) validated these results. Compound 5i exhibited a broad spectrum of excellent activity against Sclerotinia sclerotiorum with EC50 = 0.30 mg/ L (>10 times more active than oxathiapiprolin and azoxystrobin in vitro), good activity against Botrytis cinerea, Cercospora arachidicola, and Gibberella zeae with EC50 of 14.54, 5.57, and 14.03 mg/L in vitro and against P. cubensis and P. infestans with 60% and 30% inhibition rates, respectively, at 1 mg/L in vivo. Mode of action studies by RNA sequencing analysis discovered oxysterol-binding protein (OSBP), chitin synthase (CHS1), and (1,3)-beta-glucan synthase (FKS2) as the potent target of 5i against S. sclerotiorum. Quenching studies validated that OSBP was the same target of both 5i and oxathiapiprolin; it was quenched by both of them. Our studies discovered isothiazole-containing piperidinylthiazole as an OSBP target-based novel lead for fungicide development.

Welcome to talk about 50-84-0, If you have any questions, you can contact Wu, QF; Zhao, B; Fan, ZJ; Guo, XF; Yang, DY; Zhang, NL; Yu, B; Zhou, S; Zhao, JB; Chen, F or send Email.. HPLC of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Synthesis and Cytotoxicity Evaluation of Panaxadiol Derivatives WOS:000505828500001 published article about ANTITUMOR EVALUATION; PROTEIN-LEVELS; GINSENG; SEMISYNTHESIS; APOPTOSIS; CANCER in [Xiao, Shengnan; Lin, Zhe; Wang, Xude; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Red Wine, Shenyang 110016, Liaoning, Peoples R China; [Lu, Jincai] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2020, Cited 24. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. COA of Formula: C7H4Cl2O2

In this study, 13 panaxadiol (PD) derivatives were synthesized via reactions with aromatic compounds and amino acids. Following this, the cytotoxicity of these compounds was evaluated against four cancer cell lines (human hepatoma cells HepG-2, human lung cancer cells A549, human breast cancer cells MCF-7, and human colon cancer cells HCT-116) and one normal cell lines (human gastric epithelial cells GES-1). The results showed that the panaxadiol derivatives 3, 12, and 13 showed significant inhibition of cellular proliferation against cancer cells compared with PD, and the panaxadiol derivative 12 had the lowest IC50 value for A549 (IC50=18.91 +/- 1.03 mu m). For MCF-7 cells, most compounds exhibited good inhibition of cellular proliferation, and the panaxadiol derivative 13 showed the strongest inhibitory effect (IC50=8.62 +/- 0.23 mu m), which significantly increased the cytotoxicity of PD and was stronger than the positive control (mitomycin). For normal cells, all compounds exhibited low or no toxic effects; thus, these derivatives can be used to develop novel antiproliferative agents.

Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Engineering; Environmental Sciences & Ecology; Water Resources very interesting. Saw the article Biodegradation of PCBs in contaminated water using spent oyster mushroom substrate and a trickle-bed bioreactor published in 2020. COA of Formula: C7H4Cl2O2, Reprint Addresses Cajthaml, T (corresponding author), Czech Acad Sci, Inst Microbiol, Videnska 1083, Prague 14220 4, Czech Republic.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Due to their persistence, polychlorinated biphenyls (PCBs) represent a group of important environmental pollutants, but conventional physicochemical decontamination techniques for their removal are usually expensive. The main aim of this work was to develop a cost-effective method for PCB bioremediation, focusing on contaminated water and utilizing the well-known degradation capability of Pleurotus ostreatus (the oyster mushroom). For this purpose, the conditions of several laboratory-scale reactors (working volume 1 L) were optimized. Spent oyster mushroom substrate obtained from a commercial farm was used as a fungal inoculum and growth substrate. The highest degradation efficiency (87%) was recorded with a continuous low-flow setup, which was subsequently scaled up (working volume 500 L) and used for the treatment of 4000 L of real contaminated groundwater containing 0.1-1 mu g/L of PCBs. This trickle-bed pilot-scale bioreactor was able to remove 82, 80, 65, and 30-50% of di-, tri-, tetra- and pentachlorinated PCB congeners, respectively. No degradation was observed for hexa- or heptachlorinated congeners. Multiple mono- and dichlorobenzoic acids (CBAs) were identified as transformation products by mass spectrometry, confirming the role of biodegradation in PCB removal. A Vibrio fischeri bioluminescence inhibition test revealed slight ecotoxicity of the primary reactor effluent (sampling after 24 h), which was quickly suppressed once the effluent passed through the reactor for the second time. Moreover, no other effluent exhibited toxicity for the rest of the experiment (71 days in total). Microbial analyses (phospholipid fatty acid analysis and next-generation sequencing) showed that P. ostreatus was able to degrade PCBs in the presence of an abundance of other fungal species as well as aerobic and anaerobic bacteria. Overall, this study proved the suitability of the use of spent oyster mushroom substrate in a bioremediation practice, even for pollutants as recalcitrant as PCBs. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 50-84-0, If you have any questions, you can contact Sredlova, K; Skrob, Z; Filipova, A; Masin, P; Holecova, J; Cajthaml, T or send Email.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Three closely related 1-[(1,3-benzodioxol-5-yl)-methyl]-4-(halobenzoyl)pinerazines: similar molecular structures but different intermolecular interactions WOS:000457717300021 published article about HYDROGEN-BOND PATTERNS; GRAPH-SET ANALYSIS; ABSOLUTE-STRUCTURE; PHENYLPHOSPHONIC ACID; 4,4′-SULFONYLDIPHENOL; 4,4′-THIODIPHENOL; PIRIBEDIL; ADDUCTS in [Mahesha, Ninganayaka; Sagar, Belakavadi K.; Yathirajan, Hemmige S.] Univ Mysore, Dept Studies Chem, Mysuru 570006, India; [Furuya, Tetsundo; Haraguchi, Tomoyuki; Akitsu, Takashiro] Tokyo Univ Sci, Fac Sci, Dept Chem, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan; [Glidewell, Christopher] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland in 2019, Cited 27. SDS of cas: 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

In each of the compounds 1-[(1,3-benzodioxol-5-yl)methyl]-4-(3-fluorobenzoyl)piperazine, C19H19 FN2O3 (I), 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,6-difluorobenzoyl)piperazine, C19H18F2N2O3 (II), and 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,4-dichlorobenzoyl)piperazine, C19H19Cl2N2O3 (III), the piperazine rings adopt a chair conformation with the (1,3-benzodioxol-5-yl)methyl substituent occupying an equatorial site: the five-membered rings are all slightly folded across the O center dot center dot center dot O line leading to envelope conformations. The dihedral angle between the planar amidic fragment and the haloaryl ring is 62.97 (5)degrees in (I) but 77.72 (12)degrees and 75.50 (5)degrees in (II) and (III), respectively. Despite their similarity in constitution and conformation, the supramolecular interactions in (I)-(III) differ: in (I), a combination of C-H center dot center dot center dot O and C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into a three-dimensional framework structure, but there are no hydrogen bonds of any sort in either (II) or (III), although the structure of (III) contains a short Cl center dot center dot center dot Cl contact between inversion-related pairs of molecules.

SDS of cas: 50-84-0. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Improvements of C-H Radio-Iodination of N-Acylsulfonamides toward Implementation in Clinics WOS:000498564900008 published article about RADIOIODINATION; ARYL; TRACERS in [Dubost, Emmanuelle; Babin, Victor; Benoist, Florian; Hebert, Alexandra; Fabis, Frederic; Cailly, Thomas] Normandie Univ, UNICAEN, CERMN, F-14000 Caen, France; [Pigree, Gilbert; Cailly, Thomas] Normandie Univ, UNICAEN, IMOGERE, F-14000 Caen, France; [Bouillon, Jean-Philippe] Normandie Univ, UNIROUEN, CNRS, INSA Rouen,COBRA UMR 6014, F-76000 Rouen, France; [Cailly, Thomas] CHU Cote Nacre, Dept Nucl Med, F-14000 Caen, France in 2019, Cited 17. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. COA of Formula: C7H4Cl2O2

An improved protocol to perform C-H radio-iodination is described. These new conditions allow rapid and clean formation of radio-iodinated N -acylsulfonamides using [ (125) I]NIS and catalytic amounts of palladium acetate and para -toluenesulfonic acid. No pre-functionalized precursors are required and the products are obtained with radiochemical conversions (RCC) of 27-84%.

Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H4Cl2O2. In 2019 J MED CHEM published article about 20S PROTEASOMES; CRYSTAL-STRUCTURE; IMMUNOPROTEASOME; SITES; YEAST; GENERATION; BORTEZOMIB; MECHANISM; SUBSTRATE; KNOWLEDGE in [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Leiden Inst Chem, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Netherlands Prote Ctr, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Huber, Eva M.; Heinemeyer, Wolfgang; Groll, Michael] Tech Univ Munich, Lehrstuhl Biochem, Dept Chem, Ctr Integrated Prot Sci, D-85748 Garching, Germany; [Driessen, Christoph] Kantonsspital St Gallen, Dept Hematol & Oncol, CH-9007 St Gallen, Switzerland; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Kisselev, Alexei F.] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA in 2019, Cited 43. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the beta 1c, beta 1i, beta 5c, and beta 5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting beta 2c or beta 2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the beta 2c- and beta 2i-selective-compounds LU-002c (4; IC50 beta 2c: 8 nM, IC50 beta 2i/beta 2c: 40-fold) and LU-002i (5; IC50 beta 2i: 220 nM, IC50 beta 2c/beta 2i: 45-fold), respectively. Co-crystal structures with beta 2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of beta 2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.

Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, YM; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019 J HAZARD MATER published article about MODIFIED NICKEL FOAM; WASTE-WATER TREATMENT; TITANIUM CARBIDE; 2,4-DICHLOROPHENOXYACETIC ACID; REDUCTIVE DECHLORINATION; CARBON NANOTUBES; AQUEOUS-SOLUTION; ELECTROCHEMICAL DECHLORINATION; ELECTRODE; NANOPARTICLES in [Lou, Zimo; Li, Yizhou; Zhou, Jiasheng; Yang, Kunlun; Liu, Yuanli; Xu, Xinhua] Zhejiang Univ, Coll Environm & Resource Sci, Dept Environm Engn, Hangzhou 310058, Zhejiang, Peoples R China; [Baig, Shams Ali] Abdul Wali Khan Univ, Dept Environm Sci, Mardan 23200, Pakistan in 2019, Cited 77. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Application In Synthesis of 2,4-Dichlorobenzoic acid

Titanium carbide (TiC) with excellent electrical conductivity, chemical and thermal stabilities has been recognized as one of the most promising electrocatalysts. A novel cathode, titanium carbide doped palladium/nickel foam (TiC-Pd/Ni foam), was synthesized via electroless deposition to improve the performance of Pd/Ni foam in electrocatlytic hydrodechlorination (ECH). TiC can be co-precipitated onto the surface of cathode during galvanic replacement reaction between Pd(II) solution and Ni foam. Both constant potential and constant current tests proved that TiC-Pd/Ni foam cathode performed remarkably higher activity for 2,4-dichlorobenzoic acid (2,4-DCBA) than Pd/Ni foam cathode, owing to the excellent conductivity of TiC and enhanced water dissociation over TiC-Pd/Ni foam cathode. Under the optimized reaction conditions of -0.85 V (vs Ag/AgCl), electrolyte of 10 mM and initial pH of 4, 99.8% of aqueous 2,4-DCBA (0.2 mM) was removed within 90 min. The removal process of the aqueous 2,4-DCBA obeyed first-order decay kinetic model. Over 86.3% of 2,4-DCBA can still be removed by TiC-Pd/Ni foam cathode in the fifth consecutive run within 120 min, which was much higher than that of Pd/Ni foam cathode (37.5%). Consequently, TiC-Pd/Ni foam cathode was a promising design for enhanced ECH activity and reduced operation cost.

Application In Synthesis of 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about ELECTROCHEMICAL DEGRADATION; PALLADIUM NANOPARTICLES; OXYGEN REDUCTION; FOAM ELECTRODES; HYDRODECHLORINATION; CARBON; CATHODE; MECHANISM; 2,4-DICHLOROPHENOL; DECHLORINATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21872009]; Beijing Forestry University Outstanding Young Talent Cultivation Project [2019JQ03007]. Published in ESG in BELGRADE ,Authors: Li, N; Song, XZ; Wang, H. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Formula: C7H4Cl2O2

Dual effects of cathodic dechlorination and oxidative decomposition of 2,4-dichlorobenzoic acid (2,4-DCBA) can be achieved using electrochemical reduction-oxidation technology. The removal efficiency was improved by optimizing the experimental conditions affecting electrode activity and contaminant degradation. The 2,4-DCBA removal efficiency reached 90.8% at a current density at 50 mA.cm(-2), initial pH of 5, and sodium sulfate concentration of 0.05 mol.L-1, with a 2,4-DCBA concentration of 20 mg.L-1. Furthermore, a good total organic carbon removal efficiency of 81.6% was achieved in the electrocatalytic reduction and oxidation process, with the present system retaining high stability after many experiment cycles. The reaction mechanism under different conditions is discussed, which provides new approaches to the degradation of chlorinated organic compounds.

Welcome to talk about 50-84-0, If you have any questions, you can contact Li, N; Song, XZ; Wang, H or send Email.. Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics