Category: 50-84-0

I found the field of Pharmacology & Pharmacy very interesting. Saw the article The Triazole Ring as a Privileged Scaffold for Putative Antifungals: Synthesis and Evaluation of a Series of New Analogues published in 2021. Recommanded Product: 2,4-Dichlorobenzoic acid, Reprint Addresses Zoidis, G (corresponding author), Natl & Kapodistrian Univ Athens, Dept Pharm, Athens 15771, Greece.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

The significant antifungal activity of a series of novel 1,2,4-triazole derivatives against different strains ofCandida albicans,Candida kruseiandAspergillus fumigatus, compared to the commercial fungicides ketoconazole and itraconazole, is reported. Systemic mycosis and invasive fungal infections, whether from immunodeficiency or hospital-acquired infection, have been on an upward trend for several years. The 1,2,4-triazole ring substituted with other aromatic and heteroaromatic systems plays an important role in the field of antifungal drug discovery and development. Thus, an extensive series of 29 triazoles, substituted in different positions with a variety of aromatic rings, has been designed, synthesized, and evaluated for their fungicidal activity. Almost all the agents testedin vitroshowed high activity against all examined fungal strains. It is noteworthy that, in the case ofA. fumigatus, all the examined compounds achieved equal or higher antifungal activity than ketoconazole, but less activity than itraconazole. Among all the derivatives studied, the dichlorourea analogue and bromo-substituted triazole stand out as the most promising compounds. Quantitative structure-activity relationship (QSAR) models were built for a systematic structure-activity relationship (SAR) profile to explain and potentially explore the potency characteristics of 1,2,4-triazole analogues.

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zoidis, G; Kritsi, E; Lecinska, P; Ivanov, M; Zoumpoulakis, P; Sokovic, M; Catto, M or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP in [Wang, Meng-Fan; Hu, Fei-Long; Niu, Zheng; Wang, Hui-Fang; Lang, Jian-Ping] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Wang, Meng-Fan; Mi, Yan; Hu, Fei-Long; Yin, Xian-Hong; Huang, Qin] Guangxi Univ Nationalities, Guangxi Key Lab Chem & Engn Forest Prod, Nanning 530006, Peoples R China published Coordination-Driven Stereospecific Control Strategy for Pure Cycloisomers in Solid-State Diene Photocycloaddition in 2020, Cited 49. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

To obtain a pure product without the isomer byproducts is a goal that many chemists are pursuing. As one kind of very important synthesis method, the photochemical reaction is simple and straightforward yet low-selective. In this work, a coordination interaction based oriented synthesis strategy has been proposed to realize the precise stereochemical control of the isomeric cyclic compounds in the photocycloaddition reaction. Through fixing the reactants via coordination interactions, the arrangements and configurations of the reactants can be adjusted, thereby successfully producing all of the related photocycloaddition products without isomer byproducts for the first time. This work not only provides a new route to synthesize the pure cyclic compounds but also expands the application of the photocycloaddition reaction.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Authors Purkait, A; Jana, CK in GEORG THIEME VERLAG KG published article about DONOR-ACCEPTOR CYCLOPROPANES; ASYMMETRIC ALPHA-AMINOXYLATION; DIELS-ALDER; CYCLOADDITION REACTIONS; ANNULATION REACTION; EFFICIENT APPROACH; CARBONYL-COMPOUNDS; ALDOL SYNTHESIS; ENE REACTION; ONE-POT in [Purkait, Anisha; Jana, Chandan K.] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India in 2019, Cited 76. Quality Control of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Unlike other alkylamines, benzylamines upon reaction with a nitrosoarene undergo oxidation to the corresponding imines. A direct amination of benzylamines, which was difficult to achieve due to its facile oxidation, to the corresponding hydrazones is reported. A wide variety of benzylamines and N-heterocycles were reacted with nitrosoarenes to provide structurally diverse hydrazones and hydrazides, respectively. Moreover, the direct N-amination reaction was applied to the one-pot synthesis of triazoles.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Purkait, A; Jana, CK or concate me.. Quality Control of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. In 2019 J MED CHEM published article about MYOFIBROBLAST DIFFERENTIATION; MURINE MODEL; FIBROSIS; PATHWAY; TISSUE; CYTOSKELETON; CONTRACTION; DERIVATIVES; MECHANISMS; BLEOMYCIN in [Kahl, Dylan J.; Hutchings, Kim M.; Larsen, Scott D.] Univ Michigan, Coll Pharm, Vahlteich Med Chem Core, Ann Arbor, MI 48109 USA; [Wen, Bo; Sun, Duxin] Univ Michigan, Coll Pharm, UM Pharmcokinet Core, Ann Arbor, MI 48109 USA; [Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.] Univ Michigan, Med Ctr, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA; [Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.] Univ Michigan, Med Ctr, Clin Autoimmun Ctr Excellence, Ann Arbor, MI 48109 USA; [Lisabeth, Erika Mathes; Haak, Andrew J.; Leipprandt, Jeffrey R.; Dexheimer, Thomas; Neubig, Richard R.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA; [Bailie, Marc] Michigan State Univ, Vivo Facil, E Lansing, MI 48824 USA in 2019, Cited 47. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Through a phenotypic high-throughput screen using a serum response element luciferase promoter, we identified a novel 5-aryl-1,3,4-oxadiazol-2-ylthiopropionic acid lead inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription with good potency (IC50 = 180 nM). We were able to rapidly improve the cellular potency by 5 orders of magnitude guided by sharply defined and synergistic SAR. The remarkable potency and depth of the SAR, as well as the relatively low molecular weight of the series, suggests, but does not prove, that binding to the unknown molecular target may be occurring through a covalent mechanism. The series nevertheless has no observable cytotoxicity up to 100 mu M. Ensuing pharmacokinetic optimization resulted in the development of two potent and orally bioavailable anti-fibrotic agents that were capable of dose-dependently reducing connective tissue growth factor gene expression in vitro as well as significantly reducing the development of bleomycin-induced dermal fibrosis in mice in vivo.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Kahl, DJ; Hutchings, KM; Lisabeth, EM; Haak, AJ; Leipprandt, JR; Dexheimer, T; Khanna, D; Tsou, PS; Campbell, PL; Fox, DA; Wen, B; Sun, DX; Bailie, M; Neubig, RR; Larsen, SD or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. In 2019 J MED CHEM published article about PLASMODIUM-BERGHEI; CATALYZED AMINATION; CYTOCHROME-B; LIVER-STAGE; MALARIA; VIVAX; CHALLENGES; RESISTANT; PROPHYLAXIS; MUTATIONS in [Dodean, Rozalia A.; Kancharla, Papireddy; Li, Yuexin; Winter, Rolf W.; Riscoe, Michael K.; Kelly, Jane X.] Portland State Univ, Dept Chem, Portland, OR 97201 USA; [Dodean, Rozalia A.; Li, Yuexin; Smilkstein, Martin J.; Pou, Sovitj; Winter, Rolf W.; Riscoe, Michael K.; Kelly, Jane X.] Dept Vet Affairs Med Ctr, Portland, OR 97239 USA; [Melendez, Victor; Read, Lisa; Bane, Charles E.; Vesely, Brian; Kreishman-Deitrick, Mara; Black, Chad; Li, Qigui; Sciotti, Richard J.; Olmeda, Raul; Thu-Lan Luong; Gaona, Heather; Potter, Brittney; Sousa, Jason; Marcsisin, Sean; Caridha, Diana; Xie, Lisa; Vuong, Chau; Zeng, Qiang; Zhang, Jing; Zhang, Ping; Lin, Hsiuling; Butler, Kirk; Roncal, Norma; Gaynor-Ohnstad, Lacy; Leed, Susan E.; Nolan, Christina] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA; [Huezo, Stephanie J.; Rasmussen, Stephanie A.; Cooper, Roland A.] Dominican Univ Calif, Dept Nat Sci & Math, San Rafael, CA 94901 USA; [Stephens, Melissa T.; Tan, John C.] Univ Notre Dame, Genom Core Facil, Notre Dame, IN 46556 USA; [Tan, John C.] Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA in 2019, Cited 53. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-stage activity against both liver stage and blood-stage malaria. Several lead compounds generated from structural optimization of a large library of novel acridones exhibit efficacy in the following systems: (1) picomolar inhibition of in vitro Plasmodium falciparum blood-stage growth against multidrug-resistant parasites; (2) curative efficacy after oral administration in an erythrocytic Plasmodium yoelii murine malaria model; (3) prevention of in vitro Plasmodium berghei sporozoite-induced development in human hepatocytes; and (4) protection of in vivo P. berghei sporozoite-induced infection in mice. This study offers the first account of liver-stage antimalarial activity in an acridone chemotype. Details of the design, chemistry, structure-activity relationships, safety, metabolic/pharmacokinetic studies, and mechanistic investigation are presented herein.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dodean, RA; Kancharla, P; Li, YX; Melendez, V; Read, L; Bane, CE; Vesely, B; Kreishman-Deitrick, M; Black, C; Li, QG; Sciotti, RJ; Olmeda, R; Luong, TL; Gaona, H; Potter, B; Sousa, J; Marcsisin, S; Caridha, D; Xie, LS; Vuong, C; Zeng, Q; Zhang, J; Zhang, P; Lin, HL; Butler, K; Roncal, N; Gaynor-Ohnstad, L; Leed, SE; Nolan, C; Huezo, SJ; Rasmussen, SA; Stephens, MT; Tan, JC; Cooper, RA; Smilkstein, MJ; Pou, S; Winter, RW; Riscoe, MK; Kelly, JX or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2020 INORG CHIM ACTA published article about THERMAL-DECOMPOSITION KINETICS; ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURE; BUILDING UNITS; COMPLEXES; IONS; ACID; 3D; EUROPIUM(III); TERBIUM(III) in [Zhang, Ju-Wen; Wang, Cen-Ru; Liu, Wen-Hua; Xu, Shuang; Liu, Bin-Qiu] Bohai Univ, Dept Chem, Jinzhou 121013, Peoples R China; [Zhang, Ju-Wen] Bohai Univ, Coll Chem & Chem Engn, Profess Technol Innovat Ctr Liaoning Prov Convers, Jinzhou 121013, Peoples R China in 2020, Cited 57. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Recommanded Product: 2,4-Dichlorobenzoic acid

Ln(NO3)(3)center dot nH(2)O reacted with 2,4-dichlorobenzoic acid (2,4-HDCB) and NaOH under solvothermal conditions of water and ethanol to yield four lanthanide-organic coordination polymers (CPs) [Eu(2,4-DCB)(3)(CH3CH2OH)(2)] (1) and [Ln(2,4-DCB)(3)(H2O)] [Ln = Gd (2), Tb (3), Dy (4)]. The second ligand 4,4′-bipyridine (4,4′-bpy) was introduced into the above reaction systems to provide four new lanthanide-organic CPs [Ln(2)(2,4-DCB)(6)(4,4′-bpy)(H2O)(2)] [Ln = Eu (5), Gd (6), Tb (7), Dy (8)]. Single-crystal and powder X-ray diffraction analyses reveal that CPs 1 and 2 possess similar one-dimensional (1D) structures, and CPs 2-4 and 5-8 are isostructural, respectively. In 1-4, the 2,4-DCB anions bridge the Ln(III) ions to form a 1D chain. In 5-8, six 2,4-DCB anions link two Ln(III) ions into a binuclear Ln(2)(2,4-DCB)(6) unit, and the Ln(2)(2,4-DCB)(6) units are further connected by the 4,4′-bpy co-ligands to generate a 1D chain. The photoluminescent and magnetic properties of 1-8 were investigated.

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhang, JW; Wang, CR; Liu, WH; Xu, S; Liu, BQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Li, N; Song, XZ; Wang, L; Geng, XL; Wang, H; Tang, HY; Bian, ZY in [Li, Ning; Song, Xiaozhe; Wang, Li; Geng, Xinle; Wang, Hui] Beijing Forestry Univ, Coll Environm Sci & Engn, Beijing 00083, Peoples R China; [Tang, Hanyu; Bian, Zhaoyong] Beijing Normal Univ, Coll Water Sci, Beijing 100875, Peoples R China published Single-Atom Cobalt Catalysts for Electrocatalytic Hydrodechlorination and Oxygen Reduction Reaction for the Degradation of Chlorinated Organic Compounds in 2020, Cited 55. COA of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Electrochemical reduction-oxidation processes with the aid of cathode catalysts are promising technologies for the decomposition of organic compounds. High-efficiency and low-cost catalysts for electrochemical reductive dechlorination and two-electron oxygen reduction reaction (ORR) are vital to the overall degradation of chlorinated organic compounds. This study reports electrochemical dechlorination using a single-atom Co-loaded sulfide graphene (Co-SG) catalyst via atomic hydrogen generated from the electrochemical reduction of H2O and electrolysis of hydrogen. The Co-SG electrocatalyst exhibited a remarkable performance for H2O2 synthesis with a half-wave potential of 0.70 V (vs RHE) and selectivity over 90%. The high electrochemical performance was achieved for bifunctional electrocatalysis with regard to the smaller overpotentials, faster kinetics, and higher cycling stability compared to the noble metal-based electrocatalysts. In this study, 2,4-dichlorobenzoic acid was well degraded and the TOC concentration was effectively reduced. This work introduces the preparation of a new active site for high-performance single-atom catalysts and also promotes its application in the electrochemical degradation of chlorinated organic pollutants.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Li, N; Song, XZ; Wang, L; Geng, XL; Wang, H; Tang, HY; Bian, ZY or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry; Engineering very interesting. Saw the article Electrocatalytic dechlorination of 2,4-dichlorobenzoic acid using different carbon-supported palladium moveable catalysts: Adsorption and dechlorination activity published in 2019. Computed Properties of C7H4Cl2O2, Reprint Addresses Xu, XH (corresponding author), Zhejiang Univ, Dept Environm Engn, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China.; Xu, J (corresponding author), Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

In the present study, carbon black (CB), multi walled carbon nanotubes (MWCNTs), and granular activated carbon (GAC) were employed to support palladium (Pd) catalyst. The prepared Pd/CB, Pd/MWCNTs and Pd/GAC moveable catalysts were aimed to address the common issues (easy loss of catalyst and poor long-term performance) of normal fixed catalysts. The results of various characterizations (e.g., TEM, XRD, and XPS) clearly show that the Pd nanopartides were successfully loaded onto the carbon-supports, especially CB and MWCNTs. And more importantly, the morphologies, Pd distribution, and chemical structure of these moveable catalysts were almost not changed after 3 h reaction. The moveable Pd/CB, Pd/MWCNTs, and Pd/GAC catalysts had good reactivity for 2,4-dichlorobenzoic acid (2,4-DCBA) dechlorination, and Pd/CB exhibited the best performance. The Pd/CB also shows the best adsorption capacity of 2,4-DCBA and dechlorination product (benzoic acid, BA), and the adsorption of BA was significantly inhibited in the presence of current due to the repulsion between the both negatively charged compounds and adsorbents. The removal of 2,4-DCBA and the generation rate of BA was improved with a pre-adsorption process, which was a promising strategy with higher dechlorination rate and shortened electrolysis time. Moreover, the loss of Pd catalyst was negligible during the 10 consecutive cycles experiment, and the improved longevity could be expected. These results suggested the good reactivity, stability, and reusability of moveable Pd/CB catalyst.

Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, JS; Lou, ZM; Yang, KL; Xu, J; Li, YZ; Liu, YL; Baig, SA; Xu, XH or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about SYNERGIST, Saw an article supported by the BASF CanadaBASF; Natural Sciences and Engineering Research Council of Canada CRD programNatural Sciences and Engineering Research Council of Canada (NSERC) [CRDPJ417954-1]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Carballo-Arce, AF; Raina, V; Liu, SQ; Liu, R; Jackiewicz, V; Carranza, D; Arnason, JT; Durst, T. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Quality Control of 2,4-Dichlorobenzoic acid

Synthesis of 50 analogues of the natural insecticide synergists, dillapiol and sesamol, is reported. These were evaluated as potential insecticide synergists based on their inhibition of human CYP3A4. The most potent inhibitors have a relatively large hydrophobic substituent at either position 5 or 6 of these molecules. For example, 5-(benzyloxy)-6-(3-phenylsulfonyl)propyl)benzo[d] [1,3]dioxole (18) and the diphenyl acetate of (6,7-dimethoxybenzo[d] [1,3]dioxol-5-yl)propan-1-ol (5n) show inhibitory concentrations for 50% activity IC50 values of 0.086 and 0.2 mu M, respectively. These compounds are 106 and 46 times more potent than dillapiol whose IC50 for the inhibition of CYP3A4 is 9.2 mu M. The ortho-chloro analogue (8f), whose activity is 86 times the activity of dillapiol, is the most potent of the fourteen 5-(benzyloxy-6-(2-propenyl)benzo[d][1,3]dioxoles prepared for this study.

Quality Control of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Carballo-Arce, AF; Raina, V; Liu, SQ; Liu, R; Jackiewicz, V; Carranza, D; Arnason, JT; Durst, T or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples WOS:000488136700013 published article about NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SENSITIVE FLUORESCENCE DETERMINATION; COLUMN-SWITCHING TECHNIQUE; TANDEM MASS-SPECTROMETRY; METAL-ORGANIC FRAMEWORK; SOLID-PHASE EXTRACTION; ION CHROMATOGRAPHY; HUMAN SERUM; HPLC in [Muhammad, Nadeem; Cui, Hairong] Wuchang Univ Technol, Dept Environm Engn, Wuhan, Hubei, Peoples R China; [Muhammad, Nadeem; Guo, Dandan; Zhang, Yun; Subhani, Qamar] Zhejiang Univ, Dept Chem, Xixi Campus, Hangzhou 310028, Zhejiang, Peoples R China; [Guo, Dandan] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China; [Intisar, Azeem; Qadir, Muhammad Abdul] Univ Punjab, Inst Chem, Lahore, Pakistan; [Subhani, Qamar] Higher Educ Dept, Lahore, Punjab, Pakistan in 2019, Cited 46. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Analysis of acidic pharmaceuticals in complex biological samples is a challenging and formidable task due to the existence of interfering constituents within the sample matrices. Therefore, in order to avoid analytical column clogging and suppression/enhancement of signals of the analyte of interest, herein a simple, cost-effective and quick online ion chromatography based clean-up setup was introduced. This system was further coupled with a cost-effective homemade photochemically induced fluorimetric (PIF) setup for direct online conversion of non fluorescent acidic pharmaceutical drugs into their respective fluorescent species. This advantageous system was favorably applied for the determination of four non-fluorescent acidic compounds in two complex biological samples (human serum and oral fluid) with minimum labor and organic solvent consumption. At optimized conditions, the developed method has shown good sensitivity, selectivity, satisfactory recoveries (88.68-102.14%) and low limits of detection (0.35-8.10 mu g/L) with minimum or zero matrix effect.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Muhammad, N; Guo, DD; Zhang, Y; Intisar, A; Subhani, Q; Qadir, MA; Cui, HR or concate me.. Computed Properties of C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics