Category: 50-84-0

I found the field of Archaeology; Art; Chemistry; Spectroscopy very interesting. Saw the article Crystalline Deposits in New Display Cases at the Rijksmuseum: Characterisation and Origin published in 2021. HPLC of Formula: C7H4Cl2O2, Reprint Addresses van Iperen, J (corresponding author), Rijksmuseum, Conservat & Sci Dept, Museumstr 1,Postbus 74888, NL-1070 DN Amsterdam, Netherlands.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

An unusual phenomenon occurred in new display cases at the Rijksmuseum four months after their installation in April 2013. White deposits were visible on glass windows, silicone door gaskets, black structural adhesive seals, and on works of art. The works of art most affected by these deposits were bronze sculptures, wooden and waxed objects, tempera, and oil paintings. In this study the deposits were chemically characterised using (pyrolysis-)gas chromatography-mass spectrometry ((Py-)GC-MS), mu-Raman spectroscopy (mu-Raman), ion chromatography (IC), and scanning electron microscopy combined with energy dispersive X-ray spectroscopy (SEM-EDX). Five chemically different crystalline deposits were found. They were identified as organic salts of the base 2,2,6,6-tetramethyl-4-piperidinol (TMP-ol), a secondary amine, and five different carboxylic acids. It was found that TMP-ol, which is part of the UV-light stabiliser Tinuvin-770, emitted from the structural adhesive Terostat-9220. Terostat-9220 was used in large quantities in the display cases to adhere glass windows to metal parts. The carboxylic acids derived from both construction materials used to build the cases and from conservation materials present on the exhibited works of art. The carboxylic acids involved were 2,4-dichlorobenzoic acid, formic acid, methacrylic acid, palmitic acid, and an unknown carboxylic acid, respectively emitted from peroxide-cured silicone gaskets, panels of medium-density fibreboard (MDF), UV-adhesive, beeswax containing products, and from an unknown acidic conservation product or binding medium. The identification of the crystalline deposits was supported by their syntheses in the laboratory. Since 2013, similar deposits have been observed in a number of museum collections worldwide. A treatment for preventing further growth of the deposits was developed and applied in the Rijksmuseum showcases.

HPLC of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact van Iperen, J; van Keulen, H; Keune, K; Abdulah, K; van Langh, R or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents WOS:000536458600001 published article about OXIDATIVE STRESS; DESIGN; RESVERATROL; HESPERIDIN in [Zheng, Xian-Jing; Song, Ze-Wen; Bai, Xue-Qian; Liang, Cheng-Wu; Wang, Hui-Yan; Zhang, Tian-Yi] Jilin Med Univ, Jilin 132013, Jilin, Peoples R China; [Li, Chun-Shi; Cui, Ming-Yue] Third Peoples Hosp Dalian, Dalian 116000, Liaoning, Peoples R China; [Zheng, Xian-Jing; Song, Ze-Wen] Yanbian Univ, Dept Pharm, Yanji 133002, Jilin, Peoples R China in 2020, Cited 26. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Recommanded Product: 50-84-0

Twenty benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety were synthesized and evaluated for their anti-oxidant and anti-inflammatory activities. Among these compounds, 8h and 81 were appeared to have high radical scavenging efficacies as 0.05 +/- 0.02 and 0.07 +/- 0.03 mmol/L of IC50, values in ABTS(+center dot) bioassay, respectively. In anti-inflammatory tests, compound 8h displayed good activity with 57.35% inhibition after intraperitoneal administration, which was more potent than the reference drug (indomethacin). Molecular modeling studies were performed to investigate the binding mode of the representative compound 8h into COX-2 enzyme. In vitro enzyme study implied that compound 8h exerted its anti-inflammatory activity through COX-2 inhibition.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zheng, XJ; Li, CS; Cui, MY; Song, ZW; Bai, XQ; Liang, CW; Wang, HY; Zhang, TY or concate me.. Recommanded Product: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Two kinds of 2,4-dichlorobenzoate-based lanthanide coordination polymers tuned by 4,4 ‘-bipyridine: Syntheses, structures, photoluminescence, and magnetism WOS:000531818500011 published article about THERMAL-DECOMPOSITION KINETICS; ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURE; BUILDING UNITS; COMPLEXES; IONS; ACID; 3D; EUROPIUM(III); TERBIUM(III) in [Zhang, Ju-Wen; Wang, Cen-Ru; Liu, Wen-Hua; Xu, Shuang; Liu, Bin-Qiu] Bohai Univ, Dept Chem, Jinzhou 121013, Peoples R China; [Zhang, Ju-Wen] Bohai Univ, Coll Chem & Chem Engn, Profess Technol Innovat Ctr Liaoning Prov Convers, Jinzhou 121013, Peoples R China in 2020, Cited 57. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Name: 2,4-Dichlorobenzoic acid

Ln(NO3)(3)center dot nH(2)O reacted with 2,4-dichlorobenzoic acid (2,4-HDCB) and NaOH under solvothermal conditions of water and ethanol to yield four lanthanide-organic coordination polymers (CPs) [Eu(2,4-DCB)(3)(CH3CH2OH)(2)] (1) and [Ln(2,4-DCB)(3)(H2O)] [Ln = Gd (2), Tb (3), Dy (4)]. The second ligand 4,4′-bipyridine (4,4′-bpy) was introduced into the above reaction systems to provide four new lanthanide-organic CPs [Ln(2)(2,4-DCB)(6)(4,4′-bpy)(H2O)(2)] [Ln = Eu (5), Gd (6), Tb (7), Dy (8)]. Single-crystal and powder X-ray diffraction analyses reveal that CPs 1 and 2 possess similar one-dimensional (1D) structures, and CPs 2-4 and 5-8 are isostructural, respectively. In 1-4, the 2,4-DCB anions bridge the Ln(III) ions to form a 1D chain. In 5-8, six 2,4-DCB anions link two Ln(III) ions into a binuclear Ln(2)(2,4-DCB)(6) unit, and the Ln(2)(2,4-DCB)(6) units are further connected by the 4,4′-bpy co-ligands to generate a 1D chain. The photoluminescent and magnetic properties of 1-8 were investigated.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhang, JW; Wang, CR; Liu, WH; Xu, S; Liu, BQ or concate me.. Name: 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ in [Dong, Lili; Shen, Shengqiang; Lu, Huizhe; Xu, Dongdong; Jin, Shuhui; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Appl Chem, Beijing, Peoples R China; [Chen, Wei; Yang, Qing] Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China published Glycosyl triazoles as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations in 2019, Cited 36. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

The insect enzyme GH20 beta-N-acetyl-D-hexosaminidase OfHex1 represents an important chitinolytic enzyme found in the agricultural pest Ostrinia furnacalis (Guenee) and inhibition of this enzyme has been considered a promising strategy for the development of eco-friendly pesticides. In this article, based on the structure of the catalytic domains of OfHex1, a series of novel glycosyl triazoles were designed and synthesized via Cu-catalyzed azide-alkyne [3+ 2] cycloaddition reaction. To investigate the potency and selectivity of these glycosyl triazoles, the inhibition activities towards OfHex1 and HsHexB (human beta-N-acetylhexosaminidase B) were studied. Particularly compound 17c (OfHex1, K-i= 28.68 mu M; HsHexB, K-i > 100 mu M) exhibited a suitable activity and selectivity against OfHex1. Furthermore, the possible inhibitory mechanisms of 17c with OfHex1 were studied using molecular docking and MD simulations. The structure-activity relationship results as well as the formed binding patterns may provide promising insights into the further development of novel OfHex1 inhibitors.

Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about KINETIC DIASTEREOSELECTIVE ACYLATION; ALKYLATING-AGENTS; GLYCOSYL DONORS; IN-VITRO; GLUCURONIDES; DERIVATIVES; OXIDATION; GLUCOSIDES; DELIVERY; ESTERS, Saw an article supported by the CNRSCentre National de la Recherche Scientifique (CNRS)European Commission; University Paris-Sud; ANRFrench National Research Agency (ANR) [ANR-15-CE29-0002]; Ligue Contre le Cancer through an Equipe Labellisee 2014 grant; Algerian Ministry of Education and Research; [ANR-10-LABX-33]. Recommanded Product: 50-84-0. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bennai, N; Chabrier, A; Fatthalla, MI; Tran, C; Yen-Pon, E; Belkadi, M; Alami, M; Grimaud, L; Messaoudi, S. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

We have discovered a new mode of reactivity of 1-thiosugars in the presence of Cu(II) or Co(II) for a stereoselective O-glycosylation reaction. The process involves the use of a catalytic amount of Cu(acac)(2) or Co(acac)(2) and Ag2CO3 as an oxidant in alpha,alpha,alpha-trifluorotoluene. Moreover, this protocol turned out to have a broad scope, allowing the preparation of a wide range of complex substituted O-glycoside esters in good to excellent yields with an exclusive 1,2-trans-selectivity. The late-stage modification of pharmaceuticals by this method was also demonstrated. To obtain a closer insight into the reaction mechanism, cyclic voltammetry was performed.

Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Bennai, N; Chabrier, A; Fatthalla, MI; Tran, C; Yen-Pon, E; Belkadi, M; Alami, M; Grimaud, L; Messaoudi, S or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Quality Control of 2,4-Dichlorobenzoic acid. I found the field of Chemistry very interesting. Saw the article Oxidative C-H Acyloxylation of Acetone with Carboxylic Acids under Iodine Catalysis published in 2021, Reprint Addresses Zhou, XY (corresponding author), Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

Iodine-catalyzed oxidative C(sp(3))-H acyloxylation of acetone with carboxylic acids has been developed. The method employs iodide-as catalyst and sodium chlorite as oxidant. Substituted benzoic acids, naphthoic acids and heteroaromatic carboxylic acids can be used, and 2-oxopropyl carboxylates are obtained with good to excellent yields.

Quality Control of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, XY; Chen, X or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2020 RSC ADV published article about MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL EVALUATION; IN-VITRO; DOCKING; ANALOGS in [Srinivasarao, Singireddi; Nandikolla, Adinarayana; Suresh, Amaroju; Aggarwal, Himanshu; Sekhar, Kondapalli Venkata Gowri Chandra] Birla Inst Technol & Sci, Dept Chem, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Calster, Kevin Van; De Voogt, Linda; Cappoen, Davie] Univ Ghent, Fac Biosci Engn, Dept Green Chem & Technol, Coupure Links 653, B-9000 Ghent, Belgium; [Ghosh, Balaram] Birla Inst Technol & Sci, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Murugesan, Sankaranarayanan] Birla Inst Technol & Sci, Dept Pharm, Med Chem Res Lab, Pilani 333031, Rajasthan, India in 2020, Cited 34. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Quality Control of 2,4-Dichlorobenzoic acid

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among the tested compounds, five compounds (6a, 6e, 6h, 6j and 6k) from Series-I and one compound (7e) from Series-II exhibited significant activity against Mycobacterium tuberculosis H37Ra with 50% inhibitory concentrations (IC50) ranging from 1.35 to 2.18 mu M. To evaluate the efficacy of these compounds, we examined their IC90 values. Five of the most active compounds were found to be more active with IC(90)s ranging from 3.73 to 4.00 mu M and one compound (6e) showed an IC90 of 40.32 mu M. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.

Quality Control of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Srinivasarao, S; Nandikolla, A; Suresh, A; Van Calster, K; De Voogt, L; Cappoen, D; Ghosh, B; Aggarwal, H; Murugesan, S; Sekhar, KVGC or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2,4-Dichlorobenzoic acid. Recently I am researching about SOLUBLE MICROBIAL PRODUCTS; POLYCYCLIC AROMATIC-HYDROCARBONS; MOLECULAR-WEIGHT; EXCITATION; SMP; IDENTIFICATION; SPECTROSCOPY; FRACTIONS; SPECTRA; FENTON, Saw an article supported by the Natural Science of Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51608350, 51478291]; Mega-Projects of Science Research for Water Environment improvement [2015ZX07203]. Published in HARD in OLSZTYN 5 ,Authors: Wang, D; Wang, C; Ji, M; Sun, LP; Qiu, CS; Lo, SL. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

In this study, the transformation characteristics of fluorescent dissolved organic matter (FDOM) were investigated to characterize the removal of dissolved organic matter (DOM) during biological treatment of commingled chemical industrial wastewater. The results of fluorescence excitation and emission spectroscopy and parallel factor analysis revealed three components (C1, C2, and C3) of FDOM, which were related not only to surface and sewage sources but also chemical industrial wastewater sources. Resin fractionation results showed that the removal of DOM was affected not only by substrate biodegradability but also by DOM generation, such as intermediates, end products, and soluble microbial products, during biological treatment. However, the same variation tendency between DOM and FDOM, based on molecular weight (MW) distribution, was observed during MW fractionation. The changes in DOM in MW>10 kDa fraction apparently corresponded with C2 variation; the tendency of DOM removal in MW of 0.5-10 kDa fraction was possibly related to the evolutions of all three components; and lastly, the removal of DOM in MW<0.5 kDa fraction was found in accordance with C1 and C3 transformations. The removal and transformation of DOM and FDOM were investigated using gas chromatography-mass spectrometer and Fourier transform infrared spectroscopy. Application In Synthesis of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Wang, D; Wang, C; Ji, M; Sun, LP; Qiu, CS; Lo, SL or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H4Cl2O2. Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ in [Chen, Bin; Wu, Ronghui; Jin, Shouwen; Bai, Liqun] Zhejiang A&F Univ, Linan 311300, Peoples R China; [Chen, Bin; Lin, Zhihao; Jin, Shouwen; Dong, Lingfeng; Xu, Weiqiang] Zhejiang A&F Univ, Jiyang Coll, Zhuji 311800, Zhejiang, Peoples R China; [Wang, Daqi] Liaocheng Univ, Dept Chem Engn, Liaocheng 252059, Shandong, Peoples R China published Nine Supramolecular Adducts of 4-dimethylaminopyridine and Carboxylic acids Assembled by Classical Hydrogen Bonds and Other Noncovalent Intermolecular Interactions in 2021, Cited 86. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Cocrystallization of the widely available 4-dimethylaminopyridine, with a series of carboxylic acids gave nine molecular adducts 4-dimethylaminopyridinium trifluoroacetate (1) , 4-dimethylaminopyridinium glycolate glycolic acid (2) , 4-dimethylaminopyridinium 2-furoate dihydrate (3) , tri(4-dimethylaminopyridinium) tri(o-chlorobenzoate) tetrahydrate (4) , 4-dimethylaminopyridinium 4-bromobenzoate 4-bromobenzoic acid (5) , 4-dimethylaminopyridinium 4-formylbenzoate 4-formylbenzoic acid (6) , 4-dimethylaminopyridinium 2,4-dichlorobenzoate (7) , 4-dimethylaminopyridinium 2-aminobenzoate 2-aminobenzoic acid (8) and bis(4-dimethylaminopyridinium) 5-nitroisophthalate 5-nitroisophthalic acid methanol solvate (9) . The nine adducts have been characterised by X-ray diffraction, IR and elemental analysis, the melting points were also reported. Their structural and supramolecular aspects are fully analyzed. The result reveals that among the nine investigated crystals only the ring Ns in the 4-dimethylaminopyridine moieties are protonated when the carboxylic acids are deprotonated. The crystal packing is interpreted by the strong charge-assisted N-H center dot center dot center dot O hydrogen bond between the NH+ and the deprotonated acidic groups. Except the N-H center dot center dot center dot O hydrogen bonds, the charge assisted or neutral O-H center dot center dot center dot O hydrogen bonds were also found at 2-6, 8 and 9 . The COOH center dot center dot center dot COO- synthon has been at 2, 5-6 and 8-9. Further analysis of the crystal packing indicated that a different family of additional CH-O/CH2-O/CH3-O, F-F, Br-Br, CH-Cl, CH3-Cl, CH-pi/CH3-pi, C-H center dot center dot center dot C-pi, C-pi, Cl-O, O-C, O-pi and pi-pi contacts contribute to the stabilization and expansion of the total high-dimensional (2D-3D) framework structures. For the synergism of the various nonbonding contacts there created homo/hetero supramolecular synthons or both. (C) 2021 Elsevier B.V. All rights reserved.

HPLC of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2,4-Dichlorobenzoic acid. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers published in 2020, Reprint Addresses Lee, S (corresponding author), Korea Inst Sci & Technol, Brain Sci Inst, Seoul, South Korea.; Kim, E (corresponding author), Ajou Univ, Dept Mol Sci & Technol, Suwon, South Korea.; Babu, KS (corresponding author), Sri Krishnadevaraya Univ, Dept Chem, Anantapur, Andhra Pradesh, India.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-molecule IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. In this study, we assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To investigate structure-activity relationship, we designed and synthesized a series of ARP analogues and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 5i was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. Our results suggested a beneficial therapeutic potential of 5i as an anti-viral agent.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chu, Y; Reddy, BRS; Gajulapalli, VPR; Babu, KS; Kim, E; Lee, S or concate me.. Application In Synthesis of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics